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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu qiao Chun Cui Chenmeng qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li Hui-Min Xing Hai-Dong Qian qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya Cheng Duan-Rui qiao Yi-Ying liu Wen-Na Shi Hai-Jun li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

The parametric symmetry and numbers of the entangled class of 2×M×N system

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Science China(Physics,Mechanics & Astronomy) 2011年第8期54卷 1471-1475页

作者： li XiKun li junli liU Bin qiao congfeng Department of Physics Graduate University Chinese Academy of Sciences Beijing 100049 China Theoretical Physics Center for Science Facilities (TPCSF) Chinese Academy of Sciences Beijing 100049 China

We present in the work two intriguing results in the entanglement classification of a pure and true tripartite entangled state of 2 × M × N under stochastic local operation and classical communication: (i) the internal symmetric properties of the nonlocal parameters in the continuous entangled class; (ii) the analytic expression for the total numbers of the true and pure entangled class 2 × M × N states. These properties help better understand the nature of the 2 × M × N entangled system.

关键词： entanglement quantum information matrix theory

Effect of experimental warming on soil respiration under conventional tillage and no-tillage farmland in the North China Plain

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Journal of Integrative Agriculture 2017年第4期16卷 967-979页

作者： TU Chun li Fa-dong qiao Yun-feng ZHU Nong GU cong-ke ZHAO Xin Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101P.R.China University of Chinese Academy of Science Beijing 100049P.R.China

Understanding the response of soil respiration to global warming in agro-ecosystem is crucial for simulating terrestrial carbon （C） cycle. We conducted an infrared warming experiment under conventional tillage （CT） and no-tillage （NT） farmland for winter wheat and summer maize rotation system in North China Plain （NCP）. Treatments include CT with and without warming （CTW and CTN）, NT with and without warming （NTW and NTN）. The results indicated that warming had no sig- nificant effect on soil moisture in irrigated farmland of NCP （P〉0.05）. The elevated average soil temperature of 1.1-116℃ in crop growing periods could increase annual soil CO2 emission by 10.3% in CT filed （P〉0.05）, but significantly increase it by 12.7% in NT field （P〈0.05）, respectively. The disturbances such as plowing, irrigation and precipitation resulted in the obvious soil CO2 emission peaks, which contributed 36.6-40.8% of annual soil cumulative CO2 emission. Warming would enhance these soil CO2 emission peaks; it might be associated with the warming-induced increase of autotrophic respiration and heterotrophic respiration. Compared with un-warming treatments, dissolved organic carbon （DOC） and soil microbial biomass carbon （MBC） in warming treatments were significantly increased by 11.6-23.4 and 12.9-23.6%, respectively, indicating that the positive responses of DOC and MBC to warming in both of two tillage systems. Our study highlights that climate warming may have positive effects on soil C release in NCP in association with response of labile C substrate to warming.

关键词： global warming conventional tillage no-tillage soil respiration dissolved organic carbon soil microbial biomasscarbon

Preface to the Special Issue in Celebration of Professor Shouwen Yu’s 85th Birthday

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Acta Mechanica Solida Sinica 2024年第3期37卷 361-362页

作者： Xi-qiao feng Qunyang li Department of Engineering Mechanics Tsinghua UniversityBeijing100084China

Shouwen Yu,Emeritus Professor of Applied Mechanics at Tsinghua University,was born on May 4,1939 in Xianyou County,Fujian Province,*** pursued his undergraduate studies from 1955 to 1958 in the Department of Civil Str... 详细信息

关键词： Fujian Preface pursue

Oxidation of alcohols to aldehydes and ketones using selenium ionic liquid

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Chinese Chemical Letters 2012年第7期23卷 801-804页

作者： Xian Yi Cheng Kang feng li qiao Jian Wang cong Ying Wang Tao Kai Ying College of Chemistry and life Sciences Zhejiang Normal UniversityJinhua 321004China Institute of Physical Chemistry Zhejiang Normal UniversityJinhua 321004China

A new type of ionic liquid supported selenium reagents were synthesized and found to be an excellent catalyst in the oxidation of alcohols to aldehydes and ketones in the presence of 30%H_2O_*** predictable solubility of ionic liquids allows an easy separation of the oxidation products from the reaction ***,the oxidation reaction can be carried out using an ionic liquid as the solvent,and the ionic liquid-supported selenium reagents can be recycled and used for four times with a little decrease in catalytic performance.

关键词： Selenium ionic liquids Aldehydes Ketones Oxidation

Fully Differential Cross Sections for Single Ionization of Helium by AuQ+ Impact

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Chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： li-li feng Shi-yan Sun qiao-qiao Duan Xiang-fu Jia School of Physics and Information Engineering Shanxi Normal University Linfen 041004 China

We present fully differential cross sections (FDCS) within three-body distorted wave (3DW) for the single ionization of He by 3.6 MeV/amu AuQ+ (Q=24, 53) ions. By comparing our calculations with experimental data and other theoretical predictions, we find the cross sections are strongly influenced by highly charged projectile, ejected electron would be “pulled” along in the forward direction. However, all of the theoretical approaches can not display experimental unique forward peak structures in the FDCS.

关键词： Highly charged ions Fully differential cross section Three-body distorted wave

Maximum relative entropy of coherence for quantum channels

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 1-6页

作者： Zhi-Xiang Jin Long-Mei Yang Shao-Ming Fei Xianqing li-Jost Zhi-Xi Wang Gui-Lu Long cong-feng qiao School of Physics University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Max-Planck-Institute for Mathematics in the Sciences Leipzig 04103Germany Frontier Science Center for Quantum Information Beijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China CAS Center for Excellence in Particle Physics Beijing 100049China

Based on the resource theory for quantifying the coherence of quantum channels, we introduce a new coherence quantifier for quantum channels via maximum relative entropy. We prove that the maximum relative entropy for coherence of quantum channels is directly related to the maximally coherent channels under a particular class of superoperations, which results in an operational interpretation of the maximum relative entropy for coherence of quantum channels. We also introduce the conception of subsuperchannels and sub-superchannel discrimination. For any quantum channels, we show that the advantage of quantum channels in sub-superchannel discrimination can be exactly characterized by the maximum relative entropy of coherence for quantum channels. Similar to the maximum relative entropy of coherence for channels, the robustness of coherence for quantum channels has also been investigated. We show that the maximum relative entropy of coherence for channels provides new operational interpretations of robustness of coherence for quantum channels and illustrates the equivalence of the dephasing-covariant superchannels,incoherent superchannels, and strictly incoherent superchannels in these two operational tasks.

关键词： maximum relative entropy quantum channels quantum coherence resource theory