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352-Gbit/s single line rate THz wired transmission based on PS-4096QAM employing hollow-core fiber

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Digital Communications and Networks 2023年第3期9卷 717-722页

作者： junjie Ding Yuxuan Tan Yanyi Wang Jiao Zhang Menghui He Feng Zhao Li Zhao wen Zhou Yiwei Shi Min Zhu Jianjun Yu Key Laboratory for Information Science of Electromagnetic Waves(MOE) Fudan UniversityShanghaiChina Purple Mountain Laboratories NanjingJiangsuChina Xian University of Posts and Telecommunications XianShanxiChina

We successfully demonstrate 32-Gbaud Probabilistically Shaped 4096-ary Quadrature Amplitude Modulation(PS-4096QAM)TeraHertz(THz)signal wired transmission at 325 GHz over the 1-m Hollow-Core Fiber(HCF)in a photon-assisted THz-wave communication *** employing advanced Digital Signal Processing(DSP)and the PS technique,the 352-Gbit/s line rate(288-Gbit/s net rate)delivery with a net Spectral Efficiency(SE)of 9 bit/s/Hz is realized in the experiment,satisfying the 0.86-Normalized Generalized Mutual Information(NGMI)Low-Density Parity-Check(LDPC)threshold.

关键词： Hollow-core fiber Terahertz-wave communication Photonics-aided scheme Probabilistic shaping

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1241-1256页

作者： Pengfei Xu Yue Xi Jong-Won Kim junjie Zhu Min Zhang Meishu Xu Songrong Ren Da Yang Xiaochao Ma wen Xie Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Pharmacology&Chemical Biology University of PittsburghPittsburghPA 15261USA

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology.3’-Phosphoadenosine 5’-phosphosulfate(PAPS)synthase 2(PAPSS2)is the primary enzyme to generate the universal sulfonate donor *** involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli(APC)mutation-promoted colonic carcinogenesis has not been ***,we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages,and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon *** epithelial-specific heterozygous Apc deficient and Papss2-knockout(Apc^(Δgut-Het)Papss2^(Δgut))mice were created,and the phenotypes were compared to the spontaneous intestinal tumorigenesis of Apc^(Δgut-Het)***^(Δgut-Het)Papss2^(Δgutmice) were more sensitive to gut tumorigenesis,which was mechanistically accounted for by the activation of Wnt/β-catenin signaling pathway due to the suppression of chondroitin sulfation and inhibition of the farnesoid X receptor(FXR)-transducin-like enhancer of split 3(TLE3)gene regulatory *** sulfate supplementation in Apc^(Δgut-Het)Papss2^(Δgutmice) alleviated intestinal *** summary,we have uncovered the protective role of PAPSS2-mediated chondroitin sulfation and bile acids-FXR-TLE3 activation in the prevention of gut carcinogenesis via the antagonization of Wnt/β-catenin *** sulfate may be explored as a therapeutic agent for Papss2 deficiency-associated colonic carcinogenesis.

关键词： Colon cancer APC Wnt/b-catenin PAPSS2 Chondroitin sulfate Sulfation Bile acids FXR

Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice)

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Liver Research 2022年第4期6卷 251-257页

作者： Anqi Cheng Saifei Lei junjie Zhu Jie Lu Mary F.Paine wen Xie Xiaochao Ma Center for Pharmacogenetics Department of Pharmaceutical SciencesSchool of PharmacyUniversity of PittsburghPittsburghPAUSA Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical SciencesWashington State UniversitySpokaneWAUSA

Background and aims:The herbal supplement Gancao,also known as licorice,belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective *** studies have raised concerns about potential herb-drug interactions associated with Gancao via pregnane X receptor(PXR)-mediated induction of hepatic cytochrome P4503A4(CYP3A4).The current work aimed to determine the phytochemicals in Gancao that activate PXR and induce ***:DPX2 cells were used for cell-based PXR reporter *** phytochemicals in Gancao extract were identified using a metabolomics *** effects of PXR activators identified from in vitro studies were further investigated in PXR-and CYP3A4-humanized mouse ***:Gancao was verified to be a PXR-activating *** major phytochemicals in Gancao,gly-cyrrhizin(GZ)and glycyrrhetinic acid(GA),did not activate PXR in the cell-based reporter ***,glabridin was shown to activate PXR in a dose-dependent *** vivo studies confirmed that GZ is not a PXR activator and glabridin is a weak PXR *** GA did not active PXR in vitro,it induced CYP3A4 expression in a PXR-dependent manner in the PXR-and CYP3A4-humanized mice.

关键词： Gancao Licorice Glabridin Pregnane X receptor(PXR) Cytochrome P4503A4(CYP3A4) Herb-drug interactions

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通孔电极对正装LED光电性能影响的研究

中国照明电器 2021年第6期 11-18页

作者：戴泽毫陈斯盼温俊杰陈仁梁宏辉周兰君李进梁晓东魏美霞佛山科学技术学院物理与光电工程学院广东佛山528000 佛山科学技术学院粤港澳智能微纳光电技术联合实验室广东佛山528000 佛山市国星半导体技术有限公司广东佛山528000

传统LED的电极为圆环电极加电流扩展线,需要刻蚀部分有源层,减少发光面积,导致LED芯片亮度降低。本文采用光刻刻蚀法在电流拓展层表面制作3个及以上的电极通孔,使连续的电流扩展线变成不连续的电极孔洞,从而在理论上提高发光效率。通过... 详细信息

传统LED的电极为圆环电极加电流扩展线,需要刻蚀部分有源层,减少发光面积,导致LED芯片亮度降低。本文采用光刻刻蚀法在电流拓展层表面制作3个及以上的电极通孔,使连续的电流扩展线变成不连续的电极孔洞,从而在理论上提高发光效率。通过高温加速老化试验,测试通孔电极结构的LED芯片发光效率、光衰等光电性能参数,并通过发光分布测试通孔电极对电流拓展能力的改变。结果表明,优化电极结构后LED总体亮度水平可提升4%~6%,且电流拓展能力增强,光衰减少,芯片寿命提高,可直接减少工艺步骤,单片节约工艺流程时间约9 h,提高生产效率。

关键词：正装LED 电流拓展线通孔电极发光效率光衰

Proteomic analysis of insulin secretory granules in INS-1 cells by protein correlation profiling

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Biophysics Reports 2018年第6期4卷 329-338页

作者： Min Li wen Du Maoge Zhou Li Zheng Eli Song junjie Hou National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences

Insulin secretory granules(ISGs), a group of distinguishing organelles in pancreatic b cells, are responsible for the storage and secretion of insulin to maintain blood glucose homeostasis. The molecular mechanisms of ISG biogenesis, maturation, transportation, and exocytosis are still largely unknown because the proteins involved in these distinct steps have not been fully identified. Subcellular fractionation by density gradient centrifugation has been successfully employed to analyze the proteomes of numerous organelles. However, use of this method to elucidate the ISG proteome is limited by co-fractionated contaminants because ISGs are very dynamic and have abundant exchanges or contacts with other organelles, such as the Golgi apparatus, lysosomes, and endosomes. In this study,we developed a new strategy for identifying ISG proteins by protein correlation profiling(PCP)-based proteomics, which included ISG purification by Opti Prep density gradient centrifugation, label-free quantitative proteome, and identification of ISG proteins by correlating fractionation profiles between candidates and known ISG markers. Using this approach, we were able to identify 81 ISG *** them, TM9SF3, a nine-transmembrane protein, was considered a high confidence ISG candidate protein highlighted in the PCP network. Further biochemical and immunofluorescence assays indicated that TM9SF3 localized in ISGs, suggesting that it is a potential new ISG marker.

关键词： Insulin secretory granules (ISGs) Label-free proteomics Protein correlation profiling Proteome

An Air‑Rechargeable Zn Battery Enabled by Organic–Inorganic Hybrid Cathode

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Nano-Micro Letters 2023年第4期15卷 138-152页

作者： junjie Shi Ke Mao Qixiang Zhang Zunyu Liu Fei Long Li wen Yixin Hou Xinliang Li Yanan Ma Yang Yue Luying Li Chunyi Zhi Yihua Gao Wuhan National Laboratory for Optoelectronics(WNLO)and School of Physics Center for Nanoscale Characterization&Devices(CNCD)Huazhong University of Science and Technology(HUST)Wuhan 430074People’s Republic of China Guangxi Key Laboratory of Optical and Electronic Materials and Devices College of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004People’s Republic of China Hong Kong Center for Cerebro-Cardiovascular Health Engineering Hong Kong SAR 999077People’s Republic of China Hubei Key Laboratory of Critical Materials of New Energy Vehicles and School of Mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyan 442002People’s Republic of China Information Materials and Intelligent Sensing Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601People’s Republic of China

Self-charging power systems collecting energy harvesting technology and batteries are attracting extensive *** solve the disadvantages of the traditional integrated system,such as highly dependent on energy supply and complex structure,an airrechargeable Zn battery based on MoS_(2)/PANI cathode is *** from the excellent conductivity desolvation shield of PANI,the MoS_(2)/PANI cathode exhibits ultra-high capacity(304.98 mAh g^(−1) in N_(2) and 351.25 mAh g^(−1) in air).In particular,this battery has the ability to collect,convert and store energy simultaneously by an airrechargeable process of the spontaneous redox reaction between the discharged cathode and O2 from *** air-rechargeable Zn batteries display a high open-circuit voltage(1.15 V),an unforgettable discharge capacity(316.09 mAh g^(−1) and the air-rechargeable depth is 89.99%)and good air-recharging stability(291.22 mAh g^(−1) after 50 air recharging/galvanostatic current discharge cycle).Most importantly,both our quasi-solid zinc ion batteries and batteries modules have excellent performance and *** work will provide a promising research direction for the material design and device assembly of the next-generation self-powered system.

关键词： Air-rechargeable MoS_(2)/PANI Cathode Desolvation shield Energy storage mechanism Zn batteries module

Progress in watershed geography in the Yangtze River Basin and the affiliated ecological security perspective in the past 20 years,China

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Journal of Geographical Sciences 2020年第6期30卷 867-880页

作者： GAO Yang JIA junjie LU Yao SUN Xiaomin wen Xuefa HE Nianpeng YANG Tiantian Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resources and Environment University of Chinese Academy of Sciences.Beijing 100049China School of Civil Engineering and Environmental Science.University of Oklahoma NormanOK 73019United States

Bibliometrics was used to statistically analyze key zones within the Yangtze River Basin(YRB)funded by the National Natural Science Foundation of China(NSFC)and national ministries over the past 20 *** study determined that funds that derived from national ministries have mainly focused on issues related to environmental pollution,ecological security,technological water regulations,and river basin ecosystems,which offer a better understanding of the national requirements and the scientific knowledge of the YRB in combination with data from the *** a background of bolstering the construction of green ecological corridors in the economic belt of the YRB,this study proposes future conceptual watershed research initiatives in this region as a study objective by reinforcing the implementation of the Chinese Ecosystem Research Network(CERN)and by emphasizing the use of new technologies,new methods,and new concepts for the prospective design of frontier research under the perspective of geoscience and earth system *** study promotes large-scale scientific field and research objectives based on big science and big data.

关键词： watershed physiography ecological security earth system science critical zone C-N-H20 coupling Yangtze River Basin

Noninvasive Ultrasound Stimulation of Ventral Tegmental Area Induces Reanimation from General Anaesthesia in Mice

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Research 2021年第1期2021卷 81-93页

作者： Tianyuan Bian wen Meng Meihong Qiu Zhigang Zhong Zhengrong Lin junjie Zou Yibo Wang Xiaowei Huang Lisheng Xu Tifei Yuan Zhili Huang Lili Niu Long Meng Hairong Zheng Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences1068 Xueyuan AvenueShenzhenChina 518055 Department of Pharmacology School of Basic Medical SciencesFudanUniversityShanghaiChina 200032 College of Medicine and Biological Information Engineering Northeastern University195 Innovation RoadShenyang 110016China Shanghai Mental Health Center Shanghai Jiaotong University School of MedicineShanghaiChina 200030

Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness(DOC).However,these treatments require invasive *** report presents a noninvasive strategy to stimulate central nervous system neurons selectively for recovery from DOC in *** the delivery of ultrasound energy to the ventral tegmental area,mice were aroused from an unconscious,anaesthetized state in this study,and this process was controlled by adjusting the ultrasound *** mice in the sham group under isoflurane-induced,continuous,steady-state general anaesthesia did not regain their righting *** insonation,the emergence time from inhaled isoflurane anaesthesia decreased(sham.13.63±0.53 min,ultrasound.1.5±0.19 min,p<0.001).Further,the induction time(sham.12.0±0.6 min,ultrasound.17.88±0.64 min,p<0.001)and the concentration for 50%of the maximal effect(EC50)of isoflurane(sham.0.6%,ultrasound.0.7%)*** addition,ultrasound stimulation reduced the recovery time in mice with traumatic brain injury(sham.30.38±1.9 min,ultrasound.7.38±1.02 min,p<0.01).This noninvasive strategy could be used on demand to promote emergence from DOC and may be a potential treatment for such disorders.

关键词： stimulation treatment consciousness

Self-powered sensor based on compressible ionic gel electrolyte for simultaneous determination of temperature and pressure

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InfoMat 2024年第7期6卷 62-75页

作者： junjie Zou Yanan Ma Chenxu Liu Yimei Xie Xingyao Dai Xinhui Li Shuxuan Li Shaohui Peng Yang Yue Shuo Wang Ce-wen Nan Xin Zhang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and Devices&International School of Materials Science and EngineeringWuhan University of TechnologyWuhanthe People's Republic of China Hubei Key Laboratory of Energy Storage and Power Battery School of MathematicsPhysics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyanthe People's Republic of China Information Materials and Intelligent Sensing Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information TechnologyAnhui UniversityHefeithe People's Republic of China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijingthe People's Republic of China

The simultaneous detection of multiple stimuli,such as pressure and temperature,has long been a persistent challenge for developing electronic skin(eskin)to emulate the functionality of human ***,the demand for integrated power supply units is an additional pressing concern to achieve its lightweightness and ***,we propose a self-powered dual temperature–pressure(SPDM)sensor,which utilizes a compressible ionic gel electrolyte driven by the potential difference between MXene and Al *** SPDM sensor exhibits a rapid and timely response to changes in pressure-induced deformation,while exhibiting a slow and hysteretic response to temperature *** distinct response characteristics enable the differentiation of current signals generated by different stimuli through machine learning,resulting in an impressive accuracy rate of 99.1%.Furthermore,the developed SPDM sensor exhibits a wide pressure detection range of 0–800 kPa and a broad temperature detection range of 5–75C,encompassing the environmental conditions encountered in daily human *** dual-mode coupled strategy by machine learning provides an effective approach for temperature and pressure detection and discrimination,showcasing its potential applications in wearable electronics,intelligent robots,human–machine interactions,and so on.

关键词： e-skin gel electrolyte machine learning self-powered dual-mode sensor