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Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

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Neural Regeneration Research 2019年第9期14卷 1511-1512页

作者： Luke McAlary justin J.Yerbury Illawarra Health and Medical Research Institute WollongongNSWAustralia School of Chemistry and Molecular Bioscience Molecular HorizonsFaculty of ScienceMedicine and HealthUniversity of WollongongNSWAustralia

(Cu)^IIATSM(CuATSM)promotes the proper folding of familial amyotrophic lateral sclerosis(fALS)-associated copper,zinc superoxide dismutase(SOD1):ALS is a progressive neurodegenerative disease that affects motor neurons in the cortex and spinal cord,resulting in paralysis and ultimately *** majority of cases are sporadic and the remainder are fALS where a subset of cases are associated with over 160,mostly missense,mutations in the SOD1 enzyme ***,these mutations impede the correct folding of SOD1 by disrupting either metal binding,disulfide formation,and/or dimerization,leading to the accumulation of misfolded SOD1 which can form the intracellular inclusions observed in patient tissue.

关键词： (Cu)^IIATSM(CuATSM) familial amyotrophic patient tissue

Representing the retinal line spread shape with mathematical functions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第12期9卷 996-1002页

作者： Yi-rong YANG justin WANEK Mahnaz SHAHIDI Department of Bioengineering University of lllinois at Chicago IL 60607 USA Department of Ophthalmology and Visual Sciences University of Illinois at Chicago IL 60607 USA

Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. Determining analytical functions that represent the double-pass LSF is important because it allows modeling the optical performance of the eye. Methods: Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface. Three mathematical functions (Lorentzian, Gaussian, exponential) were fitted to the double-pass LSF and the root mean square error (RMSE) was calculated to provide a measure of the goodness of fit. Results: The Lorentzian function provided the best representation of the double-pass LSF of normal human eyes. The full width at half maximum (FWHM) of the Lorentzian fitted curve was positively correlated with age, indicating that the double-pass LSF broadens with age. Furthermore, the goodness of fit of the Lorentzian function was significantly better in younger subjects as compared with older subjects, suggesting that the fitted function to the double-pass LSF may vary according to age. Conclusion: The results demonstrate an age-related change in the double-pass LSF width and the goodness of fit of the Lorentzian function.

关键词： Retina Double-pass line spread function (LSF) Lorentzian Gaussian Exponential

Proteoglycans: Road Signs for Neurite Outgrowth

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Neural Regeneration Research 2014年第4期9卷 343-355页

作者： justin A.Beller Diane M.Snow Spinal Cord and Brain Injury Research Center The University of Kentucky

Proteoglycans in the central nervous system play integral roles as ＂traffic signals＂ for the direction of neurite outgrowth. This attribute of proteoglycans is a major factor in regeneration of the injured central nervous system. In this review, the structures of proteoglycans and the evidence suggesting their involvement in the response following spinal cord injury are presented. The review further describes the methods routinely used to determine the effect proteoglycans have on neurite outgrowth. The effects of proteoglycans on neurite outgrowth are not completely understood as there is disagreement on what component of the molecule is interacting with growing neurites and this ambiguity is chronicled in an historical context. Finally, the most recent findings suggesting possible receptors, interactions, and sulfation patterns that may be important in eliciting the effect of proteoglycans on neurite outgrowth are discussed. A greater understanding of the proteoglycan-neurite interaction is necessary for successfully promoting regeneration in the iniured central nervous system.

关键词： chondroitin sulfate proteoglycans heparan sulfate proteoglycans glycosaminoglycans protein core extracellular matrix neuronal growth cones axon outgrowth and regeneration spinalcord injury glial scar tissue culture

On the Centre of Mass Motion in Human Walking

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International Journal of Automation and computing 2017年第5期14卷 542-551页

作者： justin Carpentier Mehdi Benallegue Jean-Paul Laumond LAAS-CNRS University of Toulouse Humanoids Research Group National Institute of Advanced Industrial Science and Technology

The center of mass （CoM） is a key descriptor in the understanding and the analysis of bipedal locomotion. Some approaches are based on the premise that humans minimize the CoM vertical displacement. Other approaches express walking dynamics through the inverted pendulum model. Such approaches are contradictory in that they lead to two conflicting patterns to express the CoM motion： straight line segments for the first approaches and arcs of a circle for the second ones. In this paper, we show that CoM motion is a trade-off between both patterns. Specifically, CoM follows a ＂curtate cycloid＂, which is the curve described by a point rigidly attached to a wheel rolling on a flat surface. We demonstrate that all the three parameters defining a curtate cycloid only depend on the height of the subjects.

关键词： Human locomotion analytical model centre of mass locomotion signature synergies.

Effectiveness of a fixed-depth sensor deployed from a buoy to estimate water-column cyanobacterial biomass depends on wind speed

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Journal of Environmental Sciences 2020年第7期32卷 23-29页

作者： justin D.Chaffin Douglas D.Kane Alex Johnson F.T Stone Laboratory and Ohio Sea Grant the Ohio State UniversityOH 43456USA Division of Natural Science Applied Scienceand MathematicsDefiance CollegeDefiance OHF.T Stone LaboratoryThe Ohio State University and Ohio Sea GrantOH 43456USA

Water quality sondes have the advantage of containing multiple sensors,extended deployment times,high temporal resolution,and telecommunication with stakeholder accessible data ***,sondes that are part of buoy deployments often suffer from typically being fixed at one *** water treatment plants are interested in water quality at a depth of the water intake and other stakeholders(*** and swimmers)are interested in the surface,we examined whether a fixed depth of approximately 1 m could cause over-or under-estimation of cyanobacterial *** sampled the vertical distribution of cyanobacteria adjacent to a water quality sonde buoy in the western basin of Lake Erie during the summers of 2015–2017.A comparison of buoy cyanobacteria RFU(Relative Fluorescence Unit)at 1 m to cyanobacteria chlorophyll a(chla)measured throughout the water column showed occurrences when the buoy both under and overestimated the cyanobacteria chl a at specific *** differences between buoy measurements and at-depth grab samples occurred during low wind speeds(4.5 m/sec)resulted in better agreement between the buoy and at-depth *** wind speeds 12 hr before sample collection decreased the difference between the buoy and at-depth samples for high wind speeds but not low *** suggest that sondes should be placed at a depth of interest for the appropriate stakeholder group or deploy sondes with the ability to sample at various depths.

关键词： Buoyancy Harmful algal bloom Lake Erie Microcystis Water quality

Quantifying aluminosilicate manganese release and dissolution rates across organic ligand treatments for rocks, minerals,and soils

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Acta Geochimica 2021年第4期40卷 484-497页

作者： justin B.Richardson LeAnn X.Zuniga Department of Geosciences University of MassachusettsMorrill Science Center 3611 North Pleasant StreetAmherstMA 01003USA

Manganese is ubiquitous in terrestrial environments and most studies have focused on dissolution of Mn oxides,but aluminosilicates also release ***,we evaluated oxic Mn dissolution from six rocks and minerals(amphibolite,anorthosite,kaolinite,kyanite,muscovite,orthoclase feldspar) and soils from four Critical Zone Observatories(CZOs) under four LMWOLs treatments(catechol,citric acid,oxalic acid,control).Overall rock and mineral Mn mass-normalized release was 1.4 ± 0.5 nM μM^(-1) 14 d^(-1) and dissolution rate was 2403 ± 935 nM m^(-2) d^(-1) x 10^(3).Overall CZO soil Mn release was 16.7±5.1 nM μM^(-1) 14 d^(-1) and dissolution rate was 7010 ± 2570 nM m^(-2) d^(-1) × 10^(3).Anorthosite and kyanite had the highest Mn dissolution rates but kaolinite and kyanite had the highest Mn mass-normalized release *** hypothesize the structural location of Mn,surface area,and potential inclusions of highly-weatherable-phases control Mn dissolution for rocks and *** soils with the highest solid phase Mn had the highest Mn release and dissolution *** acid and catechol had higher Mn release and dissolution rates than the control while oxalic acid did *** rocks and minerals,we found pH 4 had higher Mn release and dissolution rates than pH6,but not for control treatments without *** study highlights that the abundance of Mn drove Mn release in soils but not rocks and ***,LMWOLs are important for Mn dissolution,even under acidic pH conditions.

关键词： Aluminosilicates Weathering rates organic acids Critical zone Mn oxides

Attribution of Fano resonant features to plasmonic particle size, lattice constant, and dielectric wavenumber in square nanoparticle lattices

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Photonics Research 2014年第1期2卷 15-23页

作者： Drew DeJarnette justin Norman D.Keith Roper Microelectronics and Photonics Graduate Program University of ArkansasFayettevilleArkansas 72701USA Department of Chemical Engineering University of ArkansasFayettevilleArkansas 72701USA

Fano resonances between plasmons and diffracted light offer tunable energies and locales,but attribution of Fano resonance features to geometry and physicochemistry of metal nanostructures and adjacent dielectrics has been confounded by complexity and computational *** work shows predictable modal shifts of Fano resonance in square lattices of plasmonic nanostructures can be attributed directly to changes in medium wavenumber,particle size,and lattice constant that alter plasmon polarizability and diffractive *** 45 to 80 nm radius particles,a window of lattice constants that support Fano resonances is identified in a range from 500 to 900 *** constants that support high intensity resonances are determined by individual particle polarizability and medium *** resonance wavelengths redshift from diffracted photon energies as local refractive index(RI)changes due to coupling with particle polarizability in the *** sensitivities for quadrupole,dipole,and Fano resonances are 150,348,and 541 nm,respectively,per RI *** resonance intensity may be enhanced more than tenfold by selecting nanoparticle sizes and lattice *** quantitative effects of such parametric changes are rapidly and intuitively distinguished using a semi-analytic approach,consisting of an exact expression for particle polarizability,a trigonometric description of diffraction,and a semianalytical coupled dipole approximation.

关键词： lattice particle wave

Unveiling a new regulator: Vacuolar V-ATPase mediates brassinosteroid signaling in Arabidopsis

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Molecular Plant 2024年第2期17卷 227-229页

作者： Shikha Malik justin W.Walley Department of Plant Pathology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Plant growth and development are intricately regulated by hormones such as auxins,gibberellins,jamonates,cytokinins,and brassinosteroids(BRs).BRs are a group of plant steroid hormones that play a vital role in plant growth and response to the *** regulate many biological processes including cell elongation,cell division,and male fertility,as well as abiotic and biotic stress responses.

关键词： media fertility brassinosteroid

Genetic polymorphism in pathogenesis of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第47期20卷 17693-17698页

作者： Cynthia KY Cheung justin CY Wu Institute of Digestive Disease The Chinese University of Hong Kong

Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3 mo according to ROME III: relief by defecation, onset associated with a change in stool frequency or onset with change in appearance or form of stool. Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms, as well as the therapeutic responses in treating IBS patients. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS.

关键词： Irritable bowel syndrome Genetic polymorphism Cytokines Serotonin Psychiatric distress Endocannabinoids