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Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 251-259页

作者： CHANG junli ZHAO Fulai SUN Xingyuan MA Xiaoping ZHAO Peng ZHOU Chujie shi Binhao GU Wenchao WANG Yongjun YANG Yanping Spine Disease Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Diagnostic and Interventional Radiology University of TsukubaIbaraki 315-0114Japan

OBJECTIVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)on the growth of osteosarcoma cells through downregulating the Wnt/β-catenin signaling pathway.METHODS:Cell viability,apoptosis and cell cycle distribution were examined using cell counting kit-8 and flow cytometry assays.The morphology of cancer cells was observed with inverted phase contrast microscope.The migration and invasion abilities were examined by xCELLigence real time cell analysis DP system and transwell assays.The expressions of poly(adenosine diphosphate-ribose)polymerase,C-Myc,Cyclin B1,cyclin-dependent kinases 1,N-cadherin,Vimentin,Active-β-catenin,β-catenin,p-glycogen synthase kinase 3β(GSK-3β)and GSK-3βwere determined by Western blotting assay.RESULTS:PPⅠ sensitized TRAIL-induced decrease of viability,migration and invasion,as well as increase of apoptosis and cell cycle arrest of MG-63 and U-2 OS osteosarcoma cells.The synergistic effect of PPⅠwith TRAIL in inhibiting the growth of osteosarcoma cells was at least partially realized through the inactivation of Wnt/β-catenin signaling pathway.CONCLUSION:The combination of PPⅠ and TRAIL is potentially a novel treatment strategy of osteosarcoma.

关键词： osteosarcoma tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway beta-catenin polyphyllinⅠ

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High-Porosity Foam-Based Iontronic Pressure Sensor with Superhigh Sensitivity of 9280 kPa^(-1)

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Nano-Micro Letters 2022年第2期14卷 12-23页

作者： Qingxian Liu Yuan Liu junli shi Zhiguang Liu Quan Wang Chuan Fei Guo School of Astronautics Harbin Institute of TechnologyHarbin 150001HeilongjiangPeople’s Republic of China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongPeople’s Republic of China Department of Civil and Environmental Engineering Shantou UniversityShantou 515063GuangdongPeople’s Republic of China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Physics and TcSUH University of HoustonHoustonTX 77204USA Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055GuangdongPeople’s Republic of China Present Address:320 Crescent Village Circle Unit 1413 San JoseCA 95134USA

Flexible pressure sensors with high sensitivity are desired in the fields of electronic skins,human-machine interfaces,and health monitoring.Employing ionic soft materials with microstructured architectures in the functional layer is an effective way that can enhance the amplitude of capacitance signal due to generated electron double layer and thus improve the sensitivity of capacitive-type pressure sensors.However,the requirement of specific apparatus and the complex fabrication process to build such microstructures lead to high cost and low productivity.Here,we report a simple strategy that uses open-cell polyurethane foams with high porosity as a continuous three-dimensional network skeleton to load with ionic liquid in a one-step soak process,serving as the ionic layer in iontronic pressure sensors.The high porosity(95.4%) of PU-IL composite foam shows a pretty low Young's modulus of 3.4 kPa and good compressibility.A superhigh maximum sensitivity of 9,280 kPa^(-1) in the pressure regime and a high pressure resolution of 0.125% are observed in this foam-based pressure sensor.The device also exhibits remarkable mechanical stability over 5,000 compression-release or bending-release cycles.Such high porosity of composite structure provides a simple,cost-effective and scalable way to fabricate super sensitive pressure sensor,which has prominent capability in applications of water wave detection,underwater vibration sensing,and mechanical fault monitoring.

关键词： High porosity Elastic modulus Compression deformation Iontronic pressure sensor Superhigh sensitivity

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牛肉源热杀索丝菌的致腐差异和比较基因组学研究

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中国食品学报 2024年第1期24卷 12-20页

作者：方金玉张俊吴诗媛施永清石双妮朱军莉浙江工商大学食品与生物工程学院浙江省食品安全重点实验室杭州310018

为探究牛肉中热杀索丝菌的致腐能力和致腐基因分布特点,经分离纯化、形态观察和PCR鉴定,获得29株热杀索丝菌。将其接种于4℃牛肉汁中,测定挥发性盐基氮(TVB-N)值和乙偶姻指标,评价分离菌株的致腐能力。采用比较基因组学技术分析热杀索... 详细信息

为探究牛肉中热杀索丝菌的致腐能力和致腐基因分布特点,经分离纯化、形态观察和PCR鉴定,获得29株热杀索丝菌。将其接种于4℃牛肉汁中,测定挥发性盐基氮(TVB-N)值和乙偶姻指标,评价分离菌株的致腐能力。采用比较基因组学技术分析热杀索丝菌强、弱腐败株基因特点。结果表明,29株热杀索丝菌分离株的TVB-N含量形成较慢,仅有2株菌在第9天超过11.5 mg N/100 g,而产乙偶姻能力强,且有明显差异,其中菌株BT27和BT25含量分别为139.3μg/mL和59.5μg/mL。测定强、弱致腐菌株BT27和BT25的全基因组序列,结果发现,热杀索丝菌基因组中存在大量参与碳水化合物代谢的基因,其中编码糖苷水解酶的基因数量最多,糖基转移酶基因次之。比较基因组学显示,强致腐株BT27被注释到碳水化合物代谢和相应酶的编码基因数量均多于弱致腐株BT25,而两者在编码氨基酸代谢的基因数量相近。研究表明,热杀索丝菌致腐性强、弱与编码碳水化合物代谢基因数量密切相关,研究从基因层面为阐明肉源微生物的致腐机理奠定了良好的基础。

关键词：牛肉比较基因组学热杀索丝菌致腐能力

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1300—2019年江苏沿海风暴潮灾害时空分布特征

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古地理学报 2024年第1期26卷 241-254页

作者：李亮郭俊丽时连强张永战南京大学地理与海洋科学学院江苏南京210023 南京大学海岸与海岛开发教育部重点实验室江苏南京210023 自然资源部第二海洋研究所浙江杭州310012

历史上江苏沿海曾频发2类风暴潮灾害,给当地带来了巨大损失。建立该地区长时间尺度的风暴潮灾害序列对了解过去与预测未来意义重大。以历史文献、地方志、海洋灾害公报等记载的风暴潮资料为基础,建立了风暴潮灾害识别体系,重建了1300—2... 详细信息

历史上江苏沿海曾频发2类风暴潮灾害,给当地带来了巨大损失。建立该地区长时间尺度的风暴潮灾害序列对了解过去与预测未来意义重大。以历史文献、地方志、海洋灾害公报等记载的风暴潮资料为基础,建立了风暴潮灾害识别体系,重建了1300—2019年江苏沿海风暴潮灾害序列,分析了风暴潮灾害时空变化规律,探究了其与气候异常和黄河、长江入海口变迁之间的关系。结果表明:江苏沿海地区主要受台风风暴潮灾害的影响,1300—2019年间共发生246次风暴潮灾害,平均周期为2.9年,且近100年来发生频率有增大的趋势;小波分析结果显示,风暴潮灾害年际变化存在17年、61年和115年的时间尺度周期,其中115年周期最为明显。海气相互作用影响下,厄尔尼诺活跃年江苏沿海台风风暴潮灾害偏少;气温与台风风暴潮灾害频次有一定的正相关性,但其影响机制尚不明确。盐城、南通和苏州为风暴潮灾害高发地区,常州和无锡发生频率较小。在气候变暖与江苏海岸冲淤变化的作用下,1855年后盐城和南通地区风暴潮灾害发生频率增加,连云港地区明显增加;随着海岸线的变迁与长江河口的演变,镇江、扬州、泰州与苏锡常地区受风暴潮灾害影响减少。

关键词：江苏沿海风暴潮灾害厄尔尼诺海岸冲淤

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金融素养高的农户更愿意创业吗?——基于异质性信贷约束视角

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西南大学学报（自然科学版） 2024年第7期46卷 103-114页

作者：李俊丽徐国立石德强福州外语外贸学院财务与会计学院福州350202 澳门理工大学人文与社会科学学院澳门999078 山东大学管理学院济南250100

基于14528个农户样本数据,实证分析了农户金融素养是否及如何影响其创业进入决策.研究发现:(1)金融素养对农户是否创业存在显著正向影响,金融素养水平较高的农户更愿意创业.(2)信贷约束在金融素养与农户创业决策间发挥中介作用.其中,需... 详细信息

基于14528个农户样本数据,实证分析了农户金融素养是否及如何影响其创业进入决策.研究发现:(1)金融素养对农户是否创业存在显著正向影响,金融素养水平较高的农户更愿意创业.(2)信贷约束在金融素养与农户创业决策间发挥中介作用.其中,需求型及供给型信贷约束均发挥中介作用,需求型信贷约束的中介作用贡献度更高,说明金融素养主要通过缓解需求型信贷约束促进农户创业.(3)与金融素养水平较低的农户相比,信贷约束对金融素养较高的农户创业决策抑制作用更显著.该文提出了着力农户金融教育、适当缓解供给型信贷约束、着重缓解需求型信贷约束、实施倾斜性信贷政策等建议.

关键词：金融素养创业决策信贷约束供给型信贷约束需求型信贷约束

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Slurry-like hybrid electrolyte with high lithium-ion transference number for dendrite-free lithium metal anode

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Journal of Energy Chemistry 2020年第9期29卷 375-382,I0011页

作者： Hewei Xu Ying He Zibo Zhang junli shi Pingying Liu Ziqi Tian Kan Luo Xiaozhe Zhang Suzhe Liang Zhaoping Liu Advanced Li-ion Battery Engineering Laboratory and Key Laboratory of Graphene Technologies and Applications of Zhejiang Province Ningbo Institute of Materials Technology and Engineering(NIMTE)Chinese Academy of SciencesNingbo 315201ZhejiangChina School of Materials Science and Engineering Jingdezhen Ceramic InstituteJingdezhen 333403JiangxiChina

Lithium metal anode is regarded as the ultimate choice for next-generation energy storage systems,due to the lowest negative electrochemical potential and super high theoretical specific capacity.However,the growth of lithium dendrite during the cycling process is still one of the most critical bottlenecks for its application.In this work,a slurry-like hybrid electrolyte is proposed towards the application for lithium metal anode,which is composed of a liquid electrolyte part and a nanometric silane-Al2O3 particle part.The hybrid electrolyte shows high ionic conductivity(3.89×10-3 S cm-1 at 25℃)and lithium-ion transference number(0.88).Especially,the resistance of hybrid electrolyte decreases compared to that of liquid electrolyte,while the viscosity of hybrid electrolyte increases.It is demonstrated that the hybrid electrolyte can effectively suppress the growth of lithium dendrite.Stable cycling of Li/Li cells at a current density up to 1 mA cm-2 is possible.The hybrid electrolyte helps to uniform the lithium ion flux inside the battery and partly comes from the formation of a rigid and highly conductive hybrid interfacial layer on the surface of lithium metal.This work not only provides a fresh way to stabilize lithium metal anode but also sheds light on further research for electrolyte optimization and design of lithium metal battery system.

关键词： Hybrid electrolyte Slurry Organic-inorganic Lithium-ion transference number Lithium metal batteries

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Anode reaction mechanisms of Na|NaCl-CaCl2|Zn liquid metal battery

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Journal of Energy Chemistry 2022年第9期31卷 81-87,I0003页

作者： Fang Zhang jingyun Jin junli xu Zhongning shi School of Metllurgy Northeastem UniversityShenyang110819LiaoningChina Colege of Sciences Northeastem UniversityShenyang100819LiaoningChina State Key Laboratory of Roling and Automation Northeastern UniversiyShenyang 110819LiaoningChina

Na|NaCl-CaCl_(2)|Zn liquid metal battery is regarded as a promising energy storage system for power grids.Despite intensive attempts to present a real mechanism of metal electrodes reaction, those for Na||Zn LMBs are not clear yet. Herein, the anode reactions for the multiple discharge potential plateaus were deduced by means of FactSage thermochemical software, which were subsequently validated by X-ray diffraction analysis and the modeling of phase transformation in the cooling process. A pre-treatment process was proposed for the analysis of anode product composition using the atomic absorption spectrometry method, and the anode states at working temperature(560 ℃) were obtained by the Na-CaZn ternary phase for the first time. The results indicate the discharge of Na and Ca led to the formation of Ca-Zn intermetallic compounds, whilst the extraction of Ca in Ca-Zn intermetallic compounds was responsible for the multiple discharge plateaus. Moreover, it was found that the charging product was in electrochemical double liquid metal layers, which are composed of Na and Ca with dissolved Zn respectively.

关键词： Liquid metal battery Thermodynamic calculation Discharge plateaus Reaction mechanisms Ca-Zn intermetallic compounds

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温度自适应SMO算法估计锂离子电池的SOC

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电池 2024年第3期54卷 334-339页

作者：吕高樊郭宇张嘉蕾杜君莉史书怀山西大学电力与建筑学院山西太原030000 国网河南省电力公司电力科学研究院河南郑州450000

现有对锂离子电池荷电状态(SOC)的估计,没有考虑温度变化导致的SOC估计准确度降低。提出一种考虑温度的滑模观测(SMO)法进行SOC估计。基于混合脉冲功率测试(HPPC)实验的数据,得到18650型LiFePO4锂离子电池的SOC与温度、参数之间的拟合式... 详细信息

现有对锂离子电池荷电状态(SOC)的估计,没有考虑温度变化导致的SOC估计准确度降低。提出一种考虑温度的滑模观测(SMO)法进行SOC估计。基于混合脉冲功率测试(HPPC)实验的数据,得到18650型LiFePO4锂离子电池的SOC与温度、参数之间的拟合式,通过台风(Typhoon)系统进行半实物实验分析。温度自适应SMO算法在低温或常温工况下的平均误差较传统SMO算法降低0.3~0.5个百分点,直接通过拟合式所快速估计的SOC较温度自适应SMO算法平均误差在2%左右,常温25℃工况下误差低于1%,能够实现较高的估计精准度,为快速估计SOC提供了较好的算法参考。

关键词：荷电状态(SOC)估计滑模观测(SMO) 温度影响锂离子电池半实物实验分析

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以IMB模型为指导的康复训练在初产妇产后盆底康复中应用研究

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现代医药卫生 2024年第11期40卷 1884-1887页

作者：李文霞石俊丽项城市中医院妇产科河南周口466200

目的探讨基于信息-动机-行为理论(IMB)模型指导的康复训练对初产妇产后盆底功能康复效果的影响。方法选取2020年3月至2023年3月该院收治的80例初产妇为研究对象,按照随机数字表法分为2组。对照组40例产妇实施常规指导康复训练,观察组40... 详细信息

目的探讨基于信息-动机-行为理论(IMB)模型指导的康复训练对初产妇产后盆底功能康复效果的影响。方法选取2020年3月至2023年3月该院收治的80例初产妇为研究对象,按照随机数字表法分为2组。对照组40例产妇实施常规指导康复训练,观察组40例产妇实施基于IMB模型指导的康复训练。对比2组产妇的盆底肌力分级情况、盆底功能、生活质量。结果观察组产妇的盆底肌肌力分级优于对照组,差异有统计学意义(P<0.05);观察组的盆底收缩压、简明健康状况量表(SF-36)中情感职能、心理健康、躯体疼痛、总体健康、生理职能、生理功能、精神健康、社会功能均高于对照组,差异均有统计学意义(P<0.05);观察组产妇的盆底静息压低于对照组,差异有统计学意义(P<0.05)。结论基于IMB模型指导的康复训练能够促进初产妇产后盆底功能提升,改善盆底肌力,从而提高产妇的生活质量。

关键词：初产妇盆底功能信息-动机-行为理论模型康复训练康复效果依从性生活质量

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Morphodynamic response of an embayed beach to different typhoon events with varying intensities

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Acta Oceanologica Sinica 2023年第7期42卷 51-63页

作者： Lianqiang shi junli Guo Shenliang Chen Yang Chang Daheng Zhang Zhaohui Gong Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China Key Laboratory of Ocean Space Resource Management Technology Ministry of Natural ResourcesHangzhou 310012China Guangxi Key Laboratory of Beibu Gulf Marine Resources Environment and Sustainable DevelopmentFourth Institute of OceanographyMinistry of Natural ResourcesBeihai 536000China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China

Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the morphodynamic response of Dongsha beach to typhoon events,based on beach topographies and surficial sediment characteristics acquired before and after four typhoon events with varying intensities.The four typhoons had different effects on the topography and sediment characteristics of Dongsha beach.Typhoons Ampil and Danas caused the largest(-51.72 m3/m)and the smallest erosion(-8.01 m3/m),respectively.Remarkable alongshore patterns of beach profile volumetric changes were found after the four typhoon events,with more erosion in the southern and central parts of the beach and few changes in the northern part.Grain size coarsening and poor sorting were the main sediment patterns on the beach influenced by different typhoons.Typhoons that occurred in the same year after another typhoon enhanced the effect of the previous typhoon on sediment coarsening and sorting variability,but this cumulative effect was not found between typhoons that occurred during different years.A comparison of the collected data revealed that the topographic state of the beach before the typhoon,typhoon characteristics,and tidal conditions were possible reasons for the difference in the responses of Dongsha beach to typhoon events.More severe beach erosion was caused by typhoons with higher intensity levels and longer durations,and high tide levels during typhoons can determine the upper limit of the beach profile erosion site.Taken together,these results can be used to improve beach management for storm prevention.

关键词： beach morphodynamic response typhoon event beach profile grain size characteristic human intervention

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