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Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

Research in Astronomy and Astrophysics 2024年第9期24卷 85-100页

作者： Bing-Ru wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang junzhi wang Gary J.Melnick Jin-Zeng Li Gary A.Fuller Jinjin Xie National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Tsinghua University Research Center for Astronomical Computing Zhejiang Laboratory Jet Propulsion Laboratory California Institute of Technology Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Xinjiang Astronomical Observatory Chinese Academy of Sciences Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi University Center for Astrophysics Harvard&Smithsonian60 Garden Street Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of Manchester I.Physikalisches Institut University of Cologne

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite （SWAS） *** obtained an averaged O2spectrum based on this sample using the （SWAS） survey data （O2,487.249 GHz,N=3–1,J=3–2）.No emission or absorption feature is seen around the supposed central velocity with a total integration time of ttotal=8.67×10～3hr and an rms noise per channel of 1.45 m *** a kinetic temperature Tkin=30 K,we derive the 3σupper limit of the O2column density to be 3.3×1015cm-2,close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O2abundance upper limit is6.7×10-8,lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O2abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： galaxies: abundances Galaxy: abundances ISM: lines and bands ISM: molecules

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New strategy for COVID-19 vaccination:targeting the receptor-binding domain of the SARS-CoV-2 spike protein

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Cellular & Molecular Immunology 2021年第2期18卷 243-244页

作者： junzhi wang Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products National Institutes for Food and Drug ControlBeijingChina

The unexpected outbreak of SARS-CoV-2 infection,with over 42.5 million confirmed cases and more than 1.1 million deaths globally,^(1)has posed a great threat to public *** global efforts to control this viral infection,the pandemic is still *** facing such a serious,unprecedented situation,vaccines are likely the most promising method to control this newly identified coronavirus.A recent study from Yang et al.^(2)showed that a recombinant spike receptor-binding domain(RBD)protein of SARS-CoV-2 prepared from insect cells induced protective immunity in nonhuman primates,providing a feasible vaccine candidate for COVID-19 control(Fig.1).

关键词： protective immunity vaccine

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A bivalent recombinant vaccine:a promising strategy against both SARS-CoV-2 variants and wild type of the virus

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2266-2267页

作者： junzhi wang Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products National Institutes for Food and Drug ControlBeijingChina

A recent study published in Medcomm by He et al.1 introduced protein subunit vaccines with wild-type and mutant S1 subunit(S1-WT and S1-Mut)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)to evaluate their immunoprotective *** team further analyzed the neutralization activity of bivalent vaccine composed of S1-WT and S1-Mut for SARS-CoV-2 and mutant strains to explore a universal protective vaccine.

关键词： protective vaccine

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基于深度强化学习的无人机路径规划与无线电测绘

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应用科学学报 2024年第2期42卷 200-210页

作者：王鑫仲伟志王俊智肖丽君朱秋明南京航空航天大学航天学院江苏南京211106 南京航空航天大学电子信息工程学院江苏南京211106

针对传统无人机轨迹优化设计方法在构建通信模型上具有局限性的问题,本文面向蜂窝连接无人机通信方式,引入一种基于深度强化学习的无人机路径规划与无线电测绘方法。该方法利用扩展后的双深Q网络模型,结合无线电预测网络,生成无人机轨... 详细信息

针对传统无人机轨迹优化设计方法在构建通信模型上具有局限性的问题,本文面向蜂窝连接无人机通信方式,引入一种基于深度强化学习的无人机路径规划与无线电测绘方法。该方法利用扩展后的双深Q网络模型,结合无线电预测网络,生成无人机轨迹并预测由于动作选择而累计的奖励值。此外,基于Dyna框架将实际飞行和模拟飞行相结合,进一步训练双深Q网络模型,从而大大提高学习效率。仿真结果表明,与Direct-RL算法相比,该方法能更有效地利用学习到的覆盖区域概率图,使无人机避开弱覆盖区域,减小飞行时间和预期中断时间的加权和。

关键词：无人机蜂窝通信路径规划深度强化学习无线电测绘

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CO observation of SNR IC 443

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Science China(Physics,Mechanics & Astronomy) 2010年第7期53卷 1357-1369页

作者： ZHANG ZhiYu GAO Yu wang junzhi Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China Graduate University of Chinese Academy of Sciences Beijing 100080China Astronomy Department Nanjing UniversityNanjing 210093China

We present our 12CO and 13CO mapping observations of SNR IC 443 interacting with molecular *** is the first largescale high-resolution 13CO mapping observation in the surrounding *** morphologies of IC 443 in 12CO and 13 CO are compared with the optical,infrared,Spitzer far-infrared,X-ray,and neutral atomic gas(HI).We also make comparison and analysis in the kinematics,using the date-cubes of 12CO,13CO and HI,to help distinguish the complicated gas motions in the shocked *** on the work of wang & Scoville(1992),we present a new model to explain the coexistence of multiple shocks with different speeds in a pc-scale region at the central clump *** test this new model by analyzing the HI and CO distribution in both velocity and space *** also establish the relationship between the dissociation rate of shocked molecular gas and the shock velocity in this ***,we derive the optical depth of 12CO with the 13CO spectra in clump B,and discuss the validity of the assumption of optically thin emission for the shocked 12CO.

关键词： supernova remnant shock molecular clouds molecular spectrum IC 443

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Optimized functional and structural design of dual-target LMRAP,a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment

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Acta Pharmaceutica Sinica B 2020年第2期10卷 262-275页

作者： Meng Li Hanmei Xu junzhi wang Shenyang Pharmaceutical University Shenyang 110016China Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products National Institutes for Food and Drug ControlBeijing 102629China State Key Laboratory of Natural Medicines Ministry of Educationthe Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu ProvinceDepartment of Marine PharmacyChina Pharmaceutical UniversityNanjing 211198China

To develop fusion protein of a GnRH Fc fragment and the integrin targeting AP25 antitumor peptide for GnRH receptor-expressing cancer *** LMRAP fusion protein was constructed.A transwell invasion assay was *** gene mRNA and protein levels of GnRHR-I,α5β1,andαvβ3 in different cancer cell lines were *** proliferation was measured using a cell counting *** antagonist assay was performed on GnRH ***-tumor activity was evaluated with a mouse xenograft tumor ***(IHC)was applied to detect CD31 and CD34 *** characteristics were determined with an indirect competition *** developed bifunctional fusion protein LMRAP not only inhibited HUVEC invasion,but also inhibited proliferation of GnRHR-I,α5β1,and high expression cancer *** IC50 for LMRAP in the GnRH receptor was 6.235 x 10-4 mol/*** significantly inhibited human prostate cancer cell line22 RV1 proliferation in vivo and in *** significantly inhibited CD31 and CD34 *** elimination half-life of the fusion protein LMRAP was 33 h in *** fusion protein made of a GnRH Fc fragment and the integrin targeting AP25 peptide retained the bifunctional biological activity of GnRHR blocking,angiogenesis inhibition,prolonged half-life and good tolerance.

关键词： Fusion protein GnRH Integrin Angiogenesis Prostate cancer

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Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China

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Engineering 2022年第3期8卷 127-132页

作者： Zhiming Huang Zhihao Fu junzhi wang National Medical Products Administration Beijing 100053China National Institutes for Food and Drug Control Beijing 102629China

Regulatory science is a discipline that uses comprehensive methods of natural science,social science,and humanities to provide support for administrative decision-making through the development of new tools,standards,and approaches to assess the safety,efficacy,quality,and performance of regulated *** the pandemics induced by infectious diseases,such as H1N1 flu,severe acute respiratory syndrome(SARS),and Middle East respiratory syndrome(MERS),regulatory science strongly supported the development of drugs and vaccines to respond to the *** particular,with the support of research on drug regulatory science,vaccines have played a major role in the prevention and control of coronavirus disease 2019(COVID-19).This review summarizes the overall state of the vaccine industry,research and development(R&D)of COVID-19 vaccines in China,and the general state of regulatory science and supervision for vaccines in ***,this review highlights how regulatory science has promoted the R&D of Chinese COVID-19 vaccines,with analyses from the aspects of nationallevel planning,relevant laws and regulations,technical guidelines,quality control platforms,and postmarketing ***,this review provides a reference for the formulation of a vaccine development strategy in response to the current pandemic and the field of vaccine development in the post-pandemic era,as well as guidance on how to better respond to emerging and recurring infectious diseases that may occur in the future.

关键词： Regulatory science COVID-19 vaccine Vaccine industry

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孕晚期妇女母胎依恋现状及其与分娩恐惧的相关性研究

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军事护理 2024年第3期41卷 1-4页

作者：李海云张国春褚梁梁王君芝山东第一医科大学第一附属医院护理部山东济南250014

目的了解孕晚期妇女母胎依恋现状,分析其影响因素,并探讨其与分娩恐惧的相关性,为实施干预措施提供科学的依据。方法2023年1-2月,采用便利抽样法选取济南市某三级甲等医院就诊的孕晚期妇女329名为研究对象,采用分娩态度量表、产前依恋... 详细信息

目的了解孕晚期妇女母胎依恋现状,分析其影响因素,并探讨其与分娩恐惧的相关性,为实施干预措施提供科学的依据。方法2023年1-2月,采用便利抽样法选取济南市某三级甲等医院就诊的孕晚期妇女329名为研究对象,采用分娩态度量表、产前依恋问卷等对其调查。结果孕晚期妇女分娩恐惧总分为(29.12±6.39)分,母胎依恋总分为(48.54±7.85)分。不同年龄、胎次、文化程度以及是否计划内妊娠、有无孕期并发症和孕期抑郁情绪等的孕晚期妇女,母胎依恋得分差异均有统计学意义(均P<0.05)。分娩恐惧与母胎依恋得分呈负相关(r=-0.471,P<0.001)。年龄、胎次、长期居住地、文化程度、是否计划内妊娠、孕期睡眠时间≥10 h/d、有无孕期并发症和孕期抑郁情绪是母胎依恋的主要影响因素(均P<0.05)。结论孕晚期妇女分娩恐惧和母胎依恋处于中等水平,两者呈负相关。医护人员可采取针对性的干预预防孕妇分娩恐惧,从而改善母胎依恋关系。

关键词：孕晚期分娩恐惧母胎依恋横断面研究相关性

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Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues

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Engineering 2019年第1期5卷 122-131页

作者： Yonghong Li Yan Huo Lei Yu junzhi wang National Institutes for Food and Drug Control Beijing 100050 China

Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.

关键词： Chimeric antigen receptor T cells Quality control Nonclinical research Safety Efficacy Clinical trials Cancer immunotherapy

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A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3925-3934页

作者： Zhihao Fu Hongchuan Liu Lan wang Chuanfei Yu Yalan Yang Meiqing Feng junzhi wang Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products National Institutes for Food and Drug ControlBeijing 102629China Department of Biological Medicines&Shanghai Engineering Research Center of Immunotherapeutics School of PharmacyFudan UniversityShanghai 201203China

T cell immunoglobulin and ITIM domain(TIGIT)is a novel immune checkpoint that has been considered as a target in cancer *** available bioassays for measuring the biological activity of therapeutic antibodies targeting TIGIT are restricted to mechanistic investigations because donor primary T cells are highly ***,we designed a reporter gene assay comprising two cell lines,namely,CHO-CD112-CD3 scFv,which stably expresses CD 112(PVRL2,nectin-2)and a membranebound anti-CD3 single-chain fragment variable(scFv)as the target cell,and Jurkat-NFAT-TIGIT,which stably expresses TIGIT as well as the nuclear factor of activated T-cells(NFAT)response element-controlled luciferase gene,as the effector *** anti-CD3 scFv situated on the target cells activates Jurkat-NFATTIGIT cells through binding and crosslinking CD3 molecules of the effector cell,whereas interactions between CD 112 and TIGIT prevent *** presence of anti-TIGIT mAbs disrupts their interaction,which in turn reverses the inactivation and luciferase *** and validation studies have demonstrated that this assay is superior in terms of specificity,accuracy,linearity,and *** summary,this reliable and effective reporter gene assay may potentially be utilized in lot release control,stability assays,screening,and development of novel TIGIT-targeted therapeutic antibodies.

关键词： TIGIT Therapeutic antibodies Bioactivity determination Reporter gene assay Method validation

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