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Effect of Methylprednisolone on Mortality and Clinical Courses in Patients with Severe CoVID-19: A Propensity Score Matching Analysis

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Infectious Diseases & Immunity 2023年第1期3卷 20-28页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Shi Lei Huang Xuechun Lu Junliang Fu Medical School of Chinese PLA Beijing 100853China Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Infectious Diseases Beijing 100039China Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijing 100853China.

Background Whether methylprednisolone therapy can reduce the mortality rate of patients with severe coronavirus disease 2019(COVID-19)remains controversial,and its effects on the length of hospital stay and virus shedding time are also unknown.This retrospective study investigates the previous issues to provide more evidence for methylprednisolone treatment in severe COVID-19.Methods This retrospective study included 563 of 4827 patients with confirmed COVID-19 admitted to Wuhan Huoshenshan Hospital or Wuhan Guanggu Hospital between February 3,2020 and March 30,2020 who met the screening criteria.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death,and the secondary outcomes were 2 clinical courses:length from admission to viral clearance and discharge.Univariate and multivariate logistic or linear regression analyses were used to assess the role of methylprednisolone in different outcomes.Propensity score matching was performed to control for confounding factors.Results Of the 563 patients who met the screening criteria and were included in the subsequent analysis,138 were included in the methylprednisolone group and 425 in the nonmethylprednisolone group.The in-hospital death rate between the methylprednisolone and nonmethylprednisolone groups showed a significant difference(23.91%vs.1.65%,Pfurther multivariate logistic regression analysis found comorbidities(OR,3.327;95%CI,1.702 to 6.501;P<0.001),lower lymphocyte count(OR,0.076;95%CI,0.012 to 0.461;P=0.005),higher lactate dehydrogenase(LDH)levels(OR,1.008;95%CI,1.003 to

关键词： COVID-19 Clinical courses In-hospital death Methylprednisolone SARS-CoV-2

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Effect of methylprednisolone therapy on hospital stay and viral clearance in patients with moderate COVID-19

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Infectious Medicine 2022年第4期1卷 236-244页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Huang Lei Shi Xuechun Lu fu-Sheng Wang Junliang Fu Medical School of Chinese PLA BeijingChina Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalBeijingChina National Clinical Research Center for Infectious Diseases BeijingChina Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijingChina

Background:The benefits and harms of methylprednisolone treatment in patients with moderate coronavirus disease 2019(COVID-19)remain controversial.In this study,we investigated the effect of methylprednisolone on mortality rate,viral clearance,and hospitalization stay in patients with moderate COVID-19.Methods:This retrospective study included 4827 patients admitted to Wuhan Huoshenshan and Wuhan Guanggu hospitals from February to March 2020 diagnosed with COVID-19 pneumonia.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death;secondary outcomes were time from admission to viral clearance and hospital stay.Univariate and multivariate logistic or linear regression analysis were used to assess the roles of methylprednisolone in different outcomes.The propensity score matching(PSM)method was used to control for confounding factors.Results:A total of 1320 patients were included in this study,of whom 100 received methylprednisolone.Overall,in-hospital mortality was 0.91%(12/1320);the 12 patients who died were all in the methylprednisolone group,though multivariate logistic regression analysis showed methylprednisolone treatment was not a risk factor for in-hospital death in moderate patients before or after adjustment for confounders by PSM.Methylprednisolone treatment was correlated with longer length from admission to viral clearance time and hospital stay before and after adjustment for confounders.Conclusions:Methylprednisolone therapy was not associated with increased in-hospital mortality but with delayed viral clearance and extended hospital stay in moderate COVID-19 patients.

关键词： COVID-19 Hospital stay In-hospital death Moderate Viral clearance

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Facile controlled synthesis of hierarchically structured mesoporous Li_(4)Ti_(5)O_(12)/C/rGO composites as high-performance anode of lithium-ion batteries

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Frontiers in Energy 2022年第4期16卷 607-612页

作者： Cehuang fu Shuiyun SHEN Ruofei WU Xiaohui YAN Guofeng XIA junliang ZHANG Institute of fuel Cells Key Laboratory of Power and Machinery EngineeringSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

t In this paper,a facile strategy is proposed to controllably synthesize mesoporous Li_(4)Ti_(5)O_(12)/C nanocomposite embedded in graphene matrix as lithium-ion battery anode via the co-assembly of Li_(4)Ti_(5)O_(12)(LTO)precursor,GO,and phenolic resin.The obtained composites,which consists of a LTO core,a phenolic-resin-based carbon shell,and a porous frame constructed by rGO,can be denoted as LTO/C/rGO and presents a hierarchical structure.Owing to the advantages of the hierarchical structure,including a high surface area and a high electric conductivity,the mesoporous LTO/C/rGO composite exhibits a greatly improved rate capability as the anode material in contrast to the conventional LTO electrode.

关键词： Li_(4)Ti_(5)O_(12) phenolic-resin-based carbon mesoporous composite graphene

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Influence of Fe on electrocatalytic activity of iron-nitrogendoped carbon materials toward oxygen reduction reaction

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Frontiers in Energy 2022年第5期16卷 812-821页

作者： Lin LI Cehuang fu Shuiyun SHEN Fangling JIANG Guanghua WEI junliang ZHANG Institute of fuel Cells School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China SJTU-ParisTech Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

The development of highly active nitrogendoped carbon-based transition metal(M-N-C)compounds for the oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs)greatly helps reduce fuel cell cost,thus rapidly promoting their commercial applications.Among different M-N-C electrocatalysts,the series of Fe-N-C materials are highly favored because of their high ORR activity.However,there remains a debate on the effect of Fe,and rare investigations focus on the influence of Fe addition in the second heat treatment usually performed after acid leaching in the catalyst synthesis.It is thus very critical to explore the influences of Fe on the ORR electrocatalytic activity,which will,in turn,guide the design of Fe-N-C materials with enhanced performance.Herein,a series of Fe-N-C electrocatalysts are synthesize and the influence of Fe on the ORR activity are speculated both experimentally and theoretically.It is deduced that the active site lies in the structure of Fe-N4,accompanied with the addition of appropriate Fe,and the number of active sites increases without the occurrence of agglomeration particles.Moreover,it is speculated that Fe plays an important role in stabilizing N as well as constituting active sites in the second pyrolyzing process.

关键词： oxygen reduction reaction Fe-N-C active sites Fe addition second heat treatment

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Legionella sainthelensi Pneumonia with Abdominal Symptoms as Prominent Manifestations:A Case Report

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Infectious Diseases & Immunity 2022年第4期2卷 285-288页

作者： Xin Yuan Fanglin Meng Xinting Yu Changqing Bai Rui Jia Fanping Meng fu-sheng Wang Junliang Fu Department of Respiratory and Critical Care Medicine Senior Department of Infectious Diseasesthe Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Senior Department of Infectious Diseases the Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China

Fewstudies have reported Legionella sainthelensi infection.This infection primarily presents with respiratorymanifestations.Here,we report an immunocompromised patient with cavitary pneumonia caused by L.sainthelensi who mainly had abdominal symptoms.The timely administration of moxifloxacin provided clinical improvement and resolution of symptoms.To our knowledge,this is one of the rare cases of L.sainthelensi infection presenting uniquelywith abdominal distension and liver function impairment butwithout obvious respiratory symptoms.

关键词： Next-generation sequencing Abdominal distension Cavitary pneumonia Legionella sainthelensi

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Meta-analysis of the immunogenicity of standard and booster SARS-CoV-2 vaccination in patients with chronic liver disease and post-liver transplantation

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Portal Hypertension & Cirrhosis 2023年第2期2卷 61-77页

作者： Wen-Xin Wang Jitao Wang Rui Jia Silvia Martini Jiaye Liu Yifei Huang fu-Sheng Wang Xiaolong Qi Junliang Fu Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina Peking University 302 Clinical Medical School BeijingChina CHESS-COVID-19 Group Xingtai People's HospitalXingtaiHebeiChina Department of Gastroenterology The 985th Hospital of Joint Logistic Support Force of Chinese PLATaiyuanShanxiChina Neonatal Intensive Care Unit AOU BolognaDepartment of Medical and Surgical Sciences(DIMEC)University of BolognaBolognaItaly CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhouGansuChina Center of Portal Hypertension Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsuChina

Aims:Patients with liver disease may exhibit higher infection rates and mortality rates from coronavirus disease 2019(COVID-19)than healthy individuals,and vaccination against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an effective prevention strategy.This metaanalysis aimed to assess the effectiveness and safety of SARS-CoV-2 vaccines in patients with chronic liver disease(CLD)and post-liver transplantation(LT).Methods:The PubMed,Embase,and Cochrane databases were searched.A random-effects model meta-analysis was used to determine the seropositivity rates of SARS-CoV-2 antibodies,odds ratio(OR)compared with healthy controls(HC),risk ratio(RR)between the booster and standard vaccination regimen,and the rate of adverse reactions(ADR).Results:In the standard vaccination regimen analysis,17 controlled articles were included for effectiveness analysis,and six articles for ADR analysis.The pooled seropositivity rates of SARS-CoV-2 antibodies in patients with CLD and post-LT were 93.3%(95%confidence interval[CI]:89.0%-97.6%)and 69.1%(95%CI:63.0%-75.3%),respectively.Both rates were lower than those in HC(p<0.001).The differences remained significant after sorting by detection interval,vaccine type,antibody type,or CLD type.LT recipients showed much lower seropositivity rates of antibodies than patients with CLD(69.1%vs.93.3%)or HC(OR:0.055).The pooled total ADR rate of patients was 24.0%(95%CI:16.2%-31.8%).In the booster vaccination regimen analysis,11 prospective studies were enrolled,and the seropositivity rates of antibodies after the booster dose were increased by 27%compared with those of the standard vaccination regimen(RR:1.27,95%CI:1.15-1.41,p<0.001).Conclusion:Patients with CLD and post-LT can gain protection against COVID-19 from standard vaccines,demonstrating a potentially weaker immunogenic response than HC.Booster vaccines can compensate for this deficiency.Therefore,patients with CLD and post-LT should be prioritized for receiving the COVID-19 booster vaccine.

关键词： COVID‐19 serological testing COVID‐19 vaccine booster shot COVID‐19 vaccines liver diseases liver transplantation

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Efficient NO_x abatement by passive adsorption over a Pd-SAPO-34 catalyst prepared by solid-state ion exchange

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Chinese Chemical Letters 2024年第4期35卷 210-213页

作者： Linhui Liu Wuwan Xiong Mingli fu junliang Wu Zhenguo Li Daiqi Ye Peirong Chen National Engineering Laboratory for VOCs Pollution Control Technology and Equipment Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution ControlSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.Ltd.Tianjin 300300China

Palladium-exchanged chabazite(Pd-CHA) zeolites as passive NO_x adsorbers(PNAs) enable efficient purification of nitrogen oxides(NO_x) in cold-start diesel exhausts. Their commercial application, however,is limited by the lack of facile preparation method. Here, high-performance CHA-type Pd-SAPO-34 zeolite was synthesized by a modified solid-state ion exchange(SSIE) method using PdO as Pd precursor,and demonstrated superior PNA performance as compared to Pd-SAPO-34 prepared by conventional wetchemistry strategies. Structural characterization using Raman spectroscopy and X-ray diffraction revealed that the SSIE method avoided water-induced damage to the zeolite framework during Pd loading. Mechanistic investigations on the SSIE process by in situ infrared spectroscopy and X-ray photoelectron spectroscopy disclosed that, while PdO precursor was mainly converted to Pd^(2+) cations coordinated to the zeolite framework by consuming the-OH groups of the zeolite, a portion of PdO could also undergo thermal decomposition to form highly dispersed Pd~0 clusters in the pore channels. This simplified and scalable SSIE method paves a new way for the cost-effective synthesis of defect-free high-performance Pd-SAPO-34 zeolites as PNA catalysts.

关键词： Pd-SAPO-34 Passive NO_x adsorber Pd loading Solid-state ion exchange Pd transformation

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Design and Verification of High Attenuation Vibration Isolation Damper in Remote Sensing Satellite Transport

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Journal of Harbin Institute of Technology(New Series) 2021年第6期28卷 63-71页

作者： Hao fu Wei Zhang junliang Liu Shangjie Pan Beijing Institute of Spacecraft Environment Engineering Beijing 100094China Harbin Institute of Technology School of Mechatronics EngineeringHarbin 150001China

To solve the safe horizontal transportation by rail&road of remote sensing satellite problem in the process of unpredictable dynamic load,a high attenuation vibration isolation damper(hereinafter referred to as vibration isolation damper)was developed.By simulation analysis and transportation test using satellite structural model and engineering prototype,validity and reliability of the vibration isolation damper was verified,which can meet the requirements of vibration and shock from various transportation conditions.

关键词： satellite structural model high attenuation vibration isolation damper dynamic analysis

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Modulating Myofibroblastic Differentiation of Fibroblasts through Actin-MRTF Signaling Axis by Micropatterned Surfaces for Suppressed Implant-Induced Fibrosis

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Research 2023年第3期6卷 609-618页

作者： Weiju Han Qi Chu junliang Li Zixuan Dong Xuetao Shi Xiaoling fu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510006P.R.China National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction Guangzhou 510006P.R.China Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou 510006P.R.China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442P.R.China

Myofibroblasts,the primary effector cells for implant-induced fibrosis,contribute to this process by secreting excessive collagen-rich matrix and contracting.Thus,approaches that suppress myofibroblasts may achieve desirable suppression effects in the fibrotic process.As one of the important physical properties of materials,material topographical structures have been proven to affect various aspects of cell behaviors,so is it possible to manipulate the formation of myofibroblasts by tailoring the topographical properties of medical devices?In this study,polycaprolactone(PCL)surfaces with typical micropatterns(micro column and micro pit)were fabricated.The regulatory effects of surface micropatterns on the myofibroblastic differentiation of fibroblasts were investigated.Compared to the flat surfaces and surfaces with micro pit,surfaces with micro columns triggered the F-to G-actin transition,inhibiting the nuclear transfer of myocardin-related transcription factor-A.Subsequently,the downstream geneα-smooth muscle actin,which is a marker of myofibroblasts,was suppressed.further in vivo investigation showed that PCL implants with micro-column-patterned surfaces inhibited the formation of peri-implant fibrotic capsules.Our results demonstrate that surface topographical properties are a potent regulator of fibroblast differentiation into myofibroblasts and highlight the antifibrotic potential of modifying surfaces with micro-column patterns.

关键词： process column pressed

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Heparinized PGA host-guest hydrogel loaded with paracrine products from electrically stimulated adipose-derived mesenchymal stem cells for enhanced wound repair

再生工程(英文)

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再生工程(英文) 2023年第3期4卷 225-237页

作者： Mengyao Li junliang Li Xueru Xiong Yushi Wang Yong-Guang Jia Xuetao Shi Xiaoling fu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction Guangzhou 510006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou 510006China

The microenvironment of the wound bed is essential in the regulation of wound repair.In this regard,strategies that provide a repairing favorable microenvironment may effectively improve healing outcomes.Herein,we attempted to use electrical stimulation(ES)to boost the paracrine function of adipose-derived stem cells from rats(rASCs).By examining the concentrations of two important growth factors,VEGF and PDGF-AA,in the cell culture supernatant,we found that ES,especially 5𝜇A ES,stimulated rASCs to produce more paracrine factors(5𝜇A-PFs).further studies showed that ES may modulate the paracrine properties of rASCs by upregulating the levels of TRPV2 and TRPV3,thereby inducing intracellular Ca^(2+) influx.To deliver the PFs to the wound to effectively improve the wound microenvironment,we prepared a heparinized PGA host-guest hydrogel(PGA-Hp hydrogel).Moreover,PGA-Hp hydrogel loaded with 5𝜇A-PFs effectively accelerated the repair process of the full-thickness wound model in rats.Our findings revealed the effects of ES on the paracrine properties of rASCs and highlighted the potential application of heparinized PGA host-guest hydrogels loaded with PFs derived from electrically stimulated rASCs in wound repair.

关键词： Wound repair Electrical stimulation Paracrine factors Heparinized PGA host-guest hydrogel

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