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Synergistic effects of mTOR inhibitors with VEGFR3 inhibitors on the interaction between TSC2-mutated cells and lymphatic endothelial cells

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Science China Life Sciences 2025年

作者： Hanghang Wang Danjing Hu Chongsheng Cheng Xiaoxin Zhang junya Liu Xinlun Tian Hongbing Zhang Kaifeng Xu Department of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell Ecosystem Department of Physiology Institute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences & Peking Union Medical College

Lymphangioleiomyomatosis(LAM) is a rare neoplastic disease affecting the lung, kidney, and lymphatic system with a molecular mechanism of tuberous sclerosis complex 2(TSC2) mutations. Vascular endothelial growth factor D(VEGF-D), a ligand for vascular endothelial growth factor receptor 3(VEGFR3), is a diagnostic biomarker of LAM and is associated with lymphatic circulation abnormalities. This study explored the interaction between LAM cells and lymphatic endothelial cells(LECs) and the effects of rapamycin on this interaction, which may help to identify new targets for LAM treatment. This study used direct and indirect cocultures of TSC2-null cells and LECs. The xenograft model was applied to explore the therapeutic feasibility. Single-cell sequencing revealed increased LECs in the lungs of LAM patients through activation of pathways involved in lymphangiogenesis. TSC2-null cells attracted LECs and promoted tube formation. VEGF-D/VEGFR3 was a key mediator of the above interaction. Rapamycin can directly inhibit recruitment but not the tube formation of LECs in *** combination of rapamycin with VEGFR3 inhibitors not only enhanced the effect of rapamycin but also inhibited lymphatic related manifestations including the tube formation and the lymphatic metastasis. Our findings demonstrated that LAM cells recruit LECs and promote tube formation via VEGF-D/VEGFR3. Rapamycin only partially blocked this interaction. The synergistic effects of rapamycin and VEGFR3 inhibitors suggest a novel strategy for the treatment of LAM and other TSC2-mutated diseases.

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马克思主义理论与中国近代社会的大众认知

华中师范大学学报(人文社会科学版) 2025年第1期64卷 9-19页

作者：马俊亚南京大学历史学院江苏南京210008

作为全世界无产阶级领袖和导师的马克思、恩格斯极为关注社会发展及其动因。其对社会问题的阐释,由表及里、寻根究底,探寻与统治者歪曲并宣扬的全然不同的因果本质。马克思对小农属性的阐述,是认识底层大众的理论基石。普通小农把统治... 详细信息

作为全世界无产阶级领袖和导师的马克思、恩格斯极为关注社会发展及其动因。其对社会问题的阐释,由表及里、寻根究底,探寻与统治者歪曲并宣扬的全然不同的因果本质。马克思对小农属性的阐述,是认识底层大众的理论基石。普通小农把统治者的“好事”作为自己的“好事”,把统治者的“坏事”作为自己的“坏事”;他们不但是统治者为了一己利益的牺牲品,而且是统治阶层虔诚的赞美者。马克思主义史学兴起后,这种研究方法非常适合解释中国近代社会形态及其发展动因,不但可以重新审视主导和影响中国近代社会的传统认知,对资本、市场、企业、商人、私欲、边沁乃至社会形态、人类共同的精神产品等条分缕析,犀燃烛照,给予更加客观公允的历史论断,肯定其在历史上的作用,而且使作为被统治阶级的最广大的民众更加明了自己的利益所在,弄清自己的利益与统治者利益的区别,不再与统治者同是非、共命运。

关键词：马克思主义史学新社会史底层民众中国近代社会

在转型中向“绿”而行:产业结构调整与企业绿色创新

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数量经济技术经济研究 2025年第1期42卷 93-115页

作者：王海郭冠宇尹俊雅浙江工商大学现代商贸研究中心浙江工商大学经济学院上海财经大学公共经济与管理学院浙江工商大学泰隆金融学院

在产业结构调整中加快绿色创新、形成绿色新质生产力是促进发展方式转变与新旧动能转换的重大举措,更是实现中国经济高质量发展与中国式现代化建设的重要支撑。本文实证考察了《产业结构调整指导目录》(以下简称《指导目录》)对企业绿... 详细信息

在产业结构调整中加快绿色创新、形成绿色新质生产力是促进发展方式转变与新旧动能转换的重大举措,更是实现中国经济高质量发展与中国式现代化建设的重要支撑。本文实证考察了《产业结构调整指导目录》(以下简称《指导目录》)对企业绿色创新的影响,发现《指导目录》能促进企业绿色创新。机制分析发现,《指导目录》既能通过促进产业结构绿色化调整、给予企业财政扶持和信贷支持来优化企业面临的外部绿色创新环境,也可以通过促进要素结构向研发型转变、提高企业绿色投资水平、促使企业制定绿色发展战略来强化内部绿色创新能力。异质性分析表明,《指导目录》对市场化程度、政府环保重视度和公众环保关注度较高地区、劳动密集型和污染密集型行业、非国有和小规模企业的影响更为明显。基于产业关联的研究结果表明,《指导目录》的影响存在行业溢出效应,并能促进上游企业绿色创新。进一步研究发现,《指导目录》的绿色创新效应可以降低企业碳排放强度。本文结论可为中国实现碳达峰碳中和目标提供理论支撑与决策参考,也可为中国完善产业政策体系、优化支持绿色低碳发展的经济政策工具箱提供实践反思与经验证据。

关键词：产业结构调整《产业结构调整指导目录》绿色创新低碳发展

First discovery of fossil Nesolagus (Leporidae,Lagomorpha) from Southeast Asia

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Science China Earth Sciences 2010年第8期53卷 1134-1140页

作者： tomida Yukimitsu National Museum of Nature and Science 3-23-1 HyakuninchoShinjukuTokyo 169-0073Japan

A new leporid species, Nesolagus sinensis sp. nov., is described here representing the only leporid member of the Early Pleistocene Gigantopithecus fauna from Sanhe Cave, Chongzuo, Guangxi, South China and also the first fossil taxon of the Southeast Asian genus Nesolagus. Compared with two extant Nesolagus species from Indonesia and Vietnam and other related leprids, the new species has a relatively small size and an extraordinarily weak anterior internal reentrant (AIR) on p3, but it also retains the simplified paedomorphic pattern during the ontogenetic process as in extant species, which suggests that the new species is more primitive than and probably directly ancestral to extant Nesolagus species. The new species seems closely related to Alilepus longisinuosus from the Late Miocene strata of Lufeng, Yunnan, and probably diverged from a leporid similar to its ancestral form. It also indicates that Nesolagus originated in Southwest China.

关键词： Guangxi of China Early Pleistocene Nesolagus sinensis sp. nov. Gigantopithecus fauna

共同体关系的消解与重塑:村落社会的变迁机制研究

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济南大学学报(社会科学版) 2025年第1期35卷 147-156页

作者：李文祥王俊雅吉林大学哲学社会学院吉林长春130012

村落是关系性的存在,村落社会的变迁是村落共同体关系的转换。在传统社会,村民在生存理性驱动下建立了具有凝聚性和向心力的血缘共同体关系,封闭稳固、彼此依存的地缘共同体关系,以及以“共同领会”为基础的精神共同体关系。改革开放后... 详细信息

村落是关系性的存在,村落社会的变迁是村落共同体关系的转换。在传统社会,村民在生存理性驱动下建立了具有凝聚性和向心力的血缘共同体关系,封闭稳固、彼此依存的地缘共同体关系,以及以“共同领会”为基础的精神共同体关系。改革开放后,随着生存理性转变为旨在注重物质享受的消费理性、追求现金收入最大化的收入理性和社交功利化的人情理性,传统村落共同体关系趋于弱化、消解。而随着近年来乡村振兴政策对乡村产业的推动,村民行动的理性基础转而跃迁至以追求自我实现为目标的经济理性、社会理性及交往理性的多元调和,趋于弱化与消解的传统村落共同体关系,在新时代村民的理性行动中走向重塑,村落共同体关系展现出新的形态。

关键词：村落社会共同体关系理性行动变迁机制

批判与建构:马克思精神生产理论对精神生活共同富裕的启思——基于《德意志意识形态》分析

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西部学刊 2025年第2期 29-33,94页

作者：王珺雅同济大学马克思主义学院上海200092

在《德意志意识形态》中,马克思针对黑格尔、鲍威尔、施蒂纳和费尔巴哈等德意志意识形态家们的错误思想及唯心主义历史观展开了鞭辟入里的批判。在此基础上,揭示了精神生产活动的逻辑起点是“历史的现实的人”、根源于物质生产且以现实... 详细信息

在《德意志意识形态》中,马克思针对黑格尔、鲍威尔、施蒂纳和费尔巴哈等德意志意识形态家们的错误思想及唯心主义历史观展开了鞭辟入里的批判。在此基础上,揭示了精神生产活动的逻辑起点是“历史的现实的人”、根源于物质生产且以现实生活中的社会实践为基础和条件、动力来源于人的精神需要和物质生活的满足等精神生产的内在规律。对于新时代推进精神生活共同富裕具有重要启示:扎实推进物质生活共同富裕,夯实精神生活共同富裕根基;深入培育和践行社会主义核心价值观,凝聚人民思想行为共识;创造更多优秀精神文化产品,满足人民多样精神文化需求;激发全社会向上向善正能量,提供源源不竭强大精神动力。

关键词：马克思精神生产精神生活共同富裕

2-D localization system utilizing M-sequence encoded laser beam scanning

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仪器仪表学报 2007年第3期28卷 408-413页

作者： Shinji Ohyama Kiyoshi Tanaka junya Takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan

In this paper, as the active position measurement system, a novel method for a two-dimensional localization system using M-sequence signal is proposed. The feature of this system is to realize a position measurement only by scanning the encoded laser beams from fixing points to a measurement field, and by observing it. First, both the system configuration and encoding method were practically considered, and an order and an initial value of M-sequence signal were selected for encoding. This method is based on discrete angle measurement therefore the resolution has its own limitation. To overcome this limitation, analogue phase shift detecting method was introduced. System design was performed and applied to position measurement experiments. The experimental results show that the measurement error of the analogue method is 1/3 of that of the discrete method.

关键词：激光电子束扫描位置测量二维定位系统 M序列离散法

Improved sampling scheme for LiDAR in Lissajous scanning mode

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Microsystems & Nanoengineering 2022年第3期8卷 29-37页

作者： junya Wang Gaofei Zhang Zheng You School of Mechanical Science and Engineering Huazhong University of Science and Technology430074 WuhanChina Department of Precision Instrument Tsinghua University10084 BeijingChina State Key Laboratory of Precision Measurement Technology and instruments Tsinghua University10084 BeijingChina

MEMS light detection and ranging(LiDAR)is becoming an indispensable sensor in vehicle environment sensing systems due to its low cost and high *** beam scanning trajectory,sampling scheme and gridding are the key technologies of MEMS LiDAR *** Lissajous scanning mode,this paper improves the sampling scheme,through which a denser Cartesian grid of point cloud data at the same scanning frequency can be *** summarizing the rules of the Cartesian grid,a general sampling scheme independent of the beam scanning trajectory patterns is *** and experiment results show that compared with the existing sampling scheme,the resolution and the number of points per frame are both increased by 2 times with the same hardware configuration and scanning frequencies for a MEMS scanning miror(MEMS-SM).This is beneficial for improving the point cloud imaging performance of MEMS LiDAR.

关键词： LiDAR scheme mode

Numerical simulation and a hybrid method of supersonic turbulent base heating

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航空动力学报 2018年第10期33卷 2442-2450页

作者： YUAN junya CAI Guobiao ZHAO Lu School of Astronautics Beijing University of Aeronautics and Astronautics Beiiing 100191 China

Detached eddy simulation(DES)model was used to better capture large vortex structure and unsteady flow feature near cone *** base heating results were achieved using proper grid and numerical *** influence of inflow conditions(like Mach number,Reynolds number)and configuration(bluntness ratio of the cone)on base heating was discussed based on numerical computational *** with base heat flux,base pressure can be predicted more accurately by numerical simulation and the time consuming was shorter.A hybrid method combining numerical simulation with experimental correlation was proposed to predict supersonic turbulent base heating.A review of base heating experiment and correlations for slender cone was presented,and a revised correlation was proposed based on the above simulation *** with the experiment data,the maximum error was 24%,agood result for base heating *** proves that the hybrid method using the revised correlation performs well in predicting supersonic turbulent base heating of slender sphere cone and can meet needs of engineering design.

关键词： base heating detached eddy simulation hybrid method experimental correlation slender sphere cone