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Monohalogenated acetamide-induced cellular stress and genotoxicity are related to electrophilic softness and thiol/thiolate reactivity

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Journal of Environmental Sciences 2017年第8期29卷 224-230页

作者： justin A.Pals Elizabeth D.Wagner Michael J.Plewa Menghang Xia Matias S.Attene-Ramos Department of Crop Sciences University of Illinois at Urbana-Champaign Urbana IL United States Department of Environmental and Occupational Health Milken Institute School of Public Health George Washington University Washington DC United States Safe Global Water Institute University of Illinois at Urbana-Champaign Urbana IL United States National Center for Advancing Translational Sciences National Institutes of Health (NIH) Department of Health and Human Services (DHHS) Bethesda MD United States

Haloacetamides（HAMs） are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an S_N2 reaction *** of the monohalogenated HAMs（iodoacetamide, IAM; bromoacetamide, BAM;or chloroacetamide, CAM） varied depending on the halogen substituent. The aim of this research was to investigate how the halogen atom affects the reactivity and toxicological properties of HAMs, measured as induction of oxidative/electrophilic stress response and genotoxicity. Additionally, we wanted to determine how well in silico estimates of electrophilic softness matched thiol/thiolate reactivity and in vitro toxicological *** of the HAMs significantly induced nuclear Rad51 accumulation and ARE signaling activity compared to a negative control. The rank order of effect was IAM 〉 BAM 〉 CAM for Rad51, and BAM ≈ IAM 〉 CAM for ARE. In general, electrophilic softness and in chemico thiol/thiolate reactivity provided a qualitative indicator of toxicity, as the softer electrophiles IAM and BAM were more thiol/thiolate reactive and were more toxic than CAM.

关键词： Drinking water disinfection byproducts Haloacetamide Toxicity Soft electrophile Oxidative stress DNA damage

Brain borders at the central stage of neuroimmunology

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四川生理科学杂志 2022年第12期44卷 2183-2183页

作者： justin Rustenhoven Center for Brain immunology and Glia (BIG) Washington University in St Louis School of Medicine St Louis MO USA Department of Pathology and Immunology Washington University in St Louis School of Medicine St Louis MO USA Department of Pharmacology and Clinical Pharmacology The University of Auckland Auckland New Zealand Center for Brain Research The University of Auckland Auckland New Zealand

The concept of immune privilege suggests that the central nervous system is isolated from the immune ***,recent studies have highlighted the borders of the central nervous system as central sites of neuro-immune *** the nervous and immune systems both function to maintain homeostasis,under rare circumstances,they can develop pathological interactions that lead to neurological or psychiatric diseases.

关键词： homeostasis maintain border

Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations

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Journal of Environmental Sciences 2016年第11期28卷 213-221页

作者： justin P.Miller-Schulze Michael Paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.Simpson Department of Chemistry University of Washington WA 98195-1700 USA. Department of Environmental and Occupational Health Sciences University of Washington WA 98195 Seattle USA Laboratory of Hygienic Chemistry Instkute of Medical Pharmaceutical and Health Sciences Faculty of Pharmacy Kanazawa UniversityKakurna-machi Kanazawa Ishikawa 920-1192 Japan Graduate School of Natural Science and Technology Kanazawa University Kakma-machi Kanazawa Ishikawa 920-1192 Japan Department of Enuironmental Health Sciences University of Georgia Athens CA 30602-2102 USA Asociacion del Aire Ambiental Lima Peru

The assessment of occupational exposure to diesel exhaust（DE） is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene（1NP）, a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples（10 m L） from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to1 NP, as well as PM_（2.5）, 2-nitropyrene and 2-nitrofluoranthene, were also *** to 1NP were similar in all studied workers, averaging 105 ± 57.9 pg/m^3（±standard deviation）. Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects（n = 17） studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However,the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle *** study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker.

关键词： Urinary biomarkers 1-Nitropyrene Diesel particulate matter

Sutureless vascular anastomotic approaches and their potential impacts

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Bioactive Materials 2024年第8期38卷 73-94页

作者： Joseph G.Ribaudo Kevin He Sarah Madira Emma R.Young Cameron Martin Tingying Lu justin M.Sacks Xiaowei Li Division of Plastic and Reconstructive Surgery Department of SurgeryWashington University in St.LouisMO63110USA Department of Plastic Surgery Johns Hopkins School of MedicineBaltimoreMD21287USA

Sutureless anastomotic devices present several advantages over traditional suture anastomosis,including expanded global access to microvascular surgery,shorter operation and ischemic times,and reduced ***,their adaptation for arterial use remains a *** review aims to provide a comprehensive overview of sutureless anastomotic approaches that are either FDA-approved or under *** approaches include extraluminal couplers,intraluminal devices,and methods assisted by lasers or vacuums,with a particular emphasis on tissue *** analyze these devices for artery compatibility,material composition,potential for intimal damage,risks of thrombosis and restenosis,and complications arising from their deployment and ***,we discuss the challenges faced in the development and clinical application of sutureless anastomotic ***,a sutureless anastomotic device or technique should eliminate the need for vessel eversion,mitigate thrombosis through either biodegradation or the release of antithrombotic drugs,and be easily deployable for broad *** transformative potential of sutureless anastomotic approaches in microvascular surgery highlights the necessity for ongoing innovation to expand their applications and maximize their benefits.

关键词： Vascular Anastomotic device Tissue adhesive Patency OUTLINE

The Effects of 5 Weeks of Leg-Drive Training on Bench Press Performance in Recreationally-Trained,College-Age Men

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Journal of Science in Sport and Exercise 2022年第3期4卷 231-236页

作者： Jacob K.Gardner justin T.Chia Brent M.Peterson Kelsey L.Miller Department of Kinesiology and Health Science Biola University13800 Biola AveLa MiradaCA 90639USA Department of Health and Human Development Western Washington University516 High StreetBellinghamWA 98225USA

Introduction The bench press is commonly used to measure upper-body *** much emphasis has been placed on the upper-body,little is known about how the lower-body can play a role in bench press ***-drive is a technique that includes flexing the knee so the feet line up posterior to the knee joint,while simultaneously contracting the knee extensors isometrically during the *** purpose of this study was to compare strength characteristics of lifters in a standard bench press versus a leg-drive bench press over the course of 5-weeks of *** Twenty-three recreationally active males(age:22.4±2.1 years,height:175.0±5.9 cm,mass:78.4±9.5 kg)were randomized into a standard bench or leg-drive bench press *** performed four sets to failure,two times per week for five *** of interests were training volume and 1-repetition maximum(1RM)*** training volume,a 2×5(group×week)repeated measures analysis of variance(RMANOVA)was *** the 1RM’s,a 2×2×2(group×press type×time)RMANOVA was used.A priori alpha levels were set to *** Over time,both groups showed an approximate 6%increase in 1RM *** volume for week 4 was 5.6%less than week 5,but was not different from weeks 1 through *** between-group differences were observed for 1RM strength or training *** This results of this work indicates that 5 weeks of leg-drive training is effective in increasing 1RM strength,but was not more effective than standard bench press ***,lifters should choose either lifting style based on personal preference.

关键词： Chest press Lower-body Weight lifting Isometric contraction

Vascularized omental tissue transfer for the treatment of lymphedema:a review

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Plastic and Aesthetic Research 2023年第1期10卷 46-55页

作者： Rachel Skladman William R.Moritz Elijah J.Tenenbaum Joani M.Christensen justin M.Sacks Division of Plastic and Reconstructive Surgery Washington University School of MedicineSt.LouisMO 63108USA

Lymphedema is a debilitating disorder caused by impaired drainage of the lymphatic *** the Western world,lymphedema most often arises secondary to the treatment of *** with lymphedema experience progressive swelling,pain,numbness,and tingling,and decreased quality of *** with persistent symptoms may be subject to chronic *** advent of microsurgery has enabled clinicians to transplant donor lymph nodes and their blood supply from a healthy site to the affected area in a procedure known as vascularized lymph node transplant(VLNT).One donor region is the *** omental lymph node transfer(VOLT)has been shown to decrease limb volume,circumference,and subjective symptoms of *** immunologic properties of the omentum make it a particularly useful lymph node donor site for patients with lymphedemarelated *** omentum may be harvested laparoscopically,with robotic assistance,or through a small laparotomy *** this review,we describe the relevant anatomy and history of VOLT as well as operative *** risks,benefits,and relevant outcome studies will be *** applications of robotic surgery to VOLT will be addressed.

关键词： Lymphedema VOLT VLNT laparoscopy laparotomy gastroepiploic vessels cellulitis

A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 77-87页

作者： Jiawei Ge justin D.Opfermann Hamed Saeidi Katherine A.Huenerberg Christopher D.Badger Jaepyeong Cha Martin J.Schnermann Arjun S.Joshi Axel Krieger Department of Mechanical Engineering Johns Hopkins University BaltimoreMD 21218USA Department of Mechanical Engineering University of Maryland College Park MD 20742USA Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital WashingtonDC 20010USA Department of Pathology George washington University WashingtonDC 20052USA Division of Otolaryngology-Head and Neck Surgery George washington University washington DC 20052USA Chemical Biology Laboratory Center for Cancer Research National Cancer InstituteNational Institutes of HealthFrederickMD 21702USA

Surgical tumor resection is a common approach to cancer *** Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the ***,India Ink tattoos are easily obscured during electrosurgical resection,and fade in intensity over *** this work,a novel near-infrared(NIR)fluorescent marker is introduced as an *** NIR marker was made by mixing indocyanine green(ICG),biocompatible cyanoacrylate,and *** marking strategy was evaluated in a chronic ex vivo feasibility study using porcine tissues,followed by a chronic in vivo mouse study while compared with India *** both studies,signal-to-noise(SNR)ratios and dimensions of the NIR markers and/or India Ink over the study period were calculated and *** was performed on the last day of the mouse study after mice were euthanized,and SNR ratios and dimensions were quantified and *** was performed at all injection sites and slides were examined by a *** proposed NIR marker achieved(i)consistent visibility in the 26-day feasibility study and(ii)improved durability,visibility,and biocompatibility when compared to traditional India Ink over the six-week period in an in vivo mouse *** effects persist after electrocautery whereas the India Ink markers were *** use of a NIR fluorescent presurgical marking strategy has the potential for intraoperative tracking during long-term treatment protocols.

关键词： Near-infrared fluorescent marker surgical tumor resection fluorescence-guided sur-gery electrosurgery India ink

Multiple partnerships and risk for HIV among the Garífuna minority population in Belize

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Health 2012年第8期4卷 474-482页

作者： justin Buszin Benjamin Nieto-Andrade Jorge Rivas Kim Longfield Pan American Social Marketing Organization Guatemala City Guatemala Research and Metrics Department Population Services International Washington DC USA

Belize has the highest rates of HIV infection in Central America and is experiencing a generalized epidemic. The Garífuna, a minority ethnic population, is at risk for HIV. This study uses survey data from Garífuna men and women to examine the frequency of multiple partnerships as well as sociodemographic characteristics and behavioral constructs correlated with having multiple partners. A high proportion of respondents reported having multiple partners, but rates were significantly higher for men, and men had a higher mean number of partners than women. A high proportion of respondents reported having a sexually transmitted infection (STI) in the last year, with more men reporting a history of STIs than women. Regression results show the importance of improving men and women’s perceived susceptibility for HIV and encouraging them to know their HIV status. Reinforcing a social norm for partner reduction would also benefit men. Study findings support the need for HIV counseling and testing in Garífuna communities as well as STI prevention, diagnosis and treatment. This study demonstrates that reducing multiple partnerships among Garífuna men and women is critical for reducing the spread of HIV in Belize.

关键词： Garífuna Belize Multiple Partnerships HIV STI

Regulating off-centering distortion maximizes photoluminescence in halide perovskites

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National Science Review 2021年第9期8卷 60-67页

作者： Xujie Lu Constantinos Stoumpos Qingyang Hu Xuedan Ma Dongzhou Zhang Songhao Guo justin Hoffman Kejun Bu Xiaofeng Guo Yingqi Wang Cheng Ji Haijie Chen Hongwu Xu Quanxi Jia Wenge Yang Mercouri G.Kanatzidis Ho-Kwang Mao Center for High Pressure Science and Technology Advanced Research Department of Chemistry Northwestern University Department of Materials Science and Technology Voutes Campus University of Crete Center for Nanoscale Materials Argonne National Laboratory Partnership for Extreme Crystallography University of Hawaii at Manoa Department of Chemistry and Alexandra Navrotsky Institute for Experimental Thermodynamics Washington State University Earth and Environmental Sciences Division Los Alamos National LaboratoryLos Alamos Department of Materials Design and Innovation University at Buffalo The State University of New York

Metal halide perovskites possess unique atomic and electronic configurations that endow them with high defect tolerance and enable high-performance photovoltaics and optoelectronics. Perovskite light-emitting diodes have achieved an external quantum efficiency of over 20%. Despite tremendous progress,fundamental questions remain, such as how structural distortion affects the optical properties. Addressing their relationships is considerably challenging due to the scarcity of effective diagnostic tools during structural and property tuning as well as the limited tunability achievable by conventional methods. Here,using pressure and chemical methods to regulate the metal off-centering distortion, we demonstrate the giant tunability of photoluminescence (PL) in both the intensity (>20 times) and wavelength(>180 nm/GPa) in the highly distorted halide perovskites [CH3NH3GeI3, HC(NH2)2GeI3, and Cs Ge I3].Using advanced in situ high-pressure probes and first-principles calculations, we quantitatively reveal a universal relationship whereby regulating the level of off-centering distortion towards 0.2 leads to the best PL performance in the halide perovskites. By applying this principle, intense PL can still be induced by substituting CH3NH~3+with Cs~+to control the distortion in (CH3NH3)1-xCsxGeI3, where the chemical substitution plays a similar role as external pressure. The compression of a fully substituted sample of CsGe I3further tunes the distortion to the optimal value at 0.7 GPa, which maximizes the emission with a10-fold enhancement. This work not only demonstrates a quantitative relationship between structural distortion and PL property of the halide perovskites but also illustrates the use of knowledge gained from high-pressure research to achieve the desired properties by ambient methods.

关键词： halide perovskites high pressure off-centering distortion optical properties lone-pair electrons quantitative relationship