检索结果-南通市图书馆

血清TgAb阳性甲状腺乳头状癌患者首次 131 I治疗的疗效及影响因素分析

在线全文

学校读者我要写书评

暂无评论

中华核医学与分子影像杂志 2024年第8期44卷 468-472页

作者：白鑫武新宇张洁李博赵尊柳舒心薛宇航徐俊玲高永举郑州大学人民医院、河南省人民医院核医学科河南省核医学新型分子探针与临床转化医学重点实验室 450003

目的探讨血清甲状腺球蛋白(Tg)抗体(TgAb)阳性的甲状腺乳头状癌(PTC)患者首次 131 I治疗的疗效及影响因素。方法回顾性分析2017年1月至2023年1月于河南省人民医院行 131 I治疗的1 624例PTC患者，根据TgAb水平将其分为TgAb阳性组[246... 详细信息

目的探讨血清甲状腺球蛋白(Tg)抗体(TgAb)阳性的甲状腺乳头状癌(PTC)患者首次 131 I治疗的疗效及影响因素。方法回顾性分析2017年1月至2023年1月于河南省人民医院行 131 I治疗的1 624例PTC患者，根据TgAb水平将其分为TgAb阳性组[246例，其中男36例、女210例；年龄43.5(31.0，52.0)岁]及TgAb阴性组[1 378例，其中男439例，女939例；年龄44.0(34.0，53.0)岁]。患者均于 131 I治疗后6～12个月接受疗效评估[基于血清TgAb和Tg检测，超声、CT、 131 I-全身显像(WBS)及颈、胸部SPECT/CT显像]，并被归类为疾病持续(复发)组及无持续(复发)组。采用 χ 2 检验比较TgAb阳性组与阴性组间的疗效差异；采用 χ 2 检验或Mann-Whitney U 检验比较TgAb阳性患者中疾病持续(复发)组及无持续(复发)组的一般特征差异，并行二元logistic回归分析，得到影响TgAb阳性患者疗效的独立危险因素。结果 TgAb阳性和阴性组中疾病持续(复发)者分别占15.4%(38/246)和10.4%(143/1 378)，2组 131 I治疗的疗效差异有统计学意义( χ 2 ＝5.42， P ＝0.020)。在TgAb阳性患者中，疾病持续(复发)组与无持续(复发)组淋巴结转移情况(35与23例)、手术与 131 I治疗间隔时间[2.0(1.5，3.0)与2.3(2.0，3.0)个月]、首次 131 I治疗前刺激性Tg(sTg)水平[0.18(0.04，5.78)与0.04(0.04，0.46) μg/L]、首次 131 I治疗前TgAb水平[40.15(19.13，156.15)与22.25(7.53，76.20) kU/L]间的差异有统计学意义( χ 2 ＝117.13， z 值：－2.29、－2.41、－2.80，均 P <0.05)。淋巴结转移是影响TgAb阳性患者 131 I疗效的独立危险因素[比值比( OR )＝89.326(95% CI ：25.005～319.106)， P <0.001]。结论 TgAb阳性PTC患者 131 I治疗的总体疗效相对较差，淋巴结转移是其疗效的独立危险因素，而首次 131 I治疗前TgAb不是独立危险因素。

关键词：甲状腺肿瘤放射疗法碘放射性同位素自身抗体甲状腺球蛋白

A New Approach of Feature Selection for Text Categorization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2006年第5期11卷 1335-1339页

作者： CUI Zifeng xu Baowen ZHANG Weifeng xu junling School of Computer Science and Engineering Southeast University Nanjing 210096 Jiangsu China Department of Computer Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003 Jiangsu China

This paper proposes a new approach of feature selection based on the independent measure between features for text categorization. A fundamental hypothesis that occurrence of the terms in documents is independent of each other, widely used in the probabilistic models for text categorization （TC）, is discussed. However, the basic hypothesis is incom plete for independence of feature set. From the view of feature selection, a new independent measure between features is designed, by which a feature selection algorithm is given to ob rain a feature subset. The selected subset is high in relevance with category and strong in independence between features, satisfies the basic hypothesis at maximum degree. Compared with other traditional feature selection method in TC （which is only taken into the relevance account）, the performance of feature subset selected by our method is prior to others with experiments on the benchmark dataset of 20 Newsgroups.

关键词： feature selection independency CHI square test text categorization

A Testing Method for Web Services Composition Based on Data-Flow

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2008年第4期13卷 455-460页

作者： HOU Jun xu Baowen xu Lei WANG Di xu junling School of Computer Science and Engineering SoutheastUniversity Nanjing 211189 Jiangsu China State Key Laboratory of Software Engineering WuhanUniversity Wuhan 430072 Hubei China

This paper proposes a method of data-flow testing for Web services composition. Firstly, to facilitate data flow analysis and constraints collecting, the existing model representation of business process execution language （BPEL） is modified in company with the analysis of data dependency and an exact representation of dead path elimination （DPE） is proposed, which over-comes the difficulties brought to dataflow analysis. Then defining and using information based on data flow rules is collected by parsing BPEL and Web services description language （WSDL） documents and the def-use annotated control flow graph is created. Based on this model, data-flow anomalies which indicate potential errors can be discovered by traversing the paths of graph, and all-du-paths used in dynamic data flow testing for Web services composition are automatically generated, then testers can design the test cases according to the collected constraints for each path selected.

关键词： Web services composition business process execution language (BPEL) Web services description language (WSDL) data flow all-du-path

ISTC: A New Method for Clustering Search Results

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2008年第4期13卷 501-504页

作者： ZHANG Wei xu Baowen ZHANG Weifeng xu junling School of Computer Science and Engineering Southeast University Nanjing 211189 Jiangsu China State Key Laboratory of Software Engineering WuhanUniversity Wuhan 430072 Hubei China Department of Computer Nanjing University of Posts andTelecommunications Nanjing 210003 Jiangsu China

A new common phrase scoring method is proposed according to term frequency-inverse document frequency （TFIDF） and independence of the phrase. Combining the two properties can help identify more reasonable common phrases, which improve the accuracy of clustering. Also, the equation to measure the in-dependence of a phrase is proposed in this paper. The new algorithm which improves suffix tree clustering algorithm （STC） is named as improved suffix tree clustering （ISTC）. To validate the proposed algorithm, a prototype system is implemented and used to cluster several groups of web search results obtained from Google search engine. Experimental results show that the improved algorithm offers higher accuracy than traditional suffix tree clustering.

关键词： Web search results clustering suffix tree term frequency-inverse document frequency (TFIDF) independence of phrases

Stable Initialization Scheme for K-Means Clustering

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2009年第1期14卷 24-28页

作者： xu junling xu Baowen ZHANG Weifeng ZHANG Wei HOU Jun School of Computer Science and Engineering Southeast University Nanjing 211189 Jiangsu China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 Hubei China Department of Computer Nanjing University of Posts and Telecommunications Nanjing 210003 Jiangsu China

Though K-means is very popular for general clustering, its performance, which generally converges to numerous local minima, depends highly on initial cluster centers. In this paper a novel initialization scheme to select initial cluster centers for K-means clustering is proposed. This algorithm is based on reverse nearest neighbor （RNN） search which retrieves all points in a given data set whose nearest neighbor is a given query point. The initial cluster centers computed using this methodology are found to be very close to the desired cluster centers for iterative clustering algorithms. This procedure is applicable to clustering algorithms for continuous data. The application of the proposed algorithm to K-means clustering algorithm is demonstrated. An experiment is carried out on several popular datasets and the results show the advantages of the proposed method.

关键词： clustering unsupervised learning K-means initialization

A New Feature Selection Method for Text Clustering

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2007年第5期12卷 912-916页

作者： xu junling xu Baowen ZHANG Weifeng CUI Zifeng ZHANG Wei School of Computer Science and Engineering Southeast University Nanjing 210096 Jiangsu China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 Hubei China Department of Computer Science and Engineering Nanjing University of Posts and Telecommunications Nanjing 210003 Jiangsu China

Feature selection methods have been successfully applied to text categorization but seldom applied to text clustering due to the unavailability of class label information. In this paper, a new feature selection method for text clustering based on expectation maximization and cluster validity is proposed. It uses supervised feature selection method on the intermediate clustering result which is generated during iterative clustering to do feature selection for text clustering; meanwhile, the Davies-Bouldin＇s index is used to evaluate the intermediate feature subsets indirectly. Then feature subsets are selected according to the curve of the Davies-Bouldin＇s index. Experiment is carried out on several popular datasets and the results show the advantages of the proposed method.

关键词： feature selection text clustering unsupervised learning data preprocessing

Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第17期127卷 3082-3087页

作者： Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng xu junling Lin Qing Li Jing Dou Shewei Shandong Medical Imaging Research Institute Shandong University Jinan Shandong 250100 China Department of Radiology People's Hospital of Zhengzhou University Zhengzhou Henan 450003 China Medical Imaging Research Institute Binzhou Medical University Yantai Shandong 264003 China

Background The diagnosis of liver fibrosis is a difficult task at any time using conventional clinical *** incoherent motion （IVIM） can be used to investigate both diffusion and perfusion changes in *** study was designed to determine the value of IVIM in the diagnosis and staging of liver *** IVIM examinations were performed on a GE 3.0T MR scanner in 25 patients with liver fibrosis and 25 healthy volunteers as the control *** with liver fibrosis diagnosis were confirmed by pathology and staged on a scale of *** standard ADC values and the values of a biexponential model （slow ADC （Dslow）,fast ADC （Dfast） and fraction of fast ADC （FF）） were measured in three liver regions per *** mean standard ADC values,Dslow values,Dfast values and FF values from the study group were compared among the right posterior hepatic lobe,right anterior hepatic lobe and medial segment of the left *** Operating Characteristic （ROC） curves and independent-samples t-tests were used to calculate the mean standard ADC values,Dslow values,Dfast values and FF values from the study group and the control *** rho correlation analysis was used for the stage of liver *** liver fibrosis stages between the groups F0-1 and F2-4,the groups F0-2 and F3-4 were *** Among the liver fibrosis,there was no significant difference in the mean standard ADC values,Dslow values,Dfast values,and FF values obtained from the right posterior hepatic lobe,right anterior hepatic lobe and medial segment of the left *** ROC analysis,the Area Under the Curve （AUC） values of standard ADC,Dslow,Dfast,FF were all between 0.7 to *** mean standard ADC values,Dslow values,Dfast values and FF values of the liver in the study group were significantly lower than the values in the control group （P ＜0.05）.As the stage of the fibrosis increased,the values decreased by Spearman rho correlation *** mean values （stand

关键词： liver fibrosis magnetic resonance imaging intravoxel incoherent motion biexponential model

Screening for metastasis-related genes in mouse melanoma cells through sequential tail vein injection

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2024年第1期10卷 15-21页

作者： Qinggang Hao Rui Dong Weiyu Bai Dong Chang Xinyi Yao Yingru Zhang Huangying xu Huiyan Li Xiang Kui Feng Wang Yan Wang Chengqin Wang Yujie Lei Yan Chen junling Shen Lei Sang Yan Bai Jianwei Sun Center for Life Sciences Yunnan Key Laboratory of Cell Metabolism and Diseases State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life Sciences Yunnan University Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province Yan'an Hospital Affiliated to Kunming Medical University Shandong Provincial Key Laboratory of Animal Resistance Biology Collaborative Innovation Center of Cell Biology in Universities of Shandong Center for Cell Structure and Function Institute of Biomedical Science College of Life Sciences Shandong Normal University Department of Pathology The Second Affiliated Hospital of Kunming Medical University State Key Laboratory of Bioactive Molecules and Druggability Assessment Institute of Genomic Medicine College of Pharmacy Jinan University Department of Pathology School of Basic Medicine Qingdao University Department of Thoracic Surgery Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center

Tumor metastasis, responsible for approximately 90% of cancer-associated mortality, remains poorly understood. Here in this study, we employed a melanoma lung metastasis model to screen for metastasis-related genes. By sequential tail vein injection of mouse melanoma B16F10 cells and the subsequently derived cells from lung metastasis into BALB/c mice, we successfully obtained highly metastatic B16F15 cells after five rounds of in vivo screening. RNA-sequencing analysis of B16F15 and B16F10 cells revealed a number of differentially expressed genes, some of these genes have previously been associated with tumor metastasis while others are novel discoveries. The identification of these metastasis-related genes not only improves our understanding of the metastasis mechanisms, but also provides potential diagnostic biomarkers and therapeutic targets for metastatic melanoma.

关键词： Melanoma Lung metastasis model Gene screening Tail vein injection

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

睡眠剥夺状态下脑功能显像的多模态研究

中华核医学与分子影像杂志 2022年第7期42卷 391-396页

作者：轩昂付畅孙萌萌王莉徐俊玲郑州大学人民医院、河南省人民医院、河南大学人民医院核医学科、河南省核医学新型分子探针与临床转化医学重点实验室郑州450003 河南省医学科学院医学研究和转化中心郑州450003

目的探讨睡眠剥夺状态下健康志愿者脑葡萄糖代谢和血流灌注的改变以及二者之间的关系,揭示睡眠剥夺后脑功能损伤的具体脑区定位。方法前瞻性选取2019年1月至2019年12月间郑州大学人民医院的17名健康志愿者[男8名、女9名,年龄(22.5±1.7)... 详细信息

目的探讨睡眠剥夺状态下健康志愿者脑葡萄糖代谢和血流灌注的改变以及二者之间的关系,揭示睡眠剥夺后脑功能损伤的具体脑区定位。方法前瞻性选取2019年1月至2019年12月间郑州大学人民医院的17名健康志愿者[男8名、女9名,年龄(22.5±1.7)岁],对志愿者进行2次磁共振三维(3D)动脉自旋标记(ASL)及^(18)F-FDG PET/CT显像,第1次在正常睡眠后2 h,第2次在睡眠剥夺24 h后。应用统计参数图(SPM)软件对3D-ASL图像和^(18)F-FDG PET/CT图像处理,分别得到睡眠剥夺前后脑代谢及灌注差异激活图,再获得代谢及灌注差异共同激活脑区图。将异常激活的脑区设为ROI,获得其脑血流量(CBF)值及SUV比(SUVR)值(以小脑为参考区),采用配对t检验及Pearson相关分析对数据进行处理。结果受试者睡眠剥夺后脑代谢与脑灌注均减低,且异常脑区相似,脑代谢减低的脑区明显多于灌注减低的脑区;睡眠剥夺后代谢及灌注共同减低的脑区集中于额叶、颞叶、顶叶等脑区;睡眠剥夺后受试者左侧背外侧额上回CBF值及SUVR值有相关性(r=0.58,P=0.014)。受试者睡眠剥夺后全脑平均CBF值[(46.32±7.39)ml·100 g^(-1)·min^(-1)]及SUVR值(1.46±0.04)均低于睡眠剥夺前全脑平均CBF值[(54.91±6.51)ml·100 g^(-1)·min^(-1)]及SUVR值(1.53±0.06),差异均有统计学意义(t值:-2.67、-3.72,P值:0.012、0.001)。结论初步揭示了睡眠剥夺后受试者脑功能损伤的具体脑区定位。对于睡眠剥夺脑功能研究,^(18)F-FDG PET/CT与3D-ASL具有一致性且前者更为敏感。左侧背外侧额上回可能是睡眠剥夺后脑功能损伤的核心脑区。

关键词：睡眠剥夺正电子发射断层显像术体层摄影术,X线计算机氟脱氧葡萄糖F18 磁共振成像