检索结果-南通市图书馆

基于“以方测证”探讨异丙肾上腺素诱导慢性心衰小鼠模型的中医证型及证候本质

在线全文

学校读者我要写书评

暂无评论

中药药理与临床 2024年第2期40卷 101-108页

作者：杨梦胡思远李琳谈宇权张君宇王菲胡志希湖南中医药大学中医学院长沙410208

目的:采用异丙肾上腺素(ISO)诱导慢性心衰小鼠模型,选用气虚证的代表方黄芪注射液、血瘀证的代表方丹红注射液、气阴两虚证的代表方参麦注射液及阳虚证的代表方参附注射液进行干预,从“以方测证”角度探索该模型的证候属性。方法:通过... 详细信息

目的:采用异丙肾上腺素(ISO)诱导慢性心衰小鼠模型,选用气虚证的代表方黄芪注射液、血瘀证的代表方丹红注射液、气阴两虚证的代表方参麦注射液及阳虚证的代表方参附注射液进行干预,从“以方测证”角度探索该模型的证候属性。方法:通过腹腔注射ISO 7.5 mg/kg进行造模,造模成功后将其分为模型对照组、黄芪注射液9.0 mL/kg组、丹红注射液9.0 mL/kg组、参麦注射液9.0 mL/kg组、参附注射液9.0 mL/kg组和卡托普利16.5 mg/kg组,另设正常对照组。药物干预15 d后,对其进行心功能评价,测定血清NT-proBNP、TNF-α、IL-6含量,检测心、脾及肾组织病理,结合宏观表征探讨其中医证型。结果:与正常对照组比较,模型对照组LVEF、LVFS、LVPWd、LVPWs、IVSd、IVSs值显著降低(P<0.01),LVIDd、LVIDs、LVEDV、LVESV水平,血清NT-proBNP、TNF-α、IL-6含量显著升高(P<0.01);与模型对照组比较,参附组、卡托普利组LVIDd、LVIDs、LVEDV、LVESV水平,血清NT-proBNP、TNF-α、IL-6含量明显降低(P<0.05或P<0.01),LVEF、LVFS LVPWd值明显升高(P<0.05或P<0.01);参附组、卡托普利组在改善心、脾、肾病理形态学疗效优于其他注射液。结论:参附注射液对ISO诱导心衰小鼠模型的疗效显著且优于黄芪、丹红、参麦注射液,推测该模型的证候属性可能为心阳虚证。

关键词：参附注射液以方测证慢性心力衰竭异丙肾上腺素

Preparation and characterization of a novel blue-TiO_(2)/PbO_(2)-carbon nanotube electrode and its application for degradation of phenol

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2023年第4期126卷 590-601页

作者： Yangchun Xu Ruizhi Feng Minglu Zhang Caigan Yan junyu Liu Tingting Zhang Xiaohui wang Beijing Engineering Research Center of Environmental Material for Water Purification College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Bishuiyuan Membrane Technology CO. Ltd.Beijing 101400China State Environmental Protection Key Laboratory of Food Chain Pollution Control Beijing Technology and Business UniversityBeijing 100048China

In this study,we fabricated a blue-TiO_(2)/PbO_(2)-carbon nanotube (CNT) electrode in which blue TiO_(2)nanotube arrays (blue-TNA) served as the substrate for PbO_(2)-CNT eletrodeposition.Scanning electron microscope (SEM) showed compact surface structure of the electrode.The β-PbO_(2)crystal structure was detected by X-ray diffraction (XRD).The distribution of Pb,O,C,and Na elements on the electrode surface have been confirmed by X-ray photoelectron spectroscopy (XPS).Blue-TiO_(2)/PbO_(2)-CNT electrode had higher response current (213.12mA),larger active surface area and lower charge transfer resistance (2.22Ω/cm^(2)) than conventional TiO_(2)/PbO_(2)-CNT electrode.The influences of current density,initial phenol concentration,initial solution pH,and Na2SO_(4)concentration on the electrochemical oxidation of phenol have been analyzed.The results showed that the 100 mg/L phenol could be destroyed completely after 210 min,and chemical oxygen demand (COD) removal rate was 89.3%within 240 min.Additionally,the electrode showed long actual lifetime (5468.80 hr) and low energy consumption (0.08 kWh/gCOD).A phenol degradation mechanism was proposed by analyzing the intermediate products with high-performance liquid chromatography-mass spectrometry (HPLC-MS).Importantly,the blue-TiO_(2)/PbO_(2)-CNT electrode exhibited superior stability and high degradation efficiency after 15 times reuse,demonstrating its promising application potential on phenol-containing wastewater treatment.

关键词： Electrochemical oxidation Electrodeposition Blue-TiO_(2) Phenol

Behaviour and mechanisms of molecular vibrations induced by a pulsed voltage in a silicone elastomer used for device encapsulation

在线全文

学校读者我要写书评

暂无评论

High Voltage 2023年第5期8卷 1020-1029页

作者： junyu Wei Dongxin He Teng Gao Lin Zhu Haochen wang Qingquan Li Gilbert Teyssedre Shandong Provincial Key Laboratory of UHV Transmission Technology and Equipment School of Electrical Engineering Shandong UniversityJinanChina School of Materials Science and Engineering Shandong UniversityJinanChina UPS INPTCNRSLAPLACE(Laboratoire Plasma et Conversion d’Energie)University of ToulouseToulouseFrance

Silicone elastomers are widely used to encapsulate power electronic devices.However,such devices may be subjected to square‐wave pulsed voltages with a high rate of change,which can create significant challenges for encapsulation insulation.In this article,the molecular vibration of silicon elastomer at the edge of pulsed electric field is studied.Firstly,the relationship between the intensity of molecular vibration and the parameters of pulsed electric field is explored.The experimental results show that the amplitude of the vibrations decreases as the pulse‐edge time increases,and it increases linearly as the pulseedge slope increases.Furthermore,the amplitude of the vibrations is proportional to the square of the amplitude of the pulsed electric field,and it increases as the space charge density increases.Then,the force analysis of charged molecule at the pulse edges is calculated,and the theoretical change law of molecular vibration intensity with pulse edge slope is deduced.Comparing the theoretical results with the experimental results,it is found that they are highly consistent.Finally,electrically induced mechanical stress caused by molecular vibration was shown to be an important factor in insulation failure.

关键词： pulsed insulation vibrations

柱层析提取黑果腺肋花楸原花青素、维生素C及体外活性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

绵阳师范学院学报 2024年第2期43卷 56-62页

作者：刘君宇王晓林钟方丽陈浩吉林化工学院化学与制药工程学院吉林吉林132022

探索了柱层析循环联合法提取黑果腺肋花楸中原花青素和维生素C的工艺条件,并对其体外活性进行研究.以提取液中原花青素及维生素C的质量为指标,确定其提取溶剂、吸涨率和浸泡平衡时间.结果表明,原花青素和维生素C的提取溶剂分别为40%乙... 详细信息

探索了柱层析循环联合法提取黑果腺肋花楸中原花青素和维生素C的工艺条件,并对其体外活性进行研究.以提取液中原花青素及维生素C的质量为指标,确定其提取溶剂、吸涨率和浸泡平衡时间.结果表明,原花青素和维生素C的提取溶剂分别为40%乙醇溶液和纯水、吸涨率分别为2.6 mL/g和3.2 mL/g、浸泡平衡时间分别为3 h和2 h.此条件下,经柱层析循环联合提取后,黑果腺肋花楸中原花青素及维生素C的提取率均可达到95%以上.体外活性试验显示,黑果腺肋花楸原花青素、维生素C提取物均具有一定的抗氧化能力、抗肿瘤活性及抑制高尿酸血症能力.柱层析循环联合法能够同时提取黑果腺肋花楸中的原花青素及维生素C,可以实现用少量溶剂同时提取多种物质.

关键词：黑果腺肋花楸柱层析原花青素维生素C 体外活性

异丙肾上腺素诱导慢性心衰模型不同方案的比较

在线全文

学校读者我要写书评

暂无评论

中国实验动物学报 2024年第2期32卷 161-167页

作者：谈宇权张君宇杨梦王菲钟森杰李琳胡志希湖南中医药大学中医诊断研究所长沙410208

目的比较3种不同方案制备的动物模型,探索稳定、可靠且重复性好的小鼠慢性心力衰竭模型。方法将25只雄性C57BL/6J小鼠随机分为4组:正常组(ZC组)、实验A组(MA组)、B组(MB组)和C组(MC组)。实验组采取不同制备方案连续注射ISO,其中MA组和M... 详细信息

目的比较3种不同方案制备的动物模型,探索稳定、可靠且重复性好的小鼠慢性心力衰竭模型。方法将25只雄性C57BL/6J小鼠随机分为4组:正常组(ZC组)、实验A组(MA组)、B组(MB组)和C组(MC组)。实验组采取不同制备方案连续注射ISO,其中MA组和MB组为浓度递减造模法,MA组(第1天10 mg/kg、第2天5 mg/kg、第3~30天2.5 mg/(kg·d);皮下注射30 d);MB组(第1天20 mg/kg、第2天10 mg/kg、第3~14天5 mg/(kg·d);皮下注射14 d);MC组(浓度恒定7.5 mg/(kg·d),腹腔注射28 d),构建慢性心衰动物模型。在注射结束后的第2天,计算各组小鼠存活率和成模率情况。通过心脏超声检测心功能,并用ELISA测定血清中NT-pro BNP、IL-6、TNF-α水平。结果在第30天注射结束后,各实验组虽都能有效诱导慢性心力衰竭,但发现7.5 mg/kg浓度MC组的造模情况最稳定,更适合后续开展中医药相关的心衰研究。结论ISO制备小鼠慢性心衰模型以恒定7.5 mg/(kg·d),连续腹腔注射28 d为最佳方案。

关键词：异丙肾上腺素慢性心衰射血分数保留型心衰模型制备

Ultrasmall AuPd nanoclusters on amine-functionalized carbon blacks as high-performance bi-functional catalysts for ethanol electrooxidation and formic acid dehydrogenation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第5期31卷 556-563页

作者： Yuhuan Cui Ming Zhao Yining Zou junyu Zhang Jiuhui Han Zhili wang Qing Jiang Key Laboratory of Automobile Materials Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022JilinChina Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversitySendai 980-8578Japan

The synthesis of ultrasmall metal nanoclusters(NCs) with high catalytic activities is of great importance for the development of clean and renewable energy technologies but remains a challenge. Here we report a facile wet-chemical method to prepare ~1.0 nm Au Pd NCs supported on amine-functionalized carbon blacks. The Au Pd NCs exhibit a specific activity of 5.98 mA cm_(AuPd)^(-2)and mass activity of 5.25 A mg_(auPd)^(-1) for ethanol electrooxidation, which are far better than those of commercial Pd/C catalysts(1.74 mAcm_(AuPd)^(-2) and 0.54 A mg_(Pd)^(-1) ). For formic acid dehydrogenation, the Au Pd NCs have an initial turn over frequency of 49339 h^(-1) at 298 K without any additive, which is much higher than those obtained for most of reported Au Pd catalysts. The reported synthesis may represent a facile and low-cost approach to prepare other ultrasmall metal NCs with high catalytic activities for various applications.

关键词： Ethanol electrooxidation Formic acid dehydrogenation AuPd Nanoclusters Bi-functional catalyst

Multi-effect anthraquinone-based polyimide enclosed SnO_(2)/reduced graphene oxide composite as high-performance anode for lithium-ion battery

在线全文

学校读者我要写书评

暂无评论

化学科学与工程前沿:英文版 2023年第9期17卷 1231-1243页

作者： Lin wang Yinjie Kuang Qian Cui junyu Shi Liubin Song Qionghua Li Tianjian Peng Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation School of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha410114China Guizhou Dalong Huicheng New Material Co. Ltd.Tongren554000China

The cycling stability of SnO_(2)anode as lithium-ion battery is poor due to volume expansion.Polyimide coatings can effectively confine the expansion of SnO_(2).However,linear polyimides are easily dissolved in ester electrolytes and their carbonyls is not fully utilized during charging/discharging process.Herein,the SnO_(2)enclosed with anthraquinone-based polyimide/reduced graphene oxide composite was prepared by self-assembly.Carbonyls from the anthraquinone unit provide fully available active sites to react with Li^(+),improving the utilization of carbonyl in the polyimide.More exposed carbonyl active sites promote the conversion of Sn to SnO_(2)with electrode gradual activation,leading to an increase in reversible capacity during the charge/discharge cycle.In addition,the introduction of reduced graphene oxide cannot only improve the stability of polyimide in the electrolyte,but also build fast ion and electron transport channels for composite electrodes.Due to the multiple effects of anthraquinone-based polyimide and the synergistic effect of reducing graphene oxide,the composite anode exhibits a maximum reversible capacity of 1266 mAh·g^(−1) at 0.25 A·g^(−1),and maintains an excellent specific capacity of 983 mAh·g^(−1) after 200 cycles.This work provides a new strategy for the synergistic modification of SnO_(2).

关键词： anthraquinone-based polyimide multi-effect tin dioxide reduced graphene oxide lithium-ion battery

Direct identification of total and missing OH reactivities from light-duty gasoline vehicle exhaust in China based on LP-LIF measurement

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2023年第11期133卷 107-117页

作者： Xuehui Liu Zibing Yuan Qing’e Sha Shengrong Lou Hongli wang Xin Li junyu Zheng Bin Yuan Min Shao School of Environment and Energy South China University of TechnologyGuangzhou 510006China Institute of Environmental and Climate Research Jinan UniversityGuangzhou 511443China State Environmental Protection Key Laboratory of the Cause and Prevention of Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China College of Environmental Science and Engineering Peking UniversityBeijing 100871China

Considerable efforts have been devoted to characterising the chemical components of vehicle exhaust.However,these components may not accurately reflect the contribution of vehicle exhaust to atmospheric reactivity because of the presence of species not accounted for(“missing species”)given the limitations of analytical instruments.In this study,we improved the laser photolysis–laser-induced fluorescence(LP-LIF)technique and applied it to directly measure the total OH reactivity(TOR)in exhaust gas from light-duty gasoline vehicles in China.The TOR for China Ⅰ to Ⅵ-a vehicles was 15.6,16.3,8.4,2.6,1.5,and 1.6×10^(4) sec^(-1),respectively,reflecting a notable drop as emission standards were upgraded.The TOR was comparable between cold and warm starts.The missing OH reactivity(MOR)values for China Ⅰ to Ⅳ vehicles were close to zero with a cold start but were much higher with a warm start.The variations in oxygenated volatile organic compounds(OVOCs)under different emission standards and for the two start conditions were similar to those of the MOR,indicating that OVOCs and the missing species may have similar production processes.Online measurement revealed that the duration of the stable driving stage was the primary factor leading to the production of OVOCs and missing species.Our findings underscore the importance of direct measurement of TOR from vehicle exhaust and highlight the necessity of adding OVOCs and other organic reactive gases in future upgrades of emission standards,such that the vehicular contribution to atmospheric reactivity can be more effectively controlled.

关键词： Total OH reactivity LP-LIF Missing OH reactivity Emission standard Light-duty gasoline vehicle

在线全文

学校读者我要写书评

暂无评论

黑果分散片的制备、质量及体外活性研究

凯里学院学报 2024年第3期42卷 46-55页

作者：刘君宇王晓林钟方丽陈浩吉林化工学院吉林吉林132022

为了探索黑果分散片的制备工艺、质量及其体外活性,通过单因素与正交试验相结合的方式考察了黑果分散片的制备工艺,采用UV法考察了黑果分散片总三萜的含量及其体外活性,采用超高效液相色谱法测定了黑果分散片中没食子酸、儿茶素、表儿... 详细信息

为了探索黑果分散片的制备工艺、质量及其体外活性,通过单因素与正交试验相结合的方式考察了黑果分散片的制备工艺,采用UV法考察了黑果分散片总三萜的含量及其体外活性,采用超高效液相色谱法测定了黑果分散片中没食子酸、儿茶素、表儿茶素的含量.结果发现黑果分散片的优选处方为微晶纤维素作稀释剂、交联聚乙烯吡咯烷酮作崩解剂、75%乙醇为黏合剂、微粉硅胶作润滑剂.分散片中总三萜的含量测定方法显色前后稳定性符合测定要求、仪器精密度和重复性良好,总三萜的加样回收率为99.48%;体外活性试验结果表明,黑果分散片具有一定的清除DPPH和抑制脂质体的能力;超高效液相色谱法测定没食子酸、儿茶素、表儿茶素的加样回收率分别为99.83%、100.69%和99.61%.优选的制剂工艺制备的分散片,其崩解时限符合要求,总三萜的含量为1.42 mg/片,没食子酸、儿茶素、表儿茶素的含量分别为111.15μg/g、940.19μg/g、598.25μg/g.试验结果为黑果分散片的应用提供了理论依据.

关键词：黑果花楸分散片制备工艺体外活性超高效液相色谱法