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磁共振成像及脑脊液细胞学对病毒性脑(膜)炎的诊断性研究

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中国现代神经疾病杂志 2011年第5期11卷 538-542页

作者：何俊瑛张楠李玉静邹月丽李美杰谷聚贤张环环河北医科大学第二医院神经内科河北省神经病学重点实验室石家庄050000

目的探讨MRI和脑脊液细胞学检测阳性率、异常程度和发病时间对病毒性脑(膜)炎诊断和制定治疗方案的指导价值。方法回顾189例病毒性脑(膜)炎患者的头部MRI及脑脊液检查资料,分析MRI正常或异常患者在疾病早期的脑脊液细胞学改变。结果 18... 详细信息

目的探讨MRI和脑脊液细胞学检测阳性率、异常程度和发病时间对病毒性脑(膜)炎诊断和制定治疗方案的指导价值。方法回顾189例病毒性脑(膜)炎患者的头部MRI及脑脊液检查资料,分析MRI正常或异常患者在疾病早期的脑脊液细胞学改变。结果 189例患者中96例(50.79%)呈现MRI异常影像、129例(68.25%)脑脊液细胞学检测异常。MRI异常患者中脑脊液细胞学检测异常率为72.92%(70/96),与MRI正常患者(63.44%,59/93)比较差异具有统计学意义(P=0.000)。结论病毒性脑(膜)炎患者在疾病早期MRI改变晚于脑脊液细胞学改变,但二者对提示诊断和制定治疗方案均具有重要临床意义。

关键词：脑膜炎,病毒性脑炎,病毒性脑脊髓液细胞学技术磁共振成像

缺血性脑血管病患者MPO的表达水平与颈动脉粥样硬化斑块类型及HCMV相关性研究

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河北医科大学学报 2012年第9期33卷 1004-1007页

作者：孔伟丽谷聚贤何俊瑛高玉林河北省定州市人民医院神经内科河北定州071500 河北医科大学第二医院神经内科河北石家庄050000

目的探讨髓过氧化物酶(marrow peroxide,MPO)与颈动脉粥样硬化斑块类型及人巨细胞病毒(human cytomegalovirus,HCMV)激活感染的相关性。方法研究对象选择符合入选条件的患者84例,均行外周血白细胞HCMV-PP65、颈动脉超声、血清MPO检查,... 详细信息

目的探讨髓过氧化物酶(marrow peroxide,MPO)与颈动脉粥样硬化斑块类型及人巨细胞病毒(human cytomegalovirus,HCMV)激活感染的相关性。方法研究对象选择符合入选条件的患者84例,均行外周血白细胞HCMV-PP65、颈动脉超声、血清MPO检查,比较不同斑块类型组HCMV-PP65、血清MPO的差别,并比较PP65阳性组与阴性组中血清MPO的差别。结果不稳定斑块组HCMV-PP65阳性率(56.76%)明显高于稳定斑块组(30.30%);HCMV-PP65阳性组MPO平均含量(132.63±5.44)μg/L高于阴性组(92.55±5.39)μg/L;有斑块组MPO平均含量(112.09±9.13)μg/L高于无斑块组(87.32±8.29)μg/L,不稳定斑块组MPO平均含量(146.91±9.56)μg/L高于稳定斑块组(73.04±9.92)μg/L;PP65阳性病例中,有斑块组MPO平均含量(138.34±13.55)μg/L高于无斑块组(92.53±1.76)μg/L,不稳定斑块组MPO平均含量(170.50±11.36)μg/L高于稳定斑块组(93.32±2.67)μg/L;以上差异均有统计学意义(P<0.05)。结论不稳定颈动脉粥样硬化斑块者HCMV-PP65阳性率显著高于稳定斑块者,HCMV激活感染在动脉粥样硬化形成中起着重要作用,HCMV激活感染可促进MPO的表达,且有促使斑块不稳定的倾向,HCMV、MPO、AS之间存在相关性。

关键词：动脉粥样硬化颈动脉狭窄过氧化物酶

Low‑Carbon‑Emission Hot Stamping:A Review from the Perspectives of Steel Grade,heating Process,and Part Design

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Automotive Innovation 2023年第3期6卷 324-339页

作者： Zeran Hou Yi Liu Qi he Jianfeng Wang junying Min School of Mechanical Engineering Tongji UniversityShanghai 201804China China Science Lab General Motors Global Research and DevelopmentShanghai 201206China

Hot stamping steels have become a crucial strategy for achieving lightweighting and enhancing crash safety in the automo-tive industry over the past two ***,the carbon emissions of the materials and their related stamping processes have been frequently *** is essential to consider these emissions during the design *** materials and technologies in hot stamping pose challenges to the automotive industry's future development in carbon emission *** review discusses the promising materials for future application and their special features,as well as the emerging manufacturing and part design processes that have extended the limit of application for new *** heating processes and corresponding equipment have been proven to improve heating efficiency and control temperature *** material utilization and the overall performance of the components are improved by tailored blanks and an integrated part design *** achieve low-carbon-emission(LCE)hot stamping,it is necessary to systematically consider the steel grade,heating process,and part design,rather than solely focusing on reducing carbon emissions during the manufacturing process *** review aims to present the latest progress in steel grade,heating process,and part design of hot stamping in the automotive industry,providing solutions for LCE from a holistic perspective.

关键词： Low-carbon-emission Hot stamping Steel grade heating process Part design

Prediction of Cancer-Associated piRNA–mRNA and piRNA–lncRNA Interactions by Integrated Analysis of Expression and Sequence Data

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Tsinghua Science and Technology 2018年第2期23卷 115-125页

作者： Yajun Liu junying Zhang Aimin Li Zhaowen Liu Zhongzhen he Xiguo Yuan Shouheng Tuo Xi'an University of Technology Xi'an 710048 China. School of Computer Science and Technology Xidian University Xi'an 710071China

piwi-interactingRNAs(piRNAs) are valuable biomarkers, but functional studies are still very *** research shows that piRNA-mediated cleavage acts on Transposable Elements(TEs), messengerRNAs(mRNAs), and long non-codingRNAs(lncRNAs). This study aimed to predict cancer-associated piRNA-mRNA and piRNA-lncRNA interactions as well as piRNA regulatory functions. Four cancer types(BRCA, HNSC, KIRC,and LUAD) were investigated. Interactions were identified by integrated analysis of the expression and sequence data. For the expression analysis, only piRNA–mRNA and piRNA–lncRNA pairs with expression profiles that were significantly inversely correlated were retained to reduce false-positive rates during the prediction. For the sequence analysis, miRanda was used for the target prediction. We identified 198 piRNA–mRNA and 10 piRNA–lncRNA pairs. Unlike mRNA and lncRNA expressions, the piRNA expression was relatively consistent across the cancer types. Furthermore, the identified piRNAs were consistent with previously published cancer biomarkers, such as piRNA-36741, piR-21032, and piRNA-57125. More importantly, predicted piRNA functions were determined by constructing an interaction network, and piRNA targets were placed in gene ontology categories related to the cancer hallmarks "activating invasion and metastasis" and "sustained angiogenesis".

关键词： co-expression piRNA-mRNA interaction piRNA-lncRNA interaction integrated analysis target prediction

1-GENERATOR QUASI-CYCLIC CODES

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Journal of Systems Science & Complexity 2007年第4期20卷 554-561页

作者： junying PEI Xuejun ZHANG Department of Mathematics Soochow University Suzhou 215006. China

This paper discusses the enumeration of 1-generator quasi-cyclic codes and describes an algorithm which will obtain one, and only one, generator for each 1-generator quasi-cyclic code.

关键词： Direct sum decomposition idempotent quasi-cyclic code.

ICP-AES 法测定信阳毛尖茶叶、茶水及茶酒中的稀土元素

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中国稀土学报 1988年第3期 81-84页

作者：王凤珍齐大荃邵宏翔何俊英高小霞北京大学化学系、地质系

本文叙述用 ICP—AES 测定茶叶、茶水及茶酒中痕量稀土元素的方法。样品经处理制得的溶液,通过阳离子交换树脂对稀土元素进行分离和富集,选用1M 盐酸和2M 硝酸作基体元素淋洗液,7M 硝酸作稀土元素淋洗液。

关键词：稀土元素富集阳离子交换树脂 ⅢB族元素基体元素淋洗液茶叶茶水茶酒 AES 信阳毛尖

Magnetospheric Physics in China

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空间科学学报 2018年第5期38卷 694-762页

作者： CAO Jinbin YANG junying Space Science Institute School of Space and Environment Beihang UniversityBeijing 100191

In the past two years, much progress has been made in magnetospheric physics by using the data of Double Star Program, Cluster, TheMIS, RBSP, Swarm, MMS, ARTEMIS, MESSENGER missions etc., or by computer simulations. This paper briefly reviews these works based on papers selected from the 227 publications from January 2016 to December 2017. The subjects cover most sub-branches of magnetospheric physics,including geomagnetic storm, magnetospheric substorm, magnetic reconnection, solar wind-magnetosphereionosphere interaction, radiation belt, plasmasphere, outer magnetosphere, magnetotail, geomagnetic field,auroras, and currents.

关键词：物理中国计算机模拟相互作用出版物暴风雨磁气圈报纸

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新型冠状病毒相关吉兰-巴雷综合征7例临床分析

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中国神经精神疾病杂志 2023年第6期49卷 340-344页

作者：杨伊江佳佳刘雅菁冯双浩张彦博赵辉邹月丽霍颖浩李奕何俊瑛卜晖河北医科大学第二医院神经内科石家庄050000

目的探讨新型冠状病毒(severe acute respiratory syndromes coronavirus 2,SARS-CoV-2)相关吉兰-巴雷综合征(Guillain-Barre syndrome,GBS)的临床特征、辅助检查及治疗,以提高对该病的认识。方法纳入2022年12月至2023年2月在河北医科大学第二医院神经内科确诊的7例SARS-CoV-2相关GBS患者,查阅病历收集其临床特征、辅助检查及治疗资料,进行回顾性分析。结果7例SARS-CoV-2相关GBS患者,男6例,女1例,年龄31~73岁,平均(57.4±16.2)岁,以肢体运动功能障碍或肢体运动感觉功能障碍伴受累肢体反射减弱或消失为主要临床特征,均伴脑脊液蛋白细胞分离现象,使用免疫调节治疗效果好。结论SARS-CoV-2相关GBS和经典GBS的临床表现、病程、对治疗的反应相似。

关键词：新型冠状病毒吉兰-巴雷综合征临床特征肌电图脱髓鞘脑脊液

The effects of S4 segments on the voltage-dependence of inactivation for Cav3.1 calcium channels

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Chinese Science Bulletin 2007年第12期52卷 1642-1647页

作者： LI junying Biophysics Department School of Physics Key Laboratory of Bioactive Materials of Education Ministry Nankai University Tianjin 300071 China

T-type calcium channels exhibit fast voltage-dependent inactivation, for which the underlying struc- ture-function relationship still remains unclear. To investigate the roles of S4 segments in volt- age-dependent inactivation of T-type calcium channels, we created S4 replacement chimeras between Cav3.1 calcium channels (fast voltage-dependent inactivation) and Cav1.2 calcium channels (little voltage-dependent inactivation) by replacing S4s in Cav3.1 with the corresponding regions in Cav1.2. Wild type and chimeric channels were expressed in Xenopus oocytes and channel currents were re- corded with two-electrode voltage-clamp. We showed that replacing S4 region in domain I shifted voltage-dependence for inactivation of Cav3.1 to the left, and the V0.5 inact and kinact value were signifi- cantly changed. However replacing S4s in domains II―IV had no effects on the voltage-dependent in- activation properties. These results suggest that the roles of S4 segments in domains I―IV are different, and S4 in domain I is likely to be involved in voltage-dependent inactivation process. Its movement during membrane depolarization may trigger a conformational change in the inactivation gate.

关键词：钙离子通道电压失活 S4片断结构-函数关系