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A modified double-tract reconstruction following laparoscopic proximal gastrectomy for Siewert Ⅱ adenocarcinoma of the esophagogastric junction (with video)

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第4期4卷 111-115页

作者： Boshi Fan Weian Song junqiang liu Shouyin Di Caiying Yue Taiqian Gong Department of Thoracic Surgery The Sixth Medical Center of Chinese PLA General HospitalBeijing 100048China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000China

Objective:The incidence of adenocarcinoma of the esophagogastric junction(AEG)is increasing.For patients with resectable Siewert II AEG,there is still a lack of consensus with regards to which surgical procedure can well balance survival time and quality of life.This study aims to describe a modified double-tract reconstruction(DTR)method following laparoscopic proximal gastrectomy(LPG)and to evaluate the feasibility,safety,and effects of this novel method.Method:This study retrospectively reviewed 29 patients who received modified DTR after LPG for Siewert Ⅱ AEG at a single center between August 2015 and October 2020.Clinicopathological characteristics,surgical outcomes,nutritional status and dietary ability were analyzed.Result:The mean surgical time was 206.4±39.2 min,mean intraoperative blood loss was 175.9±41.4 mL,and median postoperative hospital stay was 11 d(range,9-70 d).The early complication rate was 13.8%(n=4),and the late complication rate was 6.9%(n=2).No reflux esophagitis or reflux symptom was recorded.There were no perioperative deaths within three months post-operatively.At the third follow-up month after surgery,most patients(25/29,86.2%)were experiencing sufficient oral food intake,with a median frequency of 5 meal/d(range,3-6 meal/d).The median total weight loss was 8 kg(range,0-15 kg)and there were no case of post-operative malnutrition.Conclusion:The modified DTR method following LPG represents a novel,safe,and feasible method that provides sufficient nutritional support with few diet-related discomforts.Prospective large-scale randomized trials are now needed to validate the clinical applicability of this method.

关键词： Adenocarcinoma Esophagogastric junction Double-tract reconstruction Laparoscopic proximal gastrectomy

Comprehensive analyses of the proteome and ubiquitome revealed mechanism of high temperature accelerating petal abscission in tree peony

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Horticultural Plant Journal 2024年第1期10卷 205-222页

作者： Chunying liu Ziqi liu Yanchao Yuan Yuxi Zhang Yifu Fang junqiang Chen Shupeng Gai Key Laboratory of Plant Biotechnology in Shandong Province College of Life SciencesQingdao Agricultural UniversityQingdaoShandong 266109China Shandong Academy of Forestry JinanShandong 250014China

Tree peony(Paeonia suffruticosa Andrews)is a well-known ornamental plant with high economic value,but the short fluorescence is a key obstacle to its ornamental value and industry development.High temperature accelerates flower senescence and abscission,but the associated mechanisms are poorly understood.In this study,the tandem mass tag(TMT)proteome and label-free quantitative ubiquitome from tree peony cut flowers treated with 20℃for 0 h(RT0),20℃or 28℃for 60 h(RT60 or HT60)were examined based on morphological observation,respectively.Totally,6970 proteins and 1545 lysine ubiquitinated(Kub)sites in 844 proteins were identified.Hydrophilic residues(such as glutamate and aspartate)neighboring the Kub sites were in preference,and 36.01%of the Kub sites were located on the protein surface.The differentially expressed proteins(DEPs)and Kub-DEPs in HT60 vs RT60 were mainly enriched in ribosomal protein,protein biosynthesis,secondary metabolites biosynthesis,flavonoid metabolism,carbohydrate catabolism,and auxin biosynthesis and signaling revealed by GO and KEGG analysis,accompanying the increase of endogenous abscisic acid(ABA)accumulation and decrease of endogenous indoleacetic acid(IAA)level.Additionally,the expression patterns of six enzymes(SAMS,ACO,YUC,CHS,ANS and PFK)putatively with Kub modifications were analyzed by proteome and real-time quantitative RT-PCR.The cell-free degradation assays showed PsSAMS and PsACO proteins could be degraded via the 26 S proteasome system in tree peony flowers.Finally,a working model was proposed for the acceleration of flower senescence and abscission by high temperature.In summary,all results contributed to understanding the mechanism of flower senescence induced by high temperature and prolonging fluorescence in tree peony.

关键词： Tree peony Proteome Ubiquitome High temperature Flower senescence

Remaining useful life prognostics for aeroengine based on superstatistics and information fusion

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Chinese Journal of Aeronautics 2014年第5期27卷 1086-1096页

作者： liu junqiang Zhang Malan Zuo Hongfu Xie Jiwei College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Remaining useful life（RUL） prognostics is a fundamental premise to perform conditionbased maintenance（CBM） for a system subject to performance degradation. Over the past decades,research has been conducted in RUL prognostics for aeroengine. However, most of the prognostics technologies and methods simply base on single parameter, making it hard to demonstrate the specific characteristics of its degradation. To solve such problems, this paper proposes a novel approach to predict RUL by means of superstatistics and information fusion. The performance degradation evolution of the engine is modeled by fusing multiple monitoring parameters, which manifest non-stationary characteristics while degrading. With the obtained degradation curve,prognostics model can be established by state-space method, and then RUL can be estimated when the time-varying parameters of the model are predicted and updated through Kalman filtering algorithm. By this method, the non-stationary degradation of each parameter is represented, and multiple monitoring parameters are incorporated, both contributing to the final prognostics. A case study shows that this approach enables satisfactory prediction evolution and achieves a markedly better prognosis of RUL.

关键词： Degradation Information fusion Kalman filtering Performance Prognostics Remaining useful life Superstatistics

Evaluation of aileron actuator reliability with censored data

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Chinese Journal of Aeronautics 2015年第4期28卷 1087-1103页

作者： Li Huaiyuan Zuo Hongfu liu Ruochen liu junqiang Jing Cai College of Civil Aviation Nanjing University of Aeronautics and Astronautics

For the purpose of enhancing reliability of aileron of Airbus new-generation A350 XWB,an evaluation of aileron reliability on the basis of maintenance data is presented in this paper.Practical maintenance data contains large number of censoring samples, information uncertainty of which makes it hard to evaluate reliability of aileron actuator.Considering that true lifetime of censoring sample has identical distribution with complete sample, if censoring sample is transformed into complete sample, conversion frequency of censoring sample can be estimated according to frequency of complete sample.On the one hand, standard life table estimation and product limit method are improved on the basis of such conversion frequency, enabling accurate estimation of various censoring samples.On the other hand, by taking such frequency as one of the weight factors and integrating variance of order statistics under standard distribution, weighted least square estimation is formed for accurately estimating various censoring samples.Large amounts of experiments and simulations show that reliabilities of improved life table and improved product limit method are closer to the true value and more conservative; moreover, weighted least square estimate（WLSE）, with conversion frequency of censoring sample and variances of order statistics as the weights, can still estimate accurately with high proportion of censored data in samples.Algorithm in this paper has good effect and can accurately estimate the reliability of aileron actuator even with small sample and high censoring rate.This research has certain significance in theory and engineering practice.

关键词： Ailerons Civil aimraft Non-parametric data distri-butions Order statistics Parameter estimation Reliability estimation Weight

新辅助化疗联合免疫抑制剂对Ⅲ期非小细胞肺癌治疗有效性分析

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首都医科大学学报 2024年第4期45卷 660-665页

作者：王居巳宋伟安狄守印刘军强范博士周少华岳彩迎赵嘉华陈思禹龚太乾解放军总医院第六医学中心胸外科北京100037

目的探讨新辅助化学药物治疗(以下简称化疗)联合免疫抑制剂对Ⅲ期非小细胞肺癌的短期治疗效果及安全性。方法选取2021年1月至2024年2月解放军总医院第六医学中心的Ⅲ期非小细胞肺癌患者53例,均行新辅助化疗联合免疫治疗,以21 d为一个周... 详细信息

目的探讨新辅助化学药物治疗(以下简称化疗)联合免疫抑制剂对Ⅲ期非小细胞肺癌的短期治疗效果及安全性。方法选取2021年1月至2024年2月解放军总医院第六医学中心的Ⅲ期非小细胞肺癌患者53例,均行新辅助化疗联合免疫治疗,以21 d为一个周期,治疗中评估安全性及治疗结束时评估疗效。结果影像学评估显示,完全缓解8例,部分缓解34例,疾病稳定8例,疾病进展3例,客观缓解率为79.2%,疾病控制率为94.3%。新辅助治疗后经影像学评估及科室讨论后53例患者均实施微创胸腔镜肿瘤切除术,无中转开胸患者,术后并发症10例,发生率18.7%,1例患者术后出现严重肺部感染致呼吸衰竭死亡。术后组织病理学评估显示,完全缓解15例、部分缓解32例、疾病稳定5例、疾病进展1例,主要病理缓解33例(62.3%),客观缓解率为88.7%,疾病控制率98.1%。不良反应主要为1、2级,仅出现3例3级不良事件,无4级不良反应。结论新辅助化疗联合免疫治疗对于局部晚期非小细胞肺癌具有较好的疗效及安全性,值得进一步推广应用。

关键词：非小细胞肺癌新辅助治疗免疫治疗疗效安全性

微创食管切除术联合三野或二野淋巴结清扫术治疗食管鳞状细胞癌257例近期疗效的回顾性队列研究

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中国胸心血管外科临床杂志 2024年第4期31卷 556-561页

作者：孙曾锋刘军强范博士宋伟安岳彩迎狄守迎赵嘉华周少华东海王居巳陈思禹龚太乾南方医科大学第二临床医学院广州510080 解放军总医院第六医学中心胸外科北京100089

目的比较食管鳞状细胞癌(鳞癌)患者接受微创食管切除术(minimally invasive esophagectomy,MIE)联合三野淋巴结清扫术(three-field lymphadenectomy,3-FL)或二野淋巴结清扫术(two-field lymphadenectomy,2-FL)的短期结果,探讨食管癌微创3-FL的安全性。方法回顾性分析2015年7月—2022年3月于解放军总医院第六医学中心胸外科行MIE(McKeown术式)患者的临床资料。根据淋巴结清扫方式,将患者分为3-FL组和2-FL组,比较两组患者的临床资料和术后并发症。结果共257例食管鳞癌患者纳入研究,其中男211例、女46例,平均年龄(62.2±8.1)岁。3-FL组109例,2-FL组148例。3-FL组手术时间较2-FL组长约20 min,差异有统计学意义(P<0.001);两组术中出血量差异无统计学意义(P=0.376)。3-FL组比2-FL组清扫淋巴结个数更多(P<0.001)以及获得阳性淋巴结数更多(P=0.003),且两组病理N分期差异有统计学意义(P<0.001)。但3-FL组和2-FL组吻合口瘘(P=0.667)、乳糜瘘(P=0.421)、喉返神经损伤(P=0.081)、肺部并发症(P=0.601)、肺炎(P=0.061)、心脏并发症(P=0.383)、总并发症(P=0.147)发生率差异无统计学意义。两组术后并发症严重程度(Clavien-Dindo分级)差异也无统计学意义(P=0.152)。结论微创食管癌3-FL可提高淋巴结的清扫率及肿瘤淋巴结分期的准确性,但不增加手术风险,值得临床推广应用。

关键词：食管鳞癌微创食管切除术三野淋巴结清扫术二野淋巴结清扫术

National Happiness at a Time of Economic Growth: A Tracking Study Based on CGSS Data

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Social Sciences in China 2013年第4期34卷 20-37页

作者： liu junqiang Xiong Moulin Su Yanga School of Insurance Southwestern University of Finance and Economics Law School Southwestern University of Finance and Economics School of Social Sciences University of California Irvine

为回应有关中国国民幸福感的争论,并评估过去10年宏观经济和政策变化对普通人生活的影响,本文利用中国综合社会调查数据(CGSS),分析了近10年国民幸福感的变化趋势。研究基于5个时点、44,166个样本,发现中国国民幸福感在过去10年内一直... 详细信息

为回应有关中国国民幸福感的争论,并评估过去10年宏观经济和政策变化对普通人生活的影响,本文利用中国综合社会调查数据(CGSS),分析了近10年国民幸福感的变化趋势。研究基于5个时点、44,166个样本,发现中国国民幸福感在过去10年内一直处于上升趋势,不同政治身份、户口类型、年龄、收入、婚姻状况、民族等群体的幸福感在过去10年都有不同程度的提高。经济增长可能是幸福感提升的动力;如果经济收缩,那么幸福感也可能随之下降。要确保经济社会协调发展,尚需对幸福感进行更多、更细致的追踪和研究。

关键词：幸福感不平等经济增长

政策的漂移、转化和重叠——中国失业保险结余形成机制研究

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管理世界 2022年第6期38卷 101-116页

作者：刘军强清华大学社会科学学院

失业保险基金为缓和疫情带来的就业压力做出了很大贡献,但其结余率过高、领取率过低却属历史痼疾,说明其运行效率仍有改善空间。本文分析了基金结余形成机制:(1)政策漂移:支出范围限制以及过低的失业金标准导致资金流入多而流出少,基金... 详细信息

失业保险基金为缓和疫情带来的就业压力做出了很大贡献,但其结余率过高、领取率过低却属历史痼疾,说明其运行效率仍有改善空间。本文分析了基金结余形成机制:(1)政策漂移:支出范围限制以及过低的失业金标准导致资金流入多而流出少,基金难以充分转化为保障而是沉淀下来;(2)政策转化:失业保险参保率偏低且待遇发放环节因基金安全考虑而限制较多;(3)政策重叠:失业保险与财政就业补助资金、低保制度之间存在重叠,资金重复配置。根本上,失业保险与劳动力市场等宏观结构脱嵌导致“高险低保、高保低险”的错配。本研究有助于理解中国社会政策的利用率和风险再分配机制,进而改善失业保险对失业者的保障作用和对抗经济周期的功能。

关键词：失业保险基金结余政策利用率风险错配

数控机床齿轮Fe-Ni-Cu-C-Mo-V合金粉末锻造研究

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锻压技术 2022年第9期47卷 23-29页

作者：刘波刘军强济源职业技术学院机电工程系河南济源459000 河南理工大学材料科学与工程学院河南焦作454000

为了研究新型数控机床齿轮材料Fe-Ni-Cu-C-Mo-V合金粉末锻造的可行性以及探讨始锻温度对齿轮材料耐磨损性能和耐腐蚀性能的影响。采用不同的始锻温度进行了齿轮材料的粉末锻造试验,并进行了耐磨损性能、耐腐蚀性能和密度的测试与分析。... 详细信息

为了研究新型数控机床齿轮材料Fe-Ni-Cu-C-Mo-V合金粉末锻造的可行性以及探讨始锻温度对齿轮材料耐磨损性能和耐腐蚀性能的影响。采用不同的始锻温度进行了齿轮材料的粉末锻造试验,并进行了耐磨损性能、耐腐蚀性能和密度的测试与分析。结果表明:采用粉末锻造方法,可以制备出综合性能较佳的齿轮材料。随着始锻温度从800℃增至1200℃,齿轮材料的磨损体积先减小后增大、腐蚀电位先正移后负移、密度先增大后减小,齿轮材料的耐磨损性能和耐腐蚀性能先提高后下降。与始锻温度为800℃时相比,始锻温度为1100℃时,粉末锻造的齿轮材料的磨损体积减小28.4%、腐蚀电位正移23.1%、密度增大7.0%。粉末锻造新型数控机床齿轮材料Fe-Ni-Cu-C-Mo-V合金的始锻温度优选为1100℃。

关键词：粉末锻造 Fe-Ni-Cu-C-Mo-V合金耐磨损性能耐腐蚀性能齿轮材料