检索结果-南通市图书馆

Effect of methylprednisolone therapy on hospital stay and viral clearance in patients with moderate COVID-19

Infectious Medicine 2022年第4期1卷 236-244页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Huang Lei Shi Xuechun Lu fu-Sheng Wang junliang fu Medical School of Chinese PLA BeijingChina Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalBeijingChina National Clinical Research Center for Infectious Diseases BeijingChina Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijingChina

Background:The benefits and harms of methylprednisolone treatment in patients with moderate coronavirus disease 2019(COVID-19)remain *** this study,we investigated the effect of methylprednisolone on mortality rate,viral clearance,and hospitalization stay in patients with moderate ***:This retrospective study included 4827 patients admitted to Wuhan Huoshenshan and Wuhan Guanggu hospitals from February to March 2020 diagnosed with COVID-19 *** participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical *** primary outcome was in-hospital death;secondary outcomes were time from admission to viral clearance and hospital *** and multivariate logistic or linear regression analysis were used to assess the roles of methylprednisolone in different *** propensity score matching(PSM)method was used to control for confounding ***:A total of 1320 patients were included in this study,of whom 100 received ***,in-hospital mortality was 0.91%(12/1320);the 12 patients who died were all in the methylprednisolone group,though multivariate logistic regression analysis showed methylprednisolone treatment was not a risk factor for in-hospital death in moderate patients before or after adjustment for confounders by *** treatment was correlated with longer length from admission to viral clearance time and hospital stay before and after adjustment for ***:Methylprednisolone therapy was not associated with increased in-hospital mortality but with delayed viral clearance and extended hospital stay in moderate COVID-19 patients.

关键词： COVID-19 Hospital stay In-hospital death Moderate Viral clearance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong Liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang Jin-E Lu Yan Liu Xi Chen Meng-Meng Qu Yang Zhang Wei-Guo Hong Yong-Gang Li junliang fu fu-Sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients

引用

Cellular & Molecular Immunology 2015年第3期12卷 309-316页

作者： Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang junliang fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang fu-Sheng Wang Beijing Institute of Radiation Medicine Beijing China Research Center for Biological Therapy The Institute of Translational Hepatology Beijing 302Hospital Beijing 100039 China Department of Infectious Diseases 88th Hospital of PLA Taian Shandong China Department of Infectious Diseases Beijing You'an Hospital Affiliated to Capital Medical University Beijing China Department of Infectious Diseases Beijing 302 Hospital Beijing China Department of Non-infectious Diseases Beijing 302 Hospital Beijing China Institute of Basic Medicine Hebei University Baoding China Xiangsheng Xu and Qinghua Shang have contributed equally to this work.

B cells play an important role in the clearance of hepatitis B virus （HBV） and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of peripheral B-cell subsets from CHB patients in different phases： immune tolerance （IT）, immune activation （IA）, immune clearance （IC）, responders with HBsAg seroconversion （resolved patients, RP）, and healthy controls （HC）. IA patients displayed lower percentages of peripheral blood memory B cells compared with the other groups. Overall polyclonal activation of B cells, indicated by higher levels of activation markers and secretion of IgG and IgM, was observed in IA patients. This B-cell hyperactivation could be induced by increased IFN-a and soluble CD40 ligands in IA patients. Notably, the expression of the co-stimulator molecule CD80 and serum HBsAb and the frequency of HBsAg-specific B cells were significantly decreased in IT, IA, and IC patients compared with HC subjects. More importantly, the B-cell hyperactivation, co-stimulatory molecule downregulation and HBsAg-specific B-cell impairment were reversed in RP patients. The reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.

关键词： Reversal hyperactivation functional

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

民国时期北京发行的体育期刊研究

引用

首都体育学院学报 2019年第2期31卷 153-156页

作者：付俊良首都体育学院图书馆北京100191

运用文献资料法、内容分析法对民国时期北京发行的7种体育期刊进行分析。分析发现,受各种因素的制约,当时北京发行的体育期刊呈现出期刊内容丰富、涉及面广,但种类少、发行时间短暂、作者来源少等特点;这些体育期刊具有以下内容特征:1)... 详细信息

运用文献资料法、内容分析法对民国时期北京发行的7种体育期刊进行分析。分析发现,受各种因素的制约,当时北京发行的体育期刊呈现出期刊内容丰富、涉及面广,但种类少、发行时间短暂、作者来源少等特点;这些体育期刊具有以下内容特征:1)侧重学校体育教育研究,强化体育功能;2)介绍不同国家的体育思想;3)倡导民族传统体育与西方近代体育融合;4)报道体育赛事,助力扩大体育的社会影响。这些体育期刊对了解当时的学校体育和当时知名学者的学校体育思想,以及考证当时其他国家体育思想传入有一定的参考价值。

关键词：民国时期北平地区体育期刊内容特征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BTLA up-regulation associated with impaired cytotoxic CD8+ Tcell function and disease progression of patients with hepatocellular carcinoma

BTLA up-regulation associated with impaired cytotoxic CD8+ T...

引用

中华医学会第十三次全国感染病学术会议

作者： junliang fu Lin Zhou Juanjuan Zhao fu-Sheng Wang Research Center of Biological Therapy Beijing 302 Hospital Institute of Translational Hepatology Beijing 302 Hospital Center of Therapeutic Research for Hepatocellular Carcinoma Beijing 302 Hospital

B-and T-lymphocyte attenuator(BTLA)negatively regulates immune responses;however,it remains unknown the expression profile and functional role of BTLA in patients with hepatocellular carcinoma(HCC).Here,we enrolled 150 HCC patients,33 liver cirrhosis(LC)patients,and 45 healthy individuals in this *** found that BTLA expression on cytotoxic CD8+T cells in peripheral blood was significantly up-regulated in HCC patients compared with LC patients and healthy *** we divided the HCC patients into different

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Impairment of CD4+Cytotoxic T Cells Predicts Poor Survival and High Recurrence Rates in Patients with Hepatocellular Carcinoma

The Impairment of CD4+Cytotoxic T Cells Predicts Poor Surviv...

引用

中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： junliang fu Lin Zhou Zheng Zhang fu-Sheng Wang Research Center for Biological Therapy Beijing 302 Hospital

PURPOSE Although CD4 + cytotoxic T cells(CTLs) have been reported by several investigators,their significance in antitumor immunity in human cancer is *** study aims to further characterize CD4 + CTLs in hepatocellular carcinoma(HCC) patients,and to uncover the regulatory mechanisms by which they contribute to disease *** Five-hundred and forty-seven HCC patients,46 liver cirrhosis

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial

引用

Signal Transduction and Targeted Therapy 2020年第1期5卷 1010-1016页

作者： Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi junliang fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi fu-Sheng Wang Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina Immunotherapy Programme Champalimaud Centre for the UnknownLisbonPortugal I Med Clinic University of MainzMainzGermany Department of Infection Division of Infection and ImmunityUniversity College LondonLondonUK National Institute for Health Research Biomedical Research Centre University College London Hospitals NHS Foundation TrustLondonUK

No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical *** performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary *** study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and *** groups received standard COVID-treatment *** events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were *** serious UC-MSCs infusion-associated adverse events were *** patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs *** ventilation was required in one patient in the treatment group compared with four in the control *** patients recovered and were *** data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well *** 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19.

关键词： patients infusion clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Methylprednisolone on Mortality and Clinical Courses in Patients with Severe CoVID-19: A Propensity Score Matching Analysis

引用

Infectious Diseases & Immunity 2023年第1期3卷 20-28页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Shi Lei Huang Xuechun Lu junliang fu Medical School of Chinese PLA Beijing 100853China Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Infectious Diseases Beijing 100039China Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijing 100853China.

Background Whether methylprednisolone therapy can reduce the mortality rate of patients with severe coronavirus disease 2019(COVID-19)remains controversial,and its effects on the length of hospital stay and virus shedding time are also *** retrospective study investigates the previous issues to provide more evidence for methylprednisolone treatment in severe *** This retrospective study included 563 of 4827 patients with confirmed COVID-19 admitted to Wuhan Huoshenshan Hospital or Wuhan Guanggu Hospital between February 3,2020 and March 30,2020 who met the screening *** participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical *** primary outcome was in-hospital death,and the secondary outcomes were 2 clinical courses:length from admission to viral clearance and *** and multivariate logistic or linear regression analyses were used to assess the role of methylprednisolone in different *** score matching was performed to control for confounding *** Of the 563 patients who met the screening criteria and were included in the subsequent analysis,138 were included in the methylprednisolone group and 425 in the nonmethylprednisolone *** in-hospital death rate between the methylprednisolone and nonmethylprednisolone groups showed a significant difference(23.91%vs.1.65%,P<0.001),which was maintained after propensity score matching(13.98%vs.5.38%,P=0.048).However,univariate logistic analysis in the matched groups showed that methylprednisolone treatment(odds ratio[OR],5.242;95%confidence interval[CI],0.802 to 34.246;P=0.084)was not a risk factor for in-hospital death in severe *** multivariate logistic regression analysis found comorbidities(OR,3.327;95%CI,1.702 to 6.501;P<0.001),lower lymphocyte count(OR,0.076;95%CI,0.012 to 0.461;P=0.005),higher lactate d

关键词： COVID-19 Clinical courses In-hospital death Methylprednisolone SARS-CoV-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于风险的报警优先级量化设定方法研究

引用

中国安全生产科学技术 2018年第2期14卷 150-156页

作者：路帅付军良中国石油大学(华东)安全环保与节能技术中心山东青岛266580

当前主流报警优先级设定方法操作性不佳,在进行装置报警系统优化时由于考虑维度少而无法较好优化报警系统优先级,针对该问题,建立了基于风险的报警优先级设定新方法。将标定的风险图法应用于报警优先级设定,假定某报警不存在,对出现危... 详细信息

当前主流报警优先级设定方法操作性不佳,在进行装置报警系统优化时由于考虑维度少而无法较好优化报警系统优先级,针对该问题,建立了基于风险的报警优先级设定新方法。将标定的风险图法应用于报警优先级设定,假定某报警不存在,对出现危险情况的频率、后果严重度、可用时间、避免事故后果的可能性等进行标定,并对危险状况出现频率与可用时间进行矩阵分析,将结果运用于风险图中;针对某柴油加氢装置报警系统,应用该方法进行了报警优先级优化。结果表明:基于风险的报警优先级量化设定方法能够有效应用于优化装置报警优先级;经该方法优化的各级报警,数量分布更接近EEMUA的推荐值;对于"在所考虑的报警不存在时每年发生事故的次数"因素,研究给出3个不同的档次供企业选择,实践中,企业可结合自身可接受标准,作进一步完善。

关键词：风险报警优先级矩阵标定的风险图

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Legionella sainthelensi Pneumonia with Abdominal Symptoms as Prominent Manifestations:A Case Report

引用

Infectious Diseases & Immunity 2022年第4期2卷 285-288页

作者： Xin Yuan Fanglin Meng Xinting Yu Changqing Bai Rui Jia Fanping Meng fu-sheng Wang junliang fu Department of Respiratory and Critical Care Medicine Senior Department of Infectious Diseasesthe Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Senior Department of Infectious Diseases the Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China

Fewstudies have reported Legionella sainthelensi *** infection primarily presents with ***,we report an immunocompromised patient with cavitary pneumonia caused by *** who mainly had abdominal *** timely administration of moxifloxacin provided clinical improvement and resolution of *** our knowledge,this is one of the rare cases of *** infection presenting uniquelywith abdominal distension and liver function impairment butwithout obvious respiratory symptoms.

关键词： Next-generation sequencing Abdominal distension Cavitary pneumonia Legionella sainthelensi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：