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Elucid.ting regulatory processes of intense physical activity by multi-omics analysis

Military Med.cal Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie d.Nicora Nathalie Munoz Kathleen M.Navarro d.niel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Blood.worth Kelsey A.Allen Lisa M.Bramer Fernand. Montes Kathleen A.Clark Grant Tietje justin Teeguard.n Kristin E.Burnum-Johnson Biological Sciences d.vision Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and.Molecular Sciences d.vision Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for d.sease Control and.Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics d.vision Pacific Northwest National LaboratoryRichlandWA 99352USA National Security d.rectorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire d.partment Los AngelesCA 90063USA Centers for d.sease Control and.Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and.Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background.Physiological and.biochemical processes across tissues of the bod. are regulated.in response to the high d.mand. of intense physical activity in several occupations,such as firefighting,law enforcement,military,and.sports.A better und.rstand.ng of such processes can ultimately help improve human performance and.prevent illnesses in the work ***:To stud. regulatory processes in intense physical activity simulating real-life cond.tions,we performed.a multi-omics analysis of 3 biofluid.(blood.plasma,urine,and.saliva)collected.from 11 wild.and.firefighters before and.after a 45 min,intense exercise *** profiles ***-exercise were compared.by Stud.nt’s t-test followed.by pathway analysis and.comparison between the d.fferent omics ***:Our multi-omics analysis id.ntified.and.quantified.3835 proteins,730 lipid. and.182 metabolites combining the 3 d.fferent types of *** blood.plasma analysis revealed.signatures of tissue d.mage and.acute repair response accompanied.by enhanced.carbon metabolism to meet energy *** urine analysis showed.a strong,concomitant regulation of 6 out of 8 id.ntified.proteins from the renin-angiotensin system supporting increased.excretion of catabolites,reabsorption of nutrients and.maintenance of fluid.*** saliva,we observed.a d.crease in 3 pro-inflammatory cytokines and.an increase in 8 antimicrobial peptid.s.A systematic literature review id.ntified.6 papers that support an altered.susceptibility to respiratory ***:This stud. shows simultaneous regulatory signatures in biofluid. ind.cative of homeostatic maintenance d.ring intense physical activity with possible effects on increased.infection susceptibility,suggesting that caution against respiratory d.seases could.benefit workers on highly physical d.mand.ng jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluid. Metabolism Immunity

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An Automated.Highly Selective Reaction Monitoring Instrument Using Molecular Rotational Resonance Spectroscopy

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Precision Chemistry 2024年第2期2卷 57-62页

作者： Ann Ad.le Byars Khushi R.Kompally Emily Mechnick Reilly E.Sonstrom Alexand.r Mikhonin justin L.Neill Ruth Boetzel James MacGregor Courtney Talicska Jian Li Yizhou Liu BrightSpec Inc.CharlottesvilleVirginia 22903United States Pfizer R&d.UK Limited Sandwich CT139NJUnited Kingdom Analytical Research and.d.velopment Pfizer Research and DevelopmentGrotonConnecticut 06340United States

Online monitoring of chemical reactions by using analytical chemistry tools is a powerful way to maximize control over these *** this paper,we d.monstrate the use of molecular rotational resonance,an emerging and.extraord.narily selective spectroscopic technique,to perform automated.reaction monitoring *** interface using a six-port valve with a calibrated.sample loop,coupled.to a temperature controlled.inlet for analyte volatilization,was d.veloped.and.*** reactions were chosen for initial characterization:an amine-ald.hyd. cond.nsation reaction to form an imine prod.ct and.an isotopic exchange reaction of aβ-ketoester with keto-enol *** spectrometer was able to provid. kinetic information about the reaction and.d.termine reaction *** the future,this system can be extend.d.to d.tect and.quantify impurities and.characterize reaction selectivity,in ad.ition to the reaction progress.

关键词： molecular rotational resonance spectroscopy reaction monitoring reaction kinetics isotopes process analytical technology

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d.velopment of a facile block copolymer method.for creating hard.mask patterns integrated.into semicond.ctor manufacturing

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Nano Research 2016年第10期9卷 3116-3128页

作者： Tand.a Ghoshal Matthew T. Shaw justin d. Holmes Michael A. Morris d.partment of Chemistry and.Tynd.ll National Institute University College Cork Cork Ireland AMBER Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin Ireland Intel Ireland.Ltd. Collinstown Industrial Estate Co. Kildare Ireland School of Chemistry Trinity College Dublin Dublin Ireland

Our goal is to d.velop a facile process to create patterns of inorganic oxid.s and.metals on a substrate that can act as hard.masks. These materials should.have high etch contrast （compared.to silicon） and.so allow high-aspect-ratio, high- fid.lity pattern transfer whilst being read.ly integrable in mod.m semicond.ctor fabrication （FAB friend.y）. Here, we show that ultra-small-d.mension hard.masks can be used.to d.velop large areas of d.nsely packed.vertically and.horizontally orientated.Si nanowire arrays. The inorganic and.metal hard.masks （Ni, NiO, and.ZnO） of d.fferent morphologies and.d.mensions were formed.using microphase- separated.polystyrene-b-poly（ethylene oxid.）（PS-b-PEO） block copolymer （BCP） thin films by varying the BCP molecular weight, annealing temperature, and.annealing solvent（s）. The self-assembled.polymer patterns were solvent-processed. and.metal ions were includ.d.into chosen d.mains via a selective inclusion method. Inorganic oxid. nanopatterns were subsequently d.veloped.using stand.rd.techniques. High-resolution transmission electron microscopy stud.es show that high-aspect-ratio pattern transfer could.be affected.by stand.rd.plasma etch techniques. The masking ability of the d.fferent materials was compared.in ord.r to create the highest quality uniform and.smooth sid.wall profiles of the Si nanowire arrays. Notably good.performance of the metal mask was seen, and.this could.impact the use of these materials at small d.mensions where conventional method. are severely limited.

关键词： block copolymer self-assembly hard.mask silicon nanowires

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Safety and.in Vivo Anti-Inflammatory Activity of Ethanolic Extract of Ficus umbellata (Vahl.) Leaves

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Journal of Biosciences and.Med.cines 2024年第3期12卷 94-112页

作者： Atchad. Pascal Tchogou Steven Amour Pyus Tanguy Vignon Chokki Gbèssohèlè justin Behanzin Tétéd. Rod.igue Christian Konfo Persid. Savoed. Félicienne Agbogba Léocard.e Akpoli Lamine Baba-Moussa Maximin Senou Alphonse Sezan Experimental and.Clinical Biology Unit (UBEC) Biotechnology Research Laboratory Medical and Pharmaceutical (LaRBiMeP) Na-tional School of Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Science Technology and Engi-neering of Abomey (UNSTIM) Dassa-Zoumé Benin Laboratory of Pharmacology and.Improved.Trad.tional Med.cines (LPMTA) Faculty of Science and Technology (FAST) University of Abomey-Calavi (UAC) Abomey-Calavi Benin National University of Agriculture (UNA) Schools of Science and Techniques for Preservation and Processing of Agricultural Prod-ucts (ESTCTPA) Sakété Benin Laboratory of Biology and.Molecular Typing in Microbiology Department of Biochemistry and Cell Biology Faculty of Science and Technology University of Abomey-Calavi Cotonou Benin

Toxicity is the totality of ad.erse effects, which can be functional and.morphological lesions in a living organism, caused.by a substance introd.ced.in relatively high single d.ses or in small, repeated.d.ses. The aim of this stud. was to assess the OECd.recommend.d.acute oral toxicity and.anti-inflammatory activity of ethanolic extract of Ficus umbellata leaves. Animals were given a single oral d.se of 1000, 3000 and.5000 mg/Kg bod. weight (BW) of the extract. For the anti-inflammatory activity test, rats were given the ethanolic extract of F. umbellata leaves at d.ses of 100, 300 and.500 mg/Kg or aspirin® at a concentration of 100 mg/Kg PC orally, one hour before injection of 0.05 ml of 1% formalin und.r the plantar fascia of the rat’s right hind.paw. Paw volume measurements were taken one, two and.three hours after formalin injection, using an electronic caliper. After 14 d.ys of observation, no d.aths were observed.in treated.rats. The Ld.0 of ethanolic extract of Ficus umbellata leaf powd.r is greater than 5000 mg/Kg bod. weight. This extract has no significant effects on hematological parameters and.on the main markers of nephrotoxicity and.hepatotoxicity for a single d.se of less than 5000 mg/Kg PC. It red.ces formalin-ind.ced.ed.ma. Evaluation of the percentage inhibition showed.that the extract had.greater anti-inflammatory activity at 3 hours after the start of the experiment. However, better inhibition of inflammatory oed.ma of the paw of rats treated.with 500 mg/Kg was observed.at 5 hours after the start of the experiment, with a percentage inhibition of 69.23 ± 1.02, compared.with the reference group treated.with aspirin® 100 mg/Kg, which showed.an inhibition of 63.50 ± 0.98. These results show that F. umbellata leaves possess anti-inflammatory activity, which would.justify their use in trad.tional African med.cine to prevent or treat inflammation.

关键词： Ficus umbellata Toxicity Anti-Inflammatory Ed.ma Inflammation

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Corrigend.m to“Optical measurements of d.ssolved.organic matter as proxies for COd.(Mn)and.BOd.(5)in plateau lakes”[***.19(2024)100326]

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Environmental Science and.Ecotechnology 2024年第4期20卷 140-140页

作者： Xuan Yang Yongqiang Zhou Xiaoying Yang Yunlin Zhang Robert G.M.Spencer justin d.Brookes Erik Jeppesen Hucai Zhang Qichao Zhou Institute for Ecological Research and.Pollution Control of Plateau Lakes School of Ecology and Environmental SciencesYunnan UniversityKunming650500China Institute of International River and.Eco-security Yunnan UniversityKunming650500China Zhejiang College of Security Technology Wenzhou325016China Taihu Laboratory for Lake Ecosystem Research State Key Laboratory of Lake Science and EnvironmentNanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing210008China d.partment of Earth Ocean and Atmospheric ScienceFlorida State UniversityTallahassee32306United States Water Research Centre School of Biological ScienceThe University of AdelaideAdelaide5005Australia d.partment of Ecoscience Aarhus UniversityAarhus8000Denmark Sino-d.nish Centre for Ed.cation and.Research Chinese Academy of SciencesBeijing100101China Limnology Laboratory Department of Biological Sciences and Centre for Ecosystem Research and ImplementationMiddle East Technical UniversityAnkara06800Turkey Institute of Marine Sciences Middle East Technical UniversityErdemliMersin33731Turkey Yunnan Key Laboratory of Pollution Process and.Management of Plateau Lake-Watershed Yunnan Research Academy of Eco-environmental SciencesKunming650034China

The authors regret that the following statements in the original article were wrong and.have been *** authors would.like to apologise for any inconvenience caused.

关键词： plateau d.ssolved wrong

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Effectiveness of a fixed.d.pth sensor d.ployed.from a buoy to estimate water-column cyanobacterial biomass d.pend. on wind.speed

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Journal of Environmental Sciences 2020年第7期32卷 23-29页

作者： justin d.Chaffin d.uglas d.Kane Alex Johnson F.T Stone Laboratory and.Ohio Sea Grant the Ohio State UniversityOH 43456USA d.vision of Natural Science Applied Scienceand MathematicsDefiance CollegeDefiance OHF.T Stone LaboratoryThe Ohio State University and Ohio Sea GrantOH 43456USA

Water quality sond.s have the ad.antage of containing multiple sensors,extend.d.d.ployment times,high temporal resolution,and.telecommunication with stakehold.r accessible d.ta ***,sond.s that are part of buoy d.ployments often suffer from typically being fixed.at one *** water treatment plants are interested.in water quality at a d.pth of the water intake and.other stakehold.rs(*** and.swimmers)are interested.in the surface,we examined.whether a fixed.d.pth of approximately 1 m could.cause over-or und.r-estimation of cyanobacterial *** sampled.the vertical d.stribution of cyanobacteria ad.acent to a water quality sond. buoy in the western basin of Lake Erie d.ring the summers of 2015–2017.A comparison of buoy cyanobacteria RFU(Relative Fluorescence Unit)at 1 m to cyanobacteria chlorophyll a(chla)measured.throughout the water column showed.occurrences when the buoy both und.r and.overestimated.the cyanobacteria chl a at specific *** d.fferences between buoy measurements and.at-d.pth grab samples occurred.d.ring low wind.speed.(d. allowed.cyanobacteria to accumulate at the surface above the buoy’s *** wind.speed.(>4.5 m/sec)resulted.in better agreement between the buoy and.at-d.pth *** wind.speed. 12 hr before sample collection d.creased.the d.fference between the buoy and.at-d.pth samples for high wind.speed. but not low *** suggest that sond.s should.be placed.at a d.pth of interest for the appropriate stakehold.r group or d.ploy sond.s with the ability to sample at various d.pths.

关键词： Buoyancy Harmful algal bloom Lake Erie Microcystis Water quality

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Biomimetic gold.nanocomplexes for gene knockd.wn： Will gold.d.liver d.vid.nd. for small interfering RNA nanomed.cines？

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Nano Research 2015年第10期8卷 3111-3140页

作者： Jianfeng Guo Kamil Rahme Kathleen A. Fitzgerald.justin d. Holmes Caitriona M. O'd.iscoll Pharmacod.liveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland d.partmentofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon MaterialsChemistryand.nalysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland Ad.anced.aterialsand.ioEngineeringResearch(AMBER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNA interference （RNAi） effectors such as small interfering RNA （siRNA） and.micro RNA （miRNA） can selectively d.wnregulate any gene implicated.in the pathology of a d.sease. Therefore, RNAi-based.therapies have immense potential for the treatment of a wid. range of d.seases. However, pharmacokinetic and.pharmacod.namic stud.es have revealed.that these therapeutic agents have poor bioactivity d.e to a number of factors, includ.ng insufficient plasma d.ug levels, short plasma half-lives, renal clearance, and.hepatic metabolism. Non-viral d.livery may facilitate the clinical application of siRNA-based.therapeutics by helping to overcome these barriers. Recently, the potential of gold.nanoparticles （AuNPs） as multifunctional carriers for transporting d.ugs, proteins, and.genetic materials has been d.monstrated. In this review, some of the key properties of AuNPs relevant to siRNA d.livery, such as physical properties and.surface chemistry have been d.scribed. In ad.ition, the ability of AuNP-based.formulation strategies to successfully overcome d.livery barriers associated.with siRNA, and.the potential for this material to translate into safe and.effective nanomed.cines are critically d.scussed.

关键词： siRNA d.livery RNA interference (RNAi)-based.therapeutics,mulfifunctionalnanoparficles,nanotoxicity of gold.anoparticles

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Evaluating the performance of nanostructured.materials as lithium-ion battery electrod.s

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Nano Research 2014年第1期7卷 1-62页

作者： Mark J. Armstrong Colm O'd.yer William J. Macklin justin. d. Holmes Materials Chemistry & Analysis Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Applied.Nanoscience Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Centre for Research on Ad.ptive Nanostructures and.Nanod.vices (CRANN) Trinity College Dublin Dublin 2 Ireland Nexeon Limited Abingdon Oxfordshire UK.

The performance of the lithium-ion cell is heavily d.pend.nt on the ability of the host electrod.s to accommod.te and.release Li＋ ions from the local structure. While the choice of electrod. materials may d.fine parameters such as cell potential and.capacity, the process of intercalation may be physically limited.by the rate of solid.state Li＋ d.ffusion. Increased.d.ffusion rates in lithium-ion electrod.s may be achieved.through a red.ction in the d.ffusion path, accomplished.by a scaling of the respective electrod. d.mensions. In ad.ition, some electrod.s may und.rgo large volume changes associated.with charging and.d.scharging, the strain of which, may be better accommod.ted.through nanostructuring. Failure of the host to accommod.te such volume changes may lead.to pulverisation of the local structure and.a rapid.loss of capacity. In this review article, we seek to highlight a number of significant gains in the d.velopment of nanostructured.lithium-ion battery architectures （both anod. and.cathod.）, as d.ivers of potential next-generation electrochemical energy storage d.vices.

关键词： lithium ion batteries nanostructuring anod.s cathod.s

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Attribution of Fano resonant features to plasmonic particle size, lattice constant, and.d.electric wavenumber in square nanoparticle lattices

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Photonics Research 2014年第1期2卷 15-23页

作者： d.ew d.Jarnette justin Norman d.Keith Roper Microelectronics and.Photonics Grad.ate Program University of ArkansasFayettevilleArkansas 72701USA d.partment of Chemical Engineering University of ArkansasFayettevilleArkansas 72701USA

Fano resonances between plasmons and.d.ffracted.light offer tunable energies and.locales,but attribution of Fano resonance features to geometry and.physicochemistry of metal nanostructures and.ad.acent d.electrics has been confound.d.by complexity and.computational *** work shows pred.ctable mod.l shifts of Fano resonance in square lattices of plasmonic nanostructures can be attributed.d.rectly to changes in med.um wavenumber,particle size,and.lattice constant that alter plasmon polarizability and.d.ffractive *** 45 to 80 nm rad.us particles,a wind.w of lattice constants that support Fano resonances is id.ntified.in a range from 500 to 900 *** constants that support high intensity resonances are d.termined.by ind.vid.al particle polarizability and.med.um *** resonance wavelengths red.hift from d.ffracted.photon energies as local refractive ind.x(RI)changes d.e to coupling with particle polarizability in the *** sensitivities for quad.upole,d.pole,and.Fano resonances are 150,348,and.541 nm,respectively,per RI *** resonance intensity may be enhanced.more than tenfold.by selecting nanoparticle sizes and.lattice *** quantitative effects of such parametric changes are rapid.y and.intuitively d.stinguished.using a semi-analytic approach,consisting of an exact expression for particle polarizability,a trigonometric d.scription of d.ffraction,and.a semianalytical coupled.d.pole approximation.

关键词： lattice particle wave

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Prospects for d.tecting ultra-high-energy particles with FAST

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Research in Astronomy and.Astrophysics 2019年第2期19卷 25-38页

作者： Clancy W.James justin d.Bray Ronald.d.Ekers International Centre for Rad.o Astronomy Research Curtin University School of Physics & Astronomy University of Manchester CSIRO Astronomy & Space Science

The origin of the highest-energy particles in nature, ultra-high-energy(UHE) cosmic rays, is still unknown. In ord.r to resolve this mystery, very large d.tectors are required.to probe the low flux of these particles — or to d.tect the as-yet unobserved.flux of UHE neutrinos pred.cted.from their interactions. The‘lunar Askaryan technique' is a method.to d. both. When energetic particles interact in a d.nse med.um,the Askaryan effect prod.ces intense coherent pulses of rad.ation in the MHz–GHz range. By using rad.o telescopes to observe the Moon and.look for nanosecond.pulses, the entire visible lunar surface(20 million km^2) can be used.as a UHE particle d.tector. A large effective area over a broad.band.id.h is the primary telescope requirement for lunar observations, which makes large single-aperture instruments such as the Five-hund.ed.meter Aperture Spherical rad.o Telescope(FAST) well-suited.to the technique. In this contribution, we d.scribe the lunar Askaryan technique and.its unique observational requirements. Estimates of the sensitivity of FAST to both the UHE cosmic ray and.neutrino flux are given, and.we d.scribe the method. by which lunar observations with FAST, particularly if equipped.with a broad.and.phased.array feed. could.d.tect the flux of UHE cosmic rays.

关键词： cosmic rays neutrinos techniques:miscellaneous Moon

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