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Increased incidence of chemoport-related thrombosis in patients with colorectal cancer receiving bevacizumab: A single-institutional experience

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Chinese Journal of Cancer Research 2018年第4期30卷 460-467页

作者： jwa hoon kim Jeong Eun kim Yong Sang Hong Sun Young kim Kyu-pyo kim Ki Eun Choi Ji hoon Shin Tae Won kim Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

Objective： Chemoport-related thrombosis （CRT） is a serious complication that causes morbidities and interruptsadministration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer（CRC） patients treated with bevacizumab （BEV）.Methods： We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEVusing a chemoport between 2014 and ***： The participants had a median age of 58 （18-85） years, and 60.3% were male. All participants werestratified into three groups： adjuvant chemotherapy （AC）（n=670）, palliative chemotherapy （PC） without BEV（n=356）, and PC with BEV （n=508）. The median follow-up was 20.19 （interquartile range, 14.07-27.19） *** occurred in 3.8% of all patients; incidence of symptomatic and asymptomatic CRT was 2.9% and 0.9%,respectively. CRT occurred more in patients with BEV （5.7%） than in patients without BEV （2.9%, P=0.008）. Thecumulative incidence of CRT in patients administered PC with BEV was significantly higher than that in thoseadministered AC （P=0.011） and there was a trend toward increased CRY in patients administered PC with BEVcompared with those administered PC without BEV （P=0.044）. Multivariate analysis found that BEV treatment wasthe only variable that was significandy associated with CRT （hazard ratio, 2.06; 95% confidence interval, 1.24-3.43;P=0.006）.Conclusions： BEV treatment was significandy associated with increased incidence of CRT in CRC patients.

关键词： Bevacizumab central venous catheters thrombosis colorectal neoplasms

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Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors——8 cases: A case report

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World Journal of Gastroenterology 2019年第16期25卷 2010-2018页

作者： jwa hoon kim Min-Hee Ryu Young Soo Park Hyun Jin kim Hyojung Park Yoon-Koo Kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Pathology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

BACKGROUND Intra-abdominal desmoid tumors(DTs) can mimic recurrence or progression of gastrointestinal stromal tumors(GISTs). Differential diagnosis is important to avoid unnecessary or inappropriate *** SUMMARY All 8 patients experienced surgical resection of GIST, and median time to diagnosis of DT was 1.8 years after surgical resection. All sites of DT were in the peritoneum around the surgical sites of GIST. The following clinical suspicion coupled with radiological findings contributed to the suspicion of intraabdominal DTs:(1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST;(2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib;(3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and(4) a lesion showing mild or no hypermetabolic activity on 18 fluorodeoxyglucose-positron emission tomography,contrary to initially hyperactive lesion of GIST. All DTs were surgically removed except for one unresectable DT and only one DT recurred at another site of peritoneum, which was also surgically *** Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST.

关键词： Desmoid tumor Gastrointestinal stromal tumor Radiology Surgicalresection Imatinib mesylate Case report

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee kim Rudolph ETanzi Se hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Proton-pump inhibitors for prevention of upper gastrointestinal bleeding in patients undergoing dialysis

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World Journal of Gastroenterology 2015年第16期21卷 4919-4924页

作者： Young Rim Song Hyung Jik kim jwa-Kyung kim Sung Gyun kim Sung Eun kim Division of Nephrology Department of Internal MedicineHallym University Sacred Heart HospitalKidney Research InstituteHallym University College of Medicine Division of Gastroenterology Department of Internal MedicineHallym University Sacred Heart Hospital

AIM:To investigate the preventive effects of low-dose proton-pump inhibitors(PPIs) for upper gastrointestinal bleeding(UGIB) in end-stage renal ***:This was a retrospective cohort study that reviewed 544 patients with end-stage renal disease who started dialysis at our center between 2005 and *** examined the incidence of UGIB in 175 patients treated with low-dose PPIs and 369 patients not treated with PPIs(control group).RESULTS:During the study period, 41 patients developed UGIB, a rate of 14.4/1000 *** mean time between the start of dialysis and UGIB events was 26.3 ± 29.6 *** occurred in only two patients in the PPI group(2.5/1000 person-years) and in 39 patients in the control group(19.2/1000 person-years).Kaplan-Meier analysis of cumulative non-bleeding survival showed that the probability of UGIB was significantly lower in the PPI group than in the control group(log-rank test, P < 0.001).Univariate analysis showed that coronary artery disease, PPI use, anti-coagulation, and anti-platelet therapy were associated with *** adjustments for the potential factors influencing risk of UGIB, PPI use was shown to be significantly beneficial in reducing UGIB compared to the control group(HR = 13.7, 95%CI:1.8-101.6; P = 0.011).CONCLUSION:The use of low-dose PPIs in patients with end-stage renal disease is associated with a low frequency of UGIB.

关键词： Dialysis End-stage renal disease Pepticulcer Gastrointestinal hemorrhage Proton pumpinhibitors

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Combination Treatment with Herbal Medicines and Western Medicines in Atopic Dermatitis:Benefits and Considerations

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Chinese Journal of Integrative Medicine 2016年第5期22卷 323-327页

作者： Jung-hoon kim Hyungwoo kim Division of Pharmacology School of Korean MedicinePusan National University

Herbal medicines （HMs） are often used in combination with Western medicines （WMs） to improve therapeutic efficacies of orthodox medicines. This review discussed the current status of combination treatment with HMs and WMs in clinical practices. The influence of HMs on bioavailability of WMs was also discussed from the pharmacokinetic point of view. In addition, benefits and considerations of combination treatment were discussed using data obtained from clinical trials and randomized controlled trials of HMs treatment in skin diseases.

关键词： combination treatment herbal medicine atopic dermatitis psoriasis pharmacokinetics

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Successful living donor liver transplantation with a graft-to-recipient weight ratio of 0.41 without portal flow modulation:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5414-5419页

作者： Seong hoon kim Center for Liver Cancer National Cancer CenterGoyang 10408GyeonggidoSouth Korea

BACKGROUND There have been numerous efforts to lower the limit of minimum graft size to meet the metabolic demand of recipients in adult-to-adult living donor liver transplantation(LDLT).We experienced a successful case of LDLT using a verysmall-for-size graft without portal flow modulation such as splenectomy or portocaval *** SUMMARY A 49-year-old man(weighing 91 kg)suffering hepatocellular carcinoma accompanied with hepatitis B virus related cirrhosis underwent *** one and only voluntary donor was his 17-year-old daughter whose body weight was 50 kg with a body mass index(BMI)of *** procured right liver graft was 411 g with a real graft-to-recipient weight ratio(GRWR)of 0.41%,the smallest to be reported in the *** the recipient and donor had an uneventful recovery and were discharged on days 15 and 8,respectively,with normal liver *** father and daughter have had no complication so far and are still in good health with normal liver function 81 mo after *** Satisfactory outcomes can be achieved in LDLT with a GRWR as low as 0.41%even without using portal flow modulation in highly selected patients.

关键词： Small-for-size graft Living donor liver transplantation Graft-to-recipient weight ratio Case report

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Exergetical Analysis of Organic Flash Cycle with Two-Phase Expander for Recovery of Finite Thermal Reservoirs

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Journal of Thermal Science 2014年第6期23卷 572-579页

作者： Chul Ho Han Kyoung hoon kim Department of Intelligent Mechanical Engineering Kumoh National Institute of TechnologyDaehakro 61GumiGyeongbuk 730-701Korea Department of Mechanical Engineering Kumoh National Institute of TechnologyDaehakro 61GumiGyeongbuk 730-701Korea

In this work exergetical performance analysis is carried out based on the second law of thermodynamics for organic flash cycle(OFC) using a two-phase expander instead of throttle expansion in order to recover efficiently finite thermal *** exergy destructions(anergies) at various components of the system are theoretically investigated as well as the exergy *** show that the anergy of heat exchanger or two-phase expander decreases while the anergy of throttle valve increases with increasing flash temperature,and the exergy efficiency has an optimum value with respect to the flash *** the optimal conditions with respect to the flash temperature,exergy efficiency increases with the heating temperature and the component having the largest exergy destruction varies with the flash temperature or heating temperature.

关键词： organic flash cycle(OFC) low grade heat source exergy anecgy

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Entransy and Exergy Analyses for Optimizations of Heat-Work Conversion with Carnot Cycle

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Journal of Thermal Science 2016年第3期25卷 242-249页

作者： Chul Ho Han Kyoung hoon kim Department of Mechanical System Engineering Kumoh National Institute of Technology Department of Mechanical Engineering Kumoh National Institute of Technology

The concept of entransy has been newly proposed in terms of the analogy between heat and electrical conduction and could bc useful in analyzing and optimizing the heat-work conversion systems. This work presents comparative analyses of entransy and exergy for optimizations of heat-work conversion. The work production and heat transfer processes in Carnot cycle system are investigated with the formulations of exergy destruction, entransy loss, work entransy, entransy dissipation, and cfficiencics for both cases of dumping and non-dumping of used source fluid. The effects of source and condensation temperatures on the system performance arc systematically investigated for optimal condition of producing maximum work or work cntransy.

关键词： entransy exergy heat-work conversion Carnot cycle efficiency

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Influence of Center of Gravity Location on Flight Dynamic Stability in a Hovering Tailless FW-MAV: Lateral Motion

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Journal of Bionic Engineering 2020年第1期17卷 148-160页

作者： Loan Thi kim Au hoon Cheol Park Department of Smart Vehicle Engineering and Artificial Muscle Research Center Konkuk UniversitySeoul 05029Korea

This paper reports the effect of the Center of Gravity(CG)position on lateral flight dynamic stability of hovering KUBeetle,a tailless FW-MAV,providing further insights on the effects of asymmetries in body mass distribution and wing *** the current study,the standard linearized equations of motion were applied as in the previous work on longitudinal dynamic *** stability derivatives were acquired using the computational fluid dynamic methods via the commercial software of ANSYS *** exists a stable region for CG between 2.6%and 3.5%of the mean chord below the wing pivot point,in which the lateral motion of hovering KUBeetle is passively *** CG below the stable region,because of an unstable oscillatory mode,the lateral motion of the FW-MAV is unstable but can be stabilized using rolling rate *** CG above the stable region,because of a divergence mode,the system remains unstable even with the rolling rate *** with other works on an FW-MAV based on a quasi-steady aerodynamic model and on insect showed similar characteristics for flapping *** is also interesting to note that the asymmetries in body mass and wing kinematics can enlarge the stable region of the system by a non-zero Ixz which approaches the root square of√IxIz,a negative LrNp,and a positive Ix2(Ir+Np).Combining the current result with that of the previous work on longitudinal motion,the most beneficial region of the CG for full 6-DOF flight dynamic stability of hovering KUBeetle was suggested.

关键词： FW-MAV center of gravity flight dynamic stability lateral motion asymmetry computational fluid dynamics bioinspired flight

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Lower risk of subarachnoid haemorrhage in diabetes:a nationwide population-based cohort study

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Stroke & Vascular Neurology 2021年第3期6卷 402-409页

作者： Jang hoon kim Jimin Jeon Jinkwon kim Department of Neurosurgery Yongin Severance HospitalYonsei University College of MedicineSeoulSouth Korea Department of Neurology Yongin Severance HospitalYonsei University College of MedicineSeoulSouth Korea

Background and purpose Diabetes mellitus(DM)is a common metabolic disorder with increased risk of cardiovascular and cerebrovascular ***,its relationship with risk of subarachnoid haemorrhage(SAH),the most devastating form of stroke,remains *** To evaluate the relationship between DM and risk of SAH,we performed a retrospective cohort study using a nationwide,population‐based,health screening database in *** included participants without history of stroke who underwent a nationwide health screening programme between 2003 and *** outcome was occurrence of *** were followed up until development of SAH or December *** Cox proportional hazards regression analysis was performed with adjustments for age,sex,systolic blood pressure,total cholesterol,body mass index,physical activity,smoking status,alcohol habit,household income and treatment with antihypertensive agents and *** Among 421768 study participants,prevalence of DM was 9.6%.During a mean follow-up period of 11.6±1.9 years,1039 patients developed *** of DM was significantly associated with decreased risk of SAH(adjusted HR 0.68;95%CI 0.53 to 0.86;p<0.001).Elevated level of fasting blood glucose was also negatively associated with risk of SAH(adjusted HR per 1 mmol/L increase 0.90;95%CI 0.86 to 0.95;p<0.001).Conclusion DM and elevated level of fasting blood glucose were inversely associated with risk of *** studies may elucidate the possibly protective,pathophysiological role played by hyperglycaemia in patients at risk of SAH.

关键词： protective nationwide elevated

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