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Frontiers of Optoelectronics 2017年第3期10卷 273-279页

作者： Bernd KAMPE Sandra KLOβ Thomas BOCKLITZ Petra ROSCH jurgen popp Institute of Physical Chemistry and Abbe Center of Photonics University of Jena Helmholtzweg 4 D-07743 Jena Germany InfectoGnostics Research Campus Jena Center for Applied Research Philosophenweg 7 07743 Jena Germany Leibniz-Institute of Photonic Technology Albert-Einstein-Straβe 9 D-07745 Jena Germany

The presence of irrelevant and correlated data points in a Raman spectrum can lead to a decline in classifier performance. We introduce support vector machine （SVM）-based recursive feature elimination into the field of Raman spectroscopy and demonstrate its performance on a data set of spectra of clinically relevant microorganisms in urine samples, along with patient samples. As the original technique is only suitable for two-class problems, we adapt it to the multi-class setting. It is shown that a large amount of spectral points can be removed without degrading the prediction accuracy of the resulting model notably.

关键词： feature selection Raman spectroscopy pat-tern recognition chemometrics

A special issue on Biophotonics in Europe

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Frontiers of Optoelectronics 2017年第3期10卷 203-210页

作者： Valery V. TUCHIN Ekaterina BORISOVA Malgorzata JEDRZEJEWSKA-SZCZERSKA Martin J. LEAHY Francesco S. PAVONE jurgen popp Jose POZO Research-Educational Institute of Optics and Biophotonics Samtov State University (National Research University of Russia) 410012 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk State University (National Research University of Russia) 634050 Tomsk Russia Laboratory of-Laser Diagnostics of Technical and Living Systems Instituteof Precision Mechanics and Control of RAS 410028 Saratov Russia 4 Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Faculty of Electronics Telecommunicationand Informatics Gdafisk University of Technology Poland National Biophotonics and Imaging Platform Ireland Chair of Applied Physics School of Physics National University of Ireland Galway Ireland European Laboratory for Non Linear Spectroscopy (LENS) and University of Florence Sesto Fiorentino Italy Leibniz Institute of Photonic Tectmology Jena Institute of Physical chemistry & AbbeCenter of Photonics Friedrich Schiller University Jena Germany Technology and Innovation EPIC - European Photonics Industry Consortium Netherlands

Biophotonics is an emerging multidisciplinary research area, embracing all light-based technologies applied to the life sciences and medicine [1-6]. The expression itself is the combination of the Greek syllables ＂bios＂ standing for life and ＂phos＂ standing for light. Photonics is the technical term for all methodologies and technologies utilizing photons over the whole spectrum from X-ray over the ultraviolet, visible and the infrared to the terahertz region, and its interaction with any matter. Beyond this definition, biophotonics is a scientific discipline of remarkable societal importance. As a part of photonics, it has proved to be an important enabling technology for accelerated progress in medicine and biotechnology. It can do so, because it originated at the interface of the most innovative academic disciplines of the last century, i.e., photonics, biotechnology and nanotechnologies. This field of research brings together scientists from different professions, such as physicists, biologists, pharmacists, medical doctors, etc. To work on common projects, they need to understand the ideas and the techniques of their counterparts.

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快速识别食品中的细菌

实验与分析 2009年第4期 42-43页

作者： Susann Meisel Stephan Stockel Petra Rosch Markus Lankers jurgen popp 耶拿FSU大学物理化学研究所 rap.ID粒子系统有限公司耶拿光子技术研究所

食物很容易被细菌感染，进而对人类的健康造成威胁。因此，对这种污染的控制就显得十分重要。在这方面，拉曼光谱仪提供了一种简单而又灵敏的方法。

关键词：细菌感染快速识别食品拉曼光谱仪

Biophoton Emission as a Potential Measure of Organizational Order

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Science China Chemistry 1994年第9期37卷 1099-1112页

作者：顾樵 popp Fritz-Albert Also in Department of Physics Northwest University Xi'an 710069 PRC International Institute of Biophysics Technology Centre 67661 Kaiserslautern Germany

Beginning with the quantum theory of biophoton emission,a c-number equation character- izing the excited-state dynamics of a complex system of collective biomolecules in interaction with both the 'pumping'field and the biophoton field is presented,and then the order-growth process of the system in terms of both determinism and statistics is investigated.A general expression describing the order-growth dynamics of biological systems,which reduces in a limiting case to the well-known growth curve,is ob~ *** a Fokker-Planck equation for probability density function of an order parameter q of the system has been *** solution predicts that the system under consideration can evolute from an arbitrary initial state to a pure state characterized by the steady-state order parameter q_***,the evolution of the maximum entropy of the system is discussed,which shows that the system investigated is to keep an absolute maximum of entropy,and at the same time,to minimize its entropy value by reducing the uncertain- ty of the order ***,some agreements of the theoretical results with the corresponding experi- mental observations of order-growth process demonstrated by the biophoton emission are shown,which indi- cates that biophoton emission may serve as a potential measure of the organizational order.

关键词： biophoton emission complex system nonlinear dynamics organizational order maximum entropy

Inner core's seismic anisotropy is related to its rotation

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Chinese Science Bulletin 2000年第8期45卷 751-753页

作者： H.Kern T.popp Mineralogisch-Petrographisches Institut Universitat Kiel24098 KielGermanyMineralogisch-Petrographisches InstitutUniversitat Kiel24098 KielGermany

The inner core has a differential rotation relative to the crust and mantle, the relative linear velocity between the solid inner core and the molten outer core is the biggest at the eguator and zero at pole area. As a result, the inner core grows faster at the equator than at the pole area. The gravitational force drives the material flow from the equator to the pole area and makes the inner core remain quasi-orbicular. The corresponding axial symmetric stress field makes c-axes of hexagonal close packed (hep) iron align with inner core’s rotation axis, resulting in observed seismic anisotropy.

关键词： inner core growth rotation viscous flow preferred crystal orientation anisotropy.

Research on cell communication of P. elegans by means of photon emission

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Chinese Science Bulletin 1995年第1期40卷 76-79页

作者：张锦珠 popp Fritz-Albert 于文斗 Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Intemational of Biophysics Technology CenterKaisershautern 67661Gemany

Cell communication, sometimes also called cell signaling, has become a topical field in molecular biology, cell biology and biophysics. More and more biologists and physicists have focused their attention on this topic because of its importance in understanding essential features of living systems, i.e. growth, development, cell differentiation, oncogenesis, even neural activity,swarming of animals, and biological evolution.

关键词： cell communication electronagnetic communication photon emission coherence P. elegans.

Superior labral anterior posterior lesions of the shoulder:Current diagnostic and therapeutic standards

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World Journal of Orthopedics 2015年第9期6卷 660-671页

作者： Dominik popp Volker Sch?ffl Section of Sportsorthopedics SportsmedicineSportstraumatologyShoulder and Elbow SurgeryDepartment for Orthopedics and Traumatology

Surgical treatment of superior labral anterior posterior(SLAP) lesion becomes more and more frequent which is the consequence of evolving progress in both,imaging and surgical technique as well as *** first classification of SLAP lesions was described in 1990, a subdivision in four types existed. The rising comprehension of pathology and pathophysiology in SLAP lesions contributed to increase the types in SLAP classification to ten. Concerning the causative mechanism of SLAP lesions, acute trauma has to be differed from chronic degeneration. Overhead athletes tend to develop a glenohumeral internal rotation deficit which forms the basis for two controversial discussed potential mechanisms of pathophysiology in SLAP lesions: Internal impingement and peel-back mechanism. Clinical examination often remains unspecific whereas soft tissue imaging such as direct or indirect magnetic resonance arthrography has technically improved and is regarded to be indispensable in detection of SLAP lesions. Concomitant pathologies as Bankart lesions, rotator cuff tears or perilabral cysts should be taken into consideration when planning a personalized therapeutic strategy. In addition, normal variants such as sublabral recess, sublabral hole, Buford complex and other less common variants have to be distinguished. The most frequent SLAP type Ⅱ needs a sophisticated approach when surgical teatment comes into consideration. While SLAP repair is considered to be the standard operative option, overhead athletes benefit from a biceps tenodesis because improved patient-reported satisfaction and higher rate of return to pre-injury level of sports has been reported.

关键词： Superior labral anterior posterior lesion Tenodesis Superior labral anterior posterior repair Shoulder arthroscopy Biceps tendon

Risk of hepatitis B virus reactivation in cancer patients undergoing treatment with tyrosine kinase-inhibitors

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World Journal of Gastroenterology 2024年第24期30卷 3052-3058页

作者： Bansi P Savaliya Ramin Shekouhi Fatima Mubarak Harsheen K Manaise Paola Berrios Jimenez Gabrielle Kowkabany Reed A popp Kyle popp Emmanuel Gabriel Department of Surgery Medical Academy Named after SI Georgievsky of Vernadsky Crimean Federal UniversitySimferopol 295015CrimeaRussia Division of Plastic and Reconstructive Surgery Department of SurgeryUniversity of FloridaGainesvilleFL 32608United States Department of Surgery Aga Khan UniversityKarachi 74800SindhPakistan Department of Surgery Government Medical College and HospitalChandigarh 160030PunjabIndia Department of Surgery University of Puerto Rico School of MedicineSan Juan 00921Puerto Rico Department of Chemical and Biological Engineering University of AlabamaTuscaloosaAL 35487United States Department of Surgery University of Florida College of MedicineGainesvilleFL 32610United States Department of Surgery Florida State UniversityTallahasseeFL 32306United States Department of Surgery Mayo ClinicJacksonvilleFL 32224United States

This editorial commented on an article in the World Journal of Gastroenterology titled“Risks of Reactivation of Hepatitis B Virus in Oncological Patients Using Tyrosine Kinase-Inhibitors:Case Report and Literature Analysis”by Colapietro et *** this editorial,we focused on providing a more comprehensive exploration of hepatitis B virus reactivation(HBVr)associated with the usage of tyrosine kinase inhibitors(TKIs).It includes insights into the mechanisms underlying HBV reactivation,the temporal relationship between TKIs and HBV reactivation,and preventive *** aim is to understand the need for nucleos(t)ide analogs(NAT)and serial blood tests for early recognition of reactivation and acute liver injury,along with management *** are considered to be an intermediate(1%-10%)of *** guidelines stipulate that patients receiving therapy with high or moderate risks of reactivation or recent cancer diagnosis must have at least tested hepatitis B surface antigen,anti-hepatitis B core antigen(HBc),and anti-hepatitis B surface ***-HBc screening in highly endemic areas means people with negative tests should be vaccinated against *** or nucleotide analogs(NAs)like entecavir(ETV),tenofovir disoproxil fumarate(TDF),and tenofovir alafenamide(TAF)form the basis of HBV reactivation prophylaxis and treatment during ***,lamivudine,telbivudine,and adefovir are generally discouraged due to their reduced antiviral efficacy and higher risk of fostering drug-resistant viral ***,these less effective NAs may still be utilized in cases where ETV,TDF,and TAF are not feasible treatment options.

关键词： Hepatitis B virus Reactivation Chronic hepatitis B Tyrosine-kinase inhibitor Immunomodulators Immunosuppressant Nucleoside analogue Hemato-oncology

Celiac crisis, a rare occurrence in adult celiac disease: A systematic review

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World Journal of Clinical Cases 2019年第3期7卷 311-319页

作者： Daniel Vasile Balaban Alina Dima Ciprian Jurcut Alina popp Mariana Jinga Department of Internal Medicine and Gastroenterology Carol Davila University of Medicine and Pharmacy Department of Internal Medicine Dr. Carol Davila Central Military Emergency University Hospital Department of Pediatrics Carol Davila University of Medicine and Pharmacy Alessandrescu-Rusescu Institute for Mother and Child Health Center for Child Health Research University of Tampere and Tampere University Hospital

BACKGROUND Celiac crisis(CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease(CD). Several cases have been documented in the literature, mostly in *** To perform a review of CC cases reported in adult CD *** A systematic search of the literature was conducted in two databases,PubMed/MEDLINE and EMBASE, using the term "celiac crisis" and its variant"coeliac crisis", from January 1970 onwards. Altogether, 29 articles reporting 42 biopsy-proven cases were found in the search. Here, we summarized the demographic, clinical characteristics, laboratory and diagnostic work-ups, and therapeutic management in these *** Among the 42 CD cases, the median age was 50 years(range 23-83), with a 2:1 female to male ratio. The majority of patients(88.1%) developed CC prior to CDdiagnosis, while the remaining were previously diagnosed CD cases reporting low adherence to a gluten-free diet(GFD). Clinically, patients presented with severe diarrhea(all cases), weight loss(about two thirds) and, in particular situations, with neurologic(6 cases) or cardiovascular(1 case) manifestations or bleeding diathesis(4 cases). One in four patients had a precipitating factor that could have triggered the CC(e.g. trauma, surgery, infections). Laboratory workup of patients revealed a severe malabsorptive state with metabolic acidosis,dehydration, hypoalbuminemia and anemia. The evolution of GFD was favorable in all cases except one, in whom death was reported due to refeeding *** Celiac crisis is a rare but severe and potentially fatal clinical feature of CD. A high index of suspicion is needed to recognize this clinical entity and to deliver proper therapy consisting of supportive care and, subsequently, GFD.

关键词： Celiac disease Celiac crisis Malabsorption Malnutrition Diarrhea