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T cell immune responses to SARS-CoV-2 and variants of concern(Alpha and Delta)in infected and vaccinated individuals

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Cellular & molecular Immunology 2021年第11期18卷 2554-2556页

作者： Stanley C.Jordan Bong-Ha Shin Terry-Ann m.Gadsden maggie Chu Anna Petrosyan Catherine N.Le Rachel Zabner Jillian Oft Isabel Pedraza Susan Cheng Ashley Vo Noriko Ammerman Jasmine Plummer Shili Ge max Froch Anders berg mieko Toyoda Ruan Zhang Comprehensive Transplant Center Transplant Immunology LaboratoryCedars-Sinai Medical CenterLos AngelesCAUSA Division of Infectious Diseases Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Cardiology Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Bioinformatics&Functional Genomics Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Pathology&Laboratory medicine Cedars-Sinai Medical CenterLos AngelesCAUSA

Our understanding of immune responses to SARS-CoV-2 and variants of concern(VOCs)has been primarily acquired through analysis of Spike-specific IgG ***,a more comprehensive understanding of the breadth and longevity of immune responses after infection and vaccination requires analysis of cellular ***,we report on T cell immunity in infected and vaccinated individuals,identifying CD4+/CD8+T cell cytokine responses to SARS-CoV-2 and variant peptides(Alpha,B.1.1.7 and Delta,B.1.617.2).

关键词： Alpha infected immunity

macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells

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World Journal of Gastroenterology 2005年第13期11卷 1946-1950页

作者： Harry Hua-Xiang Xia Shiu Kum Lam Annie O.O.Chan marie Chia mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.berg Benjamin Chun-Yu Wong Department of medicine Institute of molecular Biology Department of molecular microbiology

AIm: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (mIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of mIF in monocytes, whether the cag pathogenicity island (PAI) is involved for this function, and whether mIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro. mETHODS: A cytotoxic wild-type H pylori strain (TN2), its three isogenic mutants (TN2Δcag,TN2ΔcagA and TN2ΔcagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/ cell ratios. mIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, mKN45, were then co-cultured with the supernatants, with and without monoclonal anti-mIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter. RESULTS: The wild-type strain and the isogenic mutants, TN2ΔcagA and TN2ΔcagE, increased mIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2Δcag did not increase the release of mIF at any of the four ratios. 3H-thymidine readings for mKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2ΔcagA and TN2ΔcagE, but not from the mutant TN2Δcag. moreover, in the presence of monoclonal anti-mIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared. CONCLUSION: H pylori stimulates mIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-mIF antibody, suggesting that mIF plays an important role in H pylori-induced gastric ep

关键词： H pylori mIF PAI

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塑料封装芯片的腐蚀

电子 1990年第2期 68-76页

作者： berg,H.m 李志国

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生产中复杂性的控制

工业工程与管理 1999年第2期4卷 8-14页

作者： W.mаβberg 王继平德国波鸿鲁尔大学生产系统和过程主控技术教研组

本文对复杂性进行了定义并且列出了复杂性动因。另外，还论述了降低和控制复杂性的方法。并更为深入地阐述了产品及工艺过程设计中的复杂性以及在控制复杂性时作为辅助工具的仿真技术。

关键词：复杂性控制产品工艺过程生产管理设计

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△控制——机械全柔性气门控制机构

汽车与新动力 1999年第2期 55-62页

作者： berg m Gerhard K Kuhn P 吴鹏

当今人们一般认为,无论是直接喷射或非直接喷射的点燃式内燃机,全柔性气门控制是最有希望的改进措施。内燃机制造商们对形形色色的控制系统进行了试验研究,但是目前只有简单的系统用于内燃机产品,而这只能满足部分要求。尽管液压系统很... 详细信息

当今人们一般认为,无论是直接喷射或非直接喷射的点燃式内燃机,全柔性气门控制是最有希望的改进措施。内燃机制造商们对形形色色的控制系统进行了试验研究,但是目前只有简单的系统用于内燃机产品,而这只能满足部分要求。尽管液压系统很适宜于找到最佳气门控制策略,但机械系统对于一系列要求的优势是显而易见的。因此,在开发出具有最多可达三种可供选择的气门升程曲线的机械移相机构和机械系统之后,利用机械系统的优势和经验来实现全柔性气门控制是顺理成章的事了。本文介绍德国卡尔斯鲁厄(Karlsruhe)大学开发了一种叫Δ控制的新型机械气门机械,这种新机构能对气门升程、开启时间和相位角进行连续调节。该机构有一个特别之处,就是仅有机构的一部分(三角形),必须加上一个常规牵引杆或挺柱气门机构。文章第一部分介绍关于系统本身的一些信息,即它的工作原理和改进气体交换的可能性。介绍了Δ控制的不同变型,并且指出了气缸盖设计特殊性能和边界条件。第二部分综述执行不同运动学和动力学任务的配气机构的设计过程及其开发工具。第三部分则叙述了Δ控制在内燃机产品中的应用和最重要的试验结果。

关键词：内燃机气门控制优化

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den berg Alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl Eleonora A.m.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(mAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(mRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University medical Center Groningen(UmCG)Genetics Lifelines Initiative(UGLI).meta-analysis of GWASs of mRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCm1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,Tm6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between mRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel mRI-PDFF genetic signals(CREB3L1 and GCm1)were replicated in the FLI *** identified two novel genes for mRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between mRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content mAFLD Genome-wide association study Fatty liver index magnetic resonance imaging proton density fat fraction

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集成电路封装热设计的发展动向

微纳电子技术 1986年第1期 41-50页

作者： H. m. berg 苏世民

本文根据半导体芯片技术的发展和用户的需求论述了影响半导体制造的热设计的发展动向。用几个特例(如双列直插式管壳,陶瓷芯片载体,针栅阵列管壳)来描述封装材料、管壳设计、外部环境和封装集成度的重要性。管壳设计的发展趋势与散热技... 详细信息

本文根据半导体芯片技术的发展和用户的需求论述了影响半导体制造的热设计的发展动向。用几个特例(如双列直插式管壳,陶瓷芯片载体,针栅阵列管壳)来描述封装材料、管壳设计、外部环境和封装集成度的重要性。管壳设计的发展趋势与散热技术的重大进展有密切关系。

关键词：管壳双列热性能热力学性质热沉热传导热阻陶瓷芯片载体自然对流冷却热设计

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显微镜能帮助机器视觉系统检测精细的部件

红外 2000年第12期21卷 23-27页

作者： David m.berg 贡树行美国纽约州罗切斯特市melles Griot光学系统视觉工程部

许多制造工艺需要联机的显微镜,它能为机器视觉或进行其他分析产生足够清晰的图像。这些显微镜(其光学系统的放大率大于1)能对精密零件的自动测量装置进行对准、检测和引导。显微镜作为一种光学系统,与“标准的”摄像机(照相机)系统是... 详细信息

许多制造工艺需要联机的显微镜,它能为机器视觉或进行其他分析产生足够清晰的图像。这些显微镜(其光学系统的放大率大于1)能对精密零件的自动测量装置进行对准、检测和引导。显微镜作为一种光学系统,与“标准的”摄像机(照相机)系统是完全不同的。为了对精细部件的成像提供所需的清晰度(分辨率),显微镜必须要有相当大的数字光阑孔径(即光圈)。这就限制了显微镜的景深。放大率大于1也就意味着从透镜镜头到成像传感器的距离是大于其它系统的。机器视觉显微镜的有效设计需要对这些差别进行深入的了解。最初在设计上进行理智的选择,会使成功的机会大大地增加。某些参数会对成本和复杂性起很大的作用;而其它参数则几乎是“自由”的,它们不起什么作用。许多应用能用成本-有效光学来描述。成像的多路传输和自动聚焦能解决其它难以处理的问题。

关键词：显微镜机器视觉系统联机放大机摄像机

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Levels of Genotoxic and Carcinogenic Ingredients in Plant Food Supplements and Associated Risk Assessment

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Food and Nutrition Sciences 2011年第9期2卷 989-1010页

作者： Suzanne J. P. L. van den berg Patrizia Restani marelle G. Boersma Luc Delmulle Ivonne m. C. m. Rietjens 不详

The present study describes the selection, analysis and risk assessment of genotoxic and carcinogenic ingredients of botanicals and botanical preparations which can be found in food and plant food supplements (PFS). First an inventory was made of botanical ingredients that are of possible concern for human health because of their genotoxic and/or carcinogenic properties. In total, 30 botanical ingredients were selected and subsequently judged for their actual genotoxic and/or carcinogenic potential. Among the 30 compounds considered, 18 compounds were judged to be both genotoxic and carcinogenic. Interestingly, the majority of these compounds belong to the group of alkenylbenzenes or unsaturated pyrrolizidine alkaloids. Subsequently, based on available carcinogenicity data and estimated daily human exposure that was determined focusing on the intake from PFS, the margin of Exposure (mOE) was calculated for the alkenylbenzenes estragole, methyleugenol, safrole and β-asarone. Calculating the mOEs for intake estimates of these alkenylbenzenes from PFS resulted in mOE values that were generally lower than 10,000 and often lower than 100. In some cases the mOE was even below 10 meaning that the estimated daily intake is in the range of dose levels causing malignant tumors in experimental animals. This result indicates that the use of PFS containing the genotoxic carcinogens estragole, methyleugenol, safrole or β-asarone might raise a potential concern for human health and would be of high priority for risk management.

关键词： Plant Food Supplements Genotoxicity Carcinogenicity Dietary Exposure Benchmark Dose modeling margin of Exposure Alkenylbenzenes Chemical Analysis Risk Assessment