检索结果-南通市图书馆

Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

引用

Genes & Diseases 2024年第2期11卷 1066-1081页

作者： junyan yan Lu Xiao Di Feng Baolin Chen Ting yang Bei Tong Ruifang Luo Yuting Wang Jie Chen Children Nutrition Research Center Children's Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Child Nutrition and HealthMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing 401122China Department of Gastroenterology Children's Hospital of Chongqing Medical UniversityChongqing 401122China

Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier ***-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is ***,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA *** the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were ***,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal *** study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its *** findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy.

关键词： CEACAM1 Colonic epithelial barrier HDAC3 Short-chain fatty acids Vitamin A deficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

晚期甲状腺乳头状癌伴淋巴结转移联合术后外放疗增加转移病灶对^(131)I摄取2例病例分析

引用

中华转移性肿瘤杂志 2024年第2期7卷 143-147页

作者：阎军艳侯双双李险峰太原市第三人民医院感染性肝病及肿瘤科太原030000 山西医科大学第一医院放疗科太原030001

对2例晚期甲状腺乳头状癌患者进行了术后根治性外放疗联合多次^(131)I治疗,并成功随访9年。根治性外放疗有效缩小了颈部转移淋巴结及残留甲状腺组织,并使得颈部转移淋巴结的摄碘能力提升,也使得肺转移灶有可能尽早获得摄碘能力并得以控... 详细信息

对2例晚期甲状腺乳头状癌患者进行了术后根治性外放疗联合多次^(131)I治疗,并成功随访9年。根治性外放疗有效缩小了颈部转移淋巴结及残留甲状腺组织,并使得颈部转移淋巴结的摄碘能力提升,也使得肺转移灶有可能尽早获得摄碘能力并得以控制、缓解病情进展、提高疗效。

关键词：甲状腺乳头状癌颈部淋巴结转移放射疗法 ^(131)I治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Porous silica nano-flowers stabilized Pt-Pd bimetallic nanoparticles as heterogeneous catalyst for efficiently synthesizing guaiacol from 2-methoxycyclohexanol

引用

Chinese Journal of Chemical Engineering 2024年第6期70卷 222-233页

作者： Junbo Feng junyan Wu Dongdong yan Yadong Zhang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Coking Coal Exploitation and Comprehensive Utilization Pingdingshan 467000China Jiyuan Research Institute Zhengzhou UniversityJiyuan 459000China School of Materials and Chemical Engineering Zhongyuan University of TechnologyZhengzhou 450007China

Porous silica nano-flowers(KCC-1)immobilized Pt-Pd alloy NPs(Pt-Pd/KCC-1)with different mass ratios of Pd and Pt were successfully prepared by a facile in situ one-step reduction,using hydrazinium hydroxide as a reducing *** as-synthesized silica nanospheres possess radial fibers with a distance of 15 nm,exhibiting a high specific surface area(443.56 m^(2)·g^(-1)).Meanwhile,the obtained Pt-Pd alloy NPs are uniformly dispersed on the silica surface with a metallic particle size of 4-6 nm,which exist as metallic Pd and Pt on the surface of monodisperse KCC-1,showing the transfer of electrons from Pd to *** as-synthesized 2.5%Pt-2.5%Pd/KCC-1 exhibited excellent catalytic activity and stability for the continuous dehydrogenation of 2-methoxycyclohexanol to prepare *** with Pt or Pd single metal supported catalysts,the obtained 2.5%Pt-2.5%Pd/KCC-1 shows 97.2%conversion rate of 2-methoxycyclohexanol and 76.8%selectivity for guaiacol,which attributed to the significant synergistic effect of bimetallic Pt-Pd alloy ***,turn over frequency value of the obtained 2.5%Pt-2.5%Pd/KCC-1 NPs achieved 4.36 s^(-1),showing higher catalytic efficiency than other two monometallic *** pathways of dehydro-aromatization of 2-methoxycyclohexanol over the obtained catalyst are ***,the obtained 2.5%Pt-2.5%Pd/KCC-1 NPs prove their potential in the dehydrogenation of 2-methoxycyclohexanol,while the kinetics and mechanistic study of the dehydrogenation reaction over the catalyst in a continuous fixed-bed reactor may provide valuable information for the development of green,outstanding and powerful synthetic pathway of guaiacol.

关键词： Supported catalyst Nanoparticles Dehydrogenation 2-Methoxycyclohexanol Guaiacol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

冠状动脉旁路移植手术中不同停搏液的应用现状及研究进展

引用

中国体外循环杂志 2024年第4期22卷 333-338页

作者：陈祥舟郝嘉刘建李建闫俊彦陈林陆军军医大学第二附属医院心血管外科重庆400037

体外循环心脏停跳下冠状动脉旁路移植术(CABG)仍旧是冠心病复杂多支病变血运重建的主要术式,心脏停搏液作为心肌保护的重要因素,一直在心脏外科手术中占据着举足轻重的地位。本文现将体外循环心脏停跳下CABG中的心脏停搏液种类、灌注方... 详细信息

体外循环心脏停跳下冠状动脉旁路移植术(CABG)仍旧是冠心病复杂多支病变血运重建的主要术式,心脏停搏液作为心肌保护的重要因素,一直在心脏外科手术中占据着举足轻重的地位。本文现将体外循环心脏停跳下CABG中的心脏停搏液种类、灌注方式、应用比较等作综述,以期为临床的合理使用提供一定参考。

关键词：心脏停搏液冠状动脉旁路移植术体外循环心肌保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Performance of composite foundations with different load transfer platforms and substratum stiffness over silty clay

引用

Journal of Mountain Science 2024年第5期21卷 1761-1774页

作者： ZHANG Shuming LIU yan YUAN Shengyang LIU Xianfeng JIANG Guanlu LIU junyan School of Civil Engineering and Architecture University of JinanJinan 250022China The Engineering Technology Research Center for Urban Underground Engineering Supporting and Risk Monitoring of Shandong Province Jinan 250022China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of High-speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China

The semi-rigid pile-supported composite foundation is widely used in highway projects due to its effectiveness in increasing the bearing capacity and stability of *** is crucial to understand the stress distribution across the embankment width and the behaviour of unreinforced ***,five centrifuge tests were conducted to examine the bearing and deformation behaviours of NPRS(Non-Connected Piled Raft Systems)and GRPS(GeosyntheticReinforced Pile-Supported systems)with varying substratum stiffness,then a comparative analysis was conducted on embankment settlement,pressures underneath the embankments,and axial forces along the *** results indicated that greater substratum stiffness correlates with reduced settlement and deformation at various *** occurring 5 meters from the embankment toe includes settlement in NPRS and upward movement in *** potential sliding surface is primarily located within the embankment in NPRS,whereas it may extend through both the embankment and foundation in *** pile-soil stress ratio and efficiency in NPRS are higher than in GRPS across the *** axial force borne by end-bearing piles is significantly greater than that by floating *** the buried depth increases,the axial force in GRPS initially rises then declines,whereas in NPRS,it remains relatively constant within a certain range before *** study aids in assessing the applicability of composite foundations in complex railway environments and provides a reference for procedural measures under similar conditions.

关键词： Centrifuge modelling Composite foundation Failure mode Load transfer platform Substratum Stiffness Silty clay

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Finite Element Method Simulation of Wellbore Stability under Different Operating and Geomechanical Conditions

引用

Fluid Dynamics & Materials Processing 2024年第1期20卷 205-218页

作者： junyan Liu Ju Liu yan Wang Shuang Liu Qiao Wang Yihe Du Oil&Gas Project Research Institute PetroChina Tarim Oilfield CompanyKorla841000China Petroleum Engineering School Southwest Petroleum UniversityChengdu610500China

The variation of the principal stress of formations with the working and geo-mechanical conditions can trigger wellbore instabilities and adversely affect the well completion.A finite element model,based on the theory of poro-elasticity and the Mohr-Coulomb rock damage criterion,is used here to analyze such a *** changes in wellbore stability before and after reservoir acidification are simulated for different pressure *** results indicate that the risk of wellbore instability grows with an increase in the production-pressure difference regardless of whether acidification is completed or not;the same is true for the instability *** acidizing,the changes in the main geomechanical parameters(i.e.,elastic modulus,Poisson’s ratio,and rock strength)cause the maximum wellbore instability coefficient to increase.

关键词： Wellbore stability finite element acidizing operation well completion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

JA-mediated MYC2/LOX/AOS feedback loop regulates osmotic stress response in tea plant

引用

Horticultural Plant Journal 2024年第3期10卷 931-946页

作者： junyan Zhu Hongrong Chen Lu Liu Xiaobo Xia Xiaomei yan Xiaozeng Mi Shengrui Liu Chaoling Wei State Key Laboratory of Tea Plant Biology and Utilization/Key Laboratory of Tea Biology and Tea Processing of Ministry of Agriculture/Anhui Provincial Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefeiAnhui 230036China

Osmotic stress caused by low-temperature,drought and salinity was a prevalent abiotic stress in plant that severely inhibited plant development and agricultural yield,particularly in tea *** acid(JA)is an important phytohormone involving in plant ***,underlying molecular mechanisms of JA modulated osmotic stress response remains *** this study,high concentration of mannitol induced JA accumulation and increase of peroxidase activity in tea *** transcriptome mined a JA signaling master,MYC2 transcription factor is shown as a hub regulator that induced by mannitol,expression of which positively correlated with JA biosynthetic genes(LOX and AOS)and peroxidase genes(PER).CsMYC2 was determined as a nuclei-localized transcription activator,furthermore,ProteinDNA interaction analysis indicated that CsMYC2 was positive regulator that activated the transcription of CsLOX7,CsAOS2,CsPER1 and CsPER3via bound with their promoters,*** of CsMYC2 expression resulted in a reduced JA content and peroxidase activity and osmotic stress tolerance of tea *** of CsMYC2 in Arabidopsis improved JA content,peroxidase activity and plants tolerance against mannitol ***,we proposed a positive feedback loop mediated by CsMYC2,CsLOX7 and CsAOS2 which constituted to increase the tolerance of osmotic stress through fine-tuning the accumulation of JA levels and increase of POD activity in tea plant.

关键词： Camellia sinensis Jasmonic acid(JA) MYC2 transcription factor Lipoxygenase(LOX) Osmotic stress Peroxidase(POD) Reactive oxygen species(ROS)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural design of light-emitting ﬁbers and fabrics for wearable and smart devices

引用

Science Bulletin 2024年第15期69卷 2439-2455页

作者： Xiaoxiao Yu Linfeng Chen junyan Zhang Wei yan Theo Hughes-Riley yanhua Cheng Meifang Zhu State Key Laboratory for Modiﬁcation of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Nottingham Trent University Nottingham NG14GGUnited Kingdom

Flexible light-emitting fibers and fabrics serve to bridge human–machine interactions. The desire for practical applications and the commercialization of flexible light-emitting fibers has accelerated structural progress and improvements. This review focuses on the structural design of light-emitting fibers and fabrics, starting with a summary of design principles, emission mechanisms, and structural evolution of coaxial structured light-emitting fibers. Subsequently, we explore recent advances in the helical structure design strategies that boost the mechanical sensitivity of light-emitting fibers. Following that, we analyze continuous preparation processes and the development of large-area intelligent light-emitting fabrics based on interwoven structures. Examples based on stiff and rigid inorganic-based lightemitting diodes integrated into flexible systems are also presented. Finally, we discuss the current challenges and future opportunities for light-emitting applications in the field of wearable and smart devices.

关键词： Light-emitting fiber Structure design Wearable electronic Flexible optoelectronic fiber Large-scale fabric Electronic textile

来源：

维普期刊数据库

同方期刊数据库评论