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The role of ubiquitination and deubiquitination in the regulation of cell junctions

Protein & Cell 2018年第9期9卷 754-769页

作者： junting cai Miranda K. Culley Yutong Zhao Jing Zhao Acute Lung Injury Center of Excellence Division of Pulmonary Asthma and Critical Care Medicine Department of Medicine The University of Pittsburgh Pittsburgh PA 15213 USA Xiangya Hospital of Central South University Changsha 410008 China

Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death. Disruption of cell junctions is implicated in a variety of human disorders, such as inflammatory diseases and cancers. Understanding molecular regulation of cell junctions is important for development of therapeutic strategies for intervention of human diseases. Ubiquitination is an important type of post-translational modification that primarily regulates endogenous protein stability, recep- tor internalization, enzyme activity, and protein-protein interactions. Ubiquitination is tightly regulated by ubiq- uitin E3 ligases and can be reversed by deubiquitinating enzymes. Recent studies have been focusing on inves- tigating the effect of protein stability in the regulation of cell-cell junctions. Ubiquitination and degradation of cadherins, claudins, and their interacting proteins are implicated in epithelial and endothelial barrier disruption. Recent studies have revealed that ubiquitination is involved in regulation of Rho GTPases＇ biological activities. Taken together these studies, ubiquitination plays a critical role in modulating cell junctions and motility. In this review, we will discuss the effects of ubiquitination and deubiquitination on protein stability and expression of key proteins in the cell-cell junctions, including junction proteins, their interacting proteins, and small Rho GTPases. We provide an overview of protein stability in modulation of epithelial and endothelial barrier integrity and introduce potential future search directions to better understand the effects of ubiquitination on human disorders caused by dysfunction of cell junctions.

关键词： cell-cell junctions protein stability ubiquitination deubiquitination Rho GTPases

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儿童药物中毒

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中国小儿急救医学 2018年第2期25卷 94-99页

作者：蔡昀庭朱晓东澳门镜湖医院儿科 999078 上海交通大学医学院附属新华医院小儿重症医学科 200092

儿童药物中毒为最常见儿童意外事件之一，比例逐年上升，其中镇痛药、非甾体类抗炎药和抗组胺药是最常见的导致中毒的药物。药物中毒处理原则首要是稳定生命体征的对症支持治疗，再是中毒药物的解毒治疗。近年的研究已不再建议将洗胃作... 详细信息

儿童药物中毒为最常见儿童意外事件之一，比例逐年上升，其中镇痛药、非甾体类抗炎药和抗组胺药是最常见的导致中毒的药物。药物中毒处理原则首要是稳定生命体征的对症支持治疗，再是中毒药物的解毒治疗。近年的研究已不再建议将洗胃作为常规药物中毒的治疗，推荐活性炭的使用。当重症或特殊情况发生时，可考虑使用机械通气、血液净化和体外膜肺氧合等高级生命支持技术的应用。

关键词：药物中毒儿童

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不同热加工方式对华贵栉孔扇贝蛋白与多糖结构及消化特性的影响

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食品与发酵工业 2022年第24期48卷 52-60页

作者：蔡君婷曹文红陈忠琴高加龙郑惠娜林海生秦小明广东海洋大学食品科技学院国家贝类加工技术研发分中心(湛江)广东省水产品加工与安全重点实验室广东省海洋食品工程技术研究中心广东省海洋生物制品工程实验室水产品深加工广东普通高等学校重点实验室广东湛江524088 海洋食品精深加工关键技术省部共建协同创新中心大连工业大学辽宁大连116034

为探究热加工处理对华贵栉孔扇贝蛋白、多糖结构与消化特性的具体影响规律,该研究对华贵栉孔扇贝进行蒸制(100℃,5 min)、油炸(150℃,2 min)及烤制(200℃,10 min)3种热加工处理,采用红外光谱、扫描电镜和体外模拟消化法,比较分析热加工... 详细信息

为探究热加工处理对华贵栉孔扇贝蛋白、多糖结构与消化特性的具体影响规律,该研究对华贵栉孔扇贝进行蒸制(100℃,5 min)、油炸(150℃,2 min)及烤制(200℃,10 min)3种热加工处理,采用红外光谱、扫描电镜和体外模拟消化法,比较分析热加工前后扇贝蛋白与多糖的含量、结构及体外消化特性变化。结果表明,热加工处理导致扇贝的盐溶性蛋白和水溶性蛋白含量显著降低(P0.05)。以上实验结果表明,热加工能改变扇贝多糖与蛋白结构,蒸制处理更有利于扇贝蛋白与多糖的消化。研究结果可为华贵栉孔扇贝合理热加工提供参考依据。

关键词：热加工华贵栉孔扇贝蛋白质多糖结构体外消化

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Traditional Chinese Medicine syndrome-related herbal prescriptions in treatment of malignant tumors

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Journal of Traditional Chinese Medicine 2013年第1期33卷 19-26页

作者： Zhizhen Liu Songyi Chen Jing cai Enda Zhang Lan Lan junting Zheng Lianming Liao Xuemei Yang Changen Zhou Jian Du The Academy of Integrative Medicine of Fujian University of TCM Department of Traditional Chinese Medicine The People's Hospital Affiliated Fujian University of TCM Fujian Medical University

OBJECTIVE： To investigate the distribution characteristics of TCM syndromes and the related herbal prescriptions for malignant tumors （MT）. METHODS： A clinical database of the TCM syndromes and the herbal prescriptions in treatment of 136 MT patients were established. The data were then analyzed using cluster and frequency analysis. RESULTS： According to the cluster analysis, the TCM syndromes in MT patients mainly included two patterns： deficiency of both Qi and Yin and internal accumulation of toxic heat. The commonlyprescribed herbs were Huangqi （Astraglus）, Nuizhenzi （Fructus Ligustri Lucidi）, Lingzhi （Ganoderma Lucidum）, Huaishan （Dioscorea Opposita）, Xiakucao （Prunella Vulgaris）, and Baihuasheshecao （Herba Hedyotidis）. CONCLUSION： Deficiency of Qi and Yin is the pri- mary syndrome of MT, and internal accumulation of toxic heat is the secondary syndrome. The herbs for Qi mainly heat-cl supplementation and Yin houris used, with earance and the assistance of detoxification. hment are herbs for

关键词： Carcinoma Syndromes Benefiting QiOr nourishing Yin Complementary therapies Clus-er analysis Data mining

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m^(6)A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels

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Cancer Communications 2022年第4期42卷 327-344页

作者： Yinan Liu Ertao Zhai junting Chen Yan Qian Risheng Zhao Yan Ma Jianqiu Liu Zhixin Huang Shirong cai Jianhui Chen Division of Gastrointestinal Surgery Center the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Gastric Cancer Center Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Laboratory of Surgery the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China

Background:Methyltransferase 3(METTL3)-mediated N6-methyladenosine(m^(6)A)RNA modification has been demonstrated to be a potential factor in promoting gastric cancer(GC).METTL3 regulates a series of signaling pathways by modifying various *** study aimed to identify novel METTL3-mediated signaling pathways and explored possible targets for use in the clinical setting of gastric ***:To investigate the proliferation and metastatic capacity ofGCcell lines with METTL3 knockdown,a xenograft,lung metastasis,and popliteal lymph node metastasis model was ***^(6)A-modified RNA immunoprecipitation(Me-RIP)sequence was utilized to explore the target mRNAs of *** counting kit 8 and transwell assays were performed to investigate the promoting function of pre-B cell leukemia homeobox 1(PBX1)and GTP cyclohydrolase 1(GCH1).Western blotting and chromatin immunoprecipitation were employed to confirm the involvement of the METTL3-PBX1-GCH1 *** and liquid chromatography-mass spectrometry were used to explore the biological function of tetrahydrobiopterin(BH_(4)).Results:Knockdown of METTL3 suppressed xenograft tumor growth and lung/lymph node metastasis in ***,we found that METTL3 combined with and stabilized PBX1 *** immunoprecipitation(ChIP)and further experiments suggested that PBX1 acted as a transcription factor inducing GCH1 ***,the METTL3-PBX1-GCH1 axis increased BH_(4)levels in GC cells,thereby promoting tumor ***:This study suggested that METTL3 enzymes promote tumor growth and lung/lymph node metastasis via METTL3-PBX1-GCH1 axis increasing BH_(4)levels in GC.

关键词： BH_(4) gastric cancer GCH1 m^(6)A metabolism reprogramming metastasis METTL3 PBX1 proliferation

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Optimization of Injection Parameters for Profile Control and Flooding in an Oilfield during High Water Cut Period

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Journal of Geoscience and Environment Protection 2023年第11期11卷 73-81页

作者： Meinan Wang Hui cai Xiaoqi Chen junting Zhang Yue Xie Bohai Oilfield Research Institute of CNOOC Ltd. Tianjin Branch Tianjin China

In order to improve the effect of water control and oil stabilization during high water cut period, a mathematical model of five point method well group was established with the high water cut well group of an Oilfield as the target area, the variation law of water cut and recovery factor of different injection parameters was analyzed, and the optimization research of injection parameters of polymer enhanced foam flooding was carried out. The results show that the higher the injection rate, the lower the water content curve, and the higher the oil recovery rate. As the foam defoamed when encountering oil, when the injection time was earlier than 80% of water cut, the later the injection time was, the better the oil displacement effect would be. When the injection time was later than 80% of water cut, the later the injection time was, the worse the oil displacement effect would be. The larger the injection volume, the lower the water content curve and the higher the recovery rate. After the injection volume exceeded 0.2 PV, the amplitude of changes in water content and recovery rate slowed down. The optimal injection parameters of profile control agent for high water content well group in Oilfield A were: injection rate of 15 m3/d, injection timing of 80% water content, and injection volume of 0.2 PV.

关键词： High Water Cut Period Profile Control Injection Rate Injection Timing Injection Volume

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一种高效星载功率调节与配电单元设计与实现

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航天器工程 2024年第1期33卷 42-48页

作者：蔡晓东杜青徐泽锋张俊亭杨袆夏宁王超北京空间飞行器总体设计部北京100094 上海空间电源研究所上海200245

文章结合深空探测供配电分系统任务特点,提出功率调节、配电、火工控制等多功能模块轻小型一体化设计的必要性。介绍了国外功率调节与配电单元的研究现状、国产功率调节与配电单元研制的意义,功率调节与配电单元组成及功能设计,并通过... 详细信息

文章结合深空探测供配电分系统任务特点,提出功率调节、配电、火工控制等多功能模块轻小型一体化设计的必要性。介绍了国外功率调节与配电单元的研究现状、国产功率调节与配电单元研制的意义,功率调节与配电单元组成及功能设计,并通过多母线融合设计、多路放电均流设计、单元集成化设计等关键技术,解决了深空探测器高可靠轻小型化功率调节与配电单元设计难题。在轨飞行结果表明:功率调节与配电单元功能正常,工作可靠,性能优良。功率调节与配电单元的国产化设计实现,可为其它航天器的设计提供参考和借鉴。

关键词：深空探测高功率质量比功率调节与配电单元

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Investigation on the electrode surface roughness effects on a repetitive self-breakdown gas switch

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Plasma Science and Technology 2022年第6期24卷 182-188页

作者： Fanzheng ZENG Song LI Hao cai Quancai ZHANG Jinhong WEI junting WANG Zhaohua LIU Lei WANG Jingming GAO Hong WAN Baoliang QIAN College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073People's Republic of China The 93986 Unit Hotan 848000People's Republic of China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073People's Republic of China

In this work,the influence of the electrode surface roughness on the self-breakdown gas switch is investigated by physical analysis,computer simulation and ***-W electrodes of different surface roughness were tested under the conditions of a pulse repetitive frequency of50 Hz,self-breakdown voltage of~30 kV,and peak current of~2 k A for~93000 shots(the total charge transferred was~15 C).The coefficients of variation of the self-breakdown voltage of Cu-W 0.8,Cu-W 3.2 and Cu-W 12.5 electrodes were~2.95%,~1.62%and~1.16%,*** the increase of electrode roughness,the erosion area decreased continuously,indicating that the breakdown positions were more stable and the coefficient of variation of breakdown voltage *** method showed that decreasing the coefficient of variation of the self-breakdown voltage by increasing the surface roughness of electrode greatly improves the stability of the self-breakdown switch,which is significant for their application in compact highpower pulse power devices over a long time with stable operation.

关键词： gas switch self-breakdown surface roughness coefficient of variation

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低碳水化合物饮食对糖尿病影响的研究进展

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糖尿病新世界 2021年第16期24卷 194-198页

作者：傅浩魏嘉禾蔡俊挺高梦源朱冰姿邓腊梅杭州医学院公共卫生学院浙江杭州310053 杭州医学院临床医学院浙江杭州310053 杭州医学院检验医学院浙江杭州310053 杭州医学院团委浙江杭州310053

糖尿病是一组以慢性高血糖为特征的代谢性疾病。研究饮食疗法对糖尿病控制具有重要意义。低碳水化合物饮食(LCD)作为一种严格限制碳水化合物量消耗的饮食模式,近年来推荐作为糖尿病预防和干预的重要饮食方案,但有研究显示长期LCD会使糖... 详细信息

糖尿病是一组以慢性高血糖为特征的代谢性疾病。研究饮食疗法对糖尿病控制具有重要意义。低碳水化合物饮食(LCD)作为一种严格限制碳水化合物量消耗的饮食模式,近年来推荐作为糖尿病预防和干预的重要饮食方案,但有研究显示长期LCD会使糖尿病患者安全性和有效性降低。目前关于LCD对糖尿病长短期影响的相关性研究在国内开展和报道较少,导致LCD对糖尿病的影响一直存在争议。该文对近年来国内外有关LCD对糖尿病影响的相关性研究作一综述,为预防糖尿病及制订安全且合理的饮食干预提供科学依据。

关键词：低碳水化合物饮食糖尿病饮食模式

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Bioinformatics Analysis Revealed Potential Tumor Suppressors (KLF4/CGN), Oncogenes (SHH/LIF) and Biomarkers of Asian Stomach Adenocarcinoma

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Yangtze Medicine 2021年第2期5卷 141-156页

作者： Yang Zhou Yingying Wang junting Cheng Ying Zhang Wenqi cai Ziwen Han Moyu Wang Qi Huang Xiaochun Peng Hongwu Xin Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Biochemistry and Molecular Biology School of Basic Medicine Health Science Center Yangtze University Jingzhou China Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Pathophysiology School of Basic Medicine Health Science Center Yangtze University Jingzhou China

Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer and the third leading cause of cancer-related death in the world and is more common in Asia than in most Western countries. There is an urgent need to identify potential novel oncogenes and tumor suppressor genes, and biomarkers for STAD. 6652 differentially expressed genes were identified between STAD and normal samples based on the transcriptome data analysis of the TCGA and GEO databases. 13 key modules were identified in STAD by WGCNA analysis. 293 potential STAD associated genes were identified from intersection by Venn Diagram. The 293 intersected genes were enriched in cell cortex and infection by GO and KEGG analysis. 10 hub genes were identified from PPI and Cytoscape analyses of the intersected genes. KLF4/CGN low and SHH/LIF high expression were associated with short overall survival of Asian STAD patients. Bioinformatics analysis revealed potential novel tumor suppressors (KLF4/CGN), oncogenes (SHH/LIF) and biomarkers for diagnosis, therapy and prognosis of STAD, specifically for Asian patients.

关键词： WGCNA (Weighted Correlation Network Analysis) Tumor Suppressors Oncogenes Stomach Adenocarcinoma (STAD) Hub Gene

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