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White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging

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Neuroscience Bulletin 2019年第5期35卷 867-876页

作者： Sugai Liang Qiang Wang Xiangzhen Kong Wei deng Xiao Yang Xiaojing Li Zhong Zhang Jian Zhang Chengcheng Zhang Xin-min Li Xiaohong Ma junming Shao Andrew J. Greenshaw Tao Li Mental Health Centre West China Hospital Sichuan University Chengdu 610041 China Huaxi Brain Research Centre West China Hospital Sichuan University Chengdu 610041 China Language and Genetics Department Max Planck Institute for Psycholinguistics 6525 XD Nijmegen Netherlands Big Data Research Center School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu 611731 China Department of Psychiatry University of Alberta Edmonton T6G 2B7 Canada

Identifying data-driven biotypes of major depressive disorder(MDD) has promise for the clarification of diagnostic heterogeneity. However, few studies have focused on white-matter abnormalities for MDD subtyping. This study included 116 patients with MDD and118 demographically-matched healthy controls assessed by diffusion tensor imaging and neurocognitive *** clustering was applied to the major fiber tracts, in conjunction with tract-based spatial statistics, to reveal white-matter alterations associated with *** and neurocognitive differences were compared between identified subgroups and healthy controls. With fractional anisotropy extracted from 20 fiber tracts, cluster analysis revealed 3 subgroups based on the patterns of abnormalities. Patients in each subgroup versus healthy controls showed a stepwise pattern of white-matter alterations as follows: subgroup 1(25.9% of patient sample),widespread white-matter disruption;subgroup 2(43.1% of patient sample), intermediate and more localized abnormalities in aspects of the corpus callosum and left cingulate;and subgroup 3(31.0% of patient sample),possible mild alterations, but no statistically significant tract disruption after controlling for family-wise error. The neurocognitive impairment in each subgroup accompanied the white-matter alterations: subgroup 1, deficits in sustained attention and delayed memory;subgroup 2, dysfunction in delayed memory;and subgroup 3, no significant deficits. Three subtypes of white-matter abnormality exist in individuals with major depression, those having widespread abnormalities suffering more neurocognitive impairments, which may provide evidence for parsing the heterogeneity of the disorder and help optimize typespecific treatment approaches.

关键词： Major depressive disorder Hierarchal clustering Diffusion tensor imaging Biotype Heterogeneity

Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes

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Virologica Sinica 2021年第2期36卷 300-310页

作者： Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei deng Shu Shen State Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuaZhong University of Science and TechnologyWuhan 430022China

Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South *** Province is one of the major SFTS epidemic areas in the central part of *** study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in *** phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new *** was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously *** Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic *** divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype ***,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/*** conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV *** provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies.

关键词： Severe fever with thrombocytopenia syndrome virus(SFTSV) Genotypes Genomic reassortment Virus migration Amino acid variations

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苍山传灯

十月 2023年第5期 226-228页

作者：霍俊明不详

《蛮书》载:“山顶高数千丈,石棱青苍。”苍山是具体的,也是虚无的;苍山是横断山脉南端云岭的十九峰、十八溪,也是世间所有的山峰、溪谷以及深渊。苍山深处,无为寺山路两侧有一种多年生蕨类植物名为“里白”一—植株高达1.5米,可以治病... 详细信息

《蛮书》载:“山顶高数千丈,石棱青苍。”苍山是具体的,也是虚无的;苍山是横断山脉南端云岭的十九峰、十八溪,也是世间所有的山峰、溪谷以及深渊。苍山深处,无为寺山路两侧有一种多年生蕨类植物名为“里白”一—植株高达1.5米,可以治病救人,但不能度心济世。激越的山泉,清流之声高于一切也低于一切。我把苍山视为一部个人传记或者一盏灯,我把自己看作黑夜、渊薮以及人间。

关键词：个人传记《蛮书》横断山脉蕨类植物

“Combined”Therapy for Acute Obstructive Suppurative Cholangeitis——Clinical Analysis of 160 Cases

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四川大学学报(医学版) 1981年第4期 369-370页

作者： Jiang junming deng Xianzhao, et al. Department of Surgery, Sichuan Medical College.

160 cases of acute obstructive suppurativecholangeitis treated with combination of traditionalChinese and western medicine were reported, ofwhich 150 cases were cured, 2 improved and 8 *** patients were equally divide... 详细信息

关键词： Therapy for Acute Obstructive Suppurative Cholangeitis Clinical Analysis of 160 Cases

EBP50 induces apoptosis in macrophages in a nitric oxide dependent mechanism to promote the clearance of intracellular Mycobacterium tuberculosis

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EBP50 induces apoptosis in macrophages in a nitric oxide dep...

避险车道末端消能桶不同组合方式下的拦截性能

第十一届全国免疫学学术大会

作者： Guo Yang deng Yating Huang Zikun Luo Qing Li junming 南昌大学第一附属医院

Mycobacterium tuberculosis infects approximately one-third of the world’s population. M. tuberculosis exploits macrophages to be the main host cell, which suggests that it has evolved mechanisms to counter bactericidal effectors of macrophages. Unfortunately, although extensively studied, the mechanisms of M. tuberculosis to defend against macrophages have not yet been elucidated completely. Mycobacterium bovis BCG is known to have the capacity to inhibit the positioning of iNOS on phagosomes by interfering with EBP50, a scaffolding protein that controls the recruitment of iNOS at the vicinity of phagosomes in macrophages. However, knockdown of the expression of EBP50 still facilitates the intracellular survival of BCG, which suggested that EBP50 may have some other unknown antimycobacterial properties. In this study we show that overexpression of EBP50 by a recombinant lentivirus had no effect on the iNOS recruitment to ***-containing phagosomes, but significantly promoted the elimination of intracellular ***. We revealed in the present study that the enhancement of intracellular killing to M. tuberculosis upon EBP50 overexpression was due to the increased level of apoptosis in macrophages. We showed that EBP50 overexpression significantly increased the expression of iNOS and generation of nitric oxide(NO), and EBP50-induced apoptosis was NO-dependentand mediated by Bax and caspase-3. Meanwhile, we found for the first time that *** significantly downregulated, while avirulent mycobacteria upregulated, the expression of EBP50 in macrophages. Thus, this study identified a novel role of EBP50 in increasing the apoptosis ratio of macrophages in an NO-dependent mechanism, and identified a novel mechanism of M. tuberculosis to evade immune elimination by suppressing the expression of EBP50 in macrophages.

关键词： EBP50 Mycobacterium tuberculosis macrophage apoptosis nitric oxide

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中国科技论文 2022年第10期17卷 1105-1110页

作者：覃频频张绍坤邓祖深黄俊明广西制造系统与先进制造技术重点实验室(广西大学) 南宁530004 广西大学机械工程学院南宁530004

针对避险车道末端消能桶布置方案不规范的问题,运用LS-DYNA软件进行了车辆撞击消能桶的动力学仿真试验,研究避险车道末端消能桶在不同组合方式下对失控车辆的拦截性能。首先,建立失控车辆-消能桶有限元模型并进行验证;然后,分析并确定... 详细信息

针对避险车道末端消能桶布置方案不规范的问题,运用LS-DYNA软件进行了车辆撞击消能桶的动力学仿真试验,研究避险车道末端消能桶在不同组合方式下对失控车辆的拦截性能。首先,建立失控车辆-消能桶有限元模型并进行验证;然后,分析并确定消能桶的布置方案;最后,进行车辆撞击消能桶的仿真试验,并对试验结果进行讨论。结果表明:15个消能桶“矩形”组合、19个消能桶“箭头形”组合、20个消能桶“梯形”组合、25个消能桶“矩形”组合方式下,消能桶可拦截的车辆速度范围分别为0~7.0、0~8.3、0~9.7、0~8.3 m/s;消能桶布置数量大于4排时,拦截性能有所下降,因此消能桶的布置方案宜采用4排布置。

关键词：避险车道失控车辆有限元消能桶布置方案拦截性能

In-Field Management Practices for Mitigating Soil CO2and CH4Fluxes under Corn (Zea mays) Production System in Middle Tennessee

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American Journal of Climate Change 2015年第4期4卷 367-378页

作者： Sam Dennis Qi deng Dafeng Hui junming Wang Stephen Iwuozo Chih-Li Yu Chandra Reddy College of Agriculture Human and Natural Sciences Tennessee State University Nashville TN USA Climate and Atmospheric Science Section Illinois State Water Survey Prairie Research Institute University of Illinois at Urbana-Champaign Champaign IL USA

The United States continues to be the largest corn producer in the world. How to maximize corn yield and at the same time reduce greenhouse gas emissions, is becoming a challenging effort for growers and researchers. As a result, our understanding of the responses of soil CO2 and CH4 fluxes to agricultural practices in cornfields is still limited. We conducted a 3-yr cornfield experiment to study the responses of soil CO2 and CH4 fluxes to various agricultural practices in middle Tennessee. The agricultural practices included no-tillage + regular applications of urea ammonium nitrate (NT-URAN);no-tillage + regular applications of URAN + denitrification inhibitor (NT-inhi- bitor);no-tillage + regular applications of URAN + biochar (NT-biochar);no-tillage + 20% applications of URAN + chicken litter (NT-litter);no-tillage + split applications of URAN (NT-split);and conventional tillage + regular applications of URAN as a control (CT-URAN). A randomized complete block design was used with six replications. The same amount of fertilizer equivalent to 217 kg·N·ha-1 was applied to all of the experimental plots. The results showed that improved fertilizer and soil management, except the NT-biochar treatment significantly increased soil CO2 flux as compared to the conventional tillage (CT-URAN, 487.05 mg CO2 m-2·h-1). Soil CO2 flux increased exponentially with soil temperature (T 2 flux tended to be positively related to corn yield and/or soil moisture. Soil CH4 flux increased linearly with soil moisture in all treatments. Improved fertilizer and soil management did not alter soil CH4 flux, but significantly affected its moisture sensitivity. Our results indicated that agricultural practices enhancing corn yield may also result in a net increase in carbon emissions from soil, hence reducing the potential of carbon sequestration in croplands.

关键词： Tillage Fertilizer Management Soil CO2 Flux Soil CH4 Flux Greenhouse Gases

黄芪对单侧输尿管梗阻大鼠肾组织转化生长因子β1表达的影响

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中国中药杂志 2009年第2期34卷 193-198页

作者：左川谢席胜邓尧樊均明四川大学华西医院肾内科四川成都610041

目的:动态观察黄芪(AM)对单侧输尿管梗阻(UUO)所致大鼠肾小管问质纤维化的拮抗作用及对转化生长因子β1(TGF-β1)表达的影响,初步探讨其可能的分子作用机制。方法:SD大鼠随机分为假手术组、UUO模型组和黄芪治疗组。在造模后3,7,14 d处... 详细信息

目的:动态观察黄芪(AM)对单侧输尿管梗阻(UUO)所致大鼠肾小管问质纤维化的拮抗作用及对转化生长因子β1(TGF-β1)表达的影响,初步探讨其可能的分子作用机制。方法:SD大鼠随机分为假手术组、UUO模型组和黄芪治疗组。在造模后3,7,14 d处死动物。观察肾脏病理改变。采用免疫组化方法检测肾组织中TGF-β1和α-平滑肌肌动蛋白(α-SMA)表达。用实时荧光定量RT-PCR检测大鼠TGF-β1 mRNA和α-SMA mRNA表达量。用Western blot检测大鼠TGF-β1蛋白表达量。结果:与假手术组相比,各时间点的UUO大鼠肾脏病理损害进行性加重,TGF-β1和α-SMA mRNA和蛋白表达随梗阻时间延长逐渐增高;黄芪治疗后可明显减轻UUO大鼠肾组织的肾小管损伤及肾间质纤维化,使UUO大鼠肾组织中高表达的TGF-β1和α-SMA降低(P<0.05)。结论:黄芪可能通过从核酸和蛋白水平抑制TGF-β1的表达,抑制肾小管上皮细胞转分化,减轻和改善UUO大鼠肾间质纤维化。

关键词：黄芪转分化转化生长因子β1 单侧输尿管梗阻

黄芪对单侧输尿管梗阻大鼠肝细胞生长因子和转化生长因子β1的调控

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卫生研究 2008年第5期37卷 566-570页

作者：左川谢席胜邓尧樊均明四川大学华西医院肾内科成都610041

目的动态观察黄芪(AM)对单侧输尿管梗阻(UUO)所致肾小管间质纤维化大鼠肝细胞生长因子(HGF)和转化生长因子β1(TGF-β1)表达的影响。方法54只SD大鼠随机分为假手术组、模型组和模型+黄芪治疗组。在造模后第3、7和14天处死动物,观察肾脏... 详细信息

目的动态观察黄芪(AM)对单侧输尿管梗阻(UUO)所致肾小管间质纤维化大鼠肝细胞生长因子(HGF)和转化生长因子β1(TGF-β1)表达的影响。方法54只SD大鼠随机分为假手术组、模型组和模型+黄芪治疗组。在造模后第3、7和14天处死动物,观察肾脏病理改变。采用免疫组化方法检测肾组织中TGF-β1、HGF表达。用实时荧光定量RT-PCR检测大鼠HGF mRNA和TGF-β1mRNA表达量。用Western blot检测大鼠HGF和TGF-β1蛋白表达量。结果与假手术组相比,各时间点的模型组大鼠肾脏病理损害进行性加重,黄芪治疗后可明显减轻模型组大鼠的肾小管损伤及肾间质纤维化程度(P<0.05)。随着梗阻时间的延长,模型组大鼠肾组织TGF-β1表达逐渐增加;HGF表达呈现先升高后下降的表达规律,在UUO术后第7天达高峰,此后大幅回落;与模型组各对应时间点比较,黄芪治疗后可使肾组织中的HGF表达显著增高,TGF-β1表达明显降低(P<0.05)。结论黄芪可能通过诱导HGF表达上调及抑制TGF-β1表达,减轻肾间质纤维化。

关键词：黄芪肾间质纤维化肝细胞生长因子转化生长因子β1