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Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis

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World Journal of Gastroenterology 2016年第19期22卷 4662-4672页

作者： David Coyle justin m.m.rphy Brian Doyle Anne m.rie O’Donnell John Gillick Prem.Puri Tem.le Street Children's University Hospital Dublin 1 Ireland National Children's Research Centre Our Lady's Children's Hospital Dublin 12 Ireland

AIm. To determ.ne if expression of colonic tryptophan hydroxylase-2(TPH2), a surrogate m.rker of neuronal 5-hydroxytryptam.ne, is altered in Hirschsprung's-associated enterocolitis. m.THODS: Entire resected colonic specim.ns were collected at the tim. of pull-through operation in children with Hirschsprung's disease(HSCR, n = 12). Five of these patients had a history of pre-operative Hirschsprung's-associated enterocolitis(HAEC). Controls were collected at colostom. closure in children with anorectal m.lform.tion(n = 10). The distribution of expression of TPH2 was evaluated using im.unofluorescence and confocal m.croscopy. Protein expression of TPH2 was quantified using western blot analysis in the deep sm.oth m.scle layers. RESULTS: TPH2 was co-expressed in nitrergic and cholinergic ganglia in the m.enteric and subm.cosal plexuses in ganglionic colon in HSCR and healthy controls. Co-expression was also seen in subm.cosal interstitial cells of Cajal and PDGFRα+ cells. The density of TPH2 im.uno-positive fibers decreased increm.ntally from.ganglionic bowel to transition zonebowel to aganglionic bowel in the m.enteric plexus. Expression of TPH2 was reduced in ganglionic bowel in those affected by pre-operative HAEC com.ared to those without HAEC and healthy controls. However, expression of TPH2 was sim.lar or high com.ared to controls in the colons of children who had undergone diverting colostom. for m.dically refractory ***: Altered TPH2 expression in colonic serotonergic nerves of patients with HSCR com.licated by HAEC m.y contribute to intestinal secretory and m.tor disturbances, including recurrent HAEC.

关键词： Serotonin Tryptophan hydroxylase 2 Hirschsprung Enterocolitis Ganglionic

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m.croRNAs in lung cancer

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World Journal of m.thodology 2014年第2期4卷 59-72页

作者： Pooja Joshi justin m.ddleton Young-Jun Jeon m.chelaGarofalo Departm.nt of m.lecular Virology Immunologyand Medical GeneticsComprehensive Cancer CenterTheOhio State University Wexner Medical CenterThe Ohio StateUniversityColumbusOH 43210United States

m.croRNAs have becom. recognized as key players in the developm.nt of cancer. They are a fam.ly of sm.ll non-coding RNAs that can negatively regulate the expression of cancer-related genes by sequence-selective targeting of m.NAs, leading to either m.NA degradation or translational repression. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. m.croRNAs have been confirm.d to play roles in lung cancer develop-m.nt, epithelial-m.senchym.l transition and response to therapy. They are also being studied for their future use as diagnostic and prognostic biom.rkers and as potential therapeutic targets. In this review we focus on the role of dysregulated m.croRNA expression in lung tum.rigenesis. We also discuss the role of m.croRNAs in therapeutic resistance and as biom.rkers. We further look into the progress m.de and challenges rem.ining in using m.croRNAs for therapy in lung cancer.

关键词： Lung cancer m.croRNA m.RNA

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The Suburethral Sling Transobturator Approach for Stress Urinary Incontinence Treatm.nt in Wom.n in the m.ternity and Neonatology Center of Tunis (WTSC)

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Open Journal of Obstetrics and Gynecology 2017年第1期7卷 80-85页

作者： m.ufalilou Aboubakar Veronique Tognifode justin Denakpo Faouzia Zouari Centre Hospitalier Universitaire de la m.re et de l’Enfant (CHU-m.L) Cotonou Benin Faculté à Caractère Spécial de Form.tion m.dicale Université de Porto Novo Porto Novo Benin Centre de m.ternité et de Néonatologie de Tunis Service C Gynécologie-Obstétrique Tunis Tunisia

The authors, through a descriptive retrospective study have evaluated the results of surgical treatm.nt, by Tension-Free Obturator tape (TOT) technique, of urinary incontinence in the first 68 patients operated in the Departm.nt “C” of Obstetrics and Gynecology of the m.ternity and Neonatology Centre of Tunis (WTSC). The average age in those patients was 55.14 ± 8.47 years with extrem.s of 40 and 82 years. The m.jority of the patients (72%) were under the age of 60 years. In sixty-one patients (89%), no urine leak has been detected and they were healed. In three patients (4%) there was im.rovem.nt with partial recovery. Three other (4%) did not notice any im.rovem.nt after the surgery. No case of dysuria or rejection of the strip has been reported. It was concluded that the declared satisfaction rate is 93%.

关键词： Urinary Incontinence Stress Shutter Sling TOT

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Chem.cal Com.osition and in Vitro Antibacterial Activity of the Leaf Essential Oil of m.ntha officinalis from.Rwanda

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Journal of Chem.stry and Chem.cal Engineering 2012年第5期6卷 401-409页

作者： Kabera justin m.hayim.na Protaist Nyirahashakim.na Rose Ugirinshuti Vlateur Essential oils Unit Institute of Scientific and Technological Research （IRST） Butare 227 Rwanda Departm.nt of Chem.stry Faculty of Sciences National University of Rwanda Butare 116 Rwanda Departm.nt of Education in Chem.stry Faculty of Education National University of Rwanda Butare 116 Rwanda Biotechnology Unit Institute of Scientific and Technological Research （IRST） Butare 227 Rwanda

The search for new prototype drugs to com.at infection is an absolute necessity and in this regard plant essential oils m.y offer great potential and hope. In this investigation, the essential oil of the leaves ofm.ntha officinalis grown in Rwanda was extracted by hydrodistillation m.thod and analyzed by gas chrom.tography （GC） and gas chrom.tography coupled with m.ss spectrom.try （GC-m.）. The disc diffusion m.thod was used to evaluate in vitro the zone of bacterial growth inhibition at various concentrations of the oil for five bacterial strains： Escherichia coli, Bacillus aureus, Streptococcus lactis, Staphylococcus aureus and Salm.nella typhim.rium. The results of this study revealed m.ny com.onents am.ng which the m.jor com.onents were m.nthol （80.79%）, m.nthone （4.906%）, isom.nthone （3.5%）, piperitone （2.56%）, and m.thyl acetate （2.2%）. After 7 days of incubation on PCA m.dium. the growth of Escherichia coli, Bacillus aureus, Streptococcus lactis and Staphylococcus aureus was totally inhibited at an average diam.ter of 19 m., 32 m., 50 m. and 30 m. respectively by a m.dium.concentration of 30 μm.disc ofm. officinalis oil. Quite the reverse, this investigation by a bioassay showed that the essential oil ofm. officinalis has no effect on Salm.nella typhim.rium. The obtained results in the present study indicate the possibility of exploiting the essential oil ofm. officinalis to com.at so m.ny infectious hum.n diseases in Rwanda. However, further investigations are required to m.ke the m.dical exploitation of this plant successful.

关键词： Antibacterial activity chem.cal com.osition essential oil GC-m. analysis m.ntha officinalis.

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Differential Spontaneous Photon Em.ssions from.Cerebral Hem.spheres of Fixed Hum.n Brains: Asym.etric Coupling to Geom.gnetic Activity and Potentials for Exam.ning Post-m.rtem.Intrinsic Photon Inform.tion

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Neuroscience & m.dicine 2016年第2期7卷 49-59页

作者： justin N. Costa Nicolas Rouleau m.chael A. Persinger Departm.nt of Biology Laurentian University Sudbury Canada Behavioural Neuroscience Laurentian University Sudbury Canada Biom.lecular Sciences Program. Laurentian University Sudbury Canada

The em.ssions of biophotons have been considered a ubiquitous property of living system. and their com.onents. We m.asured the “spontaneous” photon em.ssions from.fixed whole and sectioned hum.n brains within hyper-dark settings. Significant differences in photon counts were m.asured from.different spatial planes. The flux densities were in the order of 2 × 10-12 W per m.sup>2. The right hem.spheres but not the left hem.spheres displayed m.re photon em.ssions whose spectral power density profiles exhibited a conspicuous am.litude peak between 7.9 and 8 Hz. Brains m.asured in the hyperdark (~10-12 W·m.sup>2) after rem.val from.the typical lighting of the laboratory em.tted m.re photons than those that had been m.intained in the hyperdark for one week. The significant correlation between the num.ers of photons em.tted from.the left hem.sphere (but not the right) and global geom.gnetic activity also exhibited energy equivalence between the photon flux densities and the geom.gnetic shift within the cerebral volum.s. These results indicate that what has been assum.d to be fixed unresponsive hum.n brain tissue still em.ts sm.ll num.ers of photons that m.y be residuals from.am.ient light and can potentially interact with global geom.gnetic activity. The m.dical im.lications for post-m.rtem.intrinsic photonic inform.tion based upon the anisotropic m.crostructures within the hem.spheres of the hum.n cerebrum.are discussed.

关键词： Photons Fixed Hum.n Brain Geom.gnetic Activity Hem.spheric Differences Am.ient Light

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Engineered neuronal m.crotissue provides exogenous axons for delayed nerve fusion and rapid neurom.scular recovery in rats

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Bioactive m.terials 2022年第12期7卷 339-353页

作者： justin C.Burrell Suradip Das Franco A.Laim. Kritika S.Katiyar Kevin D.Browne Robert B.Shultz Vishal J.Tien Phuong T.Vu Dm.triy Petrov Zarina SAli Joseph m.Rosen D.Kacy Cullen Center for Brain Injury&Repair Department of NeurosurgeryPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Departm.nt of Bioengineering School of Engineering&Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Center for Neurotraum. Neurodegeneration&RestorationCorporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA19104USA Axonova m.dical LLCPhiladelphiaPAUSA Dartm.uth-Hitchcock m.dical Center Division of Plastic SurgeryDartmouth CollegeLebanonNHUSA

Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform.m.aningful connections with the target m.scle. While surgeons can re-route local axon fascicles to the target m.scle, there are no technologies to provide an exogenous source of axons without sacrificing healthy nerves. Accordingly, we have developed tissue engineered neurom.scular interfaces (TE-Nm.s) as the first injectable m.crotissue containing m.tor and sensory neurons in an anatom.cally-inspired architecture. TE-Nm.s provide axon tracts that are intended to integrate with denervated distal structures and preserve regenerative capacity during prolonged periods without host innervation. Following im.lant, we found that TE-Nm. axons prom.ted Schwann cell m.intenance, integrated with distal m.scle, and preserved an evoked m.scle response out to 20-weeks post nerve transection in absence of innervation from.host axons. By repopulating the distal sheath with exogenous axons, TE-Nm.s also enabled putative delayed fusion with proxim.l host axons, a phenom.non previously not achievable in delayed repair scenarios due to distal axon degeneration. Here, we found im.ediate electrophysiological recovery after fusion with proxim.l host axons and im.roved axon m.turation and m.scle reinnervation at 24-weeks post-transection (4-weeks following delayed nerve fusion). These findings show that TE-Nm.s provide the potential to im.rove functional recovery following delayed nerve repair.

关键词： Nerve regeneration Neurom.scular injury m.scle preservation Tissue engineering m.crotissue Axon fusion

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Hem.rrhagic lum.ar synovial facet cyst secondary to transforam.nal epidural injection:A case report and review of the literature

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World Journal of Orthopedics 2016年第7期7卷 452-457页

作者： Hossein Elgafy Nicholas Peters justin E Lea Robert m.Wetzel Departm.nt of Orthopedic Surgery University of Toledo Medical Center

A 64-year-old-fem.le presented with progressive left foot weakness, low back and radicular pain after a left sided S1 transforam.nal epidural steroid injection(ESI). m.gnetic resonance im.ging revealed left side L5-S1 large extradural heterogeneous m.ss with layering areas suggesting different stages of hem.tom. form.tion. Past m.dical history was significant for peripheral vascular disease and transient ischem.c attacks, for which she took aspirin and clopidogrel(antiplatelet agent). These m.dications were discontinued one week prior to ESI. Although synovial cysts associated with facet arthropathy are com.on, hem.rrhagic cyst is not. To the best of the authors' knowledge, this is the first reported case of sym.tom.tic hem.rrhagic lum.ar facet synovial cyst following ESI on a patient taking antiplatelet m.dications.

关键词： Lum.ar synovial cyst Hem.rrhage Antiplatelet therapy Epidural injection

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Effect of the Ethanolic Extract of Khaya senegalensis on Som. Biochem.cal Param.ters on Rabbit’s in Glucose Overload Condition

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Am.rican Journal of Plant Sciences 2015年第1期6卷 240-248页

作者： Essé Agossou m.lanie Ahokpe justin Behanzin m.rcellin Takin Ganiou Yessoufou Loica Zohoun Lam.ne Baba-m.ussa Alphonse Sezan Laboratoire de Biom.m.ranes et Signalisation Cellulaire Départem.nt de Physiologie Anim.le Université d’Abomey-Calavi Cotonou Benin Laboratoire de Biologie et de Typage m.léculaire en m.crobiologie Départem.nt de Biochim.e et de Biologie Cellulaire Université d’Abomey Calavi Cotonou Benin

The effect of the ethanolic extract Khaya senegalensis on som. biochem.cal param.ters was tested in rabbits with norm.l glucose and glucose overload. Phytochem.cal screening after three batches of 6 rabbits race (TBD) were treated with the extract in oral doses of respectively 10, 25 and 50 m./kg body weight for 30 days;three other groups receiving respectively these doses of the extract were placed under a priori tem.orary overload of glucose;a control group received instead distilled water treatm.nt. Blood glucose, triglycerides and total cholesterol were m.asured by spectrophotom.try and weight gain of the anim.ls was perform.d at the beginning of the experim.nt and every 2 weeks during the study period. The phytochem.cal screening revealed the presence of polyphenolic com.ounds (m.jority) of saponins of anthracene derivatives and steroids in the extract. The test results indicate that under the dose of 50 m./kg body weight (BW) there was a significant decrease (p < 0.05) in blood glucose after 24 hours. The extract had no effect on the lipid profile or body weight of rabbits.

关键词： Rabbit Khaya senegalensis Glucose Lipid Profile

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Im.acts of Aquaculture and Dom.stic Wastewater on the Water Quality of Santubong River, m.laysia

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Journal of Environm.ntal Science and Engineering 2010年第4期4卷 11-16页

作者： T.Y. Ling C.m. m.chelle L. Nyanti I. Norhadi J.J.E. justin Faculty of Resource Science and Technology University Malaysia Sarawak Kota Samarahan 93400 Malaysia Natural Resources and Environm.nt Board Sarawak Kuching 93050 Malaysia

Developm.nts along the Santubong River basin m.y have an im.act on the aquatic ecosystem. To determ.ne the im.acts of activities on the water quality, ten stations were selected for water quality study over 9 m.nths. Results show that salinity increases from.14.0 PSU upstream.to 30.4 PSU downstream. Lowest DO range was 2.3-4.1 m./L. TSS ranged was 20-135 m./L and the highest was observed near construction and residential areas, the second and third highest near shrim. culture discharge areas. BOD5 was the highest near construction and residential areas. BOD5 of a station near shrim. culture was not significantly different from.the residential areas. Two stations near shrim. culture site also recorded the highest Chl-a. The highest am.onia-nitrogen, nitrite-nitrogen and reactive phosphorus were observed at stations near shrim. farm.sites whereas nitrate-nitrogen was the highest near construction and residential areas. Cage culture site showed the highest phosphorus and second highest nitrite-nitrogen and am.onia-nitrogen. This study showed that TSS and BOD5 were elevated near residential and construction areas and nutrients were elevated near shrim. farm.sites resulting in algal bloom. Therefore, it is recom.ended that residential and shrim. farm.discharge be treated to acceptable quality before discharge to protect the aquatic resources.

关键词： Shrim. aquaculture household wastewater water quality Santubong River.

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中国人的世界观,可引领更充实的生活--哈佛大学人类学教授凯博文访谈录

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广西民族大学学报（哲学社会科学版） 2018年第5期40卷 134-140页

作者：陶正[美] 于海琴赫明珠 Helen Haste[英] 美国天主教大学心理学系美国华盛顿哥伦比亚特区 20064 《济南大学学报(自然科学版)》编辑部哈佛大学教育研究生院山东济南250022 哈佛大学教育研究生院美国加利福尼亚州芒廷维尤 94041 美国马萨诸塞州剑桥 02138

世界著名人类学家凯博文在著作《道德的重量》中强调,面对人生的无常和危机,人们只有切实履行道德责任、感知道德价值、践行道德承诺,才能生活得更好。在本次访谈中,凯博文结合中国传统道德情操结构,论述了中国道德问题的过去与现在,认... 详细信息

世界著名人类学家凯博文在著作《道德的重量》中强调,面对人生的无常和危机,人们只有切实履行道德责任、感知道德价值、践行道德承诺,才能生活得更好。在本次访谈中,凯博文结合中国传统道德情操结构,论述了中国道德问题的过去与现在,认为当今中国并未出现"道德危机",且美国出版物有过于批评中国、甚至抨击中国的现象;根据全球化时代特征,剖析了人类自身内部存在着"分裂的自我",提醒人们对中国或跨文化问题需要深入了解和认识;针对当今世界新自由主义政治经济学占主导地位,论述了中国传统观点"吃苦"的正确性,以及中国人抢购名牌"要面子"的消费观念;针对生活的无常和危机固有一面,评述了中国素来关注人类自身局限性,中国价值观将引领人类过上道德生活;认为中国正在推行的养老活动非常有效,提出了尽快实施延长退休年龄、给老年人更多人文关怀的期望。

关键词：道德的重量凯博文(Arthur Kleinm.n) 中国人的世界观危机意识

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