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The DrugPattern tool for drug set enrichment analysis and its prediction for beneficial effects of oxLDL on type 2 diabetes

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Journal of Genetics and Genomics 2018年第7期45卷 389-397页

作者： Chuanbo Huang Weili Yang junpei wang Yuan Zhou Bin Geng Georgios Kararigas Jichun Yang Qinghua Cui Department of Biomedical Informatics Department of Physiology and Pathophysiology MOE Key Lab of Cardiovascular Sciences School of Basic Medical Sciences Center for Non-Coding RNA Medicine Peking UniversityBeijing 100191China School of Mathematics Sciences Huaqiao University Quanzhou 362021 China Hypertension Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Beijing 100037 China Charit-Universitatsmedizin Berlin. Corporate Member of Freie Universitat Berlin Humboldt-Universitat zu Berlin Berlin Institute of Health Institute of Gender in Medicine and Center for Cardiovascular Research. DZHK (German Centre for Cardiovascular Research) 10115 Berlin Germany Center of Bioinformatics Key Laboratory for Neuro-lnformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China

Enrichment analysis methods, e.g., gene set enrichment analysis, represent one class of important bio- informatical resources for mining patterns in biomedical datasets. However, tools for inferring patterns and rules of a list of drugs are limited. In this study, we developed a web-based tool, DrugPattern, for drug set enrichment analysis. We first collected and curated 7019 drug sets, including indications, adverse reactions, targets, pathways, etc. from public databases. For a list of interested drugs, DrugPat- tern then evaluates the significance of the enrichment of these drugs in each of the 7019 drug sets. To validate DrugPattern, we employed it for the prediction of the effects of oxidized low-density lipoprotein （oxLDL）, a factor expected to be deleterious. We predicted that oxLDL has beneficial effects on some diseases, most of which were supported by evidence in the literature. Because DrugPattern predicted the potential beneficial effects of oxLDL in type 2 diabetes （T2D）, animal experiments were then performed to further verify this prediction. As a result, the experimental evidences validated the DrugPattern prediction that oxLDL indeed has beneficial effects on T2D in the case of energy restriction. These data confirmed the prediction accuracy of our approach and revealed unexpected protective roles for oxLDL in various diseases. This study provides a tool to infer patterns and rules in biomedical datasets based on drug set enrichment analysis.

关键词： Enrichment analysis Drug Data mining oxLDL Type 2 diabetes

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A bioinformatics method for predicting long noncoding RNAs associated with vascular disease

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Science China(Life Sciences) 2014年第8期57卷 852-857页

作者： LI JianWei GAO Cheng wang YuChen MA Wei TU Jian wang junpei CHEN ZhenZhen KONG Wei CUI QingHua Laboratory of Translational Biomedicine Informatics School of Computer ScienceHebei University of Technology Department of Biomedical Informatics School of Basic Medical SciencesPeking University Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University MOE Key Laboratory of Cardiovascular Sciences Peking University

Long noncoding RNAs(lncRNAs)play important roles in human diseases including vascular *** the large number of lncRNAs,however,whether the majority of them are associated with vascular disease remains *** this purpose,here we present a genomic location based bioinformatics method to predict the lncRNAs associated with vascular *** applied the presented method to globally screen the human lncRNAs potentially involved in vascular *** a result,we predicted 3043 putative vascular disease associated *** test the accuracy of the method,we selected 10 lncRNAs predicted to be implicated in proliferation and migration of vascular smooth muscle cells(VSMCs)for further experimental *** results confirmed that eight of the 10 lncRNAs(80%)are *** result suggests that the presented method has a reliable prediction ***,the presented bioinformatics method and the predicted vascular disease associated lncRNAs together may provide helps for not only better understanding of the roles of lncRNAs in vascular disease but also the identification of novel molecules for the diagnosis and therapy of vascular disease.

关键词： vascular disease lncRNAs bioinformatics

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Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury

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Neural Regeneration Research 2023年第12期18卷 2727-2732页

作者： Chao Ma junpei wang Qifeng Tu Weijuan Bo Zunlu Hu Run Zhuo Ronghua Wu Zhangji Dong Liang Qiang Yan Liu Mei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurobiology and Anatomy Drexel University College of MedicinePhiladelphiaPAUSA

Fidgetin,a microtubule-severing enzyme,regulates neurite outgrowth,axonal regeneration,and cell migration by trimming off the labile domain of microtubule *** maintenance of the microtubule labile domain is essential for axon initiation,elongation,and navigation,it is of interest to determine whether augmenting the microtubule labile domain via depletion of fidgetin serves as a therapeutic approach to promote axonal regrowth in spinal cord *** this study,we constructed rat models of spinal cord injury and sciatic nerve *** with spinal cord injury,we found that expression level of tyrosinated microtubules in the labile portion of microtubules continuously increased,whereas fidgetin decreased after peripheral nerve *** of fidgetin enhanced axon regeneration after spinal cord injury,whereas expression level of end binding protein 3(EB3)markedly ***,we performed RNA interference to knockdown EB3 or *** found that deletion of EB3 did not change fidgetin ***,deletion of fidgetin markedly increased expression of tyrosinated microtubules and *** of fidgetin increased the amount of EB3 at the end of neurites and thereby increased the level of tyrosinated ***,we deleted EB3 and overexpressed *** found that fidgetin trimmed tyrosinated tubulins by interacting with *** fidgetin was deleted,the labile portion of microtubules was elongated,and as a result the length of axons and number of axon branches were *** findings suggest that fidgetin can be used as a novel therapeutic target to promote axonal regeneration after spinal cord ***,they reveal an innovative mechanism by which fidgetin preferentially severs labile microtubules.

关键词： acetylated microtubules axon regeneration axonal branching axonal regrowth end binding protein 3 fidgetin microtubule dynamics sciatic nerve injury spinal cord injury tyrosinated microtubules

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机械设备轴承故障自动化诊断技术

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电动工具 2023年第4期 19-22页

作者：王均佩郓城县高级技工学校山东菏泽274700

常规的机械设备轴承故障自动化诊断技术主要使用权重共享函数提取轴承故障特征,易受特征提取层的组成影响,导致诊断效果较差。设计一种全新的机械设备轴承故障自动化诊断技术,结合轴承故障信号阈值进行故障信号降噪处理,利用小波熵设计... 详细信息

常规的机械设备轴承故障自动化诊断技术主要使用权重共享函数提取轴承故障特征,易受特征提取层的组成影响,导致诊断效果较差。设计一种全新的机械设备轴承故障自动化诊断技术,结合轴承故障信号阈值进行故障信号降噪处理,利用小波熵设计轴承故障自动化诊断算法,完成机械设备轴承故障自动化诊断。实验结果表明,设计的机械设备轴承故障自动化诊断技术提取的故障特征频率与实际故障特征频率较拟合,诊断效果较好。

关键词：机械设备轴承故障诊断降噪算法自动化

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N_(2)O催化分解的高效Ce/Co_(3)O_(4)催化剂研制及反应机制

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环境科学学报 2024年第12期44卷 295-305页

作者：王俊霈彭新月龚圆钰晏乃强马磊上海交通大学环境科学与工程学院上海200240

催化分解是减少N_(2)O温室气体排放的主要方法.研究合成出系列Ce/Co_(3)O_(4)催化剂,实现了低温下N_(2)O催化去除.催化性能结果表明,20%Ce/Co_(3)O_(4)具有最好的催化活性,在390℃时能够实现N_(2)O完全分解.同时,20%Ce/Co_(3)O_(4)的表... 详细信息

催化分解是减少N_(2)O温室气体排放的主要方法.研究合成出系列Ce/Co_(3)O_(4)催化剂,实现了低温下N_(2)O催化去除.催化性能结果表明,20%Ce/Co_(3)O_(4)具有最好的催化活性,在390℃时能够实现N_(2)O完全分解.同时,20%Ce/Co_(3)O_(4)的表观活化能从Co_(3)O_(4)的88.0 kJ·mol^(-1)降低到57.2kJ·mol^(-1).在含H_(2)O和O_(2)条件下,20%Ce/Co_(3)O_(4)依然表现出良好的稳定性,具备实际应用潜力.材料表征结果证实,引入CeO_(2)促进了Ce^(4+)+Co^(2+)?Ce^(3+)+Co^(3+)氧化还原循环,有利于活性位点的再生,这是催化剂性能提升的主要原因.In situ DRIFTS和催化反应动力学结果表明,20%Ce/Co_(3)O_(4)上N_(2)O的分解遵循一级反应,催化剂表面N-O键的解离是反应的速率控制步骤.

关键词：氧化亚氮直接催化分解钴基催化剂稀土氧化铈反应机制

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声-固耦合作用下蒸压加气混凝土墙隔声性能分析

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科学技术创新 2022年第20期 93-96页

作者：王钧佩陈鑫张晓亮刁东明宁惠君河南科技大学土木工程学院河南洛阳471023

为研究蒸压加气混凝土墙在实际应用中的隔声效果,考虑声-固物理场的耦合,首先对比研究了相同厚度钢筋混凝土墙与蒸压加气混凝土墙的隔声性能;其次,考虑蒸压加气混凝土墙厚度对隔声量的影响,对比研究了三种不同厚度蒸压加气混凝土墙隔声... 详细信息

为研究蒸压加气混凝土墙在实际应用中的隔声效果,考虑声-固物理场的耦合,首先对比研究了相同厚度钢筋混凝土墙与蒸压加气混凝土墙的隔声性能;其次,考虑蒸压加气混凝土墙厚度对隔声量的影响,对比研究了三种不同厚度蒸压加气混凝土墙隔声性能;最后,考虑墙体构造措施,对比研究了三种不同空气层厚度双层蒸压加气混凝土墙隔声性能。研究结果表明,相同厚度钢筋混凝土墙隔声量比蒸压加气混凝土墙的高;当采用蒸压加气混凝土墙时,随墙体厚度增加,隔声量显著提高,但当增加到一定程度时对隔声性能提高影响不大;采用双层蒸压加气混凝土墙可在一定程度上提高建筑隔墙的隔声性能,随中间空气层厚度的增加,双层墙的隔声性能显著提高。

关键词：蒸压加气混凝土墙隔声性能声传输损失数值模拟

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A Visual-Based Gesture Prediction Framework Applied in Social Robots

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IEEE/CAA Journal of Automatica Sinica 2022年第3期9卷 510-519页

作者： Bixiao Wu junpei Zhong Chenguang Yang College of Automation Science and Engineering South China University of TechnologyGuangzhou 510640China IEEE School of Intelligent Engineering South China University of TechnologyGuangzhou 511442China

In daily life,people use their hands in various ways for most daily *** are many applications based on the position,direction,and joints of the hand,including gesture recognition,gesture prediction,robotics and so *** paper proposes a gesture prediction system that uses hand joint coordinate features collected by the Leap Motion to predict dynamic hand *** model is applied to the NAO robot to verify the effectiveness of the proposed *** of all,in order to reduce jitter or jump generated in the process of data acquisition by the Leap Motion,the Kalman filter is applied to the original *** some new feature descriptors are *** length feature,angle feature and angular velocity feature are extracted from the filtered *** features are fed into the long-short time memory recurrent neural network(LSTM-RNN)with different *** results show that the combination of coordinate,length and angle features achieves the highest accuracy of 99.31%,and it can also run in real ***,the trained model is applied to the NAO robot to play the finger-guessing *** on the predicted gesture,the NAO robot can respond in advance.

关键词： Finger-guessing game gesture prediction human-robot interaction long-short time memory recurrent neural network(LSTM-RNN) social robot

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一种新型水域垃圾清理船的设计

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河南科技 2021年第12期40卷 44-46页

作者：王钧佩李之豪李中源张晓亮张世洋宁惠君河南科技大学土木工程学院河南洛阳471023

水域垃圾清理主要有人工打捞和机械清理两种方式,而水域垃圾清理船是机械清理不可或缺的设备。基于此,本文设计了一种新型水域垃圾清理船。它主要包括三部分,即水面漂浮垃圾清理装置、水生植物清理装置、水下沉积垃圾清理装置。通过聚... 详细信息

水域垃圾清理主要有人工打捞和机械清理两种方式,而水域垃圾清理船是机械清理不可或缺的设备。基于此,本文设计了一种新型水域垃圾清理船。它主要包括三部分,即水面漂浮垃圾清理装置、水生植物清理装置、水下沉积垃圾清理装置。通过聚拢收集、打碎、传送、抓取等方式,该水域垃圾清理船可以对水面漂浮垃圾、水生植物、水下沉积垃圾进行有效的清理,可应用于小型河流、湖泊、公园狭窄水流等水域的垃圾清理。

关键词：水域垃圾清理船水面漂浮垃圾水生植物水下沉积垃圾

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Creation of crystal structure reproducing X-ray diffraction pattern without using database

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npj Computational Materials 2023年第1期9卷 946-954页

作者： Joohwi Lee junpei Oba Nobuko Ohba Seiji Kajita Toyota Central R&D Labs. Inc.41-1 YokomichiNagakuteAichi 480-1192Japan

When a sample’s X-ray diffraction pattern(XRD)is measured,the corresponding crystal structure is usually determined by searching for similar XRD patterns in the ***,if a similar XRD pattern is not found,it is tremendously laborious to identify the crystal structure even for *** case commonly happens when researchers develop novel and complex *** this study,we propose a crystal structure creation scheme that reproduces a given XRD *** employed a combinatorial inverse design method using an evolutionary algorithm and crystal morphing(Evolv&Morph)supported by Bayesian optimization,which maximizes the similarity of the XRD patterns between target one and those of the created crystal *** sixteen different crystal structure systems with twelve simulated and four powder target XRD patterns,Evolv&Morph successfully created crystal structures with the same XRD pattern as the target(cosine similarity 99%for the simulated ones and>96%the experimentally measured ones).Furthermore,the present method has merits in that it is an automated crystal structure creation scheme,not dependent on a *** believe that Evolv&Morph can be applied not only to determine crystal structures but also to design materials for specific properties.

关键词： properties crystal structure

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LARGE-TIME BEHAVIOR OF SOLUTIONS TO THE INFLOW PROBLEM OF THE NON-ISENTROPIC MICROPOLAR FLUID MODEL

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Acta Mathematica Scientia 2021年第4期41卷 1169-1195页

作者： junpei GAO Haibo CUI School of Mathematical Sciences Huaqiao UniversityQuanzhou 362021China

We investigate the asymptotic behavior of solutions to the initial boundary value problem for the micropolar fluid model in a half line R+:=(0,∞).Inspired by the relationship between a micropolar fluid model and Navier-Stokes equations,we prove that the composite wave consisting of the transonic boundary layer solution,the 1-rarefaction wave,the viscous 2-contact wave and the 3-rarefaction wave for the inflow problem on the micropolar fluid model is time-asymptotic ally stable under some smallness ***,we obtain the global existence of solutions based on the basic energy method.

关键词： Micropolar fluid model composite wave inflow problem stability

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