检索结果-南通市图书馆

ZokorDB: tissue specific regulatory network annotation for non-coding elements of plateau zokor

Quantitative Biology 2020年第1期8卷 43-50页

作者： Jingxue Xin junjun Hao Lang Chen tao Zhang Lei Li Luonan Chen Wenmin Zhao Xuemei Lu Peng Shi Yong Wang CEMS NCMISMDISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China State Key Laboratory of Genetic Resources and Evolution Laboratory of Evolutionary and Functional GenomicsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Key Laboratory of Systems Biology Innovation Center for Cell Signaling NetworkInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Department of Statistics Department of Biomedical Data ScienceBio-X ProgramStanford UniversityStanfordCA 94305USA University of Chinese Academy of Sciences Beijing 100049China

Background:Plateau zokor inhabits in sealed burrows from 2,000 to 4,200 meters at Qinghai-Tibet *** extreme living env ironment makes it a great model to study animal adaptation to hypoxia,low temperature,and high carbon dioxide ***:We provide an integrated resource,ZokorDB,for tissue specific regulatory network annotation for *** is based on a high-quality draft genome of a plateau zokor at 3,300 m and its transcriptional profiles in brain,heart,liver,kidney,and *** conserved non-coding elements of zokor are annotated by their nearest genes and upstream transcriptional factor motif binding ***:ZokorDB provides a general draft gene regulatory network(GRN),Le?potential transcription factor(TF)binds to non-coding regulatory elements and regulates the expression of target genes(TG).Furthermore,we refined the GRN by incorporating matched RNA-seq and DNase-seq data from mouse ENCODE project and reconstructed five tissue-specific regulatory ***:A web-based,open-access database is developed for easily searching,visualizing,and downloading the annotation and *** pipeline of non-coding region annotation for zokor will be useful for other non-model *** is free available at the website(***/zokordb/).

关键词： tissue specific regulatory network non-coding element plateau zokor non-model species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-threshold lasing in a plasmonic laser using nanoplate InGaN/GaN

引用

Journal of Semiconductors 2021年第12期42卷 52-56页

作者： Ting Zhi tao tao Xiaoyan Liu junjun Xue Jin Wang Zhikuo tao Yi Li Zili Xie Bin Liu College of Electronic and Optical Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Microelectronics Nanjing University of Posts and TelecommunicationsNanjing 210023China Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Nanjing National Laboratory of Microstructures Nanjing UniversityNanjing 210093China School of Information Science and Technology Nantong UniversityNantong 226019China Tongke School of Microelectronics Nantong UniversityNantong 226019China

Plasmonic nanolaser as a new type of ultra-small laser,has gain wide interests due to its breaking diffraction limit of light and fast carrier dynamics ***,the main problem that need to be solved for plasmonic nanolaser is high loss induced by optical and ohmic losses,which leads to the low quality *** this work,InGaN/GaN nanoplate plasmonic nanolaser with large interface area were designed and fabricated,where the overlap between SPs and excitons can be *** lasing threshold is calculated to be~6.36 kW/cm^(2),where the full width at half maximum(FWHM)drops from 27 to 4 *** the fast decay time at 502 nm(sharp peak of stimulated lasing)is estimated to be 0.42 *** lasing characters are mainly attributed to the strong confinement of electromagnetic wave in the low refractive index material,which improve the near field coupling between SPs and *** plasmonic laser should be useful in data storage applications,biological application,light communication,especially for optoelectronic devices integrated into a system on a chip.

关键词： surface plasmon plasmonic laser GaN

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring

引用

Journal of Animal Science and Biotechnology 2021年第2期12卷 649-660页

作者： Tiantian Li Shimeng Huang Long Lei Shiyu tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin junjun Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Hubei Key Laboratory of Animal Nutrition and Feed ScienceWuhan Polytechnic UniversityWuhan 430023People’s Republic of China Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Quality and Standard for Agro-productsZhejiang Academy of Agricultural SciencesHangzhou 310021People’s Republic of China Key Laboratory of Agrifood Safety and Quality Institute of Quality Standards and Testing Technology for Agricultural ProductsChinese Academy of Agricultural SciencesMinistry of Agriculture and Rural AffairsBeijing 100081People’s Republic of China

Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also ***,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely ***,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later ***:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in *** digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW ***:The rate of portal venous blood flow did not differ beween IUGR and NBW *** concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW *** ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW *** increased hindgut microbial diversity and bacterial fermentation activity in the *** vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal ***:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing *** findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions.

关键词： Absorption Digestion Fermentation IUGR pigs Portal vein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution of surface of Pd-Rh bimetallic nanocubes and its correlation with CO oxidation

引用

Science China Materials 2019年第1期62卷 103-114页

作者： Wei Zhu junjun Shan Luan Nguyen Shiran Zhang Franklin Feng tao Ya-Wen Zhang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and Applications PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry College of Chemistry and Molecular Engineering Peking University Department of Chemical and Petroleum Engineering and Department of Chemistry University of Kansas

Typically, varying pretreatment conditions probably results in the different catalytic performances for the bimetallic catalysts, and this originates from the surface evolution of catalysts during catalytic process. Hence, it is crucial to correlate surface chemistry(e.g., composition, chemical valence, etc.) of bimetallic nanocatalysts with their corresponding performances upon different pretreatments for the fundamental understanding of catalysis. Herein, compositionvaried(100) facet terminated Pd-Rh nanocubes(NCs) with the similar shape and sizes were prepared by a facile one-pot hydrothermal method to exclude the possible size and shape effect. Surface composition and valence state of these Pd0.8 Rh0.2, Pd0.6 Rh0.4, and Pd0.2 Rh0.8 NCs were tracked under different reaction conditions and during catalysis using a homebuilt ambient pressure X-ray photoelectron spectrometer(APXPS). The correlation of active surface of Pd-Rh NCs and their corresponding catalytic performance was established.

关键词： controUable synthesis bimetallic nanocubes ambient-pressure XPS CO oxidation surface chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression

引用

Bioactive Materials 2022年第4期7卷 443-459页

作者： junjun Yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu tao Li Yang Huang ZheXiong Tang Shuo Meng Na Liu Jiajia Chen Pingju Liu Liu Yang Xiaoyuan Gong Cheng Chen Center for Joint Surgery Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing400038China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Blood Transfusion Department Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing400038China Department of Sports Medicine Peking University Shenzhen HospitalPeking UniversityShenzhen518036China Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationLaboratory of Molecular Developmental BiologySchool of Life SciencesSouthwest UniversityChongqing400038China Biomedical Analysis Center Army Medical University(Third Military Medical University)Chongqing400038China Department of Orthopedics Zunyi Traditional Chinese Medicine HospitalZunyi563099China

Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)***,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative *** this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture ***,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in *** addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint *** of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in *** conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL *** findings may provide new insights in MSCs intra-articular injection for OA treatment.

关键词： Tropoelastin Osteoarthritis Infrapatellar fat pad MSCs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intermediate phase assisted sequential deposition of reverse-graded quasi-2D alternating cation perovskites for MA-free perovskite solar cells

引用

InfoMat 2023年第3期5卷 134-149页

作者： Shaofu Wang Yumin Liu Junjie Zou junjun Jin Yun Jiang tao Zeng Wenyan Zhao Rong-Xiang He Bolei Chen Yu Chen Shuoxue Jin Hong-Xiang Li Zhipeng Xie Chang-An Wang Weiwei Sun Qiang Cao Xing-Zhong Zhao School of Materials Science and Engineering National Engineering Research Center for Domestic&Building CeramicsJingdezhen Ceramic UniversityJingdezhenthe People Republic of China School of Physics and Technology Institute of Technological SciencesKey Laboratory of Artificial Micro/Nano StructuresMinistry of EducationWuhan UniversityWuhanthe People Republic of China Institute for Interdisciplinary Research(IIR) Key Laboratory of Optoelectronic Chemical Materials and DevicesMinistry of EducationJianghan UniversityWuhanthe People Republic of China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijingthe People Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduthe People Republic of China College of Aerospace Science and Engineering National University of Defense TechnologyChangshathe People Republic of China

One-step deposition approaches have been widely applied and developed in the fabrication of quasi-2D ***,the regulation of quantum wells(QWs)and crystalline orientation is difficult and complicated when using this *** deposition is another widespread synthetic approach for preparing perovskite films and perovskite dimension *** this article,δ-CsPbI_(3)intermediate phase assisted sequential(IPAS)deposition is successfully carried out to fabricate MA-free quasi-2D ACI *** amount of theδ-CsPbI_(3)intermediate phase in the PbI2 layer and the concentration of GAI molecule in the IPA solution both play important roles in the production of MA-free quasi-2D ACI perovskite *** n value of the MA-free quasi-2D ACI perovskites can be adjusted,which affects the photovoltaic performance and device *** with one-step deposition,the MA-free quasi-2D ACI perovskites prepared via IPAS deposition have opposite reverse-graded QW distribution and improved vertical orientation,leading to a remarkable PEC of up to 18.86%and allowing the preparation of unpackaged devices with prominent working stability(80%,400 h).The underlying mechanism and crystallization pathway of IPAS deposition confirm that sequential deposition has unique superiority in regulating the QW distribution and crystalline orientation of quasi-2D perovskites.

关键词： intermediate phase quantum well distribution quasi-2D perovskite sequential deposition solar cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BRPF2 directly enhances the acetyltransferase activity of HBO1 towards H3K14

BRPF2 directly enhances the acetyltransferase activity of HB...

引用

中国生物化学与分子生物学会2016年全国学术会议

作者： Ye tao junjun Zhu Chen Zhong Shutong Xu Jianping Ding National Center for Protein Science Shanghai State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University Shanghai Science Research Center Chinese Academy of Sciences

HBO1,a member of the MYST family histone acetyltransferases(HATs),is required for global acetylation of H3K14 and embryonic *** functions in multisubunit complexes comprising of HBO1,a BRPF1/2/3 or JADE1/2/3 scaffold ... 详细信息

关键词： HAT HDAC HBO1 BRPF2 acetylation histone modification

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

肝肺综合征的诊治对策

引用

中华肝脏病杂志 2020年第5期28卷 386-390页

作者：蔡均均张倩韩涛天津市第三中心医院肝内科天津市人工细胞重点实验室天津市肝胆疾病研究所300170

肝肺综合征(HPS)是肝病和/或门静脉高压患者常见的肺部并发症,其特征表现为肺内血管扩张引起的动脉氧合异常。HPS发病机制复杂,临床上早期诊断率低,预后差。目前HPS尚缺乏有效治疗药物,肝移植是唯一根本治疗手段。现就HPS发病机制、临... 详细信息

肝肺综合征(HPS)是肝病和/或门静脉高压患者常见的肺部并发症,其特征表现为肺内血管扩张引起的动脉氧合异常。HPS发病机制复杂,临床上早期诊断率低,预后差。目前HPS尚缺乏有效治疗药物,肝移植是唯一根本治疗手段。现就HPS发病机制、临床表现、诊断及治疗进行概述,旨在进一步提高临床筛查和诊治HPS的水平。

关键词：肝硬化肝肺综合征门静脉高压肺内血管扩张肝移植

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

弹性车轮动力学复合模型及其性能研究

引用

中国铁道科学 2015年第4期36卷 93-100页

作者：杨阳李芾戚壮丁军君李涛西南交通大学机械工程学院四川成都610031 广州电力机车有限公司广东广州510850

为深入研究轻轨车辆弹性车轮的动力学作用,基于压剪复合型弹性车轮的结构,在弹性车轮动力学传统模型的基础上,综合考虑弹性车轮轮芯相对于轮毂的6个自由度,建立弹性车轮动力学复合模型。利用多体动力学软件SIMPACK进行仿真计算,对比分... 详细信息

为深入研究轻轨车辆弹性车轮的动力学作用,基于压剪复合型弹性车轮的结构,在弹性车轮动力学传统模型的基础上,综合考虑弹性车轮轮芯相对于轮毂的6个自由度,建立弹性车轮动力学复合模型。利用多体动力学软件SIMPACK进行仿真计算,对比分析传统模型和复合模型下弹性车轮车辆以及刚性车轮车辆的临界速度、平稳性、曲线通过性能和轮轨磨耗等指标。结果表明:由于传统模型未考虑车轮与车轴之间的偏转刚度和轮对两车轮之间的扭转刚度,因此计算误差较大;采用复合模型得到的弹性车轮车辆的临界速度、运行平稳性指标,以及通过小半径曲线时的轮轨横向力、轮轴横向力、脱轨系数、轮重减载率等较刚性车轮车辆都有不同程度的降低;弹性车轮车辆的轮轨磨耗情况在直线通过时与刚性车轮车辆的相似,而曲线通过时相比刚性车轮车辆降低了约5.3%。

关键词：弹性车轮动力学模型临界速度运行平稳性曲线通过性能轮轨磨耗轻轨车辆

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research Progress of Value, Extraction and Applicationof Silkworm Chrysalis Protein

引用

Animal Husbandry and Feed Science 2018年第4期10卷 241-245页

作者： zhang yuping zhang lili chen ming dai junjun wu chuanhua liu jian fan tao yin jianli Sericultural Research Institute Anhui Academy of Agricultural Sciences Hefei 230061 China 不详

Silkworm chrysalis protein is a high quality pure natural complete animal protein with high utilization value, and it has been widely usedin many industries in recent years. The nutrition, health care and medicinal value of silkworm chrysalis protein, the degreasing, deodorization anddecoloration extraction process, and its application in food, medicine, feed, etc. are summarized, in order to provide the reference for further development and industrial production of silkworm chrysalis protein.

关键词： Silkworm chrysalis protein Bioactive substances Extraction process Comprehensive utilization Research progress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：