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Dectin-2 selectively suppresses liver metastasis by facilitating the uptake of cancer cells by Kupffer cells

Dectin-2 selectively suppresses liver metastasis by facilita...

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第十一届全国免疫学学术大会

作者： Yoshitaka Kimura Hideyuki Yanai Sho Hangai Asuka Inoue junko nishio Hideo Negishi Shinobu Saijo Yoichiro Iwakura Sho Yamasaki Tadatsugu Taniguchi Institute of Industrial Science The University of Tokyo Max Planck-The University of Tokyo Center for Integrative Inflammology Department of Molecular Immunology Medical Mycology Research Center Chiba University Center for Animal Disease Models Research Institute for Biomedical Sciences Tokyo University of Science Division of Molecular Immunology Medical Institute of Bioregulation Kyushu University

Metastasis to distal organ is a fatal cause of cancer death and liver is one of the most common site of metastasis leading to bad *** it has been known that innate immune cells play critical roles in the regulation of liver metastasis,how they control the tumor development is still largely *** using in vivo cancer models,we found that Dectin-2,a C-type lectin receptor(CLR),suppressed liver metastasis although dispensable for the

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Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

Recognition of tumor cells by Dectin-1 orchestrates innate i...

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第九届全国免疫学学术大会

作者： Yoshitaka Kimura Shiho Chiba Hiroaki Ikushima Hiroshi Ueki Hideyuki Yanai Sho Hangai junko nishio Hideo Negishi Tomohiko Tamura Shinobu Saijo Yoichiro Iwakura Tadatsugu Taniguchi Department of Molecular Immunology and Center for International Research on Integrative Biomedical Systems Institute of Industrial ScienceThe University of Tokyo Max Planck-The University of Tokyo Center for Integrative Inflammology Core Research for Evolution Science and Technology Japan Science and Technology Agency Department of Immunology Yokohama City University Graduate School of Medicine Department of Molecular Immunology Medical Mycology Research CenterChiba University Center for Animal Disease Models Research Institute for Biomedical SciencesTokyo University of Science

Innate immune receptors play pivotal roles in the immune response against invading ***,the role of such receptors in anti-tumor immune responses is still *** gain insights into the role of innate immune

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Antiproliferative Effect of Amlodipine, a Dihydropyridine Ca2+ Channel Blocker, on Human Epidemioid Carcinoma A431 Cells.

Antiproliferative Effect of Amlodipine, a Dihydropyridine Ca...

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第十五届国际药理学大会

作者： junko Yoshida Takaharu Ishibashi Matomo nishio Dept.Pharmacol. Kanazawa Med.Univ. Uchinada Ishikawa 920- 0293 Japan Dept.Pharmacol. Kanazawa Med.Univ. Uchinada Ishikawa 920- 0293 Japan Dept.Pharmacol. Kanazawa Med.Univ. Uchinada Ishikawa 920- 0293 Japan

＜正＞ We have previously shown that amlodipine, an L - type voltage - dependent Ca2+ channel blocker, inhibited the cell growth of human epidermoid carcinoma A431 cells that lack relevant Ca2+ channels. In this study, we examined the effect of amlodipine on cell cycle distribution and cell cycle - specific protein expression in A431 cells by flow cytometric analysis and Western blotting, respec- tively. Treatment with amlodipine （20-30 uM for 24 hrs） induced Gl phase accumulation, which was associated with decreases in the phosphorylated form of retinoblastoma protein （pRB）, a regulator of Gl - S - phase transition and in protein levels of cyclin Dl and cyclindependent kinase 4 （CDK4）, Gl - specific cell- cycle proteins. On the other hand, the expression of p21Wafl/Cipl, an inhibitor protein of CDK/cyclin complexes, was increased by amlodipine. These data suggest that amlodipine induced the expression of p21Wafl/Cipl and con-comitantly inhibited the CDK4 and CDK4 - mediated phosphorylation of pRB, which resulted in Gl cell - cycle arrest and growth inhibition.

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