检索结果-南通市图书馆

Cortical Organoid-on-a-Chip with Physiological Hypoxia for Investigating Tanshinone IIA-Induced Neural Differentiation

引用

Research 2024年第3期2023卷 457-468页

作者： Yue Zhi Yujuan Zhu Jinglin Wang junqi zhao Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalClinical Medical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing210023China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Shenzhen Research Institute Southeast UniversityShenzhen518038China

Cortical organoids represent cutting-edge models for mimic human brain development during the early and even middle stage of pregnancy, while they often fail to recreate the complex microenvironmental factors, such as physiological hypoxia. Herein, to recapitulate fetal brain development, we propose a novel cortical organoid-on-a-chip with physiological hypoxia and further explore the effects of tanshinone IIA (Tan IIA) in neural differentiation. The microfluidic chip was designed with a micropillar array for the controlled and efficient generation of cortical organoids. With low oxygen, the generated cortical organoids could recapitulate key aspects of early-gestational human brain development. Compared to organoids in normoxic culturing condition, the promoted neurogenesis, synaptogenesis and neuronal maturation were observed in the present microsystem, suggesting the significance of physiological hypoxia in cortical development. Based on this model, we have found that Chinese herbal drug Tan IIA could promote neural differentiation and maturation, indicating its potential therapeutic effects on neurodevelopmental disorders as well as congenital neuropsychiatric diseases. These results indicate that the proposed biomimetic cortical organoid-on-a-chip model with physiological hypoxia can offer a promising platform to simulate prenatal environment, explore brain development, and screen natural neuroactive components.

关键词： promoted herbal cutting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于虚拟点的反应流Navier-Stokes特征边界条件及其应用

引用

北京理工大学学报 2024年第4期44卷 348-358页

作者：赵俊琪钱琛庚王成孙远翔北京理工大学爆炸科学与技术国家重点实验室北京100081 中国航空工业空气动力研究院高速高雷诺数气动力航空科技重点实验室辽宁沈阳110034

针对通风条件下大尺度加氢站事故模拟,从一维局部无黏特征分析出发,发展了使用虚拟点的三维反应流Navier-Stokes无反射特征边界条件,通过引入横向项和化学反应源项,有效消除了火焰面、亚声速流场与计算域边界相互作用时产生的非物理反射... 详细信息

针对通风条件下大尺度加氢站事故模拟,从一维局部无黏特征分析出发,发展了使用虚拟点的三维反应流Navier-Stokes无反射特征边界条件,通过引入横向项和化学反应源项,有效消除了火焰面、亚声速流场与计算域边界相互作用时产生的非物理反射,实现了计算域边界处通风条件的无反射施加,提高了开放空间数值模拟的计算效率.通过开展51 m×51 m×10 m加氢站中长管拖车、加注机意外氢气泄漏扩散的数值模拟,给出了多种风况下可燃气云扩散结果,探究了通风条件及复杂环境对可燃气云发展规律的影响,对潜在危险区域进行了定量分析,并选取最危险氢气泄漏扩散结果开展高度非均匀气云爆炸的数值模拟,对不同设备处接收的超压和冲量进行了定量转化,完成了加氢站典型事故的风险评估.

关键词：无反射边界条件高压氢气泄漏非均匀气云爆炸数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ synthesis of magnetic mesoporous silica via sol-gel process coupled with precipitation and oxidation

引用

Particuology 2011年第1期9卷 56-62页

作者： junqi zhao Yujun Wang Guangsheng Luo Shenlin Zhu The State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China

A novel method was proposed for the in situ synthesis of magnetite-containing mesoporous silica SBA- 16 via a sol-gel process coupled with precipitation and oxidation. The effect of the added amounts of reactants on the mesostructural and magnetic properties of the magnetic mesoporous silica was inves- tigated, It was determined that the synthesized magnetic mesoporous silica with a total pore volume of 0.64-0.96 cm3/g and an average pore diameter of 4.0-14,9 nm had a relatively high saturation mag- netization value （1.11-5.77 emu/g） and a large surface area （258-747 m2/g）, Lysozyme was chosen as a model protein to test the performance of the magnetic mesoporous silica as a protein adsorbent, The high adsorption capacity （up to 212 mg/g） suggested a promising future as bimolecular hosts for the magnetic mesoporous silica.

关键词： Magnetic mesoporous silica Mesostructural property Magnetic property Protein absorbent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficient aerobic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid on Ru/C catalysts

引用

Science China Chemistry 2017年第7期60卷 950-957页

作者： Lufan Zheng junqi zhao Zexue Du Baoning Zong Haichao Liu Research Institute of Petroleum Processing SINOPEC Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesCollege of Chemistry and Molecular Engineering Peking University

2,5-Furandicarboxylic(FDCA) is a potential substitute for petroleum-derived terephthalic acid, and aerobic oxidation of5-hydroxymethylfurfural(HMF) provides an efficient route to synthesis of FDCA. On an activated carbon supported ruthenium(Ru/C) catalyst(with 5 wt% Ru loading), HMF was readily oxidized to FDCA in a high yield of 97.3% at 383 K and 1.0 MPa O_2 in the presence of Mg(OH)_2 as base additive. Ru/C was superior to Pt/C and Pd/C and also other supported Ru catalysts with similar sizes of metal nanoparticles(1–2 nm). The Ru/C catalysts were stable and recyclable, and their efficiency in the formation of FDCA increased with Ru loadings examined in the range of 0.5 wt%–5.0 wt%. Based on the kinetic studies including the effects of reaction time, reaction temperature, O_2 pressure, on the oxidation of HMF to FDCA on Ru/C, it was confirmed that the oxidation of HMF to FDCA proceeds involving the primary oxidation of HMF to 2,5-diformylfuran(DFF) intermediate, and its sequential oxidation to 5-formyl-2-furancarboxylic acid(FFCA) and ultimately to FDCA, in which the oxidation of FFCA to FDCA is the rate-determining step and dictates the overall formation rate of FDCA. This study provides directions towards efficient synthesis of FDCA from HMF, for example, by designing novel catalysts more efficient for the involved oxidation step of FFCA to FDCA.

关键词： aerobic oxidation 5-hydromethylfurfural 2 5-furandicarboxylic supported Ru catalyst base additives reaction mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于YOLOv5s微光环境下的多模态识别网络

引用

无线电工程 2024年第7期54卷 1602-1613页

作者：吴学礼赵俊棋刘雨涵甄然河北科技大学电气工程学院河北石家庄050018 河北省生产过程自动化工程技术研究中心河北石家庄050018

近些年来,在目标检测以及图像分割等领域涌现了许多先进的算法。在能见度较差的微光场景下如夜晚、大雾天气等场景中,视频图像具有像素声高、对比度低、无彩色信息等特点,算法的检测性能受到明显限制。与目前主流的RGB相机相比,毫米波... 详细信息

近些年来,在目标检测以及图像分割等领域涌现了许多先进的算法。在能见度较差的微光场景下如夜晚、大雾天气等场景中,视频图像具有像素声高、对比度低、无彩色信息等特点,算法的检测性能受到明显限制。与目前主流的RGB相机相比,毫米波雷达对上述复杂环境具有一定的免疫能力,可以在不利条件下辅助RGB相机进行目标检测工作。以单阶段目标检测器中实时性较高的YOLOv5s为基础,结合毫米波雷达的特性,提出了用于微光环境下目标检测的多模态识别网络。与现有的传感器融合方法相比,多模态识别网络有几个关键优势。系统以基于学习的方式融合了2种模态,只需要少量新场景的标记图像和雷达数据,因为其可以充分利用已经开源的大型图像数据集进行大批量的训练。这一突出特性使新系统能够适应高度复杂的现实环境。由于使用了高度计算效率的融合方法,系统是非常轻量级的,因此适用于各个复杂场景下的实时应用。为了评估系统的性能,制作了一个小批量的雷达和摄像机融合数据集,包含普通光照和不同强度微光光照条件下的多模态数据。实验结果表明,微光场景下多模态识别网络的平均精度达到76.6%,相比Faster R-CNN算法和YOLOv7算法,全类平均精度(mean Average Precision,mAP)提高了16.8%和9.3%,且误检、漏检率低,达到了在微光环境下完成目标检测任务的要求。

关键词：多模态识别网络毫米波雷达目标检测 YOLOv5s 微光场景

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes

引用

再生工程(英文) 2023年第3期4卷 238-244页

作者： Dagan Zhang Yuze Wang junqi zhao Xueqin Li Yuanyang Zhou Sen Wang Department of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210008China

Multiplex,rapid and accurate virus quantification plays a great value in biomedical ***,a novel one step,wash-free immunoassay platform based bioinspired PhC barcodes for multiplexed virus quantification was *** barcodes were decorated with PDA by self-polymerization of DA,thus this nanocomposite hybridized PhC barcodes facilitated the adsorption of FITC labelled antibodies and quenched itself photolumines-cent,allowing a fast responsive composite *** the presence of target analyte,the FITC-labelled detection antibody was released from the surface of PDA decorated microcarrier to specifically bind to the target ana-lyte,thus recovered the *** addition,the PhC microcarrier was enabled to carry out various color barcode for different targets detection though tuning internal periodic *** on these excellent performances of the nanocomposite barcode,this method can not only capture H1N1,H5N1,SARS-CoV-2 si-multaneously with rapid,accuracy but also accomplish multiplex quantification detection with ***,our developed platform was also achieved with high-sensitivity and high-specificity through the verification of clinical samples,thus laying out a new avenue for multiplex virus detection in clinical diagnosis.

关键词： Barcode Photonic crystals Wash-free Immunoassay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Production Technology of the Monomer of Nylon-6： Caprolactam

引用

Engineering 2017年第3期3卷 379-384页

作者： Baoning Zong Bin Sun Shibiao Cheng Xuhong Mu Keyong Yang junqi zhao Xiaoxin Zhang Wei Wu Research Institute of Petroleum Processing China Petrochemical Corporation Beijing 100083 China

After two decades＇ endeavor, the Research Institute of Petroleum Processing （RIPP） has successfully de- veloped a green caprolactam （CPL） production technology. This technology is based on the integration of titanium silicate （TS）-I zeolite with the slurry-bed reactor for the ammoximation of cyclohexanone, the integration of silicalite-1 zeolite with the moving-bed reactor for the gas-phase rearrangement of cyclohex- anone oxime, and the integration of an amorphous nickel （Ni） catalyst with the magnetically stabilized bed reactor for the purification of caprolactam. The world＇s first industrial plant based on this green CPL produc- tion technology has been built and possesses a capacity of 200 kt·a-1. Compared with existing technologies, the plant investment is pronouncedly reduced, and the nitrogen （N） atom utilization is drastically improved. The waste emission is reduced significantly; for example, no ammonium sulfate byproduct is produced. As a result, the price difference between CPL and benzene drops. In 2015, the capacity of the green CPL produc- tion technology reached 3 ×10-6 t·a-1, making China the world＇s largest CPL producer, with a global market share exceeding 50%.

关键词： Green chemistry Green engineering Caprolactam Production technology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

尼龙-6单体己内酰胺绿色生产技术

引用

石油炼制与化工 2024年第1期55卷 202-207,I0002页

作者：赵俊琦孙斌王诗晴温朗友马东强林民杨克勇谢丽张晓昕慕旭宏宗保宁中石化石油化工科学研究院有限公司石油化工分子转化与反应工程全国重点实验室北京100083

中石化石油化工科学研究院有限公司历经30年持续创新,成功开发尼龙-6单体己内酰胺绿色生产技术,主要包括:环己烯酯化加氢制环己酮绿色合成新途径,空心TS-1分子筛与浆态床集成用于环己酮氨肟化,S-1分子筛与移动床集成用于环己酮肟气相贝... 详细信息

中石化石油化工科学研究院有限公司历经30年持续创新,成功开发尼龙-6单体己内酰胺绿色生产技术,主要包括:环己烯酯化加氢制环己酮绿色合成新途径,空心TS-1分子筛与浆态床集成用于环己酮氨肟化,S-1分子筛与移动床集成用于环己酮肟气相贝克曼重排,非晶态镍催化剂与磁稳定床集成用于己内酰胺精制。与引进己内酰胺生产技术相比,碳原子和氮原子利用率明显提升,三废排放显著减少,无副产低价值硫酸铵,装置投资大幅下降,生产成本明显减少。

关键词：己内酰胺环己酮贝克曼重排非晶态镍磁稳定床反应器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reversibly Cross-Linking Polyimide and Cyclophosphazene Toward Closed-Loop Recyclable Plastics with High Mechanical Strength,Excellent Flame Retardancy,and Chemical Resistance

引用

CCS Chemistry 2024年第4期6卷 976-987页

作者： Tingting Guan Xiaohan Wang Xi zhao Xingyuan Lu Xiu-Li Wang Yu-Zhong Wang junqi Sun State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012 The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu 610064

Traditional flame-retardant plastics are technically difficult to chemically *** development of newtypes of flame-retardant plastics that are intrinsically capable of being closed-loop recycled and are sufficiently robust and stable to satisfy their practical application is urgently *** this study,closed-loop recyclable flame-retardant plastics with high mechanical strength and excellent chemical resistance are fabricated by cross-linking amino-terminated polyimide(PI-NH_(2))and aldehyde-terminated cyclophosphazene(CP-CHO)with imine *** resultant flame-retardant plastic,which is denoted as PI-CP,exhibits a tensile strength of∼115.6 MPa,Young’s modulus of∼2.5 GPa,and glass transition temperature of 316°*** the PI-CP plastic,the imine bonds are isolated within hydrophobic microenvironments generated by the rigid and hydrophobic polyimide chains and the benzene ring of *** a result,the PI-CP plastics are highly stable in highly acidic and basic aqueous solutions and other commonly used organic *** PI-CP plastic shows outstanding flame retardancy with a limiting oxygen index value of 48.8%.More importantly,the PI-CP plastic can be depolymerized to generate the original PI-NH_(2)and CPCHO monomers in high yields(∼97%)and *** recovered monomers can be used to refabricate the original plastics,establishing highly efficient polymer-monomer-polymer circulation and a sustainable plastics economy.

关键词： closed-loop recyclable plastics recyclable polymers reversibly cross-linked polymers flame retardancy supramolecular polymers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

引用

Journal of Integrative Plant Biology 2024年第5期66卷 1007-1023页

作者： Meijing Yang Shuai Chen Shey-Li Lim Lang Yang Jia Yi Zhong Koon Chuen Chan Zhizhu zhao Kam-Bo Wong junqi Wang Boon Leong Lim School of Biological Sciences University of Hong KongPokfulam 999077Hong KongChina Department of Biology Southern University of Science and TechnologyShenzhen 518055China School of Biomedical Engineering Shenzhen UniversityShenzhen 518060China School of Life Sciences The Chinese Universityof Hong KongShatin 999077HongKongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatin 999077Hong KongChina HKU Shenzhen Institute of Research and Innovation Shenzhen 518052China

In plants,thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC(translocon on the outer chloroplast membrane)and the TOM(translocon on the outer mitochondrial membrane)complexes for import into those *** degradation pathways for these receptors are ***,we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored *** receptors are ubiquitinated by E3 ligase(s)and pulled from the outer membranes by the AAA+adenosine triphosphatase CDC48,after which a previously uncharacterized cytosolic protein,transmembrane domain(TMD)-binding protein for tail-anchored outer membrane proteins(TTOP),binds to the exposed TMDs at the C termini of the receptors and CDC48,and delivers these complexes to the 26S proteasome.

关键词： 26S proteasome CDC48 SP1 TOC TOM ubiquitination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：