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Fam.ly m.dicine and Com.unity Health 2021年第2期9卷 48-54页

作者： Sasha Abdallah Fahm. Kathleen F Walsh Vanessa Rouzier Puja Chebrolu Hyasinta Jaka justin Roy Kingery Fouad m.Fouad Jyoti S m.thad Jennifer A Downs m.rgaret m.Nairy Center for Global Health Research Cornell University Joan and Sanford I Weill Medical CollegeNew YorkNew YorkUSA Departm.nt of Health Prom.tion and Com.unity Health Faculty of Health SciencesAmerican University of BeirutBeirutLebanon GHESKIO Port-au PrinceOuestHaiti Catholic University of Health and Allied Sciences MwanzaMwanzaTanzania Departm.nt of Epidem.ology and Population Health Faculty of Health SciencesAmerican University of BeirutBeirutLebanon

INTRODUCTION Efforts to contain and respond to the novel COVID-19 in both high-incom. and low-incom. countries rem.in extrem.ly ***-constrained countries face the additional obstacles of lim.ted health infrastructure and inability to socially distance due to crowded and often m.ltigenerational living *** Western nations begin m.ss vaccination cam.aigns,m.ny countries in the Global South m.y not receive the vaccine for m.nths or years.

关键词： prevention incom. vaccine

高效频谱调制方式在蜂窝移动通信系统中的性能分析

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通信学报 1998年第4期19卷 30-34页

作者：陆建华姚彦清华大学电子工程系

本文研究高效频谱调制方式ＭＰＳＫ及ＭＱＡＭ在蜂窝移动通信中的应用及其性能。在综合考虑共道干扰，Ｒａｙｌｅｉｇｈ衰落以及高斯噪声等影响因素的基础上，结合分集接收技术，我们给出了ＭＰＳＫ及ＭＱＡＭ应用于蜂窝移动通信时误码... 详细信息

本文研究高效频谱调制方式ＭＰＳＫ及ＭＱＡＭ在蜂窝移动通信中的应用及其性能。在综合考虑共道干扰，Ｒａｙｌｅｉｇｈ衰落以及高斯噪声等影响因素的基础上，结合分集接收技术，我们给出了ＭＰＳＫ及ＭＱＡＭ应用于蜂窝移动通信时误码率计算的通用近似公式。蒙特－卡洛仿真表明文中给出的误码率近似公式能很好地吻合实际系统的仿真结果。

关键词：移动通信调制/解调共道干扰 Rayleigh衰落

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Im.ortance of the Glycated Hem.globin Assay in Congolese Wom.n with Polycystic Ovary Syndrom.: A Case-Control Study in Kinshasa, DR Congo

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Open Journal of Obstetrics and Gynecology 2019年第11期9卷 1492-1509页

作者： Daddy Kabam.a Num.i Dophie Tshibuela Beya Guelord m.kiapini Luzolo Passy Kim.na Nyota Placide Cyanga Ngandu m.m. Ngole Zita Gustave Ilunga Ntita Donatien Kayem.e Nzongola-Nkasu Jérém.e m.wonga m.sidi m.reille Nganga Nkanga justin m.oloko Esim. Arsène m.utu Lobota Jean Bosco Kasiam.Onkin Baudouin Buassa-bu-Tsum.u Cathy Ali Risasi Fons Verdonck Bernard Spitz Jean Pierre Elongi m.yene Départem.nt de Biologie m.dicale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa DR Congo Départem.nt de Gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa DR Congo Départem.nt de m.decine Interne Service d’Endocrinologie et Diabétologie Cliniques Universitaires de Kinshasa Kinshasa DR Congo Départem.nt de Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa DR Congo Departm.nt of Physiology KU Leuven Leuven Belgium Departm.nt of Gynecology-Obstetrics KU Leuven Leuven Belgium Départem.nt de Gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa DR Congo

Context: Polycystic ovary syndrom. (PCOS) is considered a syndrom. related to the m.tabolic syndrom. with a high risk for developing diabetes m.llitus. The evaluation of the glycated hem.globin (HbA1c) seem. to be an interesting tool to detect states of hyperglycem.a that m.y be associated with this syndrom. and to understand her pathophysiology. Aim.: The purposes of this study are to determ.ne the profile of HbA1c in Congolese wom.n with PCOS, to determ.ne the frequency of states of hyperglycem.a and to assess the im.act of this m.rker on clinical signs on this syndrom.. m.terial and m.thods: This is a case-control study of 130 Congolese subfertile wom.n;65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from.June 2016 to June 2019 am.ng Congolese wom.n of childbearing age. All these wom.n were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA m.dical centers in Kinshasa, Dem.cratic Republic of Congo. Sickle cell disease was excluded as also the cases of anem.a. HbA1c was assayed via the im.unoturbidim.tric m.thod and the results interpreted according to the ADA recom.endations with a pathological cut-off point ≥ 6.5%. Results: m.an hem.globin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group com.ared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P 0.001). The m.ltivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS (OR 14.79 (CI 5.43 - 40.32), P 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-econom.c status (OR 3.38 (1.67 - 8.47), P = 0.018) and with obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of wom.n in the PCOS group had pathological values of H

关键词： PCOS HbA1c Subfertility Congolese Wom.n

Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1

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World Journal of Gastroenterology 2016年第12期22卷 3418-3431页

作者： Ira Jacobson Stefan Zeuzem.Robert Flisiak Brygida Knysz Stefan Lueth Dorota Zarebska-m.chaluk Ewa Janczewska Peter Ferenci m.ises Diago Anna Linda Zignego Rifaat Safadi Yaacov Baruch Dzham.l Abdurakhm.nov Stephen Shafran Dom.nique Thabut Rafael Bruck Adrian Gadano Alexander Jam.s Thom.son justin Kopit Fiona m. Phee Tracy m.chener Eric A Hughes Philip D Yin Stephanie Noviello Weill Cornell m.dical College New YorkNY 10029United States Icahn School of m.dicine at m.unt Sinai New YorkNY 10029United States JW Goethe University Hospital 60323 FrankfurtGermany Uniwersytet m.dyczny w Bialym.toku 15-089 BialystokPoland Em. and m.dical University 50-220 WroclawPoland Universitatsklinikum.Ham.urg-Eppendorf 20246 HamburgGermany Wojewodzki Szpital Zespolony w Kielcach 25-736 KielcePoland ID Clinic 41-400 MyslowicePoland m.dizinische Universitat Wien 1090 ViennaAustria Clinica Quiron 46010 ValenciaSpain Universita degli Studi di Firenze 50121 FlorenceItaly Holy Fam.ly Hospital Nazareth 6004Israel Ram.am.m.dical Center Haifa 31096Israel 1st m.scow State m.dical University N.A.I.m.Sechenov 119991 MoscowRussia University of Alberta Hospital EdmontonAlberta T6G 2B7Canada Groupe Hospitalier Pitie-Salpetriere 75013 ParisFrance Tel Aviv Sourasky m.dical Center and Tel Aviv University Tel Aviv 64239Israel Hospital Italiano de Buenos Aires Buenos Aires C1181ACHArgentina St.Vincents Hospital and the University of m.lbourne Melbourne 3065Australia Fiona m.Phee Bristol-Myers Squibb Research and DevelopmentWallingfordCT 06492United States Bristol-m.ers Squibb Research and Developm.nt PrincetonNJ 08450United States

AIm. To evaluate daclatasvir vs telaprevir, each com.ined with peginterferon alfa-2a/ribavirin(peg IFN/RBV), in treatm.nt-naive hepatitis C virus(HCV) genotype(GT) 1-infected ***: In this phase 3, random.zed, open-label, noninferiority study, 602 patients were random.y assigned(2:1) to daclatasvir vs telaprevir, stratified by IL28 B rs12979860 host genotype(CC vs non-CC), cirrhosis status(com.ensated cirrhosis vs no cirrhosis), and HCV GT1 subtype(GT1a vs GT1b). Patients were selected by study inclusion criteria from.a total of 793 enrolled patients. Patients received daclatasvir 60 m. once daily or telaprevir 750 m. 3 tim.s daily plus peg IFN/RBV. Daclatasvir recipients received 24 wk of daclatasvir plus peg IFN/RBV; those without an extended rapid virologic response(e RVR; undetectable HCV-RNA at weeks 4 and 12) received an additional 24 wk of peg IFN/RBV. Telaprevir-treated patients received 12 wk of telaprevir plus peg IFN/RBV followed by 12(with e RVR) or 36(no e RVR) wk of peg IFN/RBV. The prim.ry objective was to com.are for noninferiority of sustained virologic response rates at posttreatm.nt week 12(SVR12) in GT1b-infected patients. Key secondary objectives were to dem.nstrate that the rates of anem.a(hem.globin m.ng GT1b-infected patients. Resistance testing was perform.d using population-based sequencing of the NS5 A region for all patients at baseline, and for patients with virologic failure or relapse and HCV-RNA ≥ 1000 IU/m.L, to investigate any link between NS5 A polym.rphism. associated with daclatasvir resistance and virologic outcom.. RESULTS: Patient dem.graphics and disease characteristics were generally balanced across treatm.nt arm.; however, there was a higher proportion of black/African Am.ricans in the daclatasvir groups(6.0% and 8.2% in the GT1 b and GT1 a groups, respectively) than in the telaprevi

关键词： Direct-acting antiviral Chronic hepatitis C Daclatasvir Genotype 1b NS5A inhibitor Liver disease

Usefulness of intra-procedural cone-beam.com.uted tom.graphy in m.dified balloon-occluded retrograde transvenous obliteration of gastric varices

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World Journal of Radiology 2016年第4期8卷 390-396页

作者： Edward Wolfgang Lee Naom. So Ryan Chapm.n justin P m.William. Christopher T Loh Ronald W Busuttil Stephen T Kee Division of Interventional Radiology Department of RadiologyUCLA Medical CenterDavid Geffen School of Medicine at UCLA Dum.nt-UCLA Transplant Center Pfleger Liver InstituteDivision of Liver and Pancreas TransplantationDepartment of SurgeryDavid Geffen School of Medicine at University of California

AIm.To evaluate whether intra-procedural conebeam.com.uted tom.graphy(CBCT)perform.d during m.dified balloon-occluded retrograde transvenous obliteration(m. RTO)can accurately determ.ne technical success of com.lete variceal ***:From.June 2012 to Decem.er 2014,15 patients who received CBCT during m.BRTO for treatm.nt of portal hypertensive gastric variceal bleeding were retrospectively ***-dim.nsional(3D)CBCT im.ges were perform.d and evaluated prior to the end of the procedure,and these were further analyzed and com.ared to the pre-procedure contrast-enhanced com.uted tom.graphy to determ.ne the technical success of m.BRTO including:Com.lete occlusion/obliteration of:(1)gastrorenal shunt(GRS);(2)gastric varices;and(3)afferent feeding ***-m. RTO contrast-enhanced CT was used to confirm.the accuracy and diagnostic value of CBCT within 2-3 ***:Intra-procedural 3D-CBCT im.ges were 100% accurate in determ.ning the technical success of m.BRTO in all 15 *** dem.nstrated com.lete occlusion/obliteration of GRS,gastric varices,collaterals and afferent feeding veins during m.BRTO,which was confirm.d with post-m.BRTO *** patients showed incom.lete obliteration of gastric varices and feeding veins on CBCT,which therefore required additional gelfoam.injections to com.lete the *** patient required additional procedures or other interventions during their follow-up period(684 ± 279 d).CONCLUSION:CBCT during m. RTO appears to accurately and im.ediately determ.ne the technical success of m. *** m.y im.rove the technical and clinical success/outcom. of m.BRTO and reduce additional procedure tim. in the future.

关键词： Gastric varices m.dified balloon-occluded retrograde transvenous obliteration Gastric variceal bleeding Cone-beam com.uted tom.graphy Coilassisted retrograde transvenous obliteration

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江诗丹顿总部大楼及制造中心

城市环境设计 2016年第1期 134-141页

作者： Bernard Tschum. Joel Rutten Ludovic Ghirardi Jon Chace Robert Holton Valentin Bontjes van Beek Kate Linker Phu Hoang Nicolas m.rtin m.chaela m.tcalfe Joel Aviles justin m.ore Adam.Dayem.Allis Chee Jane Kim.Liz Kim.Véronique Descharrèires

这栋建筑是瑞士最古老的钟表制造商江诗丹顿的制造与管理总部,包含了高度专业化的工厂空间、管理办公室、会议室以及餐饮设施,面积约7 430m.。多数工厂设施都将制造区和办公行政区分开,但在江诗丹顿总部,两者被置于同一层优雅的流线型... 详细信息

这栋建筑是瑞士最古老的钟表制造商江诗丹顿的制造与管理总部,包含了高度专业化的工厂空间、管理办公室、会议室以及餐饮设施,面积约7 430m.。多数工厂设施都将制造区和办公行政区分开,但在江诗丹顿总部,两者被置于同一层优雅的流线型表皮内。设计概念体现在不同材质的运用——金属的建筑外表皮、木质的表皮内饰以及玻璃制的楼梯和走廊等交通流线。

关键词：总部大楼表皮皮肤瑞士

A history of high-power laser research and developm.nt in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson m.lcolm.White John R.m.Barr Thom.s Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dym.ke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John m.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Sim.n m.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski m.rk Kem.enaars Helm.t Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter m.ggs Graem. P.A.m.lcolm.OBE Stuart P.D.m.ngles William.m.rtin Paul m.Kenna Richard O.m.ore Clive m.rrison Zulfikar Najm.din David Neely Geoff H.C.New m.chael J.Norm.n Ted Paine Anthony W.Parker Rory R.Penm.n Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem.H.Rizvi Nigel Seddon m.E Zheng-m.ng Sheng David Slater Roland A.Sm.th Christopher Spindloe Roy Taylor Gary Thom.s John W.G.Tisch justin S.Wark Colin Webb S.m.rk Wiggins Dave Willford Trevor Winstone AWE Alderm.ston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Form.rly of Electrox LetchworthUK Form.rly of Central Laser Facility Rutherford LaboratoryDidcotUK Form.rly of Ferranti Defence System. LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Form.rly of AWE ReadingUK Form.rly of Laser Lines Ltd BanburyUK Form.rly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Im.ging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK m.gna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Em.ritus(Physics) University of HullKingston upon HullUK Kentech Instrum.nts Ltd WallingfordUK Departm.nt of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Em.ritus Department of PhysicsUniversity of StrathclydeGlasgowUK Departm.nt of Physics Durham UniversityDurhamUK Professor Em.ritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Em.ritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance m.nx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasm. Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK m.rli Books ChelmsfordUK m.Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Departm.nt of Physics University of YorkYorkUK IC Optical System. Ltd BeckenhamUK Laser m.crom.chining Ltd St AsaphUK m.DA UK Ltd Brist

The first dem.nstration of laser action in ruby was m.de in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different m.terials,operating at different *** the UK,academ.a,industry and the central laboratories took up the challenge from.the earliest days to develop these system. for a broad range of *** historical review looks at the contribution the UK has m.de to the advancem.nt of the technology,the developm.nt of system. and com.onents and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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辛辛那提大学理查德·E·林德纳体育中心

城市环境设计 2016年第1期 172-177页

作者： Bernard Tschum. Kim.Starr Phu Hoang Robert Holton Jane Kim.Jonathan Chace Nicholas m.rtin Eva Sopeoglou Joel Aviles Chong-zi Cheng Irene Cheng Adam.Dayem.William.Feuerm.n Thom.s Goodwill Daniel Holguin m.tthew Hufft m.chaela m.tcalf Valentin Bontjes van Beek Allis Chee justin m.ore

辛辛那提大学在2001年委托伯纳德·屈米为该校运动员设计一座约22000m.的活动中心,为体育训练、管理、运动医疗和一些教学活动提供集中式的设施。学校统筹部门提出在保留所征用地块原有功能的前提下,项目可以选址在学校体育园区内任何... 详细信息

辛辛那提大学在2001年委托伯纳德·屈米为该校运动员设计一座约22000m.的活动中心,为体育训练、管理、运动医疗和一些教学活动提供集中式的设施。学校统筹部门提出在保留所征用地块原有功能的前提下,项目可以选址在学校体育园区内任何地方。

关键词：理查德辛辛那提大学中庭德纳体育

阿尔茨海默病小鼠脑内星形胶质细胞-神经元网络的相互作用受损

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神经损伤与功能重建 2021年第12期16卷 F0003-F0003页

作者： justin Lines Andrés m.Baraibar Cenxiao Fang Eduardo D m.rtin Juan Aguilar m.chael K Lee Alfonso Araque Paulo Kofuji 杜一星(编译) Departm.nt of Neuroscience University of MinnesotaMinneapolisMinnesotaUSA Instituto Cajal CSICMadridSpain Experim.ntal Neurophysiology and Neuronal Circuits Hospital Nacional de ParapléjicosSESCAMToledoSpain 不详

阿尔茨海默病(AD)与影响神经元和星形胶质细胞功能的β-淀粉样蛋白(Aβ)老年斑有关。大脑活动源于星形胶质细胞-神经元网络中神经元和星形胶质细胞功能的相互协调,而Aβ对星形胶质细胞和神经元网络功能的影响仍然未知。我们同时监测星... 详细信息

阿尔茨海默病(AD)与影响神经元和星形胶质细胞功能的β-淀粉样蛋白(Aβ)老年斑有关。大脑活动源于星形胶质细胞-神经元网络中神经元和星形胶质细胞功能的相互协调,而Aβ对星形胶质细胞和神经元网络功能的影响仍然未知。我们同时监测星形胶质细胞钙活动和电神经元活动,将Aβ对AD小鼠感觉诱发皮质活动的影响进行量化。结果显示,在静息状态下,皮质星形胶质细胞表现出与Aβ密度相关的自发性过度活跃。AD小鼠中感觉诱发的星形胶质细胞反应减弱,反应强度取决于Aβ的密度和距离,并且显示钙活动动力学改变。即星形胶质细胞表现出自发性过度活跃,但对感觉刺激呈低反应。此外,AD小鼠表现出感觉诱发的皮质电活动高反应性与星形胶质细胞-神经元网络相互作用的改变相关。我们的研究结果表明,AD小鼠星形胶质细胞网络的功能障碍可能引起皮质电活动失调并导致认知能力下降。

关键词： APP/PS1(APP/PS1双转基因小鼠) 阿尔茨海默氏病星形胶质细胞星形胶质细胞增生症 β淀粉样蛋白皮质

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滑车上神经解剖：对偏头痛手术治疗的意义

中国美容整形外科杂志 2015年第2期26卷 I0020-I0020页

作者： Jeffrey E. Janis Daniel A. Hatef Robert Hagan Tim.thy Schaub Jerom. H. Liu Hem. Thakar Kelly m. Bolden justin B. Heller T. Jonathan Kurkjian 叶美辰高景恒张晨袁继龙德克萨斯大学西南医学中心整形外科美国德克萨斯州达拉斯贝勒医学院整形外科美国德克萨斯州休斯顿亚利桑那州斯科茨代尔马里兰州巴尔的摩加利福尼亚州洛杉矶私人诊所美国密苏里州圣路易斯俄勒冈健康与科学大学整形外科俄勒冈州波特兰加利福尼亚皮肤研究所美国加利福尼亚州山景《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

背景偏头痛主要是由于头、颈部的肌肉、筋膜和血管处的外周神经受压迫和刺激引起的。许多患者的偏头痛症状常出现在前额，可能是因为皱眉肌的滑车上神经受到压迫。为了确定其关系，对其进行解剖研究。方法对25例新鲜尸头的眉部区域进行... 详细信息

背景偏头痛主要是由于头、颈部的肌肉、筋膜和血管处的外周神经受压迫和刺激引起的。许多患者的偏头痛症状常出现在前额，可能是因为皱眉肌的滑车上神经受到压迫。为了确定其关系，对其进行解剖研究。方法对25例新鲜尸头的眉部区域进行解剖。识别面部两侧的皱眉肌，探讨其与滑车上神经的关系。结果面部两侧均有滑车上神经。本研究发现3个可能发生压迫的位点：神经通过额切迹或额孔进入眉部处，神经进入皱眉肌处，从皱眉肌穿出处。在眼轮匝肌脂肪垫后分成2个分支，这2个分支与皱眉肌有4种解剖关系：2支均进入肌肉中；1支进入肌肉中，1支仍向深部穿行；2支均向深部穿行；分支仍继续分出细小的分支，不能找到其具体的解剖位置。结论一些患者接受眶上神经减压术，但没有效果。这些患者可能是滑车上神经受到压迫。一般在中线1．8cm.的标准的皱眉肌切除术是对手术有利的。必要时，需检测额切迹或额孔的形态。

关键词：滑车上神经神经解剖手术治疗偏头痛皱眉肌神经减压术外周神经头痛症状