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The Rational Combination Strategy of Immunomodulatory Latency Reversing Agents and Novel Immunotherapy to Achieve HIV-1 Cure

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Infectious Diseases & Immunity 2022年第4期2卷 263-273页

作者： Yangyang Li junxian hong Linqi Zhang NexVac Research Center Comprehensive AIDS Research CenterDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesTsinghua UniversityBeijing 100084China

Human immunodeficiency virus(HIV)-1 infection creates a persistent latent reservoir even after antiretroviral therapy,which is the main barrier to HIV *** of the most explored strategies is the use of latent reversal agents(LRAs)to activate HIV latent reservoirs,followed by immunotherapy to remove infected *** LRAs have the dual advantage of activating viral latency and promoting immune cell elimination of HIV-infected *** emergence of novel immunotherapies has also enhanced the possibility ofHIV *** we review the activity and potential mechanisms of immunomodulatory agonists and *** possible combinational strategies to achieve HIV functional cure and the problems encountered using this approach are discussed.

关键词： HIV-1 Combination strategy Immunomodulator latency reversing agents Immunotherapy Shock and kill

CsPbX_(3)(X=Cl,Br,I)纳米晶的制备及其应用

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化学进展 2021年第8期33卷 1362-1377页

作者：洪俊贤朱旬葛磊徐鸣川吕文珍陈润锋南京邮电大学有机电子与信息显示国家重点实验室培育基地江苏省生物传感材料与技术重点实验室信息材料与纳米技术研究院先进生物与化学制造协同创新中心南京210023

全无机钙钛矿CsPbX_(3)(X=Cl,Br,I)纳米晶作为一类新型的低成本直接带隙半导体材料,具有优异的光学性质,如吸收系数高、尺寸和发射波长易调节、半峰宽窄、荧光量子产率高等特性,在照明、能源、信息显示和探测等领域表现出巨大的应用潜力... 详细信息

全无机钙钛矿CsPbX_(3)(X=Cl,Br,I)纳米晶作为一类新型的低成本直接带隙半导体材料,具有优异的光学性质,如吸收系数高、尺寸和发射波长易调节、半峰宽窄、荧光量子产率高等特性,在照明、能源、信息显示和探测等领域表现出巨大的应用潜力,成为材料领域的研究热点。本文从CsPbX_(3)纳米晶的结构组成入手,重点综述了其常见的制备方法如高温热注入法、室温再沉淀法、溶剂热法、液滴微流控法、阴离子交换法等,对常见的形貌尺寸控制策略如反应温度和表面配体进行归纳,以及改善CsPbX_(3)纳米晶稳定性的策略,总结了此类材料在白色发光二极管、电致发光二极管、激光器、光电探测器、太阳能电池等光电领域的应用情况,最后对CsPbX3纳米晶领域存在的问题和面临的挑战进行了分析和评述。

关键词： CsPbX_(3) 钙钛矿纳米晶合成方法光电特性光电器件

早发心肌梗死患者基因检测对家族性高胆固醇血症的诊断价值评估

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中华心血管病杂志 2024年第3期52卷 281-285页

作者：崔淯夏宋俊贤李忠佑李素芳刘传芬陈红北京大学人民医院心内科急性心肌梗死早期预警与干预北京市重点实验室心血管转化医学研究中心北京100044

目的在早发心肌梗死患者中评估基因检测对家族性高胆固醇血症(FH)的诊断价值。方法该研究为单中心横断面研究。选取2015年5月1日至2017年3月31日在北京大学人民医院就诊的早发心肌梗死患者,收集患者的一般临床资料,进行FH相关基因低密... 详细信息

目的在早发心肌梗死患者中评估基因检测对家族性高胆固醇血症(FH)的诊断价值。方法该研究为单中心横断面研究。选取2015年5月1日至2017年3月31日在北京大学人民医院就诊的早发心肌梗死患者,收集患者的一般临床资料,进行FH相关基因低密度脂蛋白受体(LDLR)、前蛋白转化酶枯草溶菌素9(PCSK9)、载脂蛋白B(APOB)和低密度脂蛋白受体衔接因子蛋白1(LDLRAP1)的基因检测。临床诊断分别采用Simon Broome标准、DLCN标准和FH中国专家共识诊断FH患者。结果225例早发心肌梗死患者中,男性188例(83.6%),首次心肌梗死的年龄为(46.6±7.2)岁。共有10例(4.4%)患者携带FH致病或可能致病的突变。较单独采用Simon Broome标准、DLCN标准和FH中国专家共识3种临床标准,基因检测使FH的诊断率分别提高了53.3%,33.3%和42.1%。结论基因检测有助于提高FH的诊断,对早发心肌梗死患者及早启动FH的规范治疗具有重要的意义。

关键词：基因检测家族性高胆固醇血症早发心肌梗死

Dynamic swelling performance of hydrophobic hydrogels

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Chinese Chemical Letters 2022年第4期33卷 2178-2182页

作者： Hui Guo junxian Chen Ziang Wang hong Lei Guo Wei hong Xiaolin Wang School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055China School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina

Conventional gels manifest monotonous swelling or shrinking performance upon immersing in solvents until reaching an equilibrium state. Recently, we discovered that the “hydrophobic hydrogels” prepared from hydrophobic polymer networks demonstrated dynamic swelling performance without equilibrium states. Upon water immersion, the gels expanded tremendously at the first stage until reaching a swelling peak;subsequently, the gels shrunk at an extremely slow rate. While this phenomenon endows the material with an unusual feature, more efforts are highly demanding for the full understanding of this performance. Herein, we systematically investigate the hydrophobic hydrogels’ swelling kinetics by screening the organic solvent dependence, polymer effect, and temperature impact. It is revealed that the chemical structure of gels greatly influences the swelling kinetics. The higher the networks’ hydrophobicity, the slower the swelling kinetics. Meanwhile, organic solvents demonstrate a limited effect on the dynamic swelling performance. Moreover, higher temperature significantly accelerates the whole volume change process. Based on the swelling performance, we further develop hydrogel-based soft devices with timeprogrammable two-dimensional and three-dimensional shape-shifting performances.

关键词： Hydrophobic hydrogels Swelling kinetics Shape-shifting device Time-dependence Thermodynamically unstable state

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区块链技术在电网数据处理中的应用

计算机应用文摘 2024年第14期40卷 92-93,97页

作者：张浩海顾新桥崔跃君严俊显张红北京中电普华信息技术有限公司北京100085

为提升电网数据处理的安全性与有效性,可以尝试应用区块链技术实现数据的永久储存、资源共享、权限加密和交互调用,从而构建一个全新的电网数据运行体系。文章将深入分析和探讨区块链技术在电网数据处理中的应用。

关键词：电网数据区块链技术可行性分析

Unraveling the morphological evolution mechanism of solid sulfur species in lithium-sulfur batteries with operando light microscopy

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Journal of Energy Chemistry 2022年第10期31卷 460-468,I0012页

作者： Jingqiang Zheng Chaohong Guan Huangxu Li Yangyang Xie junxian Hu Kai Zhang Bo hong Yanqing Lai Jie Li Zhian Zhang School of Metallurgy and Environment Hunan Province Key Laboratory of Nonferrous Value-Added MetallurgyCentral South UniversityChangsha 410083HunanChina University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry City University of Hong KongKowloonHong Kong 999077China

Solid-liquid phase conversion between various sulfur species in lithium-sulfur(Li-S)batteries is a fundamental reaction of the sulfur *** the morphological evolution of solid sulfur species upon cycling is of great significance to achieving high energy ***,an in-depth investigation of the internal reaction is still *** this work,the evolution process of solid sulfur species on carbon substrates is systematically studied by using an operando light microscope combined with in situ electrochemical impedance spectra *** observation of phenomena such as bulk solid sulfur species can form and dissolve independently of the conductive substrates and the transformation of supercooled liquid sulfur to crystalline *** on the phenomena mentioned above,a possible mechanism was proposed in which the dissolution reaction of solid sulfur species is a spatially free reaction that involves isotropic physical dissolution,diffusion of molecules,and finally the electrochemical ***,the formation of solid sulfur species tends to be a form of crystallization in a saturated solution rather than electrodeposition,as is commonly *** findings offer new insights into the reaction of sulfur cathodes and provide new opportunities to design advanced sulfur cathodes for Li-S batteries.

关键词： Lithium-sulfur batteries Morphological evolution Supercooled liquid sulfur Operando light microscopy Liquid sulfur droplets

基于NB-IoT的DMA用于供水管网漏损控制的研究进展

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市政技术 2020年第4期38卷 197-199,203页

作者：洪俊贤龚珑聪许俊鸽福州大学土木工程学院福建福州350108 福州城建设计研究院有限公司福建福州350108

供水管网的分区计量在国内已有许多应用案例,但受到无法进行实时数据传输的制约,致使其在定量漏损管控和进一步降低漏损率等方面遇到瓶颈。基于窄带物联网技术的分区计量用于漏损控制便应时而生,其可将供水管网分区计量在线监测的海量... 详细信息

供水管网的分区计量在国内已有许多应用案例,但受到无法进行实时数据传输的制约,致使其在定量漏损管控和进一步降低漏损率等方面遇到瓶颈。基于窄带物联网技术的分区计量用于漏损控制便应时而生,其可将供水管网分区计量在线监测的海量数据实时传输至漏损平台,自来水公司根据平台上长期连续监测数据,确定每个独立分区的最小夜间流量检测限值,协助判断新增漏损点,相关部门可快速而针对性地排查并及时修复漏损点。因此,基于窄带物联网的供水管网分区计量管理将城市供水管网化整为零,适用于供水管网的定量漏损控制,并已在福州试点成功运行,有效地降低了供水管网漏损率,值得推广应用。

关键词：供水管网漏损控制分区计量窄带物联网

Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 75-83页

作者： Liang hong Jia Zhang junxian Geng Junle Qu Liwei Liu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen 518060P.R.China

Photodynamic therapy(PDT)has become an attractive tumor treatment modality because of its noninvasive feature and low side ***,extreme hypoxia inside solid tumors severely impedes PDT therapeutic *** overcome this obstacle,various strategies have been developed *** them,in situ oxygen generation,which relies on the decom-position of tumor endogenous H_(2)O_(2),and oxygen delivery tactic using high oxygen loading capacity of hemoglobin or perfluorocarbons,have been widely *** in situ oxygen generation strategy has high specificity to tumors,but its oxygen-generating efficiency is lim-ited by the intrinsically low tumor H_(2)O_(2)*** contrast,the oxygen delivery approach holds advantage of high oxygen loading efficiency,nevertheless lacks tumor *** this work,we prepared a nanoemulsion system containing H_(2)O_(2)-responsive catalase,highly efficient ox-ygen carrier perfiuoropolyether(PFPE),and a near-infrared(NIR)light activatable photo-sensitizer IR780,to combine the high tumor specificity of the in situ oxygen generation strategy and the high efficiency of the oxygen delivery *** concisely prepared nanoplatform exhibited enhanced and H_(2)O_(2)-controllable production of singlet oxygen under light excitation,satisfactory cytocompatibility,and ability to kill cancer cells under NIR light *** highlights the potential of this novel nanoplatform for highly efficient and selective NIR light mediated PDT against hypoxic *** research provides new insight into the design of intelligent nanoplatform for relieving tumor hypoxia and enhancing the oxygen-dependent PDT effects in hypoxic tumors.

关键词： Hypoxia catalase oxygen delivery perfluorocarbon near-infrared

胃食管反流性疾病不同疗法的总体评价(附112例临床分析)

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胃肠病学和肝病学杂志 2003年第2期12卷 186-189页

作者：朱雅碧陈军贤黎红光栾双梅浙江省丽水市人民医院消化内科丽水市323000

目的了解胃食管反流性疾病对患者生活质量的影响,评价两种“三联疗法”对胃食管反流性疾病的疗效及生活质量,经济投入的影响。方法通过丽水市6所市、县级人民医院收集同期经胃镜确诊的反流性食管病例,采用问卷调查方式,了解受试者的... 详细信息

目的了解胃食管反流性疾病对患者生活质量的影响,评价两种“三联疗法”对胃食管反流性疾病的疗效及生活质量,经济投入的影响。方法通过丽水市6所市、县级人民医院收集同期经胃镜确诊的反流性食管病例,采用问卷调查方式,了解受试者的一般情况,胃食管反流症状和疾病前后生活质量,经济投入改变情况,分别给予质子泵抑制剂+促动力剂+黏膜保护剂(方案甲),及H_2受体阻滞剂+促动力剂+黏膜保护剂(方案乙)8周治疗。记录治疗后患者生活质量(QOL)表和经济投入量表。探讨两种“三联疗法”的疗效,生活质量改变情况和经济投入关系。结果①共收集112例GERD病例,男女比24:1,平均年龄47.9+13.8岁,两组患者的临床资料具有可比性(P>0.05);②甲方案总有效率92.98%,乙方案总有效率80％。甲方案疗效优于乙方案。③GERD严重影响QOL,优质QOL由发病前63.7％降至13.7％,甲方案治疗后可恢复优质QOL至84％,乙方案为63％。两种方案经济投入无显著差异(P=0.085)。④疗效和生活质量改善有显著相关性。结论“三联疗法”治疗胃食管反流性疾病疗效高,并可显著改善患者的生活质量。以兰索拉唑促动力剂+黏膜保护剂三联组更为明显。此三联疗法是经济、高效和有效提高生活质量的疗法,值得推广。

关键词：胃食管反流性疾病质子泵抑制剂促动力剂黏膜保护剂生活质量 “三联疗法”