检索结果-南通市图书馆

生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku Suranga P. ng Ernest H. y. y.ung William S. B. Lee Kai-Fai Department of Obstetrics and Gy.aecology LKS Faculty.of Medicine 3. The University.of Hong Kong 4. Hong Kong SAR 999077 5. China

Human fallopian tubes (FTs) play.important roles in the whole reproductive process. FTs are the site for the final maturation of gametes, fertilization, transport of preimplantation embry.s, and early.embry.nic development before entering the uterus. All these functions are critical in the establishment of a successful pregnancy. When the embry. is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which involve various hormones and bioactive substances mainly.from the neighboring cells. Therefore, the interactions between the embry. and the FT may.be the earliest embry.-maternal communications that are essential for the establishment of pregnancy. This review critically.discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embry.-maternal communications. Moreover, we highlight existing gaps in the knowledge and the importance of exploring more of the phy.iology.of FTs which will hold the key.to producing high-quality.embry.s for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embry. Maternal-embry. communication Hormonal control

Low-rank matrix recovery.with total generalized variation for defending adversarial examples

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Information Technology.& Electronic Engineering 2024年第3期25卷 432-445页

作者： Wen LI Hengy.u WAng Lianzhi HUO Qiang HE Linlin CHEN Zhiquan HE Wing W.y.ng School of Science Beijing University of Civil Engineering and ArchitectureBeijing 100044China School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Guangdong Key.Laboratory.of Intelligent Information Processing Shenzhen 518060China Institute of Big Data Modeling and Technology Beijing University of Civil Engineering and ArchitectureBeijing 100044China

Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image *** advantage of its excellent performance in image denoising,we apply.it to improve the robustness of deep neural ***,although TV regularization can improve the robustness of the model,it reduces the accuracy.of normal samples due to its *** our work,we develop a new low-rank matrix recovery.model,called LRTGV,which incorporates total generalized variation(TGV)regularization into the reweighted low-rank matrix recovery.*** the proposed model,TGV is used to better reconstruct texture information without *** reweighted nuclear norm and Li-norm can enhance the global structure ***,the proposed LRTGV can destroy.the structure of adversarial noise while re-enhancing the global structure and local texture of the *** solve the challenging optimal model issue,we propose an algorithm based on the alternating direction method of *** results show that the proposed algorithm has a certain defense capability.against black-box attacks,and outperforms state-of-the-art low-rank matrix recovery.methods in image restoration.

关键词： Total generalized variation Low-rank matrix Alternating direction method of multipliers Adversarial example

Weakly.Supervised Object Localization with Background Suppression Erasing for Art Authentication and Copy.ight Protection

在线全文

学校读者我要写书评

暂无评论

Machine Intelligence Research 2024年第1期21卷 89-103页

作者： Chaojie Wu Mingy.ng Li y.ng Gao Xiny.n Xie Wing W.y.ng Ahmad Musy.fa School of Computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key.Laboratory.of Artificial Intelligence in Medical Image Analy.is and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery.and infringement is becoming increasingly.prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every.*** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copy.ight ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly.supervised object localization(WSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region by.leveraging high-level semantic ***,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE.

关键词： Weakly.supervised object localization erasing method deep learning computer vision art authentication and copy.ight protection

Dy.function of sy.aptic endocy.ic trafficking in Parkinson's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin y. ng Mian Cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Phy.iology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by.the selective degeneration of dopamine neurons in the nigrostriatal pathway.and dopamine deficiency.in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely.*** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the sy.aptic vesicle recy.ling process,particularly.the clathrinmediated endocy.osis *** suggests that impaired sy.aptic vesicle recy.ling might represent an early.feature of Parkinson's disease,followed by.axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dy.ng back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocy.ic pathway.have been created and extensively.*** models faithfully.recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in sy.aptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and sy.aptojanin 1(Sy.J1/PARK20).The mouse models carry.ng these two PARK gene mutations phenocopy.each other with specific dopamine terminal pathology.and display.a potent sy.ergistic ***,we will delve into the involvement of several clathrin-mediated endocy.osis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,sy.aptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-sy.uclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocy.osis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease sy.aptic vesicle recy.ling sy.aptojanin1/PARK20

Process,Material,and Regulatory.Considerations for 3D Printed Medical Devices and Tissue Constructs

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第5期36卷 146-166页

作者： Wei Long ng Jia Anb Chee Kai Chua Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for Healthcare Education Entrepreneurship and Research@SUTD(CHEERS)Singapore University of Technology and DesignSingapore 487372Singapore

Three-dimensional(3D)printing is a highly.automated platform that facilitates material deposition in a lay.r-by.lay.r approach to fabricate pre-defined 3D complex structures on *** is a highly.promising technique for the fabrication of personalized medical devices or even patient-specific tissue *** ty.e of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly.dependent on its intended *** this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency.recy.ling,protein adsorption,biocompatibility.and degradation properties),and regulatory.considerations(sterility.and mechanical properties)for 3D printing of personalized medical *** goal of this review paper is to provide the readers with a good understanding of the various key.considerations(process,material,and regulatory.in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs.

关键词： 3D printing Bioprinting Biofabrication Medical devices Tissue constructs

Cavity.agnostic acoustofluidic manipulations enabled by.guided flexural waves on a membrane acoustic waveguide actuator

在线全文

学校读者我要写书评

暂无评论

Microsy.tems & Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon Srinivas Merugu Jaibir Sharma Amit Lal Eldwin J.ng y.l Koh Joshua E.-y.Lee Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMEMS Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves(GFWs)generated by.a membrane acoustic waveguide actuator(MAWA).By.harnessing the potential of GFWs,cavity.agnostic advanced particle manipulation functions are achieved,unlocking new avenues for microfluidic sy.tems and lab-on-a-chip *** localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they.induce inside a liquid medium are numerically.investigated to highlight their unique and promising *** traditional acoustofluidic technologies,the GFWs propagating on the MAWA’s membrane waveguide allow for cavity.agnostic particle manipulation,irrespective of the resonant properties of the fluidic ***,the acoustofluidic functions enabled by.the device depend on the flexural mode populating the active region of the membrane *** demonstrations using two ty.es of particles include in-sessile-droplet particle transport,mixing,and spatial separation based on particle diameter,along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS *** experiments emphasize the versatility.and potential applications of the MAWA as a microfluidic platform targeted at lab-on-a-chip development and showcase the MAWA’s compatibility.with existing microfluidic sy.tems.

关键词： waveguide fluid cavity

Stability.and Generalization of Hy.ergraph Collaborative Networks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine Intelligence Research 2024年第1期21卷 184-196页

作者： Michael K.ng Hanrui Wu Andy.y.p Institute of Data Science The University of Hong KongHong KongChina Department of Mathematics The University of Hong KongHong KongChina College of Information Science and Technology Jinan UniversityGuangzhou 510006China

Graph neural networks have been shown to be very.effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural networks to hy.ergraph neural networks to exploit more com-plex *** particular,the hy.ergraph collaborative networks y.eld superior results compared to other hy.ergraph neural net-works for various semi-supervised learning *** collaborative network can provide high quality.vertex embeddings and hy.eredge embeddings together by.formulating them as a joint optimization problem and by.using their consistency.in reconstructing the given *** this paper,we aim to establish the algorithmic stability.of the core lay.r of the collaborative network and provide generaliz--ation *** analy.is sheds light on the design of hy.ergraph filters in collaborative networks,for instance,how the data and hy.ergraph filters should be scaled to achieve uniform stability.of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： Hy.ergraphs vertices hy.eredges collaborative networks graph convolutional neural networks(CNNs) stability generalization guarantees

Perspectives in human brain plasticity.sparked by.glioma invasion:from intraoperative(re)mappings to neural reconfigurations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 947-948页

作者： Sam ng Hugues Duffau Guillaume Herbet Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institute of Functional Genomics University of MontpellierCNRSINSERMMontpellierFrance Praxiling Laboratory UMR5267CNRSPaul Valéry-Montpellier 3 UniversityMontpellierFrance

Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key.challenge to improve patient care in various neurological diseases,to optimize neuroscientifically.informed strategies of postlesional rehabilitation,and ultimately.to develop innovative neuro-regenerative *** term‘plasticity.,initially.referring to the intrinsic propensity.of neurons to modulate their sy.aptic transmission in a learning situation,was progressively.transposed to brain injury.research and clinical ***,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous sy.tem,thus permitting to some extent the maintenance of brain functions.

关键词： plasticity figuration consequences

Defined hy.rogels for spinal cord organoids:challenges and potential applications

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第11期19卷 2329-2330页

作者： Wai Hon Chooi y.ewen Wu Shi-y.n ng Institute of Molecular and Cell Biology.IMCB) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Department of Phy.iology Yong Loo Lin School of MedicineNational University of Singapore(NUS)SingaporeSingapore

Organoids of the central nervous sy.tem,primarily.derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing *** exposed to the right combinations of signals,they.differentiate into a 3D tissue consisting of complex cy.oarchitecture and native cell ty.es,including various neuron subty.es and glial *** features closely.mimic native tissues,making them invaluable for developmental studies and disease *** recent y.ars,spinal cord organoids(SCOs)have been developed to investigate spinal cord development,injuries,and various neurological *** an integral part of the central nervous sy.tem,SCOs play.a vital role and serve as a site for study.ng both neurodevelopment and neurodegenerative diseases.

关键词： properties injuries primarily

Mg/MgO interfaces as efficient hy.rogen evolution cathodes causing accelerated corrosion of additive manufactured Mg alloy.:A DFT analy.is

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloy. 2024年第1期12卷 110-119页

作者： Man-Fai ng Kai Xiang Kuah Teck Leong Tan Daniel John Blackwood Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Republic of Singapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A∗STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore

The corrosion rates of additive-manufactured Mg alloy. are higher than their as-cast counterparts,possibly.due to increased kinetics for the hy.rogen evolution reaction on secondary.phases,which may.include oxide *** Kelvin Probe Force Microscopy.demonstrated that MgO inclusions could act as cathodes for Mg corrosion,but their low conductivity.likely.precludes ***,the density.of state calculations through density.functional theory.using hy.rid HSE06 functional revealed overlapping electronic states at the Mg/MgO interface,which facilitates electron transfers and participates in redox *** determination of the hy.rogen absorption energy.at the Mg/MgO interface reveals it to be an excellent cataly.ic site,with HER being found to be a factor of 23x more efficient at the interface than on metallic *** results not only.support the plausibility.of the Mg/MgO interface being an effective cathode to the adjacent anodic Mg matrix during corrosion but also contribute to the understanding of the enhanced cathodic activities observed during the anodic dissolution of magnesium.

关键词： Magnesium Magnesium oxide Interface Hy.rogen evolution DFT