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执业医师资格分阶段考试临床理论考试成绩的评价与思考

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中华医学教育探索杂志 2020年第11期19卷 1302-1305页

作者：俞斌何博学赵晓华殷朝阳李钟魁陈俊香中南大学本科生院医学教育办长沙410013 中南大学湘雅医学院长沙410011

目的分析某校医学院五年制临床医学专业学生医师资格分阶段考试临床理论考试成绩,探讨该校医学教育存在的问题和教育教学改革的方向。方法采用难度、区分度分析试题质量,采用SPSS 24.0行F检验和LSD-t检验分析基础医学、医学人文、临床... 详细信息

目的分析某校医学院五年制临床医学专业学生医师资格分阶段考试临床理论考试成绩,探讨该校医学教育存在的问题和教育教学改革的方向。方法采用难度、区分度分析试题质量,采用SPSS 24.0行F检验和LSD-t检验分析基础医学、医学人文、临床医学和预防医学各模块及二级学科掌握率。结果试卷总体难度系数为0.74,区分度为0.37;各模块难度系数均大于0.70,区分度均在0.40左右;基础医学、医学人文、临床医学和预防医学掌握率都在70%以上,临床医学最高,医学人文和基础医学最低;各二级学科掌握率均在60%以上,差异较大。结论此次考试较简单,区分度好,学生知识总体掌握较好;但仍需要根据薄弱点创新教育教学改革,提高教学质量。

关键词：临床医学理论考试临床执业医师分段式考试评价

Two-dimensional optical spatial differentiation and high-contrast imaging

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National Science Review 2021年第6期8卷 180-187页

作者： Junxiao Zhou Haoliang Qian junxiang Zhao Min Tang Qianyi Wu Ming Lei Hailu Luo Shuangchun Wen Shaochen chen Zhaowei Liu Key Laboratory for Micro-/NanoOptoelectronic Devices of Ministry of Education School of Physics and ElectronicsHunan University Department of Electrical and Computer Engineering University of California Department of Nano Engineering University of California Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Science and Technology Innovation CenterZhejiang University

Optical analog signal processing technology has been widely studied and applied in a variety of science and engineering fields, with the advantages of overcoming the low-speed and high-power consumption associated with its digital counterparts. Much attention has been given to emerging metasurface technology in the field of optical imaging and processing systems. Here, we demonstrate, for the first time, broadband two-dimensional spatial differentiation and high-contrast edge imaging based on a dielectric metasurface across the whole visible spectrum. This edge detection method works for both intensity and phase objects simply by inserting the metasurface into a commercial optical microscope. This highly efficient metasurface performing a basic optical differentiation operation opens up new opportunities in applications of fast,compactible and power-efficient ultrathin devices for data processing and biological imaging.

关键词： metasurface edge detection spatial differentiation

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16年腹膜透析的基础和临床研究回顾

中南大学学报（医学版） 2009年第3期34卷 269-276页

作者：刘伏友彭佑铭邹莎琳凌光辉聂静唐文彬周循段绍斌李军刘映红刘虹袁芳肖力卓莉陈俊香陈星成梅初朱健玲朱笑萍罗季安樊敏张浩孙林中南大学湘雅二医院肾内科中南大学肾病研究所肾脏病与血液净化学湖南省重点实验室长沙410011 中南大学湘雅三医院肾内科长沙410013

总结16年以来中南大学湘雅二医院肾内科腹膜透析的基础与临床研究的经验与成果。在国内率先成功构建了腹膜透析及腹膜纤维化动物模型,分离、鉴定了腹膜间皮细胞;利用细胞、分子生物学方法,系统研究了腹膜透析液的生物相容性、腹膜间皮... 详细信息

总结16年以来中南大学湘雅二医院肾内科腹膜透析的基础与临床研究的经验与成果。在国内率先成功构建了腹膜透析及腹膜纤维化动物模型,分离、鉴定了腹膜间皮细胞;利用细胞、分子生物学方法,系统研究了腹膜透析液的生物相容性、腹膜间皮细胞透析损伤的分子机制与防治措施,观察了促纤维化细胞因子转化生长因子-β1(TGF-β1),结缔组织生长因子(CTGF)及过氧化物酶体增生物激活受体-γ(PPAR-γ)等在腹膜纤维化发病机制中的重要作用,并初步阐明了它们的基因表达调控机制。首次在腹膜透析研究领域中利用纳米载体介导TGF-β1-shRNA与pCTGF-shRNA质粒在腹膜细胞与组织中的表达。在临床研究方面,研究了腹膜透析置管定位新方法、腹膜透析溶质转运特点及其机制、腹膜透析治疗模式及其他并发症的防治。

关键词：腹膜透析腹膜纤维化生物相容性溶质转运

ILIDViz:An incremental learning-based visual analysis system for network anomaly detection

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Virtual Reality & Intelligent Hardware 2023年第6期5卷 471-489页

作者： Xuefei TIAN Zhiyuan WU junxiang CAO Shengtao chen Xiaoju DONG Department of Computer Science Shanghai Jiao Tong UniversityShanghai 201100China

Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of *** intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real ***,there is an urgent need to implement more effective intrusion detection technologies to protect computer *** In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real *** Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious ***,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency.

关键词： Intrusion detection Machine learning Incremental learning Active learning Visual analysis

Planar-symmetry-breaking induced antisymmetric magnetoresistance in van der Waals ferromagnet Fe_(3)GeTe_(2)

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Nano Research 2022年第3期15卷 2531-2536页

作者： Ping Liu Caixing Liu Zhi Wang Meng Huang Guojing Hu junxiang Xiang Chao Feng chen chen Zongwei Ma Xudong Cui Hualing Zeng Zhigao Sheng Yalin Lu Gen Yin Gong chen Kai Liu Bin Xiang Hefei National Laboratory for Physical Sciences at the Microscale Department of Materials Science&EngineeringCAS Key Lab of Materials for Energy ConversionUniversity of Science and Technology of ChinaHefei 230026China School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031China Sichuan New Materials Research Center Institute of Chemical MaterialsCAEPChengdu 610200China Anhui Laboratory of Advanced Photon Science and Technology University of Science and Technology of ChinaHefei 230026China Physics Department Georgetown UniversityWashingtonDC 20057USA

Recently discovered magnetic van der Waals(vdW)materials provide an ideal platform to explore low-dimensional magnetism and spin *** vdW interaction nature opens up unprecedented opportunities to build vertically stacked heterostructures with novel properties and *** engineering the planar structure as an alternative degree of freedom,herein we demonstrate an antisymmetric magnetoresistance(MR)in a vdW Fe_(3)GeTe_(2)flake with a step terrace that breaks the planar *** antisymmetric MR originates from a sign change of the anomalous Hall effect and the continuity of the current transport near the boundary of magnetic domains at the step edge.A repeatable domain wall due to the unsynchronized magnetization switching is responsible for this sign *** interpretation is supported by the observation of field-dependent domain switching,and the step thickness,temperature,and magnetic field orientation dependent *** work opens up new opportunities to encode magnetic information by controlling the planar domain structures in vdW magnets.

关键词： 2D magnetism Fe_(3)GeTe_(2) planar structure engineering antisymmetric magnetoresistance

颛桥社区老年高血压患者3种干预方式的直接成本-效用研究

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上海医药 2018年第20期39卷 6-9页

作者：周梅花朱宇霞李丽秋钱洁徐丽燕万育春陈军香上海市闵行区颛桥社区卫生服务中心护理部上海201108 上海市闵行区颛桥社区卫生服务中心药剂科上海201108 上海市闵行区颛桥社区卫生服务中心医务科上海201108 上海市闵行区颛桥社区卫生服务中心门诊全科上海201108 上海市闵行区颛桥社区卫生服务中心院部上海201108

目的 :调查评价颛桥社区老年高血压患者接受不同干预方式的疾病直接成本效用。方法 :采用方便抽样方法于2017年10月选取老年高血压合并症患者148例,其中颛桥社区卫生服务中心接受住院治疗干预的患者58例、颛桥敬老院接受巡回医疗干预的... 详细信息

目的 :调查评价颛桥社区老年高血压患者接受不同干预方式的疾病直接成本效用。方法 :采用方便抽样方法于2017年10月选取老年高血压合并症患者148例,其中颛桥社区卫生服务中心接受住院治疗干预的患者58例、颛桥敬老院接受巡回医疗干预的患者30例,颛桥各社区接受"1+1+1"组合签约门诊干预的患者60例(进一步细分为门诊高龄亚组与门诊低龄亚组)。计算三组患者于2016年5月1日—2018年4月30日2年时间内接受不同干预方式的疾病直接成本—效用。结果 :2年的抗高血压药物费用为门诊高龄组最高(2 679.91元),门诊低龄组最低(2 210.43元);单纯计算抗高血压药物治疗费用,每获得一个完整QALY的成本为住院组最高(2 521.22元),门诊低龄组最低(1 627.50元);从总直接成本、自付总金额来看,总直接成本为住院组最高(179 143.29元),门诊低龄组最低(19 215.47元),三组患者每获得一个完整QALY的费用差异有统计学意义(P <0.001);自付总金额为住院组最高(63 574.97元),门诊低龄组最低(9 929.61元)。结论 :"1+1+1"组合签约服务和巡回医疗等医疗模式的开展极大地减轻了老年高血压患者的疾病经济负担,具有现实意义。

关键词： “1+1+1”组合签约服务住院治疗巡回医疗成本效用

基于“三一三”课程思政理念的检验医学专业实习教学探索

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医学教育研究与实践 2023年第5期31卷 613-617,623页

作者：唐浩能黄添隆王泽友杨佳锦任亚萍吴文静陈俊香胡敏王敏中南大学湘雅二医院检验医学科中南大学湘雅二医院教务部中南大学湘雅医学院湖南长沙410011

医学实习是医学生向医务工作者角色转化的重要阶段,是成长为卓越人才的关键步骤。基于课程思政理念开展检验医学专业实习教学有助于培养具有社会责任感和使命感、兼具检验与临床思维的高素质复合型检验人才。本研究提出了“三一三”课... 详细信息

医学实习是医学生向医务工作者角色转化的重要阶段,是成长为卓越人才的关键步骤。基于课程思政理念开展检验医学专业实习教学有助于培养具有社会责任感和使命感、兼具检验与临床思维的高素质复合型检验人才。本研究提出了“三一三”课程思政理念,即立足于“健康中国”规划,以时代精神为引领,以哲学辩证思维为武器、结合医学职业素养、科学素养和人文素养教育开展检验实习教学。从入科时岗前培训到专业组内检验前、中、后全过程的实习带教,利用各种教学手段,基于“适合、适时、适量”原则将课程思政元素有机融入实习教学中。课程思政教学反馈结果初步显示学生能较好接受并认可这种教学模式。“三一三”课程思政理念教学模式的运用能更好地实现检验医学专业教学立德树人的目的。

关键词：课程思政检验医学实习教学健康中国

枸杞蛋白酶解液对ACE活性的抑制作用及其对高血压大鼠的降压效果研究

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宁夏医科大学学报 2018年第1期40卷 11-16页

作者：王桃梅赵俊香陈琨陶秀娟高清菡范彦娜杨建军宁夏医科大学公共卫生与管理学院银川750004 宁夏银川市妇幼保健医院银川750001 扬州大学旅游烹饪学院扬州225127

目的研究枸杞蛋白经酶解后产物对血管紧张素转换酶(angiotensin converting enzyme,ACE)活性的抑制作用及其对自发性高血压大鼠的降压效果。方法以N-(3[2-呋喃]丙烯酰)-苯基丙氨酸-甘氨酸-甘氨酸(FA-Phe-Gly-Gly,FAPGG)作为ACE的底物,... 详细信息

目的研究枸杞蛋白经酶解后产物对血管紧张素转换酶(angiotensin converting enzyme,ACE)活性的抑制作用及其对自发性高血压大鼠的降压效果。方法以N-(3[2-呋喃]丙烯酰)-苯基丙氨酸-甘氨酸-甘氨酸(FA-Phe-Gly-Gly,FAPGG)作为ACE的底物,用全波长酶标仪于340nm波长下,对枸杞蛋白酶解液的ACE活性抑制率进行测定。并选用10～11周龄、体重240～280g、收缩压(SBP)>180mmHg的SPF级雄性自发性高血压大鼠(SHR组)45只,对枸杞蛋白酶解液的降压效果进行检测。SPF鼠随机分为SHR模型组、阳性对照组、枸杞蛋白酶解液的低剂量组(40mg·kg^(-1))、中剂量组(80mg·kg^(-1))和高剂量组(100mg·kg^(-1)),每组各9只。正常Wistar-Kyoto(WKY组)大鼠9只为对照组。WKY组和SHR模型组给予相应剂量的蒸馏水,阳性对照组给予10mg·kg^(-1)卡托普利。连续灌胃9周。给药前后测量大鼠血压和体重,实验结束后取大鼠心脏、肺脏、脾脏、肝脏及肾脏,称重并计算各脏器系数。结果枸杞蛋白酶解液对ACE的抑制率为(90.01±3.03)%。各组SHR的进食量、心脏、肝脏及肾脏的脏器系数均高于WKY组;SHR模型组、阳性对照组、中剂量组和高剂量组的大鼠体重增加值均低于WKY组(P均0.05)。结论枸杞蛋白酶解液对ACE的活性具有抑制作用;能够降低心脏、肝脏及肾脏的脏器系数,对心、肾功能有一定的保护作用;并通过抑制ACE的活性达到降低自发性高血压大鼠SBP的作用。

关键词：枸杞蛋白酶解液血管紧张素转化酶高血压

Ribosome profiling reveals the translational landscape and allele-specific translational efficiency in rice

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Plant Communications 2023年第2期4卷 119-135页

作者： Xi-Tong Zhu Run Zhou Jian Che Yu-Yu Zheng Muhammad Tahir ul Qamar Jia-Wu Feng Jianwei Zhang junxiang Gao Ling-Ling chen National Key Laboratory of Crop Genetic Improvement College of InformaticsHuazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Translational regulation is a critical step in the process of gene expression and governs the synthesis of proteins from *** studies have revealed translational regulation in plants in response to various environmental ***,there have been no studies documenting the comprehensive landscape of translational regulation and allele-specific translational efficiency in multiple plant tissues,especially those of rice,a main staple crop that feeds nearly half of the world’s *** we used RNA sequencing and ribosome profiling data to analyze the transcriptome and translatome of an elite hybrid rice,Shanyou 63(SY63),and its parental varieties Zhenshan 97 and Minghui *** results revealed that gene expression patterns varied more among tissues than among varieties at the transcriptional and translational *** identified 3392 upstream open reading frames(uORFs),and the uORF-containing genes were enriched in transcription *** 668 of 13492 long non-coding RNAs could be translated into ***,we discovered numerous genes with allele-specific translational efficiency in SY63 and demonstrated that some cis-regulatory elements may contribute to allelic divergence in translational ***,these findings may improve our understanding of translational regulation in rice and provide information for molecular breeding research.

关键词： Ribo-seq translational landscape uORFs lncRNAs allele-specific translational efficiency rice Oryza sativa