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Clinical and echocardiographic analysis of patients suffering from recurrent takotsubo cardiomyopathy

Journal of Geriatric Cardiology 2016年第11期13卷 888-893页

作者： Ibrahim El-Battrawy Uzair Ansari Michael Behnes Dennis Hillenbrand Katja Schramm Darius Haghi Ursula Hoffmann Theano Papavassiliu Elif Elmas Christian Fasmer Tobias Becher Stefan Baumann Christina Dosch Felix Heggemann jurgen kuschyk Martin Borggrefe Ibrahim Akin First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM) University of Heidelberg Mannheim Germany DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg-Mannheim Mannheim Germany

Background Recurrence of takotsubo cardiomyopathy （TTC） is a well-known complication. However, current literature lists only a few isolated cases. We aimed to determine the incidence and clinical significance of recurrent TTC. Methods ＆ Results Our institutional database constituted a collective of 114 patients diagnosed with TTC since 2003. Close follow-up of these patients revealed a recurrence of TTC in seven of these （6.1%）. The time interval between the index event and its recurrence varied between six months and six years. Arterial hypertension was more revealed in the recurrence group of TTC compared to non-recurrence group, （P = 0.02）. Chronic obstructive pulmo- nary disease and/or asthma was more diagnosed in the recurrence group, （P = 0.04）. Clinical events like fight ventficular involvement, TTC related complications such as life-threatening arrhythmias, pulmonary congestion and in hospital death were observed more frequently in the recurrent episode. Over a mean follow-up of one year the mortality rate was similar in both groups. Conclusions Recurrence of TTC within six years after index event is not an uncommon phenomenon. In the event of right ventricular involvement in the relapse phase, it might be associated with a higher complication rate. TTC recurrence should be the first differential diagnosis in patients with a past history of TTC.

关键词： Biventricular takotsubo cardiomyopathy Recurrent takotsubo cardiomyopathy Takotsubo cardiomyopathy related complication

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