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Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina Hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Facile fabrication of durable superhydrophobic fabrics by silicon polyurethane membrane for oil/water separation

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Chinese Journal of Chemical Engineering 2023年第3期55卷 73-83页

作者： Taoyan Mao Runhui Xiao Peng Liu Jiale Chen junqiang Luo Su Luo Fengwei Xie Cheng zheng School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Guangdong Debao Environmental Technology Research Co.Ltd Guangzhou 510300China School of Engineering Newcastle UniversityNewcastle upon Tyne NE17RUUnited Kingdom Guangzhou Vocational College of Science and Technology Guangzhou 510550China

Nowadays, oil contamination has become a major reason for water pollution, and presents a global environmental challenge. Although many efforts have been devoted to the fabrication of oil/water separation materials, their practical applications are still hindered by their weak durability, poor chemical tolerance,environmental resistance, and potential negative impact on health and the environment. To overcome these drawbacks, this work offers a facile method to fabricate the eco-friendly and durable oil/water separation membrane fabrics by alkaline hydrolysis and silicon polyurethane coating. The X-ray photoelectron spectroscopy, scanning electron microscopy, and atomic force microscopy results demonstrate that silicon polyurethane membrane could be coated onto the surface of hydrolyzed polyester fabric and form a micro-/nano-scaled hierarchical structure. Based on this, the modified fabric could have a stable superhydrophobic property with a water contact angle higher than 150°, even after repeated washing and mechanical abrasion 800 times, as well as chemical corrosion. Moreover, the modified fabrics show excellent oil/water separation efficiency of up to 99% for various types of oil–water mixture. Therefore, this durable, eco-friendly and cost-efficient superhydrophobic fabric has great potential in large-scale oil/water separation.

关键词： Superhydrophobic fabrics Silicon polyurethane membrane Durability Separation Polymers Waster water

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交趾黄檀家系采穗圃生长比较

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福建林业科技 2024年第1期51卷 116-119,136页

作者：张春吴培衍陈文琴郑俊强陈洲妍吴钰琳漳州市林业科技推广站福建漳州363000 福建省龙海林下国有林场福建龙海363118 漳州市芗城区森林病虫害防疫检疫站福建漳州363005 漳州市林业规划设计队福建漳州363000 福建省长泰岩溪国有林场福建长泰363900

为研究不同交趾黄檀家系在采穗圃的生长差异,于2016年在福建省龙海林下国有林场苗圃对21个交趾黄檀家系采穗圃母株生长指标进行调查。结果表明:插穗产量最大的为21号家系,穗条产量达39.42条,比家系平均值高81.24%;交趾黄檀不同家系在主... 详细信息

为研究不同交趾黄檀家系在采穗圃的生长差异,于2016年在福建省龙海林下国有林场苗圃对21个交趾黄檀家系采穗圃母株生长指标进行调查。结果表明:插穗产量最大的为21号家系,穗条产量达39.42条,比家系平均值高81.24%;交趾黄檀不同家系在主干地径、插穗产量、平均萌芽条数上存在显著或极显著差异;插穗产量与主干地径、主干树高、萌芽条数都存在极显著正相关、与萌芽高度存在显著正相关;采取熵权TOPSIS法,初步选出在采穗圃表现生长快、萌芽能力强、穗条产量高的4个家系(21、16、1、10号)。

关键词：交趾黄檀采穗圃生长量穗条产量

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漏斗胸治疗中行NUSS微创手术术后恢复效果及复发控制作用分析

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中外女性健康研究 2024年第3期 21-24页

作者：蒋寅刘连波唐振霆范明郑俊强王若男刘峰无锡市儿童医院心胸外科江苏无锡214023 无锡市人民医院胸外科江苏无锡214023

目的:探讨NUSS微创手术在漏斗胸患儿中的应用效果。方法:选择2019年1月至2021年12月本院收治的52例漏斗胸患儿,根据随机数表法将其分为A组和B组,每组26例,A组予以改良Ravitch手术治疗,B组采用微创Nuss手术治疗。观察两组疗效、心功能水... 详细信息

目的:探讨NUSS微创手术在漏斗胸患儿中的应用效果。方法:选择2019年1月至2021年12月本院收治的52例漏斗胸患儿,根据随机数表法将其分为A组和B组,每组26例,A组予以改良Ravitch手术治疗,B组采用微创Nuss手术治疗。观察两组疗效、心功能水平、围术期恢复及术后复发情况。结果:B组总有效率(100.00%)与A组(96.15%)差异不明显(P>0.05);两组患儿术后1周各项心功能指标均高于本组术前,且B组左室射血分数(LVEF)及每搏输出量(SV)水平高于A组,差异明显(P0.05);B组术后1年复发率发生率较A组低,差异明显(P<0.05)。结论:NUSS微创手术及改良Ravitch手术为临床治疗漏斗胸患儿有效的、安全的术式,但前者更有助于促进患儿术后恢复,且对于控制患儿术后复发更具优势。

关键词：漏斗胸 NUSS微创手术改良Ravitch手术

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong zheng Jialin Chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu Xiao Shangru Zhai Chuang Xue Guangping zheng Deqing Zhang Renchao Che Junye Cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

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Unveiling the time-temperature dependence of metastability of supercooled liquid using nano-calorimetry

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 119-127页

作者： Yijun Ding Lijian Song zheng Wang Ruiqi Yu junqiang Wang Lina Hu Yuanzheng Yue Edgar D.Zanotto Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong University Jinan 250061China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Experimental Teratology Shandong University Jinan 250061 China Department of Chemistry and Bioscience Aalborg UniversityAalborg 9220Denmark Department of Materials Engineering Federal University of Sao CarlosSao Carlos SP 13.565-905Brazil

There is a lack of understanding of both the conversion of an unstable glass into a metastable supercooled liquid(MSL) upon heating and the metastability of MSLs. In this study, we investigated the time-and temperature-dependent metastability of an MSL using an advanced nano-calorimetric technique. The chosen Au-based metallic glass(Au MG) allowed adequate probing of its MSL in a temperature range between 10 and 70 K above the standard glass transition temperature. We found that the survival time of the MSL state is a quadratic function of temperature. Beyond this duration threshold, the sample undergoes fast crystallization even if it is below the crystallization temperature that is measured using differential scanning *** transmission electron microscopy, we observed the formation of clusters with a partially ordered lattice structure during relaxation in the Au MG sample fabricated using a nano-calorimeter. The atomic ordering within the clusters was enhanced by increasing time and temperature in the MSL region. Once the as-produced glass entered the MSL stage upon heating followed by a quenching stage at a given rate, the mechanical properties of the quenched glass remained the same regardless of its holding temperature and duration within the MSL region. This work provides insights into the glass-MSL-crystal transformation and offers guidance for designing standard metallic glasses for property characterizations.

关键词： metallic glass supercooled liquid relaxation nucleation nano calorimetric technology

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智能精密播种机的优化设计

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农机化研究 2025年第1期47卷 114-119页

作者：吴政内蒙古机电职业技术学院呼和浩特010070

智能精密播种机是一种自动化的农业设备,可大幅提高种植效率、减少种植成本。但是,目前智能精密播种机依赖高精度的传感器、控制系统和算法来实现准确的种子投放和深度控制,需要较高的技术要求和技术支持,且对于一些不规则形状的种子或... 详细信息

智能精密播种机是一种自动化的农业设备,可大幅提高种植效率、减少种植成本。但是,目前智能精密播种机依赖高精度的传感器、控制系统和算法来实现准确的种子投放和深度控制,需要较高的技术要求和技术支持,且对于一些不规则形状的种子或大粒小种的种子,适应性较差。为此,提出了一种智能精密播种机优化方案,并使用高精度传感器和控制系统实现多功能播种,控制种子的投放量和调整播种深度,使用节能设备模块化设计和使用易于更换的部件、数据分析功能和简单易用的用户界面。最后,通过田间试验进行功能性试验,结果表明:经过优化后的智能精密播种机播种变异系数≤5%,满足播种农艺要求,可以实现准确的种子投放和深度控制,避免种植密度不均匀和深度不一致等问题,从而提高种植效率和作物品质。

关键词：智能精密播种机优化设计精度多功能性种植效率

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