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Integrating climate, biodiversity, and sustainable land-use strategies:innovations from China

National Science Review 2021年第7期8卷 13-17页

作者： Guido Schmidt-Traub Harvey Locke Jixi Gao Zhiyun Ouyang justin adams Lin Li Enric Sala M.Rebecca Shaw Sebastian Troёng Jing Xu Chunquan Zhu Changxin Zou Tianxiao Ma Fuwen Wei Sustainable Development Solutions Network Beyond the Aichi Targets Task Force IUCN World Commission on Protected Areas Yellowstone to Yukon Conservation Initiative Center for Satellite Applications on Ecology and Environment Ministry of Ecology and Environment Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Tropical Forest Alliance World Economic Forum Worldwide Fund for Nature National Geographic Society Conservation International Chinese Research Academy of Environmental Sciences Nature Initiatives and Tropical Forest Alliance World Economic Forum Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment Institute of Zoology Chinese Academy of Sciences

To reverse the accelerating degradation of biodiversity and ecosystem services(‘nature’) and climate [1,2], the Convention on Biological Diversity (CBD)and the UN Framework Convention on Climate Change (UNFCCC) will hold major meetings in 2021. We argue that, as a critical priority, countries need to design and implement integrated national strategies to achieve the goals of the three Rio Conventions (including the UN Convention to Combat Desertification—UNCCD) using spatially explicit analyses and policies. This integration can maximize co-benefits and help manage trade-offs to meet the Sustainable Development Goals(SDGs). Nature-based solutions (NBS)provide an important framework for such integration.

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The human malaria parasite genome is configured into thousands of coexpressed linear regulatory units

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Journal of Genetics and Genomics 2020年第9期47卷 513-521页

作者： Chengqi Wang justin Gibbons Swamy R.Adapa Jenna Oberstaller Xiangyun Liao Min Zhang John H.adams Rays H.Y.Jiang Global and Planetary Health USF GenomicsCollege of Public HealthUniversity of South FloridaTampaFL 33612USA

The human malaria parasite Plasmodium falciparum thrives in radically different host environments in mosquitoes and humans, with only a limited set of transcription factors. The nature of regulatory elements or their target genes in the P. falciparum genome remains elusive. Here, we found that this eukaryotic parasite uses an efficient way to maximally use genetic and epigenetic regulation to form regulatory units(RUs) during blood infections. Genes located in the same RU tend to have the same pattern of expression over time and are associated with open chromatin along regulatory elements. To precisely define and quantify these RUs, a novel hidden Markov model was developed to capture the regulatory structure in a genome-wide fashion by integrating expression and epigenetic evidence. We successfully identified thousands of RUs and cross-validated with previous findings. We found more genes involved in red blood cell(RBC) invasion located in the same RU as the Pf AP2-I(AP2-I) transcription factor, demonstrating that AP2-I is responsible for regulating RBC invasion. Our study has provided a regulatory mechanism for a compact eukaryotic genome and offers new insights into the in vivo transcriptional regulation of the P. falciparum intraerythrocytic stage.

关键词： Gene regulation Regulatory units ATAC-Seq RNA-Seq Hidden Markov Model Malaria Plasmodium falciparum

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