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Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation

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Science China(Life Sciences) 2021年第7期64卷 1097-1115页

作者： Yun Zhang Yanfang Yang Jun Ye Yue gao Hengfeng Liao junzhuo Zhou Yu Feng Dongdong Liu Yingying Meng Xiaoguang Chen Lili gao Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

As a potential cancer immunotherapeutic agent,chlorogenic acid(CHA)has entered phase II clinical trials in China as a lyophilized powder formulation for treating ***,the in vivo instability of CHA necessitates daily intramuscular injections,resulting in patient *** this study,CHA-phospholipid complex(PC)-containing PEGylated liposomes(CHA-PC PEG-Lipo,named as CPPL),with CHA-PC as the drug intermediate,were prepared to lower the administration *** demonstrated excellent physicochemical properties,enhanced tumor accumulation,and inhibited tumor growth even when the administration interval was prolonged to 4 days when compared to a CHA solution and CHA-PC loaded liposomes(CHA-PC Lipo,labeled as CPL),both of which only demonstrated antitumor efficacy with once-daily *** evaluation of the in vivo antitumor immune mechanism suggested that the extended antitumor immune efficacy of CPPL could be attributed to its distinct immune-stimulating mechanism when compared with CHA solution and CPL,such as stimulating both CD4+and CD8+T cell infiltration,inhibiting myeloid-derived suppressor cell expression,reducing the expression of Th2 related factors,and notably,increasing the memory T cells in tumor *** CHA-containing formulation could reduce the frequency of in vivo CHA administration during cancer treatment via T cells,especially memory T cell regulation.

关键词： chlorogenic acid PEGylated liposomes T cell regulation immunotherapy

Periphyton growth reduces cadmium but enhances arsenic accumulation in rice(Oryza sativa) seedlings from contaminated soil

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Periphyton growth reduces cadmium but enhances arsenic accum...

有机氟改性丙烯酸乳液的合成及其膜表面性能的研究

中国土壤学会土壤环境专业委员会第十九次会议暨“农田土壤污染与修复研讨会”第二届山东省土壤污染防控与修复技术研讨会

作者： gao Ling Shi Hai Ying Lu Yong Hong Wu junzhuo Liu Lai Qing Lou Hong Xiang Ma Institute of Food Crops Jiangsu Academy of Agricultural Sciences State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences College of Life Sciences Nanjing Agricultural University

Periphyton is ubiquitous in paddy fields, but its role in arsenic(As) and cadmium(Cd) bioavailability to rice plants remains unknown. A paddy field was simulated under controlled conditions to investigate the influences of periphyton on As and Cd accumulation in rice seedlings grown in soil contaminated with both As and Cd. The presence of periphyton significantly enhanced the growth of rice seedlings in As and Cd contaminated soil. Periphyton had significant effects on soil p H and Eh, resulting in a substantial decrease in the Cd concentration, but an increase in the total As and As(III) concentrations in soil solution. Corresponding with these changes, Cd concentrations in rice roots and shoots were significantly decreased in the presence of periphyton, while As concentrations increased. This study demonstrate that periphyton growth can significant affect soil As and Cd bioavailability and soil As speciation by change soil p H and Eh, thereby affect As and Cd accumulation in rice seedlings. These results suggest that controlling native periphyton growth may be an effective strategy to regulate As and Cd translocation to the edible organs of food crops.

关键词： Arsenic Bioavailability Cadmium Periphyton Rice

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宁夏大学学报（自然科学版） 2006年第3期27卷 252-254页

作者：房俊卓高继红徐崇福宁夏大学能源化工重点实验室宁夏银川750021 宁夏大学学术期刊中心宁夏银川750021

通过热分解引发体系,用有机氟单体对丙烯酸树脂进行改性,合成了性能优异的氟改性丙烯酸乳液,并研究了有机氟单体对乳胶膜吸水率及对水的接触角的影响.用红外光谱对聚合物结构进行了表征,并用X光电子能谱对乳胶膜表面特性进行了研究.

关键词：有机氟改性吸水率接触角表面性能

基于物联网的水质在线自动监测系统研究与实现

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四川理工学院学报（自然科学版） 2018年第4期31卷 56-62页

作者：李随群蔡郡倬高祥卢令四川理工学院计算机学院四川自贡643000 同济大学化学科学与工程学院上海200092 四川理工学院机械工程学院四川自贡643000 四川理工学院分析测试中心四川自贡643000

针对江河流域氨氮等水质参数含量超标,传统水质检测方法存在预处理过程复杂、检测设备体积庞大、检测周期长、不能实现连续自动检测等问题,提出采用纳氏试剂分光光度法检测水质参数,并结合西门子PLC、组态软件(MCGS)、4G移动通信等技术... 详细信息

针对江河流域氨氮等水质参数含量超标,传统水质检测方法存在预处理过程复杂、检测设备体积庞大、检测周期长、不能实现连续自动检测等问题,提出采用纳氏试剂分光光度法检测水质参数,并结合西门子PLC、组态软件(MCGS)、4G移动通信等技术,设计出基于物联网的水质在线监测系统。介绍了系统基于C/S模式的总体架构设计,并基于一个感知节点详细阐述了由PLC、MCGS、蠕动泵、分光光度计等组成的检测系统硬件结构设计,并对水质检测软件功能进行了分析,分别对检测系统、PLC控制程序和4G通信程序进行了测试。系统测试结果表明,该系统自动化程度高、检测周期短、能够实现对0 mg/L^300 mg/L范围的样品进行检测,具有实际应用价值。

关键词：水质自动监测系统检测装置控制策略组态软件 4G通信技术

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区块链在最后一公里物流配送的应用分析

物流科技 2019年第2期42卷 38-41页

作者：柯君卓汪驰升高青国博文王新雨舒齐奇国土资源部城市土地资源监测与仿真重点实验室北京100812 深圳大学土木工程学院广东深圳518060 深圳大学建筑与城市规划学院广东深圳518060 深圳市南山区教育科学研究中心广东深圳518000 深圳市育才中学广东深圳518000

在信息化高度发展以及人们工作节奏逐渐加快的今日,电子商务的营业额不断提高,随之带动物流行业高速发展。在物流配送的过程中,物流配送"最后一公里"主要指商品由配送员从配送点交至消费者签收的阶段,也是整个物流配送的最后一个步骤。... 详细信息

在信息化高度发展以及人们工作节奏逐渐加快的今日,电子商务的营业额不断提高,随之带动物流行业高速发展。在物流配送的过程中,物流配送"最后一公里"主要指商品由配送员从配送点交至消费者签收的阶段,也是整个物流配送的最后一个步骤。根据文献[1]可知,目前我国物流"最后一公里"配送花费时长大约是5小时,占据快递业务市场45%,运输距离却不足整个运输距离的5%。由此可见,如何提高"最后一公里"的运输效率是当前物流运输的重要难题。文章提出使用区块链、物联网与物流配送结合的模式,进一步提高物流配送的效率,同时解决物流配送中关于物品安全问题。

关键词：区块链最后一公里物流物联网