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Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw

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World Journal of Gastroenterology 2005年第9期11卷 1339-1344页

作者： HuiDong Fu-ErLu Zhi-QiangGao li-junxu Kai-FuWang XinZou InstituteofIntegrativeTraditionalChineseandWesternMedicine TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030HubeiProvinceChina

AIM: To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by high caloric laboratory chaw. METHODS: Non-alcoholic fatty liver model was successfully established by feeding with high caloric laboratory chaw for 12 wk. Then the model rats were randomly divided into 3 groups, namely model control group, emodin group and dietary treatment group. The rats in emodin group were given emodin at dose of 40 mg/(kg·d) while animals in other groups were given distilled water of the same volume. The rats in model control group were fed with high caloric laboratory chaw while animals in other groups were fed with normal diet. Four weeks later, liver index (liver/body weight ratio), serum activities of liver-associated enzymes, blood lipid, fasting blood glucose, fasting plasma insulin, HOMA insulin resistance index (HOMA-IR), hepatic triglyceride content and histology features of all groups were assayed. The expression of hepatic peroxisomal proliferator activated receptor (PPAR) gamma was determined by RT-PCR. RESULTS: The body weight, liver index, serum activities of alanine aminotransferase (ALT), blood lipid, hepatic triglyceride content of model control group were significantly elevated, with moderate to severe hepatocyte steatosis. The expression of hepatic PPAR gamma mRNA was obviously reduced in model control group. Compared with model control group, the body weight, liver index, serum activities of ALT, blood lipids and hepatic triglyceride of emodin group significantly decreased and hepatic histology display was also greatly improved. Meanwhile, the expression of hepatic PPAR gamma mRNA was elevated. However, high serum activities of ALT and hyperlipidemia were persisted in dietary treatment group although liver index was decreased and liver histology was somewhat improved. CONCLUSION: It is suggested that emodin might be effective in the treatment of non-alcoholic fatty liver in rats. Its therapeutic mechanism could be asso

关键词： Emodin Nonalcoholic fatty liver disease

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煤矿采矿作业中采矿工艺技术研究

机械管理开发 2017年第11期32卷 173-174页

作者：李军旭山西沁和能源集团南凹寺煤业有限公司山西晋城048205

介绍了采矿作业的特点,探讨了机械化开采法、特殊采矿法、填充法、无废开采技术、崩落采矿和空场采矿技术等六种工艺技术。在此基础上,对采矿工艺的发展前景进行了展望:在采矿作业中建立塌陷预警系统,对塌陷区域进行全面监控,通过遥感... 详细信息

介绍了采矿作业的特点,探讨了机械化开采法、特殊采矿法、填充法、无废开采技术、崩落采矿和空场采矿技术等六种工艺技术。在此基础上,对采矿工艺的发展前景进行了展望:在采矿作业中建立塌陷预警系统,对塌陷区域进行全面监控,通过遥感图像分析判断,实时掌握煤矿数据信息,并实现动态信息的数据反馈;借鉴全球定位系统的优势,形成一套完善的煤矿开采技术系统,预防安全事故的发生,降低对环境的影响,保护人类赖以生存的生态环境。因此,煤矿作业必然会朝着智能化和生态化、更加高效和安全的方向发展。

关键词：采矿工艺技术

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致幻剂

中国药物依赖性杂志 2007年第4期16卷 249-254页

作者：李俊旭德克萨斯大学医学中心药理学系圣安东尼奥德克萨斯美国78229

在所有的精神活性物质中,恐怕没有哪一类药物比致幻剂(hallucinogen)历史更悠久,与宗教文化结合更紧密,更具有争议性,最重要的是,对其科学的认识更为局限。什么是致幻剂?这个词语最初是指某些产生幻觉的物质,但现在这一词语似乎成了一... 详细信息

在所有的精神活性物质中,恐怕没有哪一类药物比致幻剂(hallucinogen)历史更悠久,与宗教文化结合更紧密,更具有争议性,最重要的是,对其科学的认识更为局限。什么是致幻剂?这个词语最初是指某些产生幻觉的物质,但现在这一词语似乎成了一个万能词汇,在媒体甚至某些科学文献中,还包括了许多其它药理分类的物质,比如大麻酯类,[第一段]

关键词：致幻剂精神活性物质科学文献宗教文化药理分类类药物词语

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药物辨别技术:理论与应用

中国药物依赖性杂志 2008年第4期17卷 267-270页

作者：李俊旭德克萨斯大学医学中心药理学系圣安东尼奥德克萨斯美国78229

自1951年Conger发表第一篇有关药物辨别的研究论文以来,有关药物辨别(drug discrimination)的理论和技术日趋成熟,越来越广泛地应用于新药的临床前药理学、行为药理学、神经精神药理学研究和药物滥用潜力评价中,有关药物辨别的论文量更... 详细信息

自1951年Conger发表第一篇有关药物辨别的研究论文以来,有关药物辨别(drug discrimination)的理论和技术日趋成熟,越来越广泛地应用于新药的临床前药理学、行为药理学、神经精神药理学研究和药物滥用潜力评价中,有关药物辨别的论文量更是迅猛增长。截至目前,药物辨别文献数据库(***)中共包括了3849篇药物辨别文献资料。[第一段]

关键词：药物辨别行为药理学研究论文精神药理学文献数据库滥用潜力文献资料临床前

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光热太阳能与风能互补清洁供暖系统特性分析

可再生能源 2022年第5期40卷 604-610页

作者：耿直李俊旭李仁凤王正鹤文振华曾庆仪刘媛媛张斌郑州航空工业管理学院航空发动机学院河南郑州450046 华电郑州机械设计研究院有限公司河南郑州450046 清华大学能源与动力工程系北京100084

为解决化石燃料燃烧带来的环境污染问题,文章提出了一种太阳能与风能互补供暖方案,包括太阳能集热系统、储热系统、风能收集系统和热泵系统。通过EBSILON软件将各组件进行合理耦合,对完整系统进行仿真计算与运行特性分析。结果表明,在... 详细信息

为解决化石燃料燃烧带来的环境污染问题,文章提出了一种太阳能与风能互补供暖方案,包括太阳能集热系统、储热系统、风能收集系统和热泵系统。通过EBSILON软件将各组件进行合理耦合,对完整系统进行仿真计算与运行特性分析。结果表明,在郑州供暖季期间,冷凝器换热量和循环冷却水出口温度都与太阳辐射能的变化趋势相同,冷凝器换热量在1596.957~2440.327 kW变化,且冷凝器循环冷却水出口温度在87.133~96.155℃波动;聚光场太阳能光学转换效率与太阳直射辐射能变化趋势相反,最大值为68.892%;冷凝器换热量与太阳能集热系统的出口温度变化趋势亦相反。该仿真结果可为太阳能与风能互补供暖系统的设计与工程化应用提供一定科学依据。

关键词：太阳能风能风光互补清洁供热热泵循环特性分析

Guaranteeing the response deadline for general aggregation trees

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Frontiers of Computer Science 2020年第6期14卷 97-110页

作者： Jiangfan li Chendie YAO junxu XIA Deke GUO Science and Technology on Information Systems Engineering Laboratory National University of Defense TechnologyChangsha 410073China

It is essential to provide responses to queries within time deadlines,even if not exact and *** reduce the query latency,systems usually partition large-scale data computations as a series of tasks over many processes and aggregate them to reduce the response time by using aggregation *** obstacle is that the involved processes of a query usually differ in their speeds,thus not all processes can complete their tasks in *** would directly degrade the response quality(the number of outputs received by the root of an aggregation tree).In this paper,we propose a general aggregation tree model,Tarot,to maximize the response quality by systematically addressing the following challenging issues:(1)fine-grained partition of the query deadline along the multi-level aggregation tree;(2)learning the distribution of durations at each level in the aggregation tree to optimize the wait durations at aggregators;(3)adaptively reassigning tasks over processes according to their status;(4)performing periodic aggregation of received outputs from the low level to avoid missing the *** prior model does not consider the four aspects *** evaluations indicate that Tarot can adapt to multi-level trees and considerably improve the response quality compared to prior work while guaranteeing the query deadline.

关键词： aggregation query performance variations tasks reassignment

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槟榔碱对小鼠吗啡行为敏化的影响

中国药物依赖性杂志 2005年第3期14卷 197-202页

作者：韩容孙艳萍李俊旭梁建辉北京大学中国药物依赖性研究所北京100083

目的:探讨槟榔嚼块的主要成分—槟榔碱,对小鼠吗啡行为敏化过程的影响。方法:测定小鼠的自主活动,观察ip槟榔碱对小鼠的自主活动及单次给予吗啡所诱导的小鼠高活动性的影响;建立吗啡诱导的小鼠行为敏化模型,观察槟榔碱对行为敏化形成、... 详细信息

目的:探讨槟榔嚼块的主要成分—槟榔碱,对小鼠吗啡行为敏化过程的影响。方法:测定小鼠的自主活动,观察ip槟榔碱对小鼠的自主活动及单次给予吗啡所诱导的小鼠高活动性的影响;建立吗啡诱导的小鼠行为敏化模型,观察槟榔碱对行为敏化形成、表达的影响。结果:(1)单次ip槟榔碱(0·25-2·0mg·kg-1)可剂量依赖性地抑制小鼠的自主活动(P<0·05),多次给药后这种抑制作用既不产生耐受,也不形成敏化;(2)槟榔碱(2·0mg·kg-1)可增强单次给予吗啡所诱导的小鼠的高活动性(P<0·05);(3)槟榔碱(2·0mg·kg-1)可增强吗啡诱导小鼠行为敏化的形成(P<0·05);(4)虽然槟榔碱(2·0mg·kg-1)多次给药降低吗啡诱导小鼠行为敏化表达的程度(P<0·05),但是槟榔碱(0·5-2·0mg·kg-1)单次给药不影响吗啡诱导小鼠行为敏化的表达。结论:槟榔嚼块中的主要成分槟榔碱能增强小鼠吗啡诱导的急性高活动性和吗啡行为敏化的形成,提示槟榔嚼块有可能增强吗啡的成瘾性。

关键词：槟榔碱小鼠吗啡行为敏化

Leakage Current Estimation of CMOS Circuit with Stack Effect

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Journal of Computer Science & Technology 2004年第5期19卷 708-717页

作者： Yong-junxu Zu-YingLuo Xiao-Weili li-Jianli Xian-LongHong InstituteofComputingTechnology TheChineseAcademyofSciencesBeijing100080P.R.China DepartmentofComputerScienceandTechnology TsinghuaUniversityBeijing100084P.R.China GraduateSchoolofChineseAcademyofSciences Beijing100039P.R.China NationalASICDesignEngineeringCenter InstituteofAutomationTheChineseAcademyofSciencesBeijin100080P.R.China

Leakage current of CMOS circuit increases dramatically with the technologyscaling down and has become a critical issue of high performance system. Subthreshold, gate andreverse biased junction band-to-band tunneling (BTBT) leakages are considered three maindeterminants of total leakage current. Up to now, how to accurately estimate leakage current oflarge-scale circuits within endurable time remains unsolved, even though accurate leakage modelshave been widely discussed. In this paper, the authors first dip into the stack effect of CMOStechnology and propose a new simple gate-level leakage current model. Then, a table-lookup basedtotal leakage current simulator is built up according to the model. To validate the simulator,accurate leakage current is simulated at circuit level using popular simulator HSPICE forcomparison. Some further studies such as maximum leakage current estimation, minimum leakage currentgeneration and a high-level average leakage current macromodel are introduced in *** on ISCAS85 and ISCAS89 benchmarks demonstrate that the two proposed leakage currentestimation methods are very accurate and efficient.

关键词： computer-aided design leakage current estimation stack effect macromodeling propagation of signal probability

Production of Bio-hydrogen Using Bio-oil as a Potential Biomass-derived Renewable Feedstock

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Chemical Research in Chinese Universities 2019年第2期35卷 285-291页

作者： liU junxu ZHU lijuan WANG Shengfei WANG Yulan HE Yuting li Quanxin Key Laboratory of Urban Pollutant Conversion of Chinese Academy of Sciences Anhui Key Laboratory of Biomass Clean EnergyDepartment of Chemical PhysicsUniversity of Science & Technology of ChinaHefei 230026P.R.China

The bio-oil derived from pyrolysis of straw can be selectively converted into high-purity hydrogen by coupling three steps:(i)steam refonning(SR)of di tierent bio-oils,(ii)water-gas shift(WGS),and(iii)the removal of *** catalytic SR reaction over the NiLaTiAl catalyst,coupled with a low-temperature WGS reaction with the CuZnAl catalyst,promoted the conversion of various oxygen-contaming organic compounds in the bio-oil into hydrogen and carbon *** the optimized condition,light bio-oil achieved the highest conversion(99.8%,molar fraction),with a high hydrogen yield of 16.4%(mass traction)and a H2 purity of 99.94%(volume fraction).The carbon deposition on the NiLaTiAl catalyst was the main factor caused catalyst *** of hydrogen from different bio-oil model compounds was also investigated in detail.

关键词： Bio-oil Higli-purity hydrogen Integrated catalytic process Oxygenated organic compound