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护生实习前死亡态度的现状及影响因素

河南医学研究 2024年第14期33卷 2600-2603页

作者：贾英岚贾亚南张君瑞郭新真郑州大学第一附属医院河南郑州450000

目的调查护生在进入临床实习前死亡态度的现状并分析其影响因素,为临床开展死亡教育培训提供参考依据。方法采用便利抽样法,于2022年6月选取来自河南省11所院校在郑州市某三甲医院即将进入临床实习阶段的408名护生为研究对象。采用一般... 详细信息

目的调查护生在进入临床实习前死亡态度的现状并分析其影响因素,为临床开展死亡教育培训提供参考依据。方法采用便利抽样法,于2022年6月选取来自河南省11所院校在郑州市某三甲医院即将进入临床实习阶段的408名护生为研究对象。采用一般资料问卷和中文版死亡态度描绘量表进行调查,并对其影响因素进行分析。结果408名护生死亡态度得分为(89.73±18.74)分,量表各维度得分从高到低依次是:自然接受、死亡逃避、死亡恐惧、趋近接受、逃离接受。单因素分析结果显示,自己宗教信仰、自认为身体状况、自认为心理状况、家中谈论死亡情景、照顾过濒死/危重的人是护生进入临床实习前死亡态度的影响因素(P<0.05)。多重线性回归分析结果显示,影响护生死亡态度的因素包括宗教信仰、自觉身体状况、家中谈论死亡的情景(P<0.05),能解释总变异的14.8%。结论在临床带教过程中,护理管理者及带教老师应正确引导护生正确看待死亡,采取个性化的死亡教育培训,构建适合实习护生的死亡教育课程体系,培养护生正确的生死观。

关键词：护生死亡态度影响因素

Application of Improved Point Cloud Streamlining Algorithm in Point Cloud Registration

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Application of Improved Point Cloud Streamlining Algorithm i...

拟杆菌属临床分离株耐药性及脆弱拟杆菌肠毒素bft基因分型特征分析

第32届中国控制与决策会议

作者： Liu Meiju Zhao junrui guo Xifeng Zhuang Rui School of Information and Control Engineering Shenyang Jianzhu University

ISBN: (数字)9781728158556

ISBN: (纸本)9781728158563

Collect point cloud data of objects with commonly used 3 D scanning equipment,the resulting point cloud data is *** point cloud registration algorithms cannot guarantee both efficiency and *** this end,combining octree-based K-means clustering point cloud streamlining algorithm with an ICP algorithm with improved weight *** using K-values of octree solid leaf nodes as mean clustering algorithm and initial clustering center,Calculate the root mean square curvature of each point and the average of the root mean square curvature of all points,the average Euclidean distance from each point to the cluster center and the average Euclidean distance from each point to the cluster center,and use this as a streamlined point cloud Data *** a set of iteration method with variable weights during each iteration of the ICP algorithm to enhance the robustness of the algorithm,Experimental results show that the resistance of the algorithm is very robust,and it improves the defects of compound iteration and improves the registration efficiency.

关键词： Point cloud Cloud Streamlining Octree Mean Clustering Iteration method with variable weights

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检验医学 2024年第1期39卷 47-52页

作者：王艳艳王俊瑞郑文琪兰海霞郭素芳内蒙古医科大学附属医院检验科内蒙古呼和浩特100050 解放军第九六九医院儿科内蒙古呼和浩特100051

目的分析拟杆菌属临床分布及其耐药特征,并探讨脆弱拟杆菌肠毒素bft基因分型特征。方法收集2016年6月—2019年6月内蒙古医科大学附属医院分离自临床样本的拟杆菌属147株,对其进行菌种鉴定和体外药物敏感性试验。采用聚合酶链反应(PCR)... 详细信息

目的分析拟杆菌属临床分布及其耐药特征,并探讨脆弱拟杆菌肠毒素bft基因分型特征。方法收集2016年6月—2019年6月内蒙古医科大学附属医院分离自临床样本的拟杆菌属147株,对其进行菌种鉴定和体外药物敏感性试验。采用聚合酶链反应(PCR)检测脆弱拟杆菌肠毒素bft基因。结果 147株拟杆菌属细菌中,脆弱拟杆菌100株(68.0%)、多形拟杆菌25株(17.0%)、卵形拟杆菌9株(6.1%)。体外药物敏感性试验结果显示,拟杆菌属细菌对克林霉素的耐药率最高(78.9%);脆弱拟杆菌对克林霉素的耐药率为85.0%,高于其他拟杆菌(66.0%)。拟杆菌属细菌对亚胺培南和甲硝唑的耐药率分别为13.6%和4.7%,对其他抗菌药物呈不同程度耐药;脆弱拟杆菌对大部分抗菌药物的耐药率均高于其他类型拟杆菌。脆弱拟杆菌bft基因阳性率为38.0%,以bft-1亚型为主要基因型(28.0%),其次为bft-2亚型(10.0%),未检出bft-3亚型。分离自非腹部临床样本的脆弱拟杆菌bft基因阳性率(55.6%)高于分离自腹部临床样本的脆弱拟杆菌(36.3%)。结论拟杆菌属临床分离株中脆弱拟杆菌分离率最高,其对临床常用抗菌药物均有一定的耐药性。分离自非腹部临床样本的脆弱拟杆菌产肠毒素的菌株流行率更高,应引起临床重视。

关键词：拟杆菌属脆弱拟杆菌耐药性 bft基因

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基于SVM模型的排水采气效果预测研究

海洋石油 2024年第3期44卷 62-66页

作者：陆国琛葛俊瑞秦丙林郭志辉田天王颖中国石油化工股份有限公司上海海洋油气分公司石油工程技术研究院上海200120 中海石油(中国)有限公司上海分公司上海200335

为解决目前排水采气工艺效果预测不佳的问题,以涡流排水采气为例,采用SVM(support vector machine)模型进行效果预测,充分考虑地层压力、油藏中深、孔隙度、渗透率、产水量、产气量、气水比等影响涡流排采效果的因素,收集7个区块涡流排... 详细信息

为解决目前排水采气工艺效果预测不佳的问题,以涡流排水采气为例,采用SVM(support vector machine)模型进行效果预测,充分考虑地层压力、油藏中深、孔隙度、渗透率、产水量、产气量、气水比等影响涡流排采效果的因素,收集7个区块涡流排水采气影响因素参数作为输入向量,平均单井日增气量和平均单井日增水量作为输出向量,通过样本训练确定SVM模型最优惩罚参数C为22.1453,最优的γ为0.30885,控制误差为0.01。利用建立的SVM模型对T气田C1、C8井涡流排采生产情况进行预测,并与实际生产情况进行对比,结果表明平均单井日增气量相对误差为8.57%,平均单井日增水量相对误差为7%。研究表明基于SVM涡流排水采气效果预测模型预测值与实际值接近,模型预测结果准确可靠。

关键词： SVM模型排水采气效果预测气田

Establishment of an optimized CTC detection model consisting of EpCAM,MUC1 and WT1 in epithelial ovarian cancer and its correlation with clinical characteristics

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Chinese Journal of Cancer Research 2022年第2期34卷 95-108页

作者： Tongxia Wang Yan Gao Xi Wang junrui Tian Yuan Li Bo Yu Cuiyu Huang Hui Li Huamao Liang David M.Irwin Huanran Tan Hongyan guo Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Pharmacology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Laboratory Medicine and Pathobiology University of TorontoToronto M5S1A8Canada

Objective:Emerging studies have demonstrated the promising clinical value of circulating tumor cells(CTCs)for diagnosis,disease assessment,treatment monitoring and prognosis in epithelial ovarian ***,the clinical application of CTC remains restricted due to diverse detection techniques with variable sensitivity and specificity and a lack of common ***:We enrolled 160 patients with epithelial ovarian cancer as the experimental group,and 90 patients including 50 patients with benign ovarian tumor and 40 healthy females as the control *** enriched CTCs with immunomagnetic beads targeting two epithelial cell surface antigens(EpCAM and MUC1),and used multiple reverse transcription-polymerase chain reaction(RT-PCR)detecting three markers(EpCAM,MUC1 and WT1)for *** then we used a binary logistic regression analysis and focused on EpCAM,MUC1 and WT1 to establish an optimized CTC detection ***:The sensitivity and specificity of the optimized model is 79.4%and 92.2%,*** specificity of the CTC detection model is significantly higher than CA125(92.2%vs.82.2%,P=0.044),and the detection rate of CTCs was higher than the positive rate of CA125(74.5%vs.58.2%,P=0.069)in early-stage patients(stage I and II).The detection rate of CTCs was significantly higher in patients with ascitic volume≥500 mL,suboptimal cytoreductive surgery and elevated serum CA125 level after 2 courses of chemotherapy(P<0.05).The detection rate of CTC;and CTC;was significantly higher in chemo-resistant patients(26.3%vs.11.9%;26.4%vs.13.4%,P<0.05).The median progression-free survival time for CTC;patients trended to be longer than CTC;patients,and overall survival was shorter in CTC;patients(P=0.043).Conclusions:Our study presents an optimized detection model for CTCs,which consists of the expression levels of three markers(EpCAM,MUC1 and WT1).In comparison with CA125,our model has high specificity and demonstrates better diagnostic values,especi

关键词： Circulating tumor cells epithelial ovarian cancer optimized detection model diagnosis and prognosis

井筒结垢对西湖油气井生产的影响及预测方法适用性评价

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海洋石油 2024年第2期44卷 45-50页

作者：郭志辉段英娇秦丙林葛俊瑞陆国琛王颖马海燕中国石油化工股份有限公司上海海洋油气分公司工程院上海200120 中国石油化工股份有限公司上海海洋油气分公司研究院上海200120 中海石油(中国)有限公司上海分公司上海200335

为了评价各结垢预测方法对西湖油气井的适用性,采用理论计算和软件模拟法分析了单独产出地层水、单独替入海水、海水和地层水混合3种条件下C11井井筒结垢情况,通过对比实际数据,在西湖油气井混合垢预测方面,Scalechem软件方法具有更强... 详细信息

为了评价各结垢预测方法对西湖油气井的适用性,采用理论计算和软件模拟法分析了单独产出地层水、单独替入海水、海水和地层水混合3种条件下C11井井筒结垢情况,通过对比实际数据,在西湖油气井混合垢预测方面,Scalechem软件方法具有更强的适用性。单一碳酸钙结垢预测方面,Ryznar法更为准确。单一硫酸盐垢预测方面,Skillman法与实际情况相匹配,分析C11井井筒结垢主要由地层出水引起,结垢类型主要为CaCO_(3)垢。对海上井筒防垢工艺展开讨论,旨在为西湖油气井结垢问题有效治理提供技术支持。

关键词：结垢预测适用性评价西湖油气井防垢工艺

OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice

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The Crop Journal 2023年第1期11卷 108-118页

作者： Xinghai Yang Baoxuan Nong Can Chen junrui Wang Xiuzhong Xia Zongqiong Zhang Yu Wei Yu Zeng Rui Feng Yanyan Wu Hui guo Haifeng Yan Yuntao Liang Shuhui Liang Yong Yan Danting Li guofu Deng Guangxi Key Laboratory of Rice Genetics and Breeding Rice Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Guangxi Key Laboratory for Polysaccharide Materials and Modifications School of Marine Sciences and BiotechnologyGuangxi University for NationalitiesNanning 530006GuangxiChina Biotechnology Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Sugarcane Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Microbiology Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina

The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental *** the N use efficiency(NUE)of rice varieties is crucial for sustainable *** we report the cloning and characterization of OsNPF3.1,a gene that controls rice *** amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated ***3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain *** OsNPF3.1 protein is located in the plasma *** OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica ***3.1 can be used as a new target gene for breeding rice varieties with high NUE.

关键词： Rice OsNPF3.1 Functional analysis Evolutionary analysis Natural variation

LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques

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Bioactive Materials 2022年第10期7卷 120-133页

作者： Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu Man Ye Yixin Zhong Shuling Liu junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing guo Department of Radiology Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444PR China Chongqing Key Laboratory of Ultrasound Molecular Imaging&Department of Ultrasound Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Radiology Children’s Hospital of Chongqing Medical UniversityChongqing400014PR China

Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular *** the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and ***,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting ***,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)*** addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging *** engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment *** specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns.

关键词： Vulnerable plaques Acoustic droplet vaporization Macrophages Apoptosis Nanomedicine

Application of improved Otsu threshold segmentation algorithm in mobile phone screen defect detection

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Application of improved Otsu threshold segmentation algorith...