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Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-Ming Xue Song Feng Yong-hao Chen Han Yi Min Xiao Pin-Jing Cheng Xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao hao-Qiang Wang Bao-Qian Li Ji-Rong Zhao Lei-Xun Tang Wen Luo Bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,In,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,eNDF/B-VIII.0,JeFF-3.3,JeNDL-5,CeNDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline

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TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease

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Science China Chemistry 2024年第4期67卷 1360-1372页

作者： Meiru Lu Changlong hao Liguang Xu Feng Yu Jiwei Jiang Yanli Wang Jun Xu Hua Kuang Chuanlai Xu Maozhong Sun International Joint Research Laboratory for Biointerface and Biodetection State Key Laboratory of Food Science and ResourcesSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Institute of Life Sciences Jiangsu UniversityZhenjiang 212013China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Clinical Research Center for Neurological Diseases Beijing 100070China

Tripartite motif 21(TRIM21)is an e3 ubiquitin ligase that shows great promise for protein degradation through ***,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were *** conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 ***,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in *** APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 ***,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,*** studies provide a method to rescue AD-like pathologies and prevent senescence.

关键词： chiral gold nanoparticles amyloid-β NLRP3 TRIM21 senescence Alzheimer's disease

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Simultaneously optimizing exciton diffusion length and nonradiative energy loss in organic solar cells via ternary strategy

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Science China Chemistry 2024年第9期67卷 3004-3011页

作者： Huanxiang Jiang hao Lu Zezhou Liang Yonghai Li Guangliu Ran Chenyu Han Yuqiang Liu Hongxiang Li Xichang Bao Zhishan Bo College of Textiles and Clothing State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao 266071China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Key Laboratory for Physical electronics and Devices of the Ministry of education&Shaanxi Key Lab of Photonic Technique for InformationSchool of Electronics Science&EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum StudiesBeijing Normal UniversityBeijing 100875China College of Polymer Science and engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Laboratory of Solar energy Shandong Energy InstituteQingdao 266101China

Significant nonradiative energy loss and short exciton diffusion length in organic solar cells(OSCs)are two major obstacles to achieving state-of-the-art *** is crucial to conduct a study on the intensive mechanism and improvement strategies for future breakthroughs in the efficiency of *** this work,nonradiative energy loss and exciton diffusion length are optimized simultaneously by incorporating a guest acceptor(LA15)to construct ternary OSC(D18:L8-BO:LA15).Firstly,LA15 exhibits excellent compatibility with the host acceptor L8-BO,and effectively improves the fluorescence quantum efficiency(FLQY),resulting in suppressed non-radiative energy ***,LA15 effectively prolongs the fluorescent lifetime of the acceptor phase from 0.85 to 1.12 ns,leading to larger exciton diffusion length,which is beneficial for reducing geminate ***,the addition of LA15 optimizes the crystallinity of the active layer with amplified charge transport *** a result,the optimized D18:L8-BO:LA15 device achieves ultralow nonradiative energy loss of 0.18 e V and improved fill factor(FF)with high efficiency up to 19.13%.These results highlight the crucial roles of regulating FLQYand exciton lifetime in achieving highefficiency OSCs.

关键词： organic solar cells nonradiative energy loss exciton lifetime exciton diffusion length

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Theoretical study of superradiant masing with solid-state spins at room temperature

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 38-47页

作者： Qilong Wu Yuan Zhang hao Wu Shi-Lei Su Kai-Kai Liu Mark Oxborrow Chong-Xin Shan Klaus Mølmer Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Academy of Quantum Information Sciences Beijing 100193China Department of Materials Imperial College LondonLondon SW72AZUK Niels Bohr Institute University of CopenhagenCopenhagen 2100Denmark

Steady-state superradiance and superradiant lasing attract significant attentions in the field of optical lattice clocks,but have not been achieved yet due to the technical challenges and atom loss *** this article,we propose that their counter-part may be observed in the microwave domain with solid-state spins,i.e.,nitrogen-vacancy center spins and pentacene molecular spins,coupled to microwave resonator at room temperature with realistic technical *** validate our proposal,we investigate systematically the system dynamics and steady-state by solving quantum master equations for the multi-level and multi-process dynamics of trillions of *** calculations show that the superradiant Rabi oscillations occur firstly due to transitions among different Dicke states,and the subsequent continuous-wave superradiant masing can achieve a linewidth well below *** work may guide further exploration of transient and steady-state superradiant masing with the mentioned and other solid-state spins *** ultra-narrow linewidth may find applications in deep-space communications,radio astronomy and high-precision metrology.

关键词： solid-state spins superradiance maser

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enhancing osteogenic bioactivities of coaxial electrospinning nanoscaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration

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Nano Research 2024年第7期17卷 6430-6442页

作者： Peng Wang Qianjin Wang Dengxian Wu Yunyang Zhang Shixiong Kang Xucai Wang Jiayu Gu hao Wu Zhihong Xu Qing Jiang School of Biomedical engineering and Informatics Nanjing Medical UniversityNanjing 211166China State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Center of Modem Analysis Nanjing UniversityNanjing 210008China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China Co-Innovation Center for efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Jiangsu Institute of Metrology Nanjing 210023China

Bone tissue engineering provides a promising strategy for the treatment of bone ***,the clinical utilization of biomaterial-based scaffolds is constrained by their inadequate mechanical strength and absence of osteo-inductive ***,we proposed to endow nano-scaffold(NS)constructed by coaxial electrospinning technique with enhanced osteogenic bioactivities and mechanical properties by incorporating biocompatible magnetic iron oxide nanoparticles(IONPs)and icaritin(ICA).Four types of nano-scaffolds(NS,ICA@NS,NS-IONPs and ICA@NS-IONPs)were *** incorporation of ICA and IONPs minimally impact their surface morphological and chemical *** enhanced the mechanical properties of NS scaffolds,including hardness,tensile strength,and elastic *** vitro assessments demonstrated that ICA@NS-IONPs exhibited enhanced osteogenic bioactivities towards mouse calvarial pre-osteoblast cell line MC3T3-e1 as evidenced by detecting the alkaline phosphatase(ALP)activity level,expressions of osteogenesis-related genes and proteins as well as mineralized nodule *** investigations revealed that MeK/eRK(MAP kinase-eRK kinase(MeK)/extracellularsignal-regulated kinase(eRK))signaling pathway could offer a plausible explanation for the osteogenic differentiation of MC3T3-e1 cells induced by ICA@***,the implantation of nano-scaffolds in rat skull defects exhibited a substantial improvement in in vivo bone ***,IONPs and ICA incorporated coaxial electrospinning nano-scaffolds present a novel strategy for the optimization of scaffolds for bone tissue engineering.

关键词： iron oxide nanoparticles icaritin coaxial electrospinning nano-scaffolds MeK/eRK signaling pathway bone regeneration

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Association between composite dietary antioxidant index and stroke among individuals with diabetes

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World Journal of Diabetes 2024年第8期15卷 1742-1752页

作者： Hong-Qiang Zhang Jie Shi Tong Yue Jia-hao Weng Xu-Lin Wang hao Wang Xiao-Yu Su Xue-Ying Zheng Si-Hui Luo Yu Ding Chao-Fan Wang Department of Cardiology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of endocrinology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and *** composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this *** previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular *** To investigate the association between CDAI and stroke risk in individuals with *** Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with *** CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and e;carotenoids;selenium;and *** logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke *** The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with *** analysis revealed a strong inverse relationship between CDAI levels and stroke ***,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various *** finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with *** Our findings suggested that CDAI was inversely associated with stroke prevalence among pa

关键词： Stroke Diabetes Composite dietary antioxidant index National Health and Nutrition examination Survey Crosssectional study

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environmental factors controlling soil warming and wetting during 2000-2020 in permafrost and non-permafrost regions across the Qinghai-Tibet Plateau

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Advances in Climate Change Research 2024年第2期15卷 285-296页

作者： Guo-An YIN Jing LUO Fu-Jun NIU Ming-hao LIU Ze-Yong GAO Tian-Chun DONG Wei-Heng NI State Key Laboratory of Frozen Soil engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway Qinghai-Tibet Group Co. Ltd.Xining 810000China University of Chinese Academy of Sciences Beijing 100049China

The Qinghai-Tibet Plateau(QTP)has experienced rapid environmental changes,including climate warming and wetting,since the *** environmental changes significantly impact the shallow soil hydrothermal conditions,which have key roles in land-atmosphere feedback and ecosystem ***,the spatial variations and responses of soil hydrothermal conditions to environmental changes over the QTP with permafrost(PF)and seasonal frost(SF)remain *** this study,we investigated the spatial variations in soil temperature(ST)and soil moisture(SM)changes over the QTP from 2000 to 2020 using 99 in-situ sites with observations at 4 depths(i.e.10,40,100 and 200 cm).The main environmental controlling factors were further identified using a calibrated statistical *** showed that significant(ped at multiple soil layers during 2000-2020 with a wide variation(i.e.0.033-0.039℃ per year on average),whereas the warming rates at PF sites were two times greater than those at SF *** addition,the soil wetting rate was high over the SF region,whereas the soil wetting rate was low over the PF *** from air temperature,changes in thawing degree days and solar radiation(Srad)contributed most to soil warming in the PF region,whereas changes in rainfall,Srad and evaporation(eVA)have been identified as the key factors in the SF *** for soil wetting,changes in snowfall,freezing degree days and vegetation have noticeable nonlinear effects over the PF region,whereas changes in eVA,Srad and rainfall highlighted distinct linear and nonlinear effects in the SF *** findings enhance our understanding of the hydrothermal impacts of future environmental changes over the QTP.

关键词： Warming amd wetting Soil hydrothermal change Factor Permafrost Seasonal frost

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A dynamic database of solid-state electrolyte(DDSe)picturing all-solid-state batteries

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Nano Materials Science 2024年第2期6卷 256-262页

作者： Fangling Yang egon Campos dos Santos Xue Jia Ryuhei Sato Kazuaki Kisu Yusuke Hashimoto Shin-ichi Orimo hao Li Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai980-8577Japan Key Laboratory of Radiation Physics and Technology Ministry of EducationCollege of PhysicsSichuan UniversityChengdu610065People's Republic of China Institute for Materials Research(IMR) Tohoku UniversitySendai980-8577Japan Tohoku Forum for Creativity Tohoku UniversitySendai980-8577Japan

All-solid-state batteries(ASSBs)are a class of safer and higher-energy-density materials compared to conventional devices,from which solid-state electrolytes(SSes)are their essential *** date,investigations to search for high ion-conducting solid-state electrolytes have attracted broad ***,obtaining SSes with high ionic conductivity is challenging due to the complex structural information and the less-explored structure-performance *** provide a solution to these challenges,developing a database containing typical SSes from available experimental reports would be a new avenue to understand the structureperformance relationships and find out new design guidelines for reasonable ***,a dynamic experimental database containing>600 materials was developed in a wide range of temperatures(132.40–1261.60 K),including mono-and divalent cations(e.g.,Li^(+),Na^(+),K^(+),Ag^(+),Ca^(2+),Mg^(2+),and Zn^(2+))and various types of anions(e.g.,halide,hydride,sulfide,and oxide).Data-mining was conducted to explore the relationships among different variates(e.g.,transport ion,composition,activation energy,and conductivity).Overall,we expect that this database can provide essential guidelines for the design and development of high-performance SSes in ASSB *** database is dynamically updated,which can be accessed via our open-source online system.

关键词： Solid-state electrolyte(SSe) All-solid-state battery(ASSB) Ionic conductivity Dynamic database Machine learning

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Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm(Bombyx mori)

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Insect Science 2024年第1期31卷 47-58页

作者： hao Sun Jingya Chen Ruolin Wang Dan Liu Na Zhang Tong Zhang Ling Jia Sanyuan Ma Qingyou Xia State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Biological Science Research Center Southwest UniversityChongqingChina

Metamorphosis is a complex developmental process involving multiple pathways and a large number of genes that are regulated by juvenile hormone(JH)and 20-hydroxyecdysone(20e).Despite important progress in understanding various aspects of silkworm biology,the hormone signaling pathway in the silkworm remains poorly ***-wide screening using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-based libraries has recently emerged as a novel method for analyzing genome function,enabling further research into essential genes,drug targets,and virus-host ***,we constructed a genome-wide CRISPR/Cas9-based library of the silkworm(Bombyx mori)and successfully revealed the genes involved in biotic or abiotic stress factor *** this study,we used our silkworm CRISPR library and large-scale genome-wide screening to analyze the key genes in the silkworm 20e signaling pathway and their mechanisms of *** annotation showed that 20e regulates key proteins in processes that mainly occur in the cytoplasm and *** enrichment analysis showed that 20e can activate phosphorylation and may affect innate immunity,interfere with intracellular nutrition and energy metabolism,and eventually cause cell *** screening results were experimentally validated by generating cells with knockout alleles of the relevant genes,which had increased tolerance to *** findings provide a panoramic overview of signaling in response to 20e in the silkworm,underscoring the utility of genome-wide CRISPR mutant libraries in deciphering hormone signaling pathways and the mechanisms that regulate metamorphosis in insects.

关键词： CRISPR/Cas9 CRISPR library screening ecdysone 20e signal transduction silkworm whole genome editing

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water

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Chinese Journal of Polymer Science 2024年第1期42卷 1-6,I0004页

作者： Zi-Shan Li Jing Lyu Bei Qiu Ying-hao Li Ruth Foley Ri-Jian Song Melissa Johnson Qiang Geng Wen-Xin Wang Institute of Precision Medicine(AUST-IPM) Anhui University of Science and TechnologyHuainan 232001China Charles Institute of Dermatology School of MedicineUniversity College DublinDublin D04 V1W8Ireland

Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关键词： Cu(0)-mediated RDRP N-isopropylacrylamide Propagation Deactivation Reaction parameters

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