检索结果-南通市图书馆

EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice

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The Journal of Biomedical Research 2023年第3期37卷 179-193页

作者： Jubiao Zhang Yang Chen Lihong Yan Xin Zhang Xiaoyan Zheng junxia qi Fen Yang Juxue Li State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingJiangsu 211166China Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjingJiangsu 211166China The Affiliated Eye Hospital of Nanjing Medical University NanjingJiangsu 210029China The Second Affiliated Hospital of Nanjing Medical University NanjingJiangsu 210011China.

Erythropoietin-producing hepatocellular carcinoma A3(EphA3)is a member of the largest subfamily of tyrosine kinase receptors-Eph *** studies have shown that EphA3 is associated with tissue ***,we have found that the expression of EphA3 is elevated in the hypothalamus of mice with diet-induced obesity(DIO).However,the role of EphA3 in hypothalamic-controlled energy metabolism remains *** the current study,we demonstrated that the deletion of EphA3 in the hypothalamus by CRISPR/Cas9-mediated gene editing promotes obesity in male mice with high-fat diet feeding rather than those with normal chow diet ***,the deletion of hypothalamic EphA3 promotes high-fat DIO by increasing food intake and reducing energy *** of EphA3 leads to smaller intracellular vesicles in GT1-7 *** current study reveals that hypothalamic EphA3 plays important roles in promoting DIO.

关键词： EphA3 hypothalamus metabolism CRISPR-Cas9 obesity

基于Z39.50的数字图书馆信息检索的研究

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现代电子技术 2016年第5期39卷 143-146页

作者：齐俊霞邯郸学院河北邯郸056005

图书馆的信息检索是面向读者服务的重要方式,读者可以方便地检索到所需要书刊的详细信息和借阅情况。基于Z39.50协议的图书馆信息系统能够实现多个图书馆之间信息的相互访问,有利于资源共享。Z39.50协议在数字图书馆的应用虽然比较广泛... 详细信息

图书馆的信息检索是面向读者服务的重要方式,读者可以方便地检索到所需要书刊的详细信息和借阅情况。基于Z39.50协议的图书馆信息系统能够实现多个图书馆之间信息的相互访问,有利于资源共享。Z39.50协议在数字图书馆的应用虽然比较广泛,但用Java语言实现的却很少见,而Java语言在网络中的应用越来越广泛,且具有优良的跨平台特性,因此用纯Java语言实现Z39.50协议很有必要。在分析Z39.50协议和JZKit2最新版本软件的基础上,对JZKit2提出了改进意见,并应用较先进的技术和工具加以实现。

关键词：信息检索 Z39.50协议 Maven2 JZKit2项目 Java I

FBXL4 serves as a clock output molecule to regulate sleep through promoting GABAA receptor degradation

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FBXL4 serves as a clock output molecule to regulate sleep th...

Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction

中国神经科学学会第十二届全国学术会议

作者： qian LI Yi LI Xiao WANG junxia qi Huawei TONG Zikai ZHOU Zi Chao ZHANG Junhai HAN Institute of Life Sciences the Key Laboratory of Developmental Genes and Human Disease Southeast University

Sleep is tightly governed by the circadian clock that contains a negative transcriptional feedback loop and synchronizes the physiology and behavior of most animals to daily environmental oscillations. In both vertebrates and invertebrates, the status of sleep and wake is controlled by the electrical activity of pacemaker neurons, which is circadian-regulated and suppressed by inhibitory GABAergic inputs. However, how the circadian clock rhythmically regulates the activity of pacemaker neuron is unclear. Here, we show that the level of Drosophila GABA receptor Resistant to Dieldrin(RDL) undergoes a daily cycle in wake-promoting large ventral lateral neurons(l-LNvs) and identify the E3 ligase Fbxl4 as a clock output molecule promoting RDL poly-ubiquitination and degradation. Depletion of Fbxl4 results in RDL accumulation, shortened sleep onset, and increased sleep time both in the day and the night. Moreover, we reveal that the expression of Fbxl4 in l-LNvs is Clock dependent but fbxl4 mutants exhibit normal locomotor rhythms. Thus, our study uncovers the critical molecular linkage between circadian clock and the electrical activity of pacemaker neurons and demonstrates that clock-dependent Fbxl4 expression downregulates GABAA receptor to increase the activity of pacemaker neurons and promote wakefulness.

关键词： Sleep circadian clock GABAA receptor E3 ligase Fbxl4 degradation

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Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-...

长三角地区神经科学论坛2017

作者： Xiao-Yan Zhang junxia qi Yu-qian Shen Xian Liu An Liu Zikai Zhou Junhai Han Zi Chao Zhang Institute of Life Sciences Southeast University

Renpenning syndrome is a group of X-linked intellectual disability syndromes caused by mutations in human polyglutamine-binding protein 1(PQBP1)*** is known about the molecular pathogenesis of the various mutations that cause the notable variability in *** this study,we examine the cellular and synaptic functions of the most com-mon mutations found in the patients:c.46162del AG,c.45962del AGAG and c.46364dup AG in an AG hexamer in PQBP1 exon *** discovered that PQBP1 c.45962del AGAG and c.46364dup AG mutations encode a new C-terminal epitope that preferentially binds non-phosphorylated fragile X mental retardation protein(FMRP)and promotes its ubiquitin-mediated *** of FMRP function up-regulates its targets such as MAP1B,and disrupts FMRP-dependent synaptic scaling in primary cultured *** Drosophila neuromuscular junction model,PQBP1 c.46364dup AG transgenic flies showed remarkable defects of synaptic over-growth,which can be rescued by exogenously expressing d *** data strongly support a gain-of-function pathogenic mechanism of PQBP1 c.45962del AGAG and c.46364dup AG mutations,and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients.

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无人机技术在金属矿山测绘中的应用研究

中国锰业 2018年第4期36卷 210-212,216页

作者：祁俊霞青海省有色地质矿产勘查局地质矿产勘查院青海西宁810007

近年来我国经济呈高速化发展之势,因此对矿产资源的需求量也在持续增加,这就使得以往所采用的测绘技术逐渐显露出了许多不足之处,难以适应当前的测绘需求。而通过实践研究发现无人机技术具备分辨率高、数据更新速度快、应用成本低及灵... 详细信息

近年来我国经济呈高速化发展之势,因此对矿产资源的需求量也在持续增加,这就使得以往所采用的测绘技术逐渐显露出了许多不足之处,难以适应当前的测绘需求。而通过实践研究发现无人机技术具备分辨率高、数据更新速度快、应用成本低及灵活性强等多种优势,因此在金属矿山测绘中能够充分发挥其优势。以青海省的金属矿山测绘工作为例,对无人机技术的应用方式及特点进行了详细介绍,可对矿山测绘工作的开展起到一定的指导作用。

关键词：无人机技术金属矿山测绘应用

基于读者信息行为分析的高校图书馆创新服务研究

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情报探索 2015年第8期 114-117页

作者：肖静齐俊霞邯郸学院图书馆河北邯郸056000

对河北普通高校图书馆读者的信息行为进行抽样调查,分析高校读者获取信息的目的、途径和渠道,获取信息的频度与满意度,获取信息遇到的障碍以及对图书馆的意见或建议等。借鉴美国高校图书馆读者服务经验,提出吸纳读者参与图书馆创新服务... 详细信息

对河北普通高校图书馆读者的信息行为进行抽样调查,分析高校读者获取信息的目的、途径和渠道,获取信息的频度与满意度,获取信息遇到的障碍以及对图书馆的意见或建议等。借鉴美国高校图书馆读者服务经验,提出吸纳读者参与图书馆创新服务、让服务商成为图书馆创新服务的重要组成部分、开展移动图书馆服务等建议。

关键词：高校图书馆读者信息行为创新服务

同方期刊数据库博看期刊评论

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自身免疫性胰腺炎影像学研究进展

国际医学放射学杂志 2018年第5期41卷 576-579页

作者：亓俊霞张翔闫建华于长路天津市第三中心医院放射科天津市肝胆疾病研究所天津市人工细胞重点实验室卫生部人工细胞工程技术研究中心天津300170

自身免疫性胰腺炎是一种由自身免疫介导的以慢性纤维硬化性改变为主要表现的少见胰腺炎。该病在普通人群中的真实发病率和流行病学特点尚未得到准确统计和进一步认识。自身免疫性胰腺炎的诊断是基于多学科的综合诊断,影像诊断在AIP的综... 详细信息

自身免疫性胰腺炎是一种由自身免疫介导的以慢性纤维硬化性改变为主要表现的少见胰腺炎。该病在普通人群中的真实发病率和流行病学特点尚未得到准确统计和进一步认识。自身免疫性胰腺炎的诊断是基于多学科的综合诊断,影像诊断在AIP的综合诊断中不可或缺。就该病的病理生理学、CT和MRI表现,特别是与胰腺癌等的鉴别诊断及当前影像研究进展予以综述。

关键词：胰腺自身免疫性疾病磁共振成像体层摄影术,螺旋计算机