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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 303-315页

作者： Jiayu Sheng junyi cheng Wenjie Chu Mengting Dong Ke Jiang Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China

Objective To investigate the mechanism underlying the effects exerted by the Qizhu prescription(QZP)in breast cancer(BC),and the respective *** Expression data from the ArrayExpress and The Cancer Genome Atlas(TCGA)were used to identify differentially expressed genes(DEGs)in *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed on the DEGs to identify genes involved in protein–protein *** docking was used to explore the dynamic relationship between active molecules and *** function experiments and animal studies were conducted to evaluate the effects of hub genes and active QZP compounds on BC cell *** Among the 25 evaluated BC-related targets of QZP,matrix metalloproteinase-1(MMP1)and epidermal growth factor receptor(EGFR)exhibited the highest degrees of *** and KEGG enrichment analyses revealed that the anti-BC targets of QZP primarily affected drug responses and pathways in cancer *** docking analysis suggested potential interactions between EGFR and quercetin/luteolin,as well as between MMP1 and luteolin/kaempferol/*** significantly reduced BC cell proliferation,migration,invasion,and tumor development in *** of BC cells with quercetin decreased the expression or activation of several associated *** The findings of our study provide new insights into the therapeutic potential of traditional Chinese medicine against BC,with particular reference to QZP.

关键词： Traditional Chinese medicine Qizhu prescription Breast cancer Quercetin Network pharmacology

复合亚固溶热处理对一种新型镍基粉末高温合金涡轮盘锻态显微组织的影响

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稀有金属材料与工程 2024年第3期53卷 768-777页

作者：刘朝峰程俊义马向东肖磊郭建政冯干江中南大学粉末冶金国家重点实验室湖南长沙410083 深圳市万泽中南研究院有限公司广东深圳518035

研究了复合亚固溶热处理工艺对一种新型镍基粉末高温合金FGH4113A(WZ-A3)γ’相组织的影响。结果表明,大尺寸锻造态涡轮盘件锻后冷速较低,γ’相的尺寸在100~4500 nm之间分布。在盘件上取小试样进行热处理试验,试样升温至1000和1050℃时... 详细信息

研究了复合亚固溶热处理工艺对一种新型镍基粉末高温合金FGH4113A(WZ-A3)γ’相组织的影响。结果表明,大尺寸锻造态涡轮盘件锻后冷速较低,γ’相的尺寸在100~4500 nm之间分布。在盘件上取小试样进行热处理试验,试样升温至1000和1050℃时,γ’相总占比下降,Oswald熟化机制及PAM机制同时存在。试样升温至1100℃时,晶内γ’相完全回溶。使用复合亚固溶热处理工艺,先将试样升温至1120℃保温2 h,快速冷却后再分别升温至1000、1050和1100℃时,γ’相总占比均下降,晶内γ’相演变以Oswald熟化机制为主导,其形貌及尺寸在升温过程中相对稳定。在盘件上取性能试棒分别进行锻造态+1000℃(不保温)+时效热处理和锻造态+1120℃/2h,80℃/min+1000℃+815℃/8h进行550℃拉伸测试,后者的屈服强度和抗拉强度显著高于前者,可为大尺寸涡轮盘件的双性能热处理工艺的制定提供参考。

关键词：镍基粉末高温合金热处理显微组织 γ’相

一种新型镍基粉末高温合金涡轮盘的双性能热处理工艺研究

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稀有金属材料与工程 2024年第9期53卷 2614-2623页

作者：程俊义刘朝峰马向东肖磊郭建政冯干江中南大学粉末冶金国家重点实验室湖南长沙410083 深圳市万泽中南研究院有限公司广东深圳518035

采用真空感应熔炼+制粉+热等静压+热挤压+等温锻工艺制备实验盘坯,在实验盘坯上取样并进行热处理和力学性能测试,得到合金FGH4113A的亚固溶和过固溶热处理温度范围和力学性能变化规律。同时,通过测温实验验证仿真模拟的热边界条件。随后... 详细信息

采用真空感应熔炼+制粉+热等静压+热挤压+等温锻工艺制备实验盘坯,在实验盘坯上取样并进行热处理和力学性能测试,得到合金FGH4113A的亚固溶和过固溶热处理温度范围和力学性能变化规律。同时,通过测温实验验证仿真模拟的热边界条件。随后,提出了一种基于实验和有限元分析方法设计盘轴一体化镍基粉末高温合金涡轮盘的热处理工艺方法。最后,采用该方法制定的热处理工艺,成功地制备出了大尺寸双性能涡轮盘,并对其不同部位的显微组织和力学性能进行系统的验证和分析。结果表明:采用该方法制备的全尺寸双性能盘件不同部位的晶粒尺寸符合预测;通过改变隔热工装的尺寸和热处理保温时间可以调整盘件热处理的温度梯度;盘件晶粒过渡区晶粒尺寸过渡平缓;细晶组织的合金具有较好的低温强度,而粗晶组织的合金则具有较好的高温抗蠕变性能。

关键词：镍基粉末高温合金双性能热处理显微组织有限元分析

社区近零碳转型要求下控制性详细规划编制优化研究

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规划师 2024年第6期40卷 110-117页

作者：池飞帆刘名瑞程俊溢靳慧罗超广州市城市规划勘测设计研究院有限公司国土综合整治与规划设计所清华大学建筑设计研究院有限公司广州分公司广州市城市规划编制研究中心广州城市理工学院建筑学院湖北美术学院视觉艺术设计学院

社区是城市碳排放的主要载体,规划和自然资源领域可以在交通出行、建筑物能源消耗等方面对其规划建设进行约束,引导社区低碳化转型。控制性详细规划是指导社区规划建设的主要依据,但其编制内容、编制模式与成果应用未能很好地适应社区... 详细信息

社区是城市碳排放的主要载体,规划和自然资源领域可以在交通出行、建筑物能源消耗等方面对其规划建设进行约束,引导社区低碳化转型。控制性详细规划是指导社区规划建设的主要依据,但其编制内容、编制模式与成果应用未能很好地适应社区低碳化转型的需要。立足“双碳”总体目标,开展社区低碳化转型的控制性详细规划编制优化研究,提出规划编制内容、规划编制模式、规划管控模式等方面的优化建议,以推动社区规划建设近零碳转型,加快构建生态文明建设新格局。

关键词：社区规划近零碳控制性详细规划碳达峰碳中和

Crystal structure,phase transitions,and thermodynamic properties of magnesium metavanadate(MgV_(2)O_(6))

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Journal of Magnesium and Alloys 2024年第4期12卷 1449-1460页

作者： Guishang Pei cheng Pan Dapeng Zhong junyi Xiang Xuewei Lv College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and Advanced Materials Chongqing UniversityChongqing 400044China Pangang Group Research Institute Co. Ltd.Panzhihua 617000China

As a promising anode material for magnesium ion rechargeable batteries,magnesium metavanadate(MgV_(2)O_(6))has attracted considerable research interest in recent years.A MgV_(2)O_(6)sample was synthesized via a facile solid-state reaction by multistep-firing stoichiometric mixtures of MgO and V2O5 powder under an air *** solid-state phase transition fromα-MgV_(2)O_(6)toβ-MgV_(2)O_(6)occurred at 841 K and the enthalpy change was 4.37±0.04 kJ/*** endothermic effect at 1014 K and the enthalpy change was 26.54±0.26 kJ/mol,which is related to the incongruent melting ofβ-MgV_(2)O_(6).In situ XRD was performed to investigate phase transition of the as-prepared MgV_(2)O_(6)at high *** cell parameters obtained by Rietveld refinement indicated that it crystallizes in a monoclinic system with the C2/m space group,and the lattice parameters of a=9.280 A°,b=3.501 A°,c=6.731 A°,β=111.76°.The solid-state phase transition fromα-MgV_(2)O_(6)toβ-MgV_(2)O_(6)was further studied by thermal kinetics,indicating that this process is controlled first by a fibril-like mechanism and then by a spherulitic-type mechanism with an increasing heating ***,the enthalpy change of MgV_(2)O_(6)at high temperatures was measured utilizing the drop calorimetry,heat capacity was calculated and given as:Cp=208.3+0.03583T-4809000T^(−2)(298-923 K)(J mol^(−1)K^(−1)),the high-temperature heat capacity can be used to calculate Gibbs free energy of MgV_(2)O_(6)at high temperatures.

关键词： MgV_(2)O_(6) Crystal structure Phase transitions Thermodynamic functions

A columnar multi-layer sliding triboelectric nanogenerator for water wave energy harvesting independent of wave height and direction

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Nano Research 2024年第4期17卷 3029-3034页

作者： Xue Miao Hanxiao Yang Zekun Li Meifei cheng Yilin Zhao Lingyu Wan Aifang Yu junyi Zhai Center on NanoEnergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Beijing Institute of Nano Energy and Nano Systems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of ScienceBeijing 101408China

The ocean,with its highly variable and complex meteorological conditions,harbors enormous renewable *** nanogenerators(TENGs),which possess unique advantages,show exciting prospects in water wave energy *** to design and optimize TENGs to cover all characteristic water wave energies and achieve efficient energy utilization is *** this paper,we carefully designed and fabricated a columnar multi-layer sliding TENG(CMLS-TENG)that can harvest water wave energy independent of wave height and *** rods with a hollow acrylic spherical shell were introduced to deliver wave energy,ensuring that the CMLS-TENG can work in all directions from 0°to 360°.Based on the sliding structure,switching the optimized CMLS-TENG is independent of wave *** optimized CMLS-TENG can achieve a total power density of 730 mW/m^(3) at a wave height of only 4.8 cm regardless of wave direction,which can illuminate multiple light-emitting diodes(LEDs)to provide lighting and provide power to a watch and a hygrometer for temperature and humidity *** work provides new choices and hopes for the effective collection of full-range water wave energy.

关键词： triboelectric nanogenerator wave energy multi-direction columnar slide

Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

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Journal of Biomedical Research 2024年第4期38卷 358-368页

作者： Yifei cheng Rongjie Shi Shuai Ben Silu Chen Shuwei Li junyi Xin Meilin Wang Gong cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Cancer Hospital Jiangsu Institute of Cancer Researchthe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the *** first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc *** then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA *** the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell ***,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting *** conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.

关键词： genetic variants prostate cancer circRNA RNA-binding protein RNA splicing sing-cell RNA sequencing

一种新型第三代镍基粉末高温合金的微观组织及其力学性能

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稀有金属材料与工程 2022年第4期51卷 1478-1487页

作者：程俊义朱立华肖磊郭建政计红军深圳市万泽中南研究院有限公司广东深圳518000 哈尔滨工业大学(深圳)先进焊接与连接国家重点实验室广东深圳518055 中南大学粉末冶金国家重点实验室湖南长沙410083

本工作研究了一种自主研发的第3代粉末高温合金WZ-A3不同工艺状态的显微组织特征以及热处理后合金的高温拉伸、蠕变以及疲劳性能。该合金采用热等静压(HIP)+热挤压(HEX)+锻造(HF)+热处理(HT)工艺加以制备。结果表明:HIP态合金晶粒度等级... 详细信息

本工作研究了一种自主研发的第3代粉末高温合金WZ-A3不同工艺状态的显微组织特征以及热处理后合金的高温拉伸、蠕变以及疲劳性能。该合金采用热等静压(HIP)+热挤压(HEX)+锻造(HF)+热处理(HT)工艺加以制备。结果表明:HIP态合金晶粒度等级为ASTM8~9级,晶界存在粗大γ’相,晶内存在相对细小的γ’相;经挤压+锻造后,合金晶粒度等级可达ASTM13~14级,晶内γ’相细化,但晶界处的γ’相数量明显增多;热处理后合金晶界处大块状的γ’相数量明显减少,晶内γ’相平均尺寸由HIP态的400nm细化至热处理态的200nm。过固溶+时效热处理后的合金700℃抗拉强度和屈服强度分别达1360和1029 MPa,延伸率和断面收缩率分别为23.5%和17%;在800℃/330 MPa条件下蠕变量达0.2%时所用时长为229 h;700℃/0%~0.8%/0.33Hz条件下的疲劳寿命为24500循环周次。蠕变性能和疲劳性能与LSHR和ME3等第3代镍基粉末高温合金相当,但700℃拉伸强度较LSHR合金高近50 MPa,延伸率为其3倍,屈服强度稍有降低。

关键词：第3代镍基粉末高温合金显微组织力学性能 γ’相

基于空地协同采样的植被覆盖度随机森林估算方法

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北京大学学报（自然科学版） 2020年第1期56卷 143-154页

作者：程俊毅张显峰孙敏罗鹏杨婉婷北京大学遥感与地理信息系统研究所

基于无人机高光谱影像,建立地形复杂地区植被覆盖度的非参数随机森林回归估算模型。为获得构建随机森林模型所需的足够数量的训练样本,利用低空无人机搭载的光学相机,在从地面难以到达的山地、水域和植被茂密区,通过垂直拍摄获得厘米分... 详细信息

基于无人机高光谱影像,建立地形复杂地区植被覆盖度的非参数随机森林回归估算模型。为获得构建随机森林模型所需的足够数量的训练样本,利用低空无人机搭载的光学相机,在从地面难以到达的山地、水域和植被茂密区,通过垂直拍摄获得厘米分辨率的航拍影像,作为对地面样方采样的补充。首先计算地面数码相机照片和无人机可见光影像的红绿蓝植被指数(red-green-bluevegetationindex,RGBVI),然后使用大津分割法提取样方的植被覆盖信息,得到构建模型所需的训练样本。在此基础上,基于2018年8月16-18日在内蒙古自治区察右中旗油娄沟矿区获取的GaiaSky-mini2无人机高光谱影像数据,利用递归特征消除算法优选参与随机森林回归的特征变量集,利用空地协同获取的训练样本构建植被覆盖度的随机森林回归估算模型。该模型在测试集上的确定系数R2为0.923,均方根误差为0.087,优于常用的像元二分模型,可用于矿区植被动态信息的精细化监测。

关键词：植被覆盖度随机森林空地协同采样无人机高光谱矿区

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转变观念开展社区卫生服务

苏州医学院学报 2000年第11期20卷 976-977页

作者：成俊义天津市河北区建昌医院天津 300240

随着市场经济体制的建立和人们就医观念的转变 ,一级医院的就诊病人显著下降 ,为此一级医院必须面向社区为居民提供“六位一体”的基本医疗保健。

关键词：卫生资源社区卫生服务中国服务模式