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Erratum to“Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer”

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Research 2024年第3期6卷 797-798页

作者： yun Zhou Mian yu Changjun Tie Yang Deng Junqing Wang yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China

In the Research Article “Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer,” the authors made an error in Fig. 6A. In Fig. 6A, the image of “pre” in the “Free Cy5-siRNA” group was misused. When incorporating the final images in Fig. 6A, another image of “24 h” in the “Free Cy5-siRNA” group was inadvertently chosen as the “Pre” image, so they appear to be remarkably similar. After the error was discovered, the authors repeated the experiments that concluded that this error did not affect the results, discussion, or conclusion of this paper. Figure 6A has now been corrected in the PDF and HTML (full text).

关键词： Internal Cancer Breast

Sesamin is an effective spleen tyrosine kinase inhibitor against IgE-mediated food allergy in computational， cell-based and animal studies

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Food Science and Human Wellness 2024年

作者： yu Li Xuerui Chen Longhua Xu Xintong Tan Dapeng Li Dongxiao Sun-Waterhouse Feng Li School of Chemical Sciences， The University of Auckland Key Laboratory of Food Nutrition and Human Health in Universities of Shandong College of Food Science and Engineering， Shandong Agricultural University

Food allergy has become a global concern. Spleen tyrosine kinase (SYK) inhibitors are promising therapeutics against allergic disorders. In this study， a total of 300 natural phenolic compounds were firstly subjected to virtual screening. Sesamin and its metabolites， sesamin monocatechol (SC-1) and sesamin dicatechol (SC-2)， were identified as potential SYK inhibitors， showing high binding affinity and inhibition efficiency towards SYK. Compared with R406 (a traditional SYK inhibitor)， sesamin， SC-1， and SC-2 had lower binding energy and inhibition constant (Ki) during molecular docking， exhibited higher bioavailability， safety， metabolism/clearance rate， and distribution uniformity ADMET predictions， and showed high stability in occupying the ATP-binding pocket of SYK during molecular dynamics simulations. In anti-dinitrophenyl-immunoglobulin E (Anti-DNP-IgE)/dinitrophenyl-human serum albumin (DNP-HSA)-stimulated rat basophilic leukemia (RBL-2H3) cells， sesamin in the concentration range of (5 – 80) μmol/L influenced significantly the degranulation and cytokine release， with 54.00% inhibition against β-hexosaminidase release and 58.45% decrease in histamine. In BALB/c mice， sesamin could ameliorate Anti-DNP-IgE/DNP-HSA-induced passive cutaneous anaphylaxis and ovalbumin (OVA)-induced active systemic anaphylaxis reactions， reduce the levels of allergic mediators (immunoglobulins and pro-inflammatory cytokines)， partially correct the imbalance of T helper (Th) cells differentiation in the spleen， and inhibit the phosphorylation of SYK and its downstream signaling proteins， including p38 mitogen-activated protein kinases (p38 MAPK)， extracellular signal-regulated kinases (ERK)， and p65 nuclear factor-κB (p65 NF-κB) in the spleen. Thus， sesamin may be a safe and versatile SYK inhibitor that can alleviate IgE-mediated food allergies.

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Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua yu Jin Zhao Song Shen Xuedong Zhou Lin yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo Kang Sung Hee Lim Min-Ji Kim Jeeyun lee Young Suk Park Ho Yeong Lim Won Ki Kang Seung Tae Kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 CPS less than 1 and those with PD-L1 CPS of 1 or more(PD-L1<1%vs PD-L1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-L1 CPS less than 5 and of 5 or more(PD-L1<5%vs PD-L1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-L1 CPS less than 10 and of 10 or more(PD-L1<10%vs PD-L1≥10%;PFS:P=0.529,OS:P=0.568).CONCLUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

Effect of CTRP13 regulates high glucose-induced autophagy dysfunction of primary rat liver sinusoidal endothelial cells through the AMPK/mTOR pathway

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 26-27页

作者：余静 Dept Geriatr Gansu Prov People's HospLanzhou 730000

Objective To investigate the effect of Clq/tumor necrosis factor-related protein 13 protein (CTRP13) on the autophagy function of primary rat liver sinusoidal endothelial cells (rLSECs) induced by high glucose through... 详细信息

关键词： AMPK/mTOR CTRP1 liver

基于全局图注意力元路径异构网络的药物-疾病关联预测

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电子科技大学学报 2024年第4期53卷 576-583页

作者：郁湧杨雨洁李虓晗高悦于倩云南大学软件学院昆明650504 云南省软件工程重点实验室昆明650504

提出了一个基于全局图注意力元路径异构网络模型(MHNGA)来进行药物-疾病关联预测。首先,收集整理药物和疾病数据,将已知的药物-疾病关联、药物相似性、疾病相似性构建为一个异构网络;其次,引入多个基于元路径的子图,使用图注意力神经网... 详细信息

提出了一个基于全局图注意力元路径异构网络模型(MHNGA)来进行药物-疾病关联预测。首先,收集整理药物和疾病数据,将已知的药物-疾病关联、药物相似性、疾病相似性构建为一个异构网络;其次,引入多个基于元路径的子图,使用图注意力神经网络提取这些子图的邻居节点的特征,并且通过通道注意力和空间注意力机制来增强特征;最后,通过十折交叉验证的评估,MHNGA取得了93.5%的精确召回曲线下的面积和99.4%的准确率。

关键词：异构图药物-疾病关联预测图注意力神经网络元路径

二维MXene材料在太阳能电池和金属离子电池中的研究进展

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化工学报 2024年第2期75卷 412-428页

作者：曹宇张国辉高昂杜心宇周静蔡永茂余璇于晓明现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林吉林132012 东北电力大学电气工程学院吉林吉林132012 东北电力大学化学工程学院吉林吉林132012 东北电力大学理学院吉林吉林132012 浙江海洋大学海洋工程装备学院浙江舟山316022

MXene是一种新型二维材料,具有导电性高、表面官能团丰富、层间距和能带结构可调等特点,从而在新能源器件中拥有重要的研究价值。综述了MXene在太阳能电池和金属离子电池中应用的相关进展。在太阳能电池中,基于MXene高电导率、高透明度... 详细信息

MXene是一种新型二维材料,具有导电性高、表面官能团丰富、层间距和能带结构可调等特点,从而在新能源器件中拥有重要的研究价值。综述了MXene在太阳能电池和金属离子电池中应用的相关进展。在太阳能电池中,基于MXene高电导率、高透明度和功函数灵活可调的特点,讨论了其在电极和载流子传输层中的相关应用研究,并对MXene功函数调整的策略进行了总结。在金属离子电池中,基于MXene独特的二维层状结构、优异的力学性能和良好的导电性,讨论了MXene作为负极材料以及与碳纳米材料、金属氧化物和硅组成的复合材料对电化学性能的提升作用,并对MXene在正极材料、集流体以及隔膜中应用也进行了介绍。最后对MXene的下一步发展进行了展望。

关键词： MXene 太阳能电池金属离子电池纳米材料器件性能

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多端交通视频分析任务卸载决策

控制与决策 2024年第8期39卷 2773-2782页

作者：温震宇胡慧峰钱滨洪榛俞立浙江工业大学网络空间安全研究院杭州310023 浙江工业大学信息工程学院杭州310023 纽卡斯尔大学计算机学院纽卡斯尔NE45TG

针对智慧交通中多点位监控视频分析时出现的计算任务繁重、设备之间资源利用不均衡的问题,提出一种基于云控制的视频分析卸载方案.首先,针对客户端算力不足而无法完成视频分析任务的问题,使用一种视频卸载框架,将部分视频分析任务切块... 详细信息

针对智慧交通中多点位监控视频分析时出现的计算任务繁重、设备之间资源利用不均衡的问题,提出一种基于云控制的视频分析卸载方案.首先,针对客户端算力不足而无法完成视频分析任务的问题,使用一种视频卸载框架,将部分视频分析任务切块卸载至云服务器处理;其次,针对服务器与多客户端之间的算力资源竞争问题,提出一种阶段优化卸载算法,平衡设备之间负荷,提高资源利用率;最后,针对不同点位的客户端需求不同的问题,在算法中加入精度和能耗偏好,满足不同客户端的需求.与其他卸载方案对比的实验表明,所提出方案能够更好地对视频分析任务进行合理分配,提高系统收益,并通过扩展实验验证所提出系统的扩展能力.

关键词：多端视频分析任务卸载资源竞争卸载决策智慧交通

考虑风电爬坡灵活调节的碳捕集电厂低碳经济调度

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电工技术学报 2024年第7期39卷 2033-2045页

作者：韩丽王冲于晓娇喻洪波王晓静中国矿业大学电气工程学院徐州221116

为实现“双碳”目标,风电等可再生能源的使用是减少碳排放的根本途径,而碳捕集电厂是降低碳排放的直接手段。但风电具有与生俱来的波动性,风电的骤升骤降会影响碳捕集电厂“电碳耦合”特性,从而对碳捕集效果带来不利影响。而储液罐通过... 详细信息

为实现“双碳”目标,风电等可再生能源的使用是减少碳排放的根本途径,而碳捕集电厂是降低碳排放的直接手段。但风电具有与生俱来的波动性,风电的骤升骤降会影响碳捕集电厂“电碳耦合”特性,从而对碳捕集效果带来不利影响。而储液罐通过增减自身溶液量可近似地存储释放能量,为解决上述问题提供了可能。该文首先搭建碳捕集电厂数学模型,分析储液罐通过增减溶液量带来的储放能量与碳捕集设备能耗之间的关联,研究储液罐的双向调节能力;然后,提出上爬坡碳超前补偿和下爬坡碳滞后补偿调度策略,双向调节储液罐使碳捕集电厂电碳解耦;接着,构建跟随风电爬坡进行调节的低碳经济调度模型;最后,对含碳捕集电厂、高碳电厂和风电场的电力系统进行仿真,证明所提方法的有效性。

关键词：碳减排风电爬坡碳捕集电厂碳补偿