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Best therapy for the easiest to treat hepatitis C virus genotype 1binfected patients

World Journal of Gastroenterology 2022年第45期28卷 6380-6396页

作者： Dorota Zarębska-Michaluk Michal Brzdęk Jerzy Jaroszewicz Magdalena Tudrujek-Zdunek Beata Lorenc Jakub Klapaczyński Włodzimierz Mazur Adam Kazek Marek Sitko Hanna Berak justyna janocha-litwin Dorota Dybowska Łukasz Supronowicz Rafal Krygier Jolanta Citko Anna Piekarska Robert Flisiak Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases and Hepatology Medical University of SilesiaKatowice 40-055Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 00-241Poland Clinical Department of Infectious Diseases Medical University of SilesiaChorzów 41-500Poland ID Clinic Mysłowice 41-400Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Hospital for Infectious Diseases Hospital for Infectious DiseasesWarszawa 02-091Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 50-367Poland Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Infectious Diseases and Hepatology Outpatient Clinic Gemini NZOZŻychlin 62-571Poland Medical Practice of Infections Regional HospitalOlsztyn 10-561Poland Department of Infectious Diseases and Hepatology Medical UniversityŁódźŁódź90-419Poland

BACKGROUND The revolution in treatment of patients with chronic hepatitis C virus(HCV)infection dates back to the introduction of direct-acting antivirals(DAAs).The increase in efficacy was most pronounced in patients infected with genotype(GT)1b,as this was the most poorly responsive population to treatment during the interferon *** To identify the most effective interferon-free therapy for GT1b-infected patients and to determine positive and negative predictors of virological *** This real-world retrospective analysis included patients chronically infected with GT1b HCV whose data were obtained from the multicenter observational EpiTer-2 *** effectiveness was evaluated for each therapeutic regimen as the percentage of sustained virological responses(SVR).Assessment of the safety was based on the evaluation of the course of therapy,the occurrence of adverse events including serious ones,deaths during treatment and in the post 12-wk follow-up *** The studied population consisted of 11385 patients with a mean age of 53±14.8 years and a female predominance(53.4%).The majority of them were treatment-naïve(74.6%)and patients with cirrhosis accounted for 24.3%.Of the DAA regimens used,76.9%were GT-specific with ombitasvir/paritaprevir/ritonavir+dasabuvir±ribavirin being the most used option(32.4%).A total of 10903 patients responded to treatment resulting in a 98.1%in the per-protocol analysis after excluding 273 patients without SVR *** effectiveness of all regimens exceeded 90%and the highest SVR of 98.9%was achieved in patients treated with a combination of glecaprevir/*** regression analyses showed that the virologic response was independently associated with female sex[odds ratio(OR)=1.67],absence of decompensated cirrhosis at baseline(OR=2.42)and higher baseline platelets(OR=1.004 per 1000/μL increase),while the presence of human immunodeficiency virus(HIV)coinfection significantly decreased the odds

关键词： Hepatitis C Genotype 1b Direct-acting antivirals Pangenotypic Genotype-specific Sustained virologic response

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Changes in characteristics of patients with hepatitis C virus-related cirrhosis from the beginning of the interferon-free era

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World Journal of Gastroenterology 2023年第13期29卷 2015-2033页

作者： Michał Brzdęk Dorota Zarębska-Michaluk Piotr Rzymski Beata Lorenc Adam Kazek Magdalena Tudrujek-Zdunek justyna janocha-litwin Włodzimierz Mazur Dorota Dybowska Hanna Berak Anna Parfieniuk-Kowerda Jakub Klapaczyński Marek Sitko Barbara Sobala-Szczygieł Anna Piekarska Robert Flisiak Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases Jan Kochanowski UniversotyKielce 25-317Poland Department of Environmental Medicine Poznan University of Medical SciencesPoznań60-806Poland Integrated Science Association Universal Scientific Education and Research NetworkPoznań60-806Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland ID Clinic Mysłowice 41-400Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 50-367Poland Clinical Department of Infectious Diseases Clinical University of Silesia in KatowiceChorzów 41-500Poland Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Daily Department Hospital for Infectious Diseases in WarsawWarszawa 01-201Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 00-241Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Department of Infectious Diseases Medical University of Silesia in KatowiceBytom 41-902Poland Department of Infectious Diseases and Hepatology Medical University ofŁódźŁódź90-419Poland

BACKGROUND Nearly 290000 patients with chronic hepatitis C die annually from the most severe complications of the *** of them is liver cirrhosis,which occurs in about 20%of patients chronically infected with the hepatitis C virus(HCV).Direct-acting antivirals(DAAs),which replaced interferon(IFN)-based regimens,significantly improved the prognosis of this group of patients,increasing HCV eradication rates and tolerability of *** study is the first to assess changes in patient profile,effectiveness,and safety in the HCV-infected cirrhotic population in the IFN-free *** To document changes in patient characteristics and treatment regimens along with their effectiveness and safety profile over the *** The studied patients were selected from 14801 chronically HCV-infected individuals who started IFN-free therapy between July 2015 and December 2021 in 22 Polish hepatology *** retrospective analysis was conducted in real-world clinical practice based on the EpiTer-2 multicenter *** measure of treatment effectiveness was the percentage of sustained virologic response(SVR)calculated after excluding patients lost to *** data collected during therapy and the 12-wk post-treatment period included information on adverse events,including serious ones,deaths,and treatment *** The studied population(n=3577)was balanced in terms of gender in 2015-2017,while the following years showed the dominance of *** decline in the median age from 63 in 2015-2016 to 61 years in 2021 was accompanied by a decrease in the percentage of patients with comorbidities and ***-experienced patients dominated in 2015-2016,while treatment-naive individuals gained an advantage in 2017 and reached 93.2%in ***(GT)-specific options were more prevalent in treatment in 2015-2018 and were supplanted by pangenotypic combinations in subsequent *** effectiveness of the therapy was comparable regardless of the

关键词： Hepatitis C Liver cirrhosis Direct-acting antivirals Pangenotypic Genotype-specific Epidemiology

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Real-world effectiveness and safety of direct-acting antivirals in hepatitis C virus patients with mental disorders

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World Journal of Gastroenterology 2023年第25期29卷 4085-4098页

作者： Dorota Dybowska Dorota Zarebska-Michaluk Piotr Rzymski Hanna Berak Beata Lorenc Marek Sitko Michal Dybowski Wlodzimierz Mazur Magdalena Tudrujek-Zdunek justyna janocha-litwin Ewa Janczewska Jakub Klapaczynski Anna Parfieniuk-Kowerda Anna Piekarska Barbara Sobala-Szczygiel Krystyna Dobrowolska Malgorzata Pawlowska Robert Flisiak Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Department of Infectious Diseases and Allergology Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases Provincial HospitalKielce 25-317Poland Department of Environmental Medicine University of Medical SciencesPoznań60-806Poland Integrated Science Association Universal Scientific Education and Research NetworkPoznań60-806Poland Outpatient Clinic Hospital for Infectious Diseases in WarsawWarsaw 01-201Poland Pomeranian Center of Infectious Diseases Medical UniversityGdańsk 80-214Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Utrecht University School of Economics Utrecht UniversityUtrecht 3584 ECNetherlands Clinical Department of Infectious Diseases Medical University of SilesiaChorzów 41-500Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Department of Infectious Diseases and Hepatology Medical University of WrocławWrocław 50-367Poland Department of Basic Medical Sciences Faculty of Public Health in BytomMedical University of SilesiaKatowice 40-007Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarsaw 00-241Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Department of Infectious Diseases and Hepatology Medical University ofŁódźŁódź91-347Poland Department of Infectious Diseases and Hepatology Medical University of SilesiaBytom 41-902Poland Collegium Medicum Jan Kochanowski UniversityKielce 25-317Poland

BACKGROUND It is estimated that 58 million people worldwide are infected with the hepatitis C virus(HCV).Patients with severe psychiatric disorders could not be treated with previously available interferon-based therapies due to their unfavorable side effect *** has changed with the introduction of direct-acting antivirals(DAA),although their real-life tolerance and effectiveness in patients with different psychiatric disorders remain to be *** To evaluate the effectiveness and safety of DAA in patients with various mental *** This was a retrospective observational study encompassing 14272 patients treated with DAA for chronic hepatitis C in 22 Polish hepatology centers,including 942 individuals diagnosed with a mental disorder(anxiety disorder,bipolar affective disorder,depression,anxiety-depressive disorder,personality disorder,schizophrenia,sleep disorder,substance abuse disorder,and mental illness without a specific diagnosis).The safety and effectiveness of DAA in this group were compared to those in a group without psychiatric illness(n=13330).Antiviral therapy was considered successful if serum ribonucleic acid(RNA)of HCV was undetectable 12 wk after its completion[sustained virologic response(SVR)].Safety data,including the incidence of adverse events(AEs),serious AEs(SAEs),and deaths,and the frequency of treatment modification and discontinuation,were collected during therapy and up to 12 wk after treatment *** entire study population was included in the intent-to-treat(ITT)***-protocol(PP)analysis concerned patients who underwent HCV RNA evaluation 12 wk after completing *** Among patients with mental illness,there was a significantly higher percentage of men,treatmentnaive patients,obese,human immunodeficiency virus and hepatitis B virus-coinfected,patients with cirrhosis,and those infected with genotype 3(GT3)while infection with GT1b was more frequent in the population without psychia

关键词： Hepatitis C Mental disorders Direct-acting antivirals

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Knowledge,management,and complications of sepsis and septic shock:A significant therapeutic challenge in the intensive care unit

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Journal of Acute Disease 2024年第2期13卷 53-59页

作者： Jakub Mizera Adrian Bystroń Karolina Matuszewska justyna Pilch Ugo Giordano Wroclaw Medical University wyb.Ludwika Pasteura 150-367 WrocławPoland

Sepsis and septic shock are life-threatening conditions that are globally responsible for almost 20%of mortality,especially in low and middle-income *** review was conducted on PubMed and Google Scholar databases with keywords sepsis,septic shock,sepsis management,and sepsis *** published up to July 2023 in English were *** and management should be carried out without unnecessary *** between various medical specialties including intensive care doctors,neurologists,hepatologists,cardiologists,and pediatric doctors is needed if a child is *** strategies have to be implemented in low and middle-income countries to decrease the sepsis incidence and reduce mortality in the population.

关键词： Sepsis Septic shock Management Complications Diagnosis Review

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Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana

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Molecular Plant 2024年第4期17卷 676-676页

作者： justyna Jadwiga Olas Federico Apelt Maria Grazia Annunziata Sheeba John Sarah Isabel Richard Saurabh Gupta Friedrich Kragler Salma Balazadeh Bernd Mueller-Roeber 不详

(Molecular Plant 14,1508-1524,September 62021)After the original publication of the above article,attentive readers identified errors in Figure 4H that needed correction as *** 4H contained the erroneous labels“10 DAP(7 DAT),”which should have each read,“7 DAP(4 DAT).”To avoid any confusion and ensure consistency across our figures,we modified some of the Col-0 images in a corrected version of Figure 4H below to resemble the exact same Col-0 images as in Figure *** details of the changes are as follows:rotation(Col-0 Primed,all timepoints;Col-0 Triggered,3 DAP and 5 DAP;Col-0 Primed/triggered,3 DAP and 5 DAP),replacement(Col-0 Triggered,7 DAP),and different cropping(Col-0 Primed/triggered,7 DAP).

关键词： Figure metabolism Prime

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Experimental analysis of ballistic trauma in a human body protected with 30 layer packages made of biaxial and triaxial Kevlar^(■)29 fabrics

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Defence Technology（防务技术） 2023年第3期21卷 73-87页

作者： justyna Pinkos Zbigniew Stempien Anna Smędra Institute of Textile Architecture Lodz University of TechnologyLodzPoland Chair and Department of Forensic Medicine Medical University of LodzLodzPoland

Behind armour blunt trauma(BABT)is a body injury resulting from the deformation of the back surface of armour as a result of a bullet *** the case of textile body armour,the severity of the injury may depend on the material of the fibres,but also on the geometric structure of the *** article focuses on experimental research into injuries of the human body protected by ballistic packets made of biaxial and triaxial fabrics,during a non-penetrating impact from a Parabellum 9 mm×19 mm Full Metal Jacket(FMJ)bullet,at a speed of 406±5 m/*** experimental research,the fabrics had a comparable surface weight and were made of the same Kevlar^(■)29 *** ballistic packages were made of 30 *** part of the work,a physical model of the human body was *** human body model consisted of a model of the heart,lungs,and skeletal and muscular *** the bullet impact,the pressure forces were recorded using sensors located at selected points of the human *** bullets hit five selected places on the body that were considered critical,from the point of view of maintaining a human’s vital *** was found that,during firing,pressure increases both at the site of impact and in the internal organs,which can lead to multi-organ *** a result of the experimental analysis,it has been shown that the pressures exerted on specific organs are always lower in the case of body protection with a ballistic packet made of triaxial fabrics,compared to a packet made of biaxial fabrics.

关键词： protected impact organs

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Humus horizon development during natural forest succession process in the Polish Carpathians

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Journal of Mountain Science 2022年第3期19卷 647-661页

作者： justyna SOKOŁOWSKA Agnieszka JÓZEFOWSKA Tomasz ZALESKI Department of Soil Science and Agrophysics University of Agriculture in Krakowal.Mickiewicza 2131-120 KrakówPoland

As a result of socio-economic changes and land abandonment,the main ecological driver of the Carpathian landscape is the progression of the natural forest succession ***,aspects of this process have become worthy of attention,especially in the context of carbon sequestration and the management of protected *** processes,especially within the topsoil,are some of the most susceptible to change,due to the accumulation of organic matter during such land-use *** purposes of this study were to investigate the differences in topsoil development using the A Horizon Development Index(ADI)and to study the composition of humic substances and advanced organic matter humification in different land-use areas in selected Carpathian national parks,***,Magura and Pieniny National Parks in southern ***,a goal of this study was to compare the ADI and the spectroscopic coefficients of humic substances as indicators of the degree of humus horizon shaping as well as advanced organic matter *** total,ten transects were selected,each consisting of three different land-use areas:semi-natural meadow,successional forest and old-growth *** colour was determined in fresh and air-dried samples using the Munsell colour *** air-dried soil samples p H,soil texture,total organic carbon and total nitrogen were *** substances were extracted and further characterized by UV-VIS *** ADI confirmed the influence of natural forest succession on soil colour darkening and the development of the uppermost soil *** analyses of humic substances showed two different patterns depending on soil *** the 0–10 cm layer,natural forest succession reduced the rate of the humification process and decreased the degree of maturity of fulvic acids;in the 10–20 cm layer,it led to an increase in the rate of the humification process and a decrease in the content of humic and fulvic acids at the beginn

关键词： Land use changes Natural forest succession Polish Carpathians Landscape transformation Protected areas management Humic substances

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Risk and mechanism of metabolic syndrome associated with radiation exposure

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Radiation Medicine and Protection 2023年第2期4卷 65-69页

作者： Ruixue Huang justyna Miszczyk Ping-Kun Zhou Department of Occupational and Environmental Health Xiangya School of Public HealthCentral South UniversityHunan 410078China Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMSBeijing 100850China Department of Experimental Physics of Complex Systems Institute of Nuclear Physics Polish Academy of SciencesKraków PL-31342Poland

Obesity, hyperglycemia, hypertension, hypertriglyceridemia and low high-density lipoprotein cholesterol are the typical features of Metabolic syndrome (MetS). Exploring the risk factors would benefit for prevention control. Several studies have revealed an association between ionizing radiation (IR) exposure and MetS, likely attributable to production of reactive oxygen species (ROS), oxidative stress, DNA damage. Understanding the health effects of IR exposure, which have long been overlooked, would improve knowledge on MetS and help identify effective strategies for targeted prevention of MetS. In this review, we first highlight the importance of IR and MetS, providing information on the wide use of IR in the field, IR-induced damage, and the prevalence and burden of MetS. Then, we summarize the findings association between IR and various components of MetS addressing the dual effects of IR on MetS in a dose-response manner. Although there remain unresolved challenges, study on the association of radiation and MetS could open new perspectives in the future.

关键词： Radiation Risk Metabolic syndrome

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Prinjective Ringel-Hall Algebras for Posets of Finite Prinjective Type

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Acta Mathematica Sinica,English Series 2009年第7期25卷 1183-1190页

作者： justyna KOSAKOWSKA Faculty of Mathematics and Computer Science Nicolaus Copernicus University

In the present paper we investigate prinjective Ringel-Hall algebras, for prinjective modules over incidence algebras of posers of finite prinjective type. Results we obtain are analogous to these, given by C. M. Ringel, for representations of Dynkin quivers. In particular we give a description of prinjective Ringel-Hall algebras by generators and relations.

关键词： prinjective modules poset representations Ringel-Hall algebras Hall polynomials

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A Specialization of Prinjective Ringel-Hall Algebra and the associated Lie algebra

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Acta Mathematica Sinica,English Series 2008年第10期24卷 1687-1702页

作者： justyna KOSAKOWSKA Faculty of Mathematics and Computer Science Nicolaus Copernicus Universityul. Chopina 12//18 87-100 Toru■ Poland

In the present paper we describe a specialization of prinjective Ringel-Hall algebra to 1, for prinjective modules over incidence algebras of posets of finite prinjective type, by generators and relations. This gives us a generalisation of Serre relations for semisimple Lie algebras. Connections of prinjective Ringel-Hall algebras with classical Lie algebras are also discussed.

关键词： Ringel-Hall algebras Lie algebras prinjective modules poset representations

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