检索结果-南通市图书馆

New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第2期67卷 531-551页

作者： junyi GE Xiaoling ZHANG Shejiang WANG Linhui LI Wei HE Yingshuai JIN Peiqi ZhANG Bing XU Chenglong DENG John WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

Research on Virtual Assembly System for Industrial Robots Based on Unity3D

在线全文

学校读者我要写书评

暂无评论

Journal of Harbin Institute of Technology(New series) 2024年

作者： junyi Ouyang Dezhang Xu The College of Artificial Intelligence Anhui Polytechnic University Wuhu Anpu Robot Industry Technology Research Institute

To address the challenges of insufficient visualization in the industrial robot assembly operation system and the limitation of visualizing only geometric attributes of physical properties， a method is proposed for constructing an industrial robot assembly system based on virtual reality technology. Focusing on the shaft hole assembly， the mechanical characteristics of the industrial robot shaft hole assembly process are analyzed and a dynamic model is established for shaft hole assembly operations. The key elements of virtual assembly operations for industrial robots are summarized and a five-dimensional model is proposed for industrial robot virtual operations. Utilizing the Unity3D engine based on the 5-D model for industrial robot virtual operations， an industrial robot shaft hole assembly system is developed. This system enables virtual assembly operations， displays physical attributes， and provides valuable references for the research of virtual systems.

关键词：

Human Expansion-Induced Biodiversity Crisis over Asia from 2000 to 2020

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第2期2023卷 647-658页

作者： Chao Yang Qingquan Li Xuqing Wang Aihong Cui junyi Chen Huizeng Liu Wei Ma Xuanyan Dong Tiezhu Shi Fanyi Meng Xiaohu Yan Kai Ding Guofeng Wu MNR Key Laboratory for Geo-Environmental Monitoring of Great Bay Area&Guangdong Key Laboratory of Urban Informatics&Shenzhen Key Laboratory of Spatial Smart Sensing and Services Shenzhen UniversityShenzhen 518060China School of Architecture and Urban Planning Shenzhen UniversityShenzhen 518060China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ) Shenzhen 518107China Center for Hydrogeology and Environmental Geology China Geological SurveyBaoding 071051China Department of Geography Hong Kong Baptist UniversityHong Kong Special Administrative Region 999077China Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China institute for Advanced Study and Tiandu-Shenzhen University Deep Space Joint Laboratory Shenzhen UniversityShenzhen 518060China School of Civil Engineering Chongqing Jjiaotong UniversityChongging 400074China Department of Cil and Environmental Engineering Tohoku UniversitySendai 980-8579Japan School of Artificial Intelligence Shenzhen PolytechnicShenzhen 518055China School of Computer Science and Technology Dongguan University of TechnologyDongguan 523419China

Asia stands out as a priority for urgent biodiversity conservation due to its large protected areas(PAs)and threatened *** the 21st century,both the highlands and lowlands of Asia have been experiencing the dramatic human ***,the threat degree of human expansion to biodiversity is poorly ***,the threat degree of human expansion to biodiversity over 2000 to 2020 in Asia at the continental(Asia),national(48 Asian countries),and hotspot(6,502 Asian terrestrial PAs established before 2000)scales is investigated by integrating multiple large-scale *** results show that human expansion poses widespread threat to biodiversity in Asia,especially in Southeast Asia,with Malaysia,Cambodia,and Vietnam having the largest threat degrees(~1.5 to 1.7 times of the Asian average level).Human expansion in highlands induces higher threats to biodiversity than that in lowlands in one-third Asian countries(most Southeast Asian countries).The regions with threats to biodiversity are present in~75%terrestrial PAs(including 4,866 PAs in 26 countries),and human expansion in PAs triggers higher threat degrees to biodiversity than that in *** findings provide novel insight for the Sustainable Development Goal 15(SDG-15 Life on Land)and suggest that human expansion in Southeast Asian countries and PAs might hinder the realization of *** reduce the threat degree,Asian developing countries should accelerate economic transformation,and the developed countries in the world should reduce the demands for commodity trade in Southeast Asian countries(i.e.,trade leading to the loss of wildlife habitats)to alleviate human expansion,especially in PAs and highlands.

关键词： Human terrestrial integrating

Aggregation-Induced Catalysis: Asymmetric Catalysis with Chiral Aggregates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 525-532页

作者： Yao Tang Yu Wang Qingkai Yuan Sai Zhang Jia-Yin Wang Shengzhou Jin Ting Xu junyi Pan Kazimierz Surowiec Guigen Li Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79409-1061USA School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China School of Pharmacy Continuous Flow Engineering Laboratory of National Petroleum and Chemical IndustryChangzhou UniversityChangzhouJiangsu 213164China

So far,there have been 4 methods to control chirality including the use of chiral auxiliaries,reagents,solvents,and catalysts documented in literature and *** them,asymmetric catalysts are normally divided into homogeneous and heterogeneous *** this report,we present a new type of asymmetric control—asymmetric catalysis via chiral aggregates that would not belong to the above *** new strategy is represented by catalytic asymmetric dihydroxylation reaction of olefins in which chiral ligands are aggregated by taking advantage of typical aggregation-induced emission systems containing tetrahydrofuran and H_(2)O *** was proven that the chiral induction can be enhanced from er of 78:22 to 97:3 simply by changing the ratios of these 2 cosolvents.

关键词： chiral asymmetric Chiral

基于BERTCA的新闻实体与正文语义相关度计算模型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中文信息学报 2022年第3期36卷 109-119页

作者：向军毅胡慧君刘茂福毛瑞彬武汉科技大学计算机科学与技术学院湖北武汉430065 智能信息处理与实时工业系统湖北省重点实验室湖北武汉430065 武汉大学信息资源研究中心湖北武汉430072

目前的搜索引擎仍然存在“重形式,轻语义”的问题,无法做到对搜索关键词和文本的深层次语义理解,因此语义检索成为当前搜索引擎中亟需解决的问题。为了提高搜索引擎的语义理解能力,该文提出一种语义相关度的计算方法。首先,标注了金融... 详细信息

目前的搜索引擎仍然存在“重形式,轻语义”的问题,无法做到对搜索关键词和文本的深层次语义理解,因此语义检索成为当前搜索引擎中亟需解决的问题。为了提高搜索引擎的语义理解能力,该文提出一种语义相关度的计算方法。首先,标注了金融类新闻标题实体与新闻正文语义相关度语料1万条,然后建立新闻实体与正文语义相关度计算的BERTCA(Bidirectional Encoder Representation from Transformers Co-Attention)模型,通过使用BERT预训练模型,综合考虑细粒度的实体和粗粒度的正文的语义信息,然后经过协同注意力,实现实体与正文的语义匹配,不仅能计算出金融新闻实体与新闻正文之间的相关度,还能根据相关度阈值来判定相关度类别,实验表明该模型在1万条标注语料上准确率超过95%,优于目前主流模型,最后通过具体搜索示例展示了该模型的优秀性能。

关键词：语义相关度计算 BERT模型协同注意力机制

氮化碳纤维涂层HS-SPME-GC-MSMS法测定酶解牛油中多种挥发性风味组分

在线全文

学校读者我要写书评

暂无评论

塑料包装 2022年第6期32卷 21-25,58页

作者：夏诗明向君毅广东省清远市质量计量监督检测所清远市食品检验中心清远市食品检验工程技术研究开发中心

本文基于固相微萃取技术(SPME,Solid-PhaseMicroextraction),建立了运用新型氮化碳纤维涂层固相微萃取(HS-SPME-GC-MSMS)结合计算机质谱数据库及气味分析数据库检索定性,用正构烷烃校正内标保留指数,多种挥发性物质SCAN和MRM同时扫描,... 详细信息

本文基于固相微萃取技术(SPME,Solid-PhaseMicroextraction),建立了运用新型氮化碳纤维涂层固相微萃取(HS-SPME-GC-MSMS)结合计算机质谱数据库及气味分析数据库检索定性,用正构烷烃校正内标保留指数,多种挥发性物质SCAN和MRM同时扫描,并利用内标标准曲线对化合物进行定量的检测酶解牛油香气组分的分析方法。对比了两种不同规格(氮化碳纤维涂层和Carbon-PMS(碳-聚二甲基硅氧烷)涂层)固定相吸附涂层对检测结果的影响。研究表明,得益于二维共轭聚合物层状结构以及较大的比表面积,氮化碳纤维涂层对挥发性气相组分的吸附效果要比Carbon-PMS涂层更好,更能满足现代化气味分析实验室多样、快速、高效的实验要求。氮化碳纤维涂层在吸附萃取挥发性组分方面具有较大的潜力。

关键词：氮化碳纤维固相微萃取酶解牛油风味组分

Biomarkers for early diagnosis of autism obtained through bioinformatics analysis of human blood sample

在线全文

学校读者我要写书评

暂无评论

Journal of Translational Neuroscience 2021年第4期6卷 7-18页

作者： Liuyin Jin Linman Wu Zhilan Yang junyi xiang Wenqian Xu Chang Shu Gaohua Wang Center for Mental Health Renmin Hospital of Wuhan UniversityWuhan 430000China School of Mental Health Wenzhou Medical UniversityWenzhou 325006China The Affiliated Mental Hospital of Kunming Medical University Kunming 650000China

Objective:autism spectrum disorder(ASD),a serious disorder that begins early in life,con-tinues throughout the *** with ASD who are diagnosed early are more responsive to therapeutic interventions and have less social and language impair-ment than children diagnosed later;however,current di-agnostic measures are mostly applied to children older than one year and lack the appropriate biological markers for early diagnosis of *** bioinformatic analy-sis,this study explores the molecular information mech-anism of ***:in this study,we used dataset GSE6575 from Gene Expression Omnibus(GEO)to an-alyze the mRNA expression profile of ASD,including 35 ASD samples and 12 normal control samples looking for different genes and we did enrichment analysis of those *** then used the STRING database to construct a protein-protein interaction(PPI)network of differential ***,Cytoscape plug-in cytoHubba was used to search for hub *** diagnostic value of the hub genes was verified by subject operating characteristic ***:we looked for 50 different genes and did an enrichment analysis of those *** results of the enrichment analysis showed that these differential genes were mainly concentrated in the response to viruses,the immune regulation of inflammation and energy *** Cytoscape plug-in cytoHubba,we found ten different *** drew ROC curves for all ten genes among which two genes,interleukin 2 receptor subunit beta(IL2Rβ)and perforin 1(PRF1),had good sensitivity and specificity for the early diagnosis of *** ar-eas under the ROC curves were 0.855,0.830 for IL2Rβ,***:data analysis using the GEO data-base can provide new insights into the etiology of ASD as well as some possible biomarkers and therapeutic targets for early diagnosis and treatment of ASD.

关键词： autism spectrum disorder(ASD) differentially expressed gene early diagnosis energy metabolism immune regulation

Genome-wide association with transcriptomics reveals a shade-tolerance gene network in soybean

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第1期12卷 232-243页

作者： Yanzhu Su Xiaoshuai Hao Weiying Zeng Zhenguang Lai Yongpeng Pan Can Wang Pengfei Guo Zhipeng Zhang Jianbo He Guangnan Xing Wubin Wang Jiaoping Zhang Zudong Sun junyi Gai Soybean Research Institute/MARA National Center for Soybean Improvement MARA Key Laboratory of Biology and Genetic Improvement of Soybean/State Key Laboratory for Crop Genetics and Germplasm Enhancement/State Innovation Platform for Integrated Production and Education in Soybean Bio-breeding/Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural UniversityNanjing 210095JiangsuChina Guangxi Academy of Agricultural Sciences Nanning 530007GuangxiChina

Shade tolerance is essential for soybeans in inter/relay cropping systems.A genome-wide association study(GWAS)integrated with transcriptome sequencing was performed to identify genes and construct a genetic network governing the trait in a set of recombinant inbred lines derived from two soybean parents with contrasting shade *** improved GWAS procedure,restricted two-stage multi-locus genome-wide association study based on gene/allele sequence markers(GASM-RTM-GWAS),identified 140 genes and their alleles associated with shade-tolerance index(STI),146 with relative pith cell length(RCL),and nine with *** of these genes by biological categories allowed the construction of a protein–protein interaction network by 187 genes,of which half were differentially expressed under shading and non-shading conditions as well as at different growth *** the identified genes,three ones jointly identified for both traits by both GWAS and transcriptome and two genes with maximum links were chosen as beginners for entrance into the ***,both STI and RCL gene systems worked for shade-tolerance with genes interacted each other,this confirmed that shadetolerance is regulated by more than single group of interacted genes,involving multiple biological functions as a gene network.

关键词： Soybean(Glycine max(L.)Merr.) Shade-tolerance Restricted two-stage multi-locus genomewide association study based on gene/allele sequence markers(GASM-RTM-GWAS) Shade-tolerance index(STI) Relative cell length(RCL) Transcriptome

Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Research 2024年第4期38卷 358-368页

作者： Yifei Cheng Rongjie Shi Shuai Ben Silu Chen Shuwei Li junyi Xin Meilin Wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Cancer Hospital Jiangsu Institute of Cancer Researchthe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the *** first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc *** then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA *** the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell ***,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting *** conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.

关键词： genetic variants prostate cancer circRNA RNA-binding protein RNA splicing sing-cell RNA sequencing