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Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil

World Journal of Hepatology 2018年第11期10卷 867-876页

作者： Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos jurema corrêa da mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar Laboratory of Viral HepatitisOswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazi Postgraduate Program in Pathology Federal University of Ceará Fortaleza Ceará 60020181 Brazil Postgraduate Program in Medical Sciences University of Fortaleza Ceará 60430160 Brazil Laboratory of Innovations in Therapies Teaching and Bioproducts Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazil Institute of Communication and Scientifc Information and Technology for Health Oswaldo Cruz Foundation Rio de Janeiro 21040900 Brazil Laboratory of Epidemiology and Molecular Systematics Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040900 Brazil Orientation and Counselling Centre Curitiba Paraná 80810070 Brazil

AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible *** A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as "low"(0-28 correct answers) or "desirable"(29-46 correct answers). Associations between sociodemographic characteristics and perception were also *** A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas.

关键词： Viral hepatitis Knowledge Perception Urban population Brazil

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Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations

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World Journal of Hepatology 2021年第4期13卷 504-514页

作者： Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Custódio Miguel Denise Vigo Potsch JoséHenrique Pilotto danielle Malta Lima JeováKeny Baima Colares Carlos Eduardo Brandão-Mello Marcia Maria Amendola Pires jurema corrêa da mota Francisco I Bastos Lia Laura Lewis-Ximenez Livia Melo Villar Viral Hepatitis Laboratory FIOCRUZRio de Janeiro 21040360Brazil Postgraduate Program in Pathology Federal University of CearáFortaleza 60020181CearaBrazil Clementino Fraga Filho Hospital Federal University of Rio de JaneiroRio de Janeiro 21040360Brazil Nova Iguaçu General Hospital Nova Iguaçu 26041061Brazil Molecular Immunology Laboratory Oswaldo Cruz InstituteRio de Janeiro 21040360Brazil Postgraduate Program in Medical Sciences University of FortalezaFortaleza 60811905CearáBrazil Escola de Medicina e Cirurgia Gaffrée&Guinle University HospitalFederal University of Rio de Janeiro StateRio de Janeiro 20270901Brazil Institute of Communication and Information on Science and Technology in Health FIOCRUZRio de Janeiro 21040360Brazil

BACKGROUND To achieve the elimination of hepatitis B and C,there is an urgent need to develop alternative strategies to increase the access of diagnosis,particularly among key populations such as people living with human immunodeficiency virus(HIV),individuals with coagulopathies and chronic kidney disease(CKD)*** To evaluate the use of dried blood spot(DBS)in the detection of hepatitis B virus(HBV)and hepatitis C virus(HCV)*** A total of 430 individuals comprised of people living with HIV,coagulopathies and CKD provided paired serum and DBS ***,anti-HBc and anti-HCV were tested in those samples using a commercial *** and selected behavioral variables were evaluated to assess possible association with HBV and HCV *** Using DBS,HBsAg prevalence varied from 3.9%to 22.1%,anti-HBc rates varied from 25.5%to 45.6%and anti-HCV positivity ranged from 15.9%to 41.2%in key *** of HBV and HCV tests using DBS varied from 88.9%to 100%.The HBsAg assay demonstrated the best performance in CKD and coagulopathy individuals and the anti-HCV test had a sensitivity and specificity of 100%in people living with *** of HBV and HCV detection in DBS varied from 90.2%to 100%.In the CKD group,HBsAg positivity was associated with infrequent use of condoms,and anti-HBc positivity was associated with sharing nail cutters/razors/***-HCV reactivity was positively associated with a history of transplantation and length of time using hemodialysis in both *** people living with HIV,only the male gender was associated with anti-HBc positivity in serum and *** DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.

关键词： Dried blood spot Electrochemiluminescence Hepatitis B Hepatitis C Key populations Diagnosis

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拟行宫内人工受精的夫妇禁欲时间对妊娠率的影响

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 38-38页

作者： jurema M. W. Vieira A. D. Bankowski B. 张剑萍(译) Dr. M.W. jurema Women and Infants' Hospital Department of Obstetrics and Gynecology 101 Dudley Street Providence RI 02905 United States 不详

To determine the optimal interval of ejaculatory abstinence for couples undergoing IUI. Design: Retrospective analysis. Setting: Reproductive endocrinology and infertility center. Patient(s): Infertile couples undergoing ovulation induction and IUI with partner’ s semen. Intervention(s): Ovulation induction with clomiphene citrate and a single IUI procedure per cycle. Main Outcome Measures(s): Clinical pregnancy rates as a function of abstinence intervals. Result(s): Four hundred seventeen women underwent 929 cycles from June 1999 to October 2002 for a median of 4 IUI attempts per couple. The median ejaculatory abstinence interval was 4 days (range 0- 30) with an overall pregnancy rate of 12% per cycle. Abstinence correlated positively with inseminate sperm count but negatively with motility. Variations in inseminate parameters did not correlate with pregnancy rates. However, abstinence intervals significantly affected pregnancy rates. The highest pregnancy rate was observed with an abstinence interval of 3 days or less (14% ) and the lowest pregnancy rate seen with an abstinence interval of 10 days or more (3% ). Conclusion(s): An abstinence interval of 3 days or less was associated with higher pregnancy rates following IUI. Prolonged abstinence decreases pregnancy rates, independent of other sperm parameters, perhaps as a result of sperm senescence and functional damage not readily identified by standard semen analysis. Abstinence intervals should be controlled for in studies examining pregnancy outcome in assisted reproduction.

关键词：临床妊娠率不孕症夫妇宫内人工受精禁欲时间精子计数辅助生殖技术女性患者精液参数生殖内分泌精子活动度

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