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Protein post-translational modifications in auxin signaling

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Journal of Genetics and Genomics 2024年第3期51卷 279-291页

作者： Xiankui Cui junxia Wang Ke Li Bingsheng Lv Bingkai Hou Zhaojun Ding The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdaoShandong 266237China Shandong Academy of Grape JinanShandong 250100China College of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China

Protein post-translational modifications(PTMs),such as ubiquitination,phosphorylation,and small ubiquitin-like modifier(SUMO)ylation,are crucial for regulating protein stability,activity,subcellular localization,and binding with cofactors.Such modifications remarkably increase the variety and complexity of proteomes,which are essential for regulating numerous cellular and physiological processes.The regulation of auxin signaling is finely tuned in time and space to guide various plant growth and development.Accumulating evidence indicates that PTMs play critical roles in auxin signaling regulations.Thus,a thorough and systematic review of the functions of PTMs in auxin signal transduction will improve our profound comprehension of the regulation mechanism of auxin signaling and auxin-mediated various processes.This review discusses the progress of protein ubiquitination,phosphorylation,histone acetylation and methylation,SUMOylation,and S-nitrosylation in the regulation of auxin signaling.

关键词： Arabidopsis thaliana Auxin Auxin signaling Post-translational modifications Protein regulation

A preliminary study on life history of marine red alga Stylonema alsidii(Zandardini)Drew f.ramosum Zheng et Li

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Journal of Oceanology and Limnology 2024年第3期42卷 915-922页

作者： Bingxin HUANG Yao ZHANG Yue CHU Youxuan GUO junxia LIANG Jianan QIN Lanping DING Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjin 300387China

Stylonema alsidii(Zandardini)Drew f.ramosum Zheng et Li is a common species in the genus Stylonema,but there are limited reports on morphological taxonomy and a lack of studies on life history and the regulation of early development.The early development,discoid formation,and erect thallus growth of Stylonema alsidii f.ramosum were observed under laboratory conditions.In addition,the influence of main environmental factors such as temperature and light intensity on its development was briefly studied,and various stages of its life history were observed.The result shows:(1)there are two reproductive modes:asexual reproduction and sexual reproduction;(2)the morphology of this species varies in different degrees under laboratory culture conditions;(3)sexual reproduction and asexual reproduction can coexist under suitable conditions.Five pathways of life history were inferred from experimental phenomena.Mature sporophytes form mature gametophytes by producing initially isolated or initially attached monospore,and mature gametophytes form mature sporophytes by fertilization of eggs and sperms.The sexual and asexual reproduction processes of Stylonema alsidii f.ramosum were reported for the first time,and this is also the first report on sexual reproduction in the genus Stylonema.

关键词： Stylonema alsidii(Zandardini)Drew f.ramosum Zheng et Li life history environmental factor asexual reproduction sexual reproduction

MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

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Genes & Diseases 2024年第4期11卷 124-127页

作者： junxia Luo Yun Li Yong Lv Xin Li Bing Qin Chuanfang Cheng Xiaorong Liu Weiping Liao Jie Wang Zaifen Gao Department of Epilepsy Center Children's Hospital Affiliated to Shandong UniversityJinanShandong 250022China Department of Epilepsy Center Jinan Children's HospitalJinanShandong 250022China Department of Brain Function and Neuroelectrophysiology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pediatrics The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)HefeiAnhui 230001China Department of Pediatrics The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Epilepsy Center and Department of Neurosurgery The First Affliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology The Second Afiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University GuangzhouGuangdong 510260China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China GuangzhouGuangdong 510260China

The multiple PDZ domain crumbs cell polarity complex component gene(MPDZ;MIM:603785),is highly expressed in the brain across the whole lifespan.It encodes the multiple PDZ domain protein,which is a member of the NMDAR signaling complex that may play a role in the control of AMPAR potentiation and synaptic plasticity in excitatory synapses."Previously,MPDZ variants have been demonstrated to be associated with autosomal recessive congenital hydrocephalus-2(HYC2;MIM:615219)which is commonly complicated by brain abnormalities and developmental delay.Seizures were reported in only one case.The association between MPDz and epilepsy requires clarification.

关键词： epilepsy febrile congenital

Study on Solid Fermentation and Antioxidant Function of Natto

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Asian Agricultural Research 2024年第1期16卷 32-36页

作者： junxia SONG Hongbing QI Yanhong MAO School of Geographical Sciences Lingnan Normal UniversityZhanjiang 524048China Life Science and Technology School Lingnan Normal UniversityZhanjiang 524048China

[Objectives]To study the optimum conditions of solid fermentation of natto with antioxidant function as an index.[Methods]Single factor experiment and orthogonal experiment were designed to study the effects of temperature,time,initial pH and inoculum amount on the antioxidant activity of natto solid fermentation.The optimum conditions of natto solid fermentation were determined and the antioxidant ac-tivity of natto extract was compared.[Results]The optimal fermentation conditions were as follows:temperature 32℃,initial pH 7.0,inocu-lation amount 8%,fermentation time 32 h.The hydroxyl radical scavenging rate of natto solid fermentation crude extract was the highest,which was 82.7%.The optimized nato fermentation extract showed stronger scavenging ability for-OH and O,:,and showed obvious dose-effect relationship.ICso was 3.63 and 4.24 mg/mL,respectively,and the scavenging efficiency was 1.3 and 1.9 times higher than that of the unoptimized fermentation extract,respectively.[Conclusions]Natto is rich in nattokinase and other functional factors,and its antioxidant ac-tivity can be improved by optimizing fermentation technology,so that natto products can be widely used,including cosmetic raw materials,nat-to skin care soap,health food and medicine,etc.,and have a broader development prospect.

关键词： Natto Solid fermentation Hydroxyl radical scavenging rate Antioxidant activity

Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway

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Food Science and Human Wellness 2024年

作者： Dan Hong Xiao Xiao Aijin Ma Zhou Chen SiTing Li junxia Xia YiLing Tian Yingmin Jia Hebei yangyuan ZhiHui Beverage Co. Ltd. Institution of Chinese Walnut Industry College of Food Science and Technology Hebei Agricultural University Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology School of Food and Health Beijing Technology and Business University

Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations. Dietary interventions are being considered as potential strategies for delaying age-related dysfunction. Unsaponifiable matter (USM)， a composition of highly active ingredients found in walnut oil， has demonstrated antioxidant effects. This study aims to explore the neuroprotective effects of USM on D-galactose-treated C57BL/6 mice and elucidate its underlying mechanism， which was validated in PC12 cells treated with D-galactose. The results of behavioral tests demonstrated that USM significantly improved cognitive deficits associated with aging. The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage， synaptic impairment， and mitochondrial dysfunction induced by D-galactose. Furthermore， USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde (MDA) andreactive oxygen species (ROS) levels. The results suggest that USM can mitigate age-related symptoms caused by D-galactose by activating the Nrf2 signaling pathway， which enhances the expression of antioxidant enzymes， restore redox balance， and improves synaptic and mitochondrial functions. This has a positive on improving cognition and memory disorders in elderly mice.

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Carbon Isotope Gradient of the Ediacaran Cap Carbonate in the Shennongjia Area and Its Implications for Ocean Stratification and Palaeogeography

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Journal of Earth Science 2017年第2期28卷 187-195页

作者： Guangzhe Wang Jiasheng Wang Zhou Wang Can Chen junxia yang State Key laboratory of Biogeology and Environment Geology School of Earth Sciences China University of Geosciences Institute of Karst Geology CAGS Key Laboratory of Karst Ecosystem and Treatment of Rocky Desertification MLR

The geochemistry and paleogeography of the Doushantuo succession in the Shennongjia area have been insufficiently studied. Here, we report on the carbon and oxygen isotope compositions of Ediacaran Doushantuo cap carbonates from four sections（Longxi, Muyu, Yazikou and Songluo） in the Shennongjia area. A large C-isotopic gradient（~5‰） between the Longxi and Songluo sections, here identified for the first time, is inferred to have been dynamically maintained by photosynthesis in surface waters and anaerobic oxidation of dissolved organic carbon（DOC） in deep waters. Spatial variation in C-isotope chemostratigraphy among the four sections was related to Marinoan post-glacial sea-level elevation changes. At Longxi, a positive δ^（13）C_（carb） shift below the horizon containing tepee-like structure resulted from intense photosynthesis during early regression. A negative δ^（13）C_（carb） shift within the tepee-horizon was triggered by sulfate reduction and freshwater mixing with ^（13）C-depleted dissolved inorganic carbon（DIC） during late regression. A positive δ^（13）C_（carb） excursion in the uppermost part of the cap carbonate was related to enhance primary productivity and organic matter burial during early transgression. At Muyu, the carbon isotopic variation tendency, which is similar to that at Longxi, may have been mildly influenced by the surface water environment. At Songluo, the positive δ^（13）C_（carb） excursion, up to-4‰ in the lower part of the cap carbonate, was probably associated with methanogenesis in deep waters during late transgression to early regression and subsequently disappeared due to decomposition of methane hydrate during late regression. At Yazikou, the consistently stable δ^（13）C_（carb） values around-4‰ indicate that the cap carbonate may have deposited at intermediate water depths. As evidenced by diagnostic sedimentary characteristics of the study sections, the palaeogeographic framework of the Shennongjia area exhibited deepening from SE to NW during the Early Ediacaran Period in the aftermath

关键词： Ediacaran Doushantuo cap carbonate carbon isotope stratification palaeogeography,Shennongjia.

地方高校视觉传达设计专业应用型课程构建与实施——以“展示设计”课程为例

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科教导刊 2024年第1期 114-117页

作者：杨军侠桂林航天工业学院传媒与艺术设计学院广西桂林541004

应用型课程建设是地方本科高校提升人才培养质量的核心与关键。文章通过分析应用型课程的概念与特点,提出应用型课程建设标准应具备以学生为中心、目标导向性、内容综合性和行动导向性,并以展示设计课程为例,基于应用型课程建设标准,探... 详细信息

应用型课程建设是地方本科高校提升人才培养质量的核心与关键。文章通过分析应用型课程的概念与特点,提出应用型课程建设标准应具备以学生为中心、目标导向性、内容综合性和行动导向性,并以展示设计课程为例,基于应用型课程建设标准,探讨了地方应用型本科高校视觉传达设计专业应用型课程的构建与实施,以期为地方高校应用型课程建设提供参考。

关键词：地方高校应用型课程产教融合职业能力以学生为中心

高比能二次锂电池电极材料的储能系统配电网运行建模与仿真研究

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储能科学与技术 2024年第1期13卷 342-344页

作者：刘红李俊霞河南农业职业学院信息工程学院河南郑州451450

对于包含储能系统的配电网运行建模与仿真,传统方法由于缺少对储能系统变量增补约束,导致建模后储能系统的电热转换效率较低。为此,提出高比能二次锂电池电极材料的储能系统配电网运行建模与仿真研究。依据储能系统在配电网中的运行特性... 详细信息

对于包含储能系统的配电网运行建模与仿真,传统方法由于缺少对储能系统变量增补约束,导致建模后储能系统的电热转换效率较低。为此,提出高比能二次锂电池电极材料的储能系统配电网运行建模与仿真研究。依据储能系统在配电网中的运行特性,建立储能系统等效电路,并以高比能二次锂电池电极材料的储能系统的经济性指标构建电网运行模型,同时对其加以变量增补约束,以动态描述配电网的运行过程。实例应用结果显示,所提方法能够有效提高储能系统的电热转换效率,建模结果更加可靠。

关键词：高比能二次锂电池电极材料储能系统配电网运行建模仿真

身残志坚的盲人数学家:列夫·塞门诺维奇·庞特里亚金

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自然辩证法通讯 2024年第6期46卷 121-126页

作者：庞军霞徐乃楠吉林师范大学数学与计算机学院吉林四平136000

庞特里亚金是前苏联一位杰出的盲人数学家,幼年因意外双目失明,却最终成为二十世纪顶尖的数学家之一。其早期工作集中在拓扑学方面,建立了著名的庞特里亚金对偶定理,被认为是拓扑学最卓越的成就之一。二十世纪五十年代转向应用数学研究... 详细信息

庞特里亚金是前苏联一位杰出的盲人数学家,幼年因意外双目失明,却最终成为二十世纪顶尖的数学家之一。其早期工作集中在拓扑学方面,建立了著名的庞特里亚金对偶定理,被认为是拓扑学最卓越的成就之一。二十世纪五十年代转向应用数学研究,主要研究振动理论和最优控制理论并成为最优化过程数学理论的奠基者,提出庞特里亚金极大值原理,取得了极高的国际声誉。本文旨在对庞特里亚金的生平传奇、数学成就和教育贡献进行全面的历史分析。

关键词：拓扑学对偶定理应用数学最优化理论