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高层中庸型领导对中层管理者建言行为影响研究

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武汉理工大学学报（信息与管理工程版） 2024年第3期46卷 426-432页

作者：张俊婷丰超陈慧王魁南京航空航天大学经济与管理学院江苏南京210016 南京师范大学金陵女子学院江苏南京210023 暨南大学管理学院广东广州510632

中层管理者作为组织知识管理者、创新执行者及方案整合者的结合体,其建言行为对高层领导有效决策、组织管理创新至关重要,如何激发中层管理者建言行为日趋迫切。为此,基于社会认知理论,探究高层中庸型领导对中层管理者建言行为的影响。... 详细信息

中层管理者作为组织知识管理者、创新执行者及方案整合者的结合体,其建言行为对高层领导有效决策、组织管理创新至关重要,如何激发中层管理者建言行为日趋迫切。为此,基于社会认知理论,探究高层中庸型领导对中层管理者建言行为的影响。通过两阶段自我报告的问卷调研,分析312位企业中层管理者的实证数据,研究结果表明:高层中庸型领导正向作用于中层管理者建言行为;心理安全感在高层中庸型领导与中层管理者建言行为之间起中介作用;非正式地位在中层管理者心理安全感与其建言行为之间具有负向调节效应。

关键词：高层中庸型领导中层管理者建言行为心理安全感非正式地位社会认知理论

CVC工作辊热辊型演变机理及其对板形的影响

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钢铁 2024年第8期59卷 83-93页

作者：赵海金李旭张君婷邢俊芳廖哲陈丰田志强东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110819 天津荣程联合金属制品有限公司热轧厂天津300457 承德钒钛新材料有限公司板带事业部河北承德067102

CVC技术是20世纪80年代出现的先进的板形控制技术,该技术通过轧机工作辊轴向横移获得所需辊缝凸度,从而控制出口带钢板形。热轧过程中CVC工作辊的热辊型变化对辊缝凸度影响显著,精确预报工作辊的热辊型对提高带钢板形控制精度和减小轧... 详细信息

CVC技术是20世纪80年代出现的先进的板形控制技术,该技术通过轧机工作辊轴向横移获得所需辊缝凸度,从而控制出口带钢板形。热轧过程中CVC工作辊的热辊型变化对辊缝凸度影响显著,精确预报工作辊的热辊型对提高带钢板形控制精度和减小轧辊磨损有着重要的意义。以某厂1780 mm带钢热连轧生产线为研究对象,运用大型有限元分析软件ANSYS/LS-DYNA分别建立第4机架的工作辊三维热凸度有限元仿真模型和三维有限元轧制仿真模型。分析不同轧制时间、轧制速度、轧制间隙时间等轧制工艺对热辊型的影响。将不同轧制工艺下得到的热辊型代入到轧制仿真模型中,分析不同轧制工艺下的热辊型对带钢板形的影响。轧制初期工作辊热辊型发生明显变化,工作辊热凸度增加,带钢凸度降低,4000 s后工作辊热辊型达到稳定状态,带钢凸度不再变化;轧制速度对热辊型影响较小,在热凸度稳定后对板形影响较小;工作辊随着轧制间歇时间的增加,冷却时间增加,热膨胀量减小,导致带钢凸度增加;随着带钢宽度的增大,工作辊边部吸收热量增加,工作辊热辊型边部发生明显变化,带钢凸度增大。仿真结果表明,轧制时间、轧制间隙时间、带钢宽度对板形影响较大,轧制速度影响较小,研究成果能为现场轧辊原始辊型曲线设计和板形控制提供参考。

关键词：热辊型 CVC工作辊板形有限元分析温度场

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晶状体核密度测量方法的研究进展

国际眼科纵览 2024年第3期48卷 194-199页

作者：安俊烨袁萍张鋆婷王韬易昀敏南昌大学附属眼科医院南昌330006

晶状体核密度不仅能客观反映核性白内障患者的晶状体浑浊程度,也能间接评估白内障超声乳化手术难度及术后视力恢复情况。目前国际通用的LOCS Ⅲ分级法及我国的Emery分级法均是通过对晶状体核的浑浊程度、颜色进行主观分级,属于定性分析... 详细信息

晶状体核密度不仅能客观反映核性白内障患者的晶状体浑浊程度,也能间接评估白内障超声乳化手术难度及术后视力恢复情况。目前国际通用的LOCS Ⅲ分级法及我国的Emery分级法均是通过对晶状体核的浑浊程度、颜色进行主观分级,属于定性分析,有一定的不可重复性。近年来,客观的晶状体核密度测量方法如Scheimpflug技术及OCT技术等不断出现,不仅可提高测量的准确性和可重复性,还可结合机器深度学习进行自动化预测白内障分级,有利于白内障患者的精细化术前评估。

关键词：白内障晶状体核密度

老年急性缺血性脑卒中后认知功能障碍预测模型的初步建立

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卒中与神经疾病 2024年第2期31卷 132-136,142页

作者：张竣婷关卓滕海艳王恩石魏然哈尔滨医科大学附属第一医院神经内科 150001

目的建立老年急性缺血性脑卒中(Acute ischemic stroke, AIS)后认知功能障碍(Post-stroke cognitive impairment, PSCI)的预测模型,并对其预测效能进行初步评价。方法回顾性选取2020年1月-2022年12月哈尔滨医科大学附属第一医院治疗的... 详细信息

目的建立老年急性缺血性脑卒中(Acute ischemic stroke, AIS)后认知功能障碍(Post-stroke cognitive impairment, PSCI)的预测模型,并对其预测效能进行初步评价。方法回顾性选取2020年1月-2022年12月哈尔滨医科大学附属第一医院治疗的236例老年AIS患者,根据6个月内是否发生PSCI,将其分为PSCI组114例(48.31%)和非PSCI组122例(51.69%);通过电子病历系统收集所有患者的临床资料,采用多因素Logistic回归法筛选老年AIS患者发生PSCI的危险因素,并据此构建预测模型,采用受试者工作特征(Receiver operating characteristi, ROC)曲线评估模型预测PSCI的效能。结果与非PSCI组比较,PSCI组年龄>75岁、糖尿病、衰弱的比例以及美国国立卫生研究院卒中量表(National institute of health stroke scale, NIHSS)评分、纤维蛋白原(Fibrinogen, Fib)、同型半胱氨酸、C-反应蛋白(C-reactive protein, CRP)升高,血红蛋白降低(P75岁、Fib, CRP、衰弱、NIHSS评分是老年AIS患者发生PSCI的独立危险因素;基于多因素Logistic回归分析显示,老年AIS患者发生PSCI的风险指数Cindex=-1.834+0.469×(年龄)+0.278×(Fib)+0.331×(CRP)+0.392×(衰弱)+0.503×(NIHSS);ROC曲线显示,Cindex预测老年AIS患者发生PSCI的曲线下面积(Area under the curve, AUC)为0.885(95%CI=0.842~0.928),敏感度为81.58%,特异度为84.43%,准确度为83.05%。结论年龄、Fib, CRP、衰弱、NIHSS评分是老年AIS患者发生PSCI的独立危险因素,以此构建的模型对于PSCI的识别能力良好,有助于临床实现PSCI高风险人群的筛查。

关键词：急性缺血性脑卒中脑卒中后认知功能障碍预测模型老年

双重异质性视角下城市群经济韧性的演化特征及其影响机制研究——以长三角为例

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科技与经济 2024年第1期37卷 91-95页

作者：刘程军张君婷陈展驰舒季君浙江工业大学经济学院杭州310023 浙江工业大学之江学院浙江绍兴312030

基于双重异质性视角,分析2007—2020年长三角41个城市经济韧性的演化特征及其影响机制。研究表明:长三角城市群不同阶段的经济韧性空间差异显著,且冷热点聚集区域出现了组团式动态转换;面对外来冲击时,固定投资、产业多样化、国企对经... 详细信息

基于双重异质性视角,分析2007—2020年长三角41个城市经济韧性的演化特征及其影响机制。研究表明:长三角城市群不同阶段的经济韧性空间差异显著,且冷热点聚集区域出现了组团式动态转换;面对外来冲击时,固定投资、产业多样化、国企对经济韧性解释力较强,而出口贸易解释力波动较大;在结构调整期时,固定投资对经济韧性支撑作用减弱,三产占比、财政支撑、技术创新及人力资本水平的提高加速了产业结构升级,提高中长期经济韧性;政府通过塑造产业结构及改善技术等要素错配程度影响经济韧性。

关键词：长三角城市群区域经济韧性双重异质性影响机制

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4840-4855页

作者： junting zhang Yiying Li Jianchao zhang Lu Liu Yuan Chen Xusheng Yang Xueyi Liao Muhua He Zihui Jia Jun Fan Jin-Song Bian Xiaowei Nie Shenzhen Institute of Respiratory Disease Shenzhen Key Laboratory of Respiratory DiseaseShenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Afiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Post-Doctoral Scientific Research Station of Basic Medicine JinanUniversityGuangzhou 510632China Department of Pharmacology School of MedicineSouthern University of Science and TechnologyShenzhen 518055China Lung Transplant Group Wuxi People's Hospital Affliated to Nanjing Medical UniversityWuxi 211103China Department of Medical Biochemistry and Molecular Biology School of MedicineJinan UniversityGuangzhou 510632China

Pulmonary hypertension(PH)is an extremely malignant pulmonary vascular disease of unknown ***1 is an RNA editing enzyme that converts adenosine in RNA to inosine,thereby affecting RNA ***,the role of ADAR1 in PH development remains *** the present study,we investigated the biological role and molecular mechanism of ADAR1 in PH pulmonary vascular *** of ADAR1 aggravated PH progression and promoted the proliferation of pulmonary artery smooth muscle cells(PASMCs).Conversely,inhibition of ADAR1 produced opposite ***-throughput whole transcriptome sequencing showed that ADAR1 was an important regulator of circRNAs in ***17 level was significantly lowered in the serum of PH *** effects of ADAR1 on cell cycle progression and proliferation were mediated by ***1 affects the stability of circCDK17 by mediating A-to-I modification at the A5 and A293 sites of circCDK17 to prevent it from mlA *** demonstrate for the first time that ADAR1 contributes to the PH development,at least partially,through m1A modification of circCDK17 and the subsequent PASMCs *** study provides a novel therapeutic strategy for treatment of PH and the evidence for circCDK17 as a potential novel marker for the diagnosis of this disease.

关键词： Pulmonary hypertension ADAR1 Circular RNA Vascular remodeling Cell proliferation

Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells

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Neuroscience Bulletin 2019年第2期35卷 216-224页

作者： Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng zhang Wenhao Wu Yu Wang Deling Li Zhen Wu junting zhang Qiaoran Xi Liwei zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical University Ministry of Education Key Laboratory of Protein Sciences School of Life Sciences Tsinghua University

Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among *** now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the *** we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG.

关键词： Diffuse intrinsic pontine glioma Neural progenitor cells Immortalization H3K27M Senescence

Human brain arteriovenous malformation:an analysis of differential expressed genes

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Chinese Neurosurgical Journal 2017年第1期3卷 21-26页

作者： Xing Liu Guolu Meng Tengfei Yu Xiangjiang Lin Liwei zhang junting zhang Zhen Wu Shengze Deng Shuo Wang Jizong Zhao Department of Pediatric Surgery Yongchuan Hospital of Chongqing Medical University 439 Xuanhua Road Yongchuan District Chongqing People's Republic of China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University 6 Tiantan Xili Chongwen District Beijing 100050 People's Republic of ChinaChina National Clinical Research for Neurological Diseases Beijing People's Republic of China

Background:Much still remains unknown about the pathogenesis of brain arteriovenous malformations (AVMs).Previous studies have revealed the abnormal expression of various angiogenesis-related genes in *** further understand this disease,we sought to identify genes differently expressed in AVMs by means of the gene microarray ***:Nine AVMs specimen and nine samples of normal vessels are *** RNA isolated from these specimen is hybridized with Oligonucleotide array and gene analysis was *** data with the help of significance analysis of microarrays (SAM) and a free web-based molecular annotation system 3.0 (MAS 3.0).Results:The SAM method identify 37 gene significantly up-regulated and 10 genes down-regulated in ***:Among those genes,VACN,SPARK and ARHGAP18 seem to play a facilitating role during the genesis of *** pathways,as MAPK pathway,may also be involved.

关键词： Brain arteriovenous malformations Gene microarray technique VCAN,SPARK ARHGAP18 MAPK pathway

An Effective Thin Reservoir Identification Method for Fine Oilfield Development

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Engineering（科研） 2023年第5期15卷 342-351页

作者： Zheng Lv Xin Wang Chunyuan Shi junting zhang Bohai Oilfield Research Institute of CNOOC Ltd.-Tianjin Branch Tianjin China

Thin reservoirs prediction method such as spectral inversion has drawn considerable attention in recent years. In order to avoid extracting wavelets within the whole field area purposeless and to make the filtered data has preferable fidelity as well as signal-to-noise ratio, an effective structural constrained thin reservoir description method which combines spectral inversion and wide-band Ricker wavelet filtering technology has been proposed in this paper. The method given here is more credible and is suitable for the prediction of middle-deep thin reservoirs. We take LD-A structure within Bohai Bay Basin as an example to show the implement of our method. Several sets of thin sand layers which are hardly to recognize originally have been finally identified. Also, with the application of this method, a high-production thin reservoir of LD-B structure has been identified accurately, which provides credible information for subsequent fine oil exploration and development.

关键词： Structure Constrained Thin Reservoir Spectral Inversion Wide-Band Ricker Wavelet Exploration and Development