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PBL-EBM教学法在骨科住院医师规范化培训中的应用

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中国继续医学教育 2024年第9期16卷 53-57页

作者：郭志勇陈汉政钟树栅吴景明黄君庭广州医科大学附属第一医院脊柱外科广东广州510120

目的探讨以问题为基础的学习结合基于循证医学(problem-based learning,evidence-based medicine,PBL-EBM)教学法在骨科住院医师规范化培训(简称“住培”)临床教学中的应用。方法选择2022年1月—2023年1月在广州医科大学附属第一医院骨... 详细信息

目的探讨以问题为基础的学习结合基于循证医学(problem-based learning,evidence-based medicine,PBL-EBM)教学法在骨科住院医师规范化培训(简称“住培”)临床教学中的应用。方法选择2022年1月—2023年1月在广州医科大学附属第一医院骨科进行住院医师规范化培训的医生作为研究对象,将其随机分为对照组和试验组,试验组57名,其中男51名,女6名;对照组56名,其中男50名,女6名。试验组采用PBLEBM教学法,对照组采用传统教学方法,教学结束后均对2组进行出科考评及教学效果评估。结果试验组出科考评成绩为(92.5±0.22)分,对照组出科考评成绩为(87.6±0.38)分;提高医学文献检索及数据研判能力[试验组(93.5±0.20)分vs.对照组(90.0±0.28)分]、提高临床问题的分析能力[试验组(93.6±0.18)分vs.对照组(89.6±0.25)分]、提高解决临床问题的能力[试验组(93.4±0.25)分vs.对照组(89.1±0.21)分]、提高专业术语交流表达能力[试验组(92.6±0.27)分vs.对照组(89.3±0.23)分],试验组与对照组差异有统计学意义(P0.05)。结果显示,同传统教学法相比,PBL-EBM教学法,更有助于提高正在进行规范化培训的住院医师的综合分析和解决问题的能力,也有利于提高文献资料检索及循证医学证据的分析辨别能力。结论在骨科住院医师规范化培训临床教学中,采用PBL-EBM教学法具有可行性,有助于提高住培生主动进行文献检索、分析文献资料的最新研究成果及证据,并将其运用到临床实践中制定最佳治疗方案的能力。

关键词： PBL EBM 骨科住院医师规范化培训临床教学教学评价

A robust & weak-nucleophilicity electrocatalyst with an inert response for chlorine ion oxidation in large-current seawater electrolysis

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Journal of Energy Chemistry 2024年第3期90卷 486-495,I0011页

作者： junting Dong Chang Yu Hui Wang Lin Chen Hongling huang Yingnan Han Qianbing Wei Jieshan Qiu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina College of Chemical Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Seawater splitting into hydrogen,a promising technology,is seriously limited by the durability and tolerance of electrocatalysts for chlorine ions in seawater at large current densities due to chloride oxidation and ***,we present a robust and weak-nucleophilicity nickel-iron hydroxide electrocatalyst with excellent selectivity for oxygen evolution and an inert response for chlorine ion oxidation which are key and highly desired for efficient seawater *** a weak-nucleophilicity electrocatalyst can well match with strong-nucleophilicity OH-compared with the weak-nucleophilicity Cl^(-),resultantly,the oxidation of OH-in electrolyte can be more easily achieved relative to chlorine ion oxidation,confirmed by ethylenediaminetetraacetic acid disodium probing ***,no strongly corrosive hypochlorite is produced when the operating voltage reaches about 2.1 V ***,a potential that is far beyond the thermodynamic potential of chlorine ion oxidatio *** concept and approach to reasonably designing weaknucleophilicity electrocatalysts that can greatly avoid chlorine ion oxidation under alkaline seawater environments can push forward the seawater electrolysis technology and also accelerate the development of green hydrogen technique.

关键词： Nickel-iron hydroxide electrocatalysts Highly selective seawater electrolysis Weak nucleophilicity Oxygen evolution reaction Hydrogen

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基于役龄回退的露天矿采剥计划优化研究

露天采矿技术 2024年第1期39卷 11-16页

作者：宋波田凤亮王忠鑫黄俊婷王磊辛凤阳曾祥玉中煤科工集团沈阳设计研究院有限公司沈阳110015 煤炭科学研究总院沈阳露天采矿技术研究分院沈阳110015 辽宁工程技术大学矿业学院辽宁阜新123000

目前采用的“以剥采比分期均衡为目标进行排产”的采剥工程计划设计理论,在实际工程应用过程中难以实现“矿山主要开采设备数量均衡稳定”的目标。基于此,凝练了设备有效生产能力参考基线及退化轨迹、主采设备分期均衡配置的均衡期动态... 详细信息

目前采用的“以剥采比分期均衡为目标进行排产”的采剥工程计划设计理论,在实际工程应用过程中难以实现“矿山主要开采设备数量均衡稳定”的目标。基于此,凝练了设备有效生产能力参考基线及退化轨迹、主采设备分期均衡配置的均衡期动态优化、综合开采工艺系统间协同运行策略问题的混合多目标优化与博弈方法3个关键科学问题;提出了各类设备作业性能退化状态建模、各系统设备配置的均衡期动态寻优建模及算法求解、多系统协同运行策略优化建模及算法求解等重点攻关任务;提供了自然采剥比条件下主采设备数量分期均衡方法、综合开采工艺设备配置整体优化方法、全生命周期采剥计划反演理论等关键技术。

关键词：露天矿采剥计划役龄回退剥采比采矿优化

基于DE-SARIMA方法的机组产出量预测

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现代信息科技 2024年第12期8卷 116-120页

作者：黄俊婷王忠鑫滕用秋宋波曾祥玉白仁喜中煤科工集团沈阳设计研究院有限公司辽宁沈阳110015 国网辽宁省电力有限公司沈阳供电公司辽宁沈阳110052 国家能源集团煤炭运输部北京100010

获得高精度机组产出量预测是维持钢铁企业库存量合理稳定的前提。受生产环境复杂多变和市场需求不确定性的影响,机组产出量表现出一定波动。为此,提出基于差分进化——季节性自回归整合移动平均(DE-SARIMA)的机组产出量预测方法。为提... 详细信息

获得高精度机组产出量预测是维持钢铁企业库存量合理稳定的前提。受生产环境复杂多变和市场需求不确定性的影响,机组产出量表现出一定波动。为此,提出基于差分进化——季节性自回归整合移动平均(DE-SARIMA)的机组产出量预测方法。为提高预测精度,设计带有分段迭代自适应变异策略和DBSCAN选择策略的DE算法对SARIMA模型的参数进行寻优。采用实际生产数据进行测试,验证了所提方法的有效性。

关键词： SARIMA DBSCAN DE 产出量预测

Controllable surface reconstruction of copper foam for electrooxidation of benzyl alcohol integrated with pure hydrogen production

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SmartMat 2024年第1期5卷 147-157页

作者： Yingnan Han Chang Yu Hongling huang Qianbing Wei junting Dong Lin Chen Jieshan Qiu State Key Lab of Fine Chemicals School of Chemical EngineeringLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalianChina State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijingChina

Electrocatalytic water splitting that is coupled with electrocatalytic chemical oxidation is considered as one of the promising methods for efficiently obtaining hydrogen energy and fine ***,we focus on an electrochemical redox activation strategy to rationally manipulate the microstructure and surface valence states of copper foam(CF)and boost the corresponding performance towards electrocatalytic benzyl alcohol oxidation(EBA),accompanied by the efficient hydrogen ***,the Cu(II)‐dominated species are gradually formed on the CF surface with the dissolution and redeposition of copper in the suitable potential *** new species containing Cu2O,CuO,and Cu(OH)2 during surface reconstruction process of the CF were confirmed by multiple characterization *** 220‐cycled activation(CF‐220),the activated CF achieves an increase of current density for EBA in anode from 9.5 for the original CF to 29.3 mmol/cm2,while the pure hydrogen yield increases threefold than that of the original CF at 1.5 *** produced new species can endow the CF‐220 with abundant acidity sites,which can enhance the adsorption toward Lewis‐basicity benzyl alcohol,confirmed by NH3‐temperature‐programmed *** situ Raman result further reveals that the as‐produced CuO,Cu(OH)2,and Cu(OH)42−are the main active species toward the EBA process.

关键词： benzyl alcohol copper electrochemical oxidation Lewis acid surface reconstruction

Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5394-5403页

作者： Yi Que Juan Wang Feifei Sun Shan Wang Jia Zhu junting huang Zhenzhen Zhao Li Zhang Juan Liu Jiaqian Xu Zijun Zhen Xiaofei Sun Suying Lu Yizhuo Zhang Department of Pediatric Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou510060PR China Department of Surgical Oncology National Clinical Research Center for ChildHealth and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of PediatricsChildren’s Hospital of Chongqing Medical UniversityChongqing400014China

The aim of this phase I study is to evaluate,for the first time,the safety and efficacy of sintilimab in pediatric patients diagnosed with advanced or recurrent *** the dose escalation phase,patients received a single intravenous infusion of sintilimab at varying doses of 1,3,and 10 mg/*** primary endpoints included the identification of dose-limiting toxicities(DLTs)as well as the evaluation of safety and *** endpoints focused on assessing objective response rate(ORR),progression-free survival(PFS),and overall survival(OS).A total of 29 patients were enrolled,including 10 individuals diagnosed with Hodgkin lymphoma(HL)and 19 patients with various other tumor ***,diverse pathological types such as thymoma,choroid plexus carcinoma,and NK/T-cell lymphoma were also included in the study *** the safety data cutoff,most adverse events were grade 1 or 2,with grade 3 or higher treatment-related adverse events(TRAE)occurring in 10%of *** the 27 evaluated subjects,four achieved confirmed complete response(CR)while seven patients exhibited confirmed partial response(PR).Additionally,seven patients maintained disease(SD)during the study ***,sintilimab demonstrated remarkable tolerability without DLTs and exhibited promising anti-tumor effects in pediatric ***-exome sequencing(WES)was conducted in 15 patients to assess the mutational landscape and copy number variation(CNV)*** completion of this phase I study establishes the foundation for potential combination regimens involving sintilimab in childhood cancer *** trial is registered on *** with the identifier NCT04400851.

关键词： patients doses phase

Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

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Chinese Physics C 2024年第9期48卷 1-7,300页

作者： Xiaoying Lu Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Lisheng Geng Karl Giboni Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di huang junting huang Zhou huang Ruquan Hou Yu Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu Congcong Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed Xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen Lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Xu Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Yuan Wu Mengjiao Xiao Xiang Xiao Kaizhi Xiong Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Wei Zhang Yang Zhang Yingxin Zhang Yuanyuan Zhang Li Zhao Jifang Zhou Ning Zhou Xiaopeng Zhou Yubo Zhou Zhizhen Zhou Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Jinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan Province Liangshan 615000China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Peking UniversityBeijing 100871Ch

The proton-proton(pp)fusion chain dominates the neutrino production in the *** uncertainty of the predicted pp neutrino flux is at the sub-percent level,whereas that of the best measurement is O(10%).In this study,for the first time,we measure solar pp neutrinos in the electron recoil energy range from 24 to 144 keV using the PandaX-4T commissioning data with 0.63 tonne×year *** pp neutrino flux is determined as(8.0±3.9(stat)±10.0(syst))×1010 s^(-1)cm^(-2),which is consistent with the Standard Solar Model and existing measurements,corresponding to an upper flux limit of 23.3×10^(10)s^(-1)cm^(-2)at 90%C.L..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum

HIGHLY SELECTIVE CATALYTIC DIMERIZATION OF PHENYLACETYLENE BY CYCLOPENTADIENYL RUTHENIUM COMPLEXES

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Chinese Journal of Catalysis 1999年第4期20卷 4-5页

作者： Jin junting, huang Jiling, Tao Xiaochun, Qian Yanlong (Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237) 华东理工大学金属有机化学国家重点实验室上海 200237

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关键词： dimerization phenylacetylene ruthenium complex substituted cyclopentadiene

An orbitofrontal cortex to midbrain projection modulates neuropathic pain

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解剖学杂志 2021年第S1期44卷 87-88页

作者： junting huang Zizhen Zhang Eder Gambeta Lina Chen Gerald W.Zamponi Department of Anatomy and Neurobiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Physiology and Pharmacology Hotchkiss Brain InstituteAlberta Children's Hospital Research InstituteCumming School of MedicineUniversity of CalgaryCalgaryABT2N 4N1Canada

Neuropathic pain is a long term and common pain disorder in clinics that is refractory to treatment,however,the neural substrates and underlying mechanisms are poorly *** the com bination of neuronal mapping,optogenetics,chemogenetics,eletrophysiological recording,in vivo fiber photometry and behavioral testing,we previously identified a new neural circuit of BLA-mPFC-vIPAG and its key role in encoding and modulation of the spared nerve injury(SNI)-induced neuropathic pain..Here we report that the V M-vlOFC-vIPAG circuit modulates neuropathic pain and dissects the underlying mechanisms at cellular and circuitry level.

关键词： pain projection neural