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中华高血压杂志 2016年第9期24卷 808-808页

作者：刘莉叶鹏 Aarup A Pedersen TX junker n Christoffersen C Bartels ED Madsen M nielsen CH nielsen LB

粥样硬化病变包含缺氧区域，但缺氧病理生理的重要性未知。缺氧诱导因子1a（hypoxia-induciblefactor-1α，HIF-1α）是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。

关键词：缺氧诱导因子1α 动脉粥样硬化巨噬细胞 HIF-1α 生物学效应病理生理转录因子低氧反应

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A Modified Treatment Failure Classification System with Complete and Exhaustive Accounting of Any Adverse Events Related to the Previous Percutaneous Coronary Intervention

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World Journal of Cardiovascular Diseases 2014年第9期4卷 405-415页

作者： Anders MGalloe Jorgen LJeppesen Soren Boesgaard John Godtfredsen niels Bligaard Jens FLassen Henning Kelbaek Anders junker Jan Ravkilde Peter Riis Hansen Carsten TLarsen Ghita BStephansen Ulrik Abildgaard Department of Cardiology Copenhagen University HospitalRoskildeDenmark Department of Medicine Copenhagen University HospitalGlostrupDenmark Department of Cardiology Copenhagen University HospitalRigshospitaletDenmark Department of Cardiology Copenhagen University HospitalHerlevDenmark Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Cardiology Aarhus University HospitalSkejbyDenmark Department of Cardiology Odense University HospitalDenmark Department of Cardiology Aalborg University HospitalDenmark

Objectives: To determine the clinical outcome related to treatment failure of the percutaneous coronary intervention (PCI) itself. Background: When considering the addition of PCI to the medical treatment of angina, it is necessary to know the balance between the benefit and the risk of the PCI itself, but the latter remains unknown. The usual outcome measures are imprecise because they contain events unrelated to the previous PCI and because some events clearly caused by PCI treatment failures are omitted. Methods: In total, 2098 unselected patients were randomized to receive either sirolimus-(n = 1065) or paclitaxel-(n = 1033) eluting coronary stents and followed for five years in the SORT OUT II. Any death, cardiac death, myocardial infarction (MI), stent thrombosis and documented stenosis was classified and combined to a “patient oriented clinical outcome” (POCO), the classical “major adverse cardiac events” (MACE) and the new “PCI-treatment oriented clinical outcome” (TOCO). Results: POCO occurred in 746 patients (35.6%), MACE in 467 patients (22.3%) and TOCO in 293 patients (14.0%), thus TOCO amounted to 39% of the POCO and to 63% of the MACE. Conclusion: By introduction of the present PCI treatment failure classification system, the clinical outcome of PCI-treatment itself may be credulously estimated by the rate of TOCO and eventually PCI is substantially better than what might be perceived from the classically used POCO and MACE rates.

关键词： PCI Angina Clinical Outcome

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