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Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

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World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers justo lorenzo bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler Department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research Dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium Department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham Digestive Diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany Department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany Division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in Digestive Disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression Anxiety Somatization

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A divergent pattern in functional connectivity: a transdiagnostic perspective

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Neural Regeneration Research 2024年第9期19卷 1885-1886页

作者： Lu Zhang lorenzo Pini Padova Neuroscience Center Universitàdegli Studi di PadovaPadovaItaly

Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at *** physics beyond... 详细信息

关键词： pattern connectivity functional

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Investigations on MoS_(2)plasma by infra-red pulsed laser irradiation in high vacuum

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Plasma Science and Technology 2024年第7期26卷 123-133页

作者： lorenzo TORRISI Letteria SILIPIGNI Alfio TORRISI Mariapompea CUTRONEO Dipartimento di Scienze Matematiche e Informatiche Scienze Fisiche e Scienze della TerraMIFTUniversitàdi MessinaMessina 98166Italy Faculty of Medicine and Surgery Kore University of EnnaEnna 94100Italy Nuclear Physics Institute of the CAS HusinecŘežPrague 25068Czech Republic

MoS_(2)targets were irradiated by infra-red(IR)pulsed laser in a high vacuum to determine hot plasma parameters,atomic,molecular and ion emission,and angular and charge state *** this way,pulsed laser deposition(PLD)of thin films on graphene oxide substrates was also *** Nd:YAG laser,operating at the 1064 nm wavelength with a 5 ns pulse duration and up to a 1 J pulse energy,in a single pulse or at a 10 Hz repetition rate,was *** yield was measured as a function of the laser *** was characterized using different analysis techniques,such as time-of-flight measurements,quadrupole mass spectrometry and fast CCD visible *** so-produced films were characterized by composition,thickness,roughness,wetting ability,and *** compared to the MoS_(2)targets,they show a slight decrease of S with respect to Mo,due to higher ablation yield,low fusion temperature and high sublimation in *** pulsed IR laser deposited Mo Sx(with 1

关键词： MoS_(2) laser ablation plasma ion acceleration quadrupole mass spectrometry PLD

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Beyond functional MRI signals:molecular and cellular modifiers of the functional connectome and cognition

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Neural Regeneration Research 2024年第5期19卷 937-938页

作者： lorenzo Pini Alessandro Salvalaggio Maurizio Corbetta Padova Neuroscience Center University of PadovaItaly Veneto Institute of Molecular Medicine VIMMPadovaItaly Department of Neuroscience University of PadovaItaly

Our brain is constantly *** at rest,the brain carries out essential functions such as maintenance of resting potentials,subthreshold synaptic activity,and spiking activity related to information *** resting activity can be assessed with several in vivo tools,such as resting-state functional magnetic resonance *** technique measures subtle changes in blood flow,volume,and oxygenation that occur over *** vascular in nature,resting-state functional magnetic resonance imaging is considered a reliable proxy of neural activity and several studies have shown that the brain is functionally divided into interacting neural networks called the“functional connectome”.

关键词： functional neural measures

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Advancing hepatic recompensation:Baveno VII criteria and therapeutic innovations in liver cirrhosis management

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World Journal of Gastroenterology 2024年第23期30卷 2954-2958页

作者： lorenzo Ridola Sara Del Cioppo Department of Medical and Surgical Sciences and Biotechnologies Sapienza University of RomePolo PontinoRome 00185Italy

The Baveno VII criteria redefine the management of decompensated liver cirrhosis,introducing the concept of hepatic recompensation marking a significant departure from the conventional view of irreversible *** to this concept is addressing the underlying cause of cirrhosis through tailored therapies,including antivirals and lifestyle *** on alcohol,hepatitis C virus,and hepatitis B virus-related cirrhosis demonstrate the efficacy of these interventions in improving liver function and patient *** intrahepatic portosystemic shunt(TIPS)emerges as a promising intervention,effectively resolving complications of portal hypertension and facilitating ***,optimal timing and patient selection for TIPS remain *** challenges,TIPS offers renewed hope for hepatic recompensation,marking a significant advancement in cirrhosis *** research is needed to refine its implementation and maximize its *** conclusion,TIPS stands as a promising avenue for improving hepatic function and patient outcomes in decompensated liver cirrhosis within the framework of the Baveno VII criteria.

关键词： Hepatic recompensation Baveno VII Transjugular intrahepatic portosystemic shunt Portal hypertension Cirrhosis Decompensation

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A Review of Basic Mechanical Properties of Bamboo Scrimber Based on Small-Scale Specimens

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Journal of Renewable Materials 2024年第4期12卷 869-894页

作者： Xin Xue Haitao Li Rodolfo lorenzo College of Civil Engineering Nanjing Forestry UniversityNanjing210037China National-Provincial Joint Engineering Research Center of Biomaterials for MACHINERY PACKAGE Nanjing Forestry UniversityNanjing210037China Jiangsu Engineering Research Center of Bamboo and Wood Carbon FixationMaterials and Structures Nanjing Forestry UniversityNanjing210037China Department of Civil Environmental and Geomatic EngineeringUniversity College LondonLondonWC1E 6BTUK

This review summarizes the existing knowledge about the mechanical properties of bamboo scrimber(BS)in *** to literature reviews,the strength of BS under different load modes is affected by a series of factors,such as the type of original bamboo,growth position,resin content,treatment method and ***,different production processes can be adopted according to different requirements,and bamboo scrimbers can also be classified *** addition,this review summarizes the changes in different factors considered by scholars in the research on the mechanical properties of BS,so that readers can have an overall understanding of the existing research and make more innovative and valuable research on this *** review provides and discusses the conclusive observations,the current research gaps and future research directions on the mechanical properties of BS.

关键词： Bamboo scrimber manufacturing process mechanical properties failure modes constitutive model

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Cardioprotective effects of glucagon-like peptide 1 receptor agonists in heart failure: Myth or truth?

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World Journal of Diabetes 2024年第5期15卷 818-822页

作者： lorenzo Nesti Domenico Trico Department of Clinical and Experimental Medicine University of PisaPisa 56126Italy Laboratory of Metabolism Nutritionand AtherosclerosisUniversity of PisaPisa 56126Italy

Therapy with glucagon-like peptide 1(GLP1)receptor agonists has raised great interest for its beneficial cardiovascular effects in preventing atherosclerosis and heart failure-related ***,while evidence about atherosclerosis consistently suggests a cardioprotective potential with class effect,controversies remain on its impact on heart ***1 receptor agonists appear to prevent hospitalization for new-onset heart failure and reduce symptoms in heart failure with preserved ejection fraction(as demonstrated by the recent STEP-HFpEF Trial).Still,GLP1 agonism has resulted in neutral or even harmful effects in patients with established heart failure with reduced ejection fraction(the LIVE trial).GLP1 receptor agonists benefit the cardiovascular system indirectly through their marked metabolic effects(improved weight management,glycemic control,blood pressure,systemic and tissue inflammation),while direct effects on the heart have been ***,weight loss alone achieved through GLP1 receptor agonists has failed in improving left ventricular *** is a dual agonist of GLP1 and glucose-dependent insulinotropic polypeptide,representing an innovative treatment option in diabetes with a major impact on weight loss and promising cardiovascular *** this class of therapies is going to change the history of heart failure is an ongoing debate.

关键词： Atherosclerosis Cardiovascular system Glucagon-like peptide-1 Heart failure Tirzepatide Type 2 diabetes Ventricular function Left

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Stratigraphy of the Alveolina elliptica group from the Middle Eocene of Iran:Calibration with calcareous nannofossils biozones and description of Alveolina ozcani n. sp.

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Journal of Palaeogeography 2024年第1期13卷 54-79页

作者： Mehdi Hadi lorenzo Consorti Ali Bahrami Mohammad Parandavar Saeed Khorramdel Department of Geology Faculty of SciencesUniversity of IsfahanIsfahanIran Institute of Marine Sciences(ISMAR-CNR) Area Science ParkBasovizza34149 TriesteItaly National Iranian Oil Company Exploration DirectorateSheikh Bahaei SquareTehranIran Department of Geology Faculty of ScienceFerdowsi University of MashhadMashhadIran

Precise taxonomy and the chronostratigraphic calibration of the Middle Eocene Alveolina from Central Iran is here undertaken from the Chah-Talkh section of the southern Sabzevar region(Central Iran). We have identified Alveolina kieli, Alveolina stercusmuris and Alveolina nuttalli along with the new species Alveolina ozcani n. sp. that we include into the Alveolina elliptica group. We have also found Nummulites uroniensis, Nummulites obesus and Nummulites cf. verneuili and associated calcareous nannofossils that look reliable to make thoughtful correlations with the Shallow Benthic Zones(SBZ). The foraminiferal biostratigraphy suggests an assignment to the upper part of the lower Lutetian-lower part of the middle Lutetian,SBZ13(Middle Eocene), further strengthened through the identification of the calcareous nannofossil NP14b-NP15b or CNE8-CNE10 biozones, providing a solid correlation with the global stratigraphic standards.

关键词： Alveolina Calcareous nannofossil Central neo-tethys Central Iran Middle Eocene Biostratigraphy

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Deep learning for broadleaf weed seedlings classification incorporating data variability and model flexibility across two contrasting environments

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Artificial Intelligence in Agriculture 2024年第2期12卷 29-43页

作者： lorenzo León Cristóbal Campos Juan Hirzel Instituto de Investigaciones Agropecuarias(INIA) INIA QuilamapuAvda.Vicente Méndez 515ChillánChile Fundacion ObservatorioÑuble Arauco 340ChillanChile

The increasing deployment of deep learning models for distinguishing weeds and crops has witnessed notable strides in agricultural ***,a conspicuous gap endures in the literature concerning the training and testing of models across disparate environmental *** methodologies either delineate a single dataset distribution into training,validation,and testing subsets or merge datasets from diverse condi-tions or distributions before their division into the *** study aims to ameliorate this gap by extending to several broadleaf weed categories across varied distributions,evaluating the impact of training convolutional neural networks on datasets specific to particular conditions or distributions,and assessing their performance in entirely distinct settings through three *** evaluating diverse network architectures and training approaches(finetuning versus feature extraction),testing various architectures,employing different training strategies,and amalgamating data,we devised straightforward guidelines to ensure the model's deployability in contrasting environments with sustained precision and *** Experiment 1,conducted in a uniform environment,accuracy ranged from 80%to 100%across all models and training strategies,with finetune mode achieving a superior performance of 94%to 99.9%compared to the feature extraction mode at 80%to 92.96%.Experiment 2 underscored a significant performance decline,with accuracy fig-ures between 25%and 60%,primarily at 40%,when the origin of the test data deviated from the train and valida-tion *** 3,spotlighting dataset and distribution amalgamation,yielded promising accuracy metrics,notably a peak of 99.6%for ResNet in finetuning mode to a low of 69.9%for InceptionV3 in feature extraction *** pivotal findings emphasize that merging data from diverse distributions,coupled with finetuned training on advanced architectures like ResNet and MobileNet,markedly enhances

关键词： Artificial neural networks Deep learning Transfer learning Precision farming Feature extraction Finetuning Generalization Out-of-domain distribution Domain adaptation Multi-domain learning

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Emergingγ-soft-like spectrum in^(196)Pt in the SU3-IBM(Ⅰ)

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Chinese Physics C 2024年第9期48卷 150-163页

作者： Tao Wang Bing-Cheng He Chun-Xiao Zhou Dong-Kang Li lorenzo Fortunato College of Physics Tonghua Normal UniversityTonghua 134000China Physics Division Argonne National LaboratoryLemontIllinois 60439USA College of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China Dipartimento di Fisica e Astronomia"G.Galilei"-Universitàdi Padova via Marzolo 8I-35131 PadovaItaly INFN-Sez.di Padova via Marzolo 8I-35131 PadovaItaly

Recently,studies have argued that a spherical-like spectrum emerges in the SU3-IBM,thus creating new approaches to understanding y-softness in realistic *** a previous study,γ-softness with degeneracy of the ground and quasi-y bands was *** this paper,another special point connected to the middle degenerate point is *** is found to be related to the properties of^(196)*** emergentγ-softness is also shown to be important for understanding the prolate-oblate asymmetric shape phase *** low-lying spectra,B(E2)values,and quadrupole moments in^(196)Pt are discussed,and we show that the new model can account for several observed *** is the first part of the discussion on theγ-soft-like spectrum of^(196)Pt.

关键词： SU3-IBM ^(196)Pt γ-soft-like spectrum

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