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Amplifying protection against acute lung injury:Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair

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Chinese Herbal Medicines 2024年第3期16卷 422-434页

作者： junjie Li Ming Dong Qing Yao Xu Dong Yuanyuan Chen Jincai wen Yingjie Xu Zhixin Wu Xiaomei Zhao Ye Xiu Xiaoyan Zhan Zhaofang Bai Xiaohe Xiao Chengde Medical University Chengde 067000China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Key Laboratory of Kidney Diseases The Fifth Medical Center of PLA General HospitalBeijing 100039China School of Stomatology Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application&Experimental Center for Stomatology EngineeringJiamusi UniversityJiamusi 154007China Southern Medical University Guangzhou 510515China

Objective:Acute lung injury(ALI)is characterized by inflammation and currently lacks an efficacious pharmacological *** medicine combination of Lonicerae Japonicae Flos(LJF)and Forsythiae Fructus(FF)demonstrates combined properties in its anti-infective,anti-inflammatory,and therapeutic effects,particularly in alleviating respiratory *** previous studies,Chinese medicine has shown promising efficacy in lipopolysaccharides(LPS)-induced ***,there have been no reports of LJF and FF pairing for lung *** aim of this study is to compare the efficacy of herb pair Lonicerae Japonicae Flos-Forsythiae Fructus(LF)with LJF or FF alone in the treatment of ALI,and to explore whether LJF and FF have a combined effect in the treatment of lung injury,along with the underlying mechanism ***:A total of 36 mice were divided into six groups(control,model,LJF,FF,LF,dexamethasone)based on the treatments they received after undergoing sham-operation/LPS tracheal instillation.H&E staining and pulmonary edema indexes were used to evaluate lung injury *** exudate cells(AECs)were counted based on cell count in bronchoalveolar lavage fluid(BALF),and neutrophil percentage in BALF was measured using flow ***(MPO)activity in BALF was measured using enzyme-linked immunosorbent assay(ELISA),while the production of IL-1β,TNF-α,and IL-6 in the lung and secretion level of them in BALF were detected by quantitative polymerase chain reaction(qPCR)and *** effect of LJF,FF,and LF on the expression of Caspase-1 and IL-1βproteins in bone marrow derived macrophages(BMDMs)supernatant was assessed using Western blot method under various inflammasome activation *** addition,the concentration of IL-1βand changes in lactatedehydrogenase(LDH)release levels in BMDMs supernatant after LJF,FF,and LF administration,respectively,were measured using ***,the effects of LJF,FF and LF on STING and IRF3 phosphor

关键词： acute lung injury BMDMS inflammasomes Lonicerae Japonicae Flos-Forsythia Fructus drug pair STING

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弹性动力学高阶核无关快速多极边界元法

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力学学报 2014年第5期46卷 776-785页

作者：荣俊杰校金友文立华西北工业大学航天学院计算力学与工程应用研究所西安710072

基于核无关的快速多极方法,发展了一种弹性动力学问题的快速、高精度边界元分析方法.采用基于二次曲面单元的Nystrm离散,将边界积分方程转化为求和形式,可以方便地进行加速计算;由于采用二次元,边界元分析精度很高.将一种新型快速多... 详细信息

基于核无关的快速多极方法,发展了一种弹性动力学问题的快速、高精度边界元分析方法.采用基于二次曲面单元的Nystrm离散,将边界积分方程转化为求和形式,可以方便地进行加速计算;由于采用二次元,边界元分析精度很高.将一种新型快速多极方法用于Nystrm边界元法的加速计算,该方法的数值实现简便、不依赖于积分方程基本解的表达式,因此通用性很好;该方法还具有最优的计算量和存储量、精度高且可以控制.结合Nystrm边界元系数矩阵和快速多极方法转换矩阵的特点,提出一种大幅度降低边界元内存消耗的策略.数值结果表明,该方法无论在分析精度,还是计算速度和内存消耗上,都大大优于同类方法,是一种快速、通用的工程弹性动力学问题大规模数值分析方法.

关键词：弹性动力学核无关快速多极算法边界元法高阶Nystrom方法

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A universal route to efficient non-linear response via Thomson scattering in linear solids

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National Science Review 2023年第7期10卷 203-212页

作者： Yongzheng wen Flavio Giorgianni Igor Ilyakov Baogang Quan Sergey Kovalev Chen Wang Carlo Vicario Jan-Christoph Deinert Xiaoyu Xiong Joe Bailey Min Chen Alexey Ponomaryov Nilesh Awari Andrea Rovere Jingbo Sun Roberto Morandotti Luca Razzari Gabriel Aeppli junjie Li Ji Zhou State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Paul Scherrer Institut Helmholtz-Zentrum Dresden-Rossendorf Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Institut de Physique école Polytechnique Fédérale de Lausanne (EPFL) Institut National de la Recherche Scientifique (INRS) Centreénergie Matériaux et Télécommunications (EMT) Department of Physics and Quantum Center ETH Zürich

Non-linear materials are cornerstones of modern optics and *** dependence on the intrinsic properties of particular materials,however,inhibits the at-will extension of demanding non-linear effects,especially those second-order ones,to widely adopted centrosymmetric materials(for example,silicon) and te chnologically important burgeoning spectral domains(for example,terahertz frequencies).Here we introduce a universal route to efficient non-linear responses enabled by exciting non-linear Thomson scattering,a fundamental process in electrodynamics that was known to occur only in relativistic electrons in metamaterial composed of linear *** a mechanism modulates the trajectory of charges,either intrinsically or extrinsically provided in solids,at twice the driving frequency,allowing second-harmonic generation at terahertz frequencies on crystalline silicon with extremely large non-linear susceptibility in our proof-of-concept *** offering a substantially material-and frequency-independent platform,our approach opens new possibilities in the fields of on-demand non-linear optics,terahertz sources,strong field light-solid interactions and integrated photonic circuits.

关键词： non-linear optical materials terahertz harmonic generation Thomson scattering magneto-electric coupling metamaterial

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慢病毒介导N2ICD过表达的人胃癌MKN45细胞稳定株的构建及鉴定

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生物技术 2018年第4期28卷 372-376页

作者：吴丹琳温俊杰叶健斌薛杨林彦青胡冰心罗美群陈中标谢金玲宁立军宁云山李妍南方医科大学检验与生物技术学院广东广州510515 珠海南医大生物医药公共服务平台有限公司广东珠海519090 南方医科大学附属佛山医院广东佛山528000 南方医科大学附属新会医院检验科广东江门529100

[目的]构建慢病毒介导Notch2受体胞内段((Notch2 intracellular domain,N2ICD)过表达的人胃癌MKN45细胞稳定株并进行鉴定。[方法]采用PCR法扩增N2ICD基因并克隆至慢病毒载体PTYE-EF1α-IRES-EGFP(简写为pLV)中,通过酶切及测序鉴定后,三... 详细信息

[目的]构建慢病毒介导Notch2受体胞内段((Notch2 intracellular domain,N2ICD)过表达的人胃癌MKN45细胞稳定株并进行鉴定。[方法]采用PCR法扩增N2ICD基因并克隆至慢病毒载体PTYE-EF1α-IRES-EGFP(简写为pLV)中,通过酶切及测序鉴定后,三质粒共转染HEK293T细胞包装病毒,收集且浓缩病毒毒液用于感染人胃癌MKN45细胞并筛选稳定细胞株,用Western Blot验证。[结果]成功构建慢病毒重组质粒N2ICD/pLV;包装病毒后,荧光显微镜下观察到大部分HEK293T细胞发出绿色荧光;收集病毒毒液感染MKN45细胞,显微镜下观察有部分细胞表达绿色荧光蛋白;流式分选技术筛选得到稳定细胞株,Western Blot鉴定结果显示:相比于空白对照组,稳定株的N2ICD过表达明显。[结论]成功构建慢病毒表达质粒N2ICD/pLV,并建立稳定过表达N2ICD的胃癌细胞株N2ICD/pLV-MKN45。

关键词： Notch2 N2ICD 慢病毒稳定株

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Si基InSb红外焦平面阵列探测器的研究

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红外与激光工程 2014年第5期43卷 1359-1363页

作者：王雯张小雷吕衍秋司俊杰中国空空导弹研究院红外探测器航空科技重点实验室河南洛阳471009

针对InSb红外焦平面芯片中InSb与Si读出电路热膨胀系数不匹配导致芯片龟裂及铟柱断裂现象,开展了Si基InSb红外焦平面探测器(FPA)的研究。运用磨抛减薄技术及金刚石点切削技术对芯片背面进行精确减薄,得到厚度为15μm的InSb芯片;研究了在... 详细信息

针对InSb红外焦平面芯片中InSb与Si读出电路热膨胀系数不匹配导致芯片龟裂及铟柱断裂现象,开展了Si基InSb红外焦平面探测器(FPA)的研究。运用磨抛减薄技术及金刚石点切削技术对芯片背面进行精确减薄,得到厚度为15μm的InSb芯片;研究了在InSb芯片和Si片上溅射及蒸发减反膜工艺,得到InSb芯片和Si片粘贴后红外中短波光谱的透过率高达88%;对器件的整体工艺路线进行了探索,最终制备出Si基128×128元InSb红外焦平面探测器器件,测试结果表明:器件探测率、响应率及串音等性能指标达到传统工艺制备的器件性能指标;经温冲试验后测试器件结构保持完好,性能未发生变化,证明该工艺路线可解决芯片受应力冲击而产生的铟柱断裂及芯片龟裂的现象,可有效提高InSb焦平面探测器芯片的成品率。

关键词： InSb 红外焦平面金刚石点切削 Si绑定

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Possible change on the runoff in the upper Yellow River basin under global climate change

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Research in Cold and Arid Regions 2009年第2期1卷 157-164页

作者： YongChao Lan Jun wen junjie Chang YeXin Xu YongPing Shen XingLin Hu JinQi Lu Key Laboratory of Ecohydrology and Integrated River Basin Science Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhouGansu 730000China Institute of the Riverhead Region of the Yellow River Water Conservancy Committee of the Yellow River BasinLanzhouGansu 730000China Institute of the Riverhead Region of the Yellow River Water Conservancy Committee of the Yellow River BasinLanzhouGansu 730030China

In this study,the characteristics and changing trends of temperature,precipitation,and runoff in the upper Yellow River basin up Tangnag station are analyzed by using hydrological and meteorological data in the past 50 years from observation stations in the ***,in this study,the evolving trend of runoff in the future decades is forecasted in the basin based on the method of suppositional climate scenes *** results indicate temperature variation in the basin has an evident positive relation with global warming,and the precipitation variations are quite complicated in the basin because of differences of located geographic positions during the past 50 *** in the basin has been decreasing continually since the end of the 1980s because the mean temperature in the basin has been rising and precipitation in the main areas of runoff formation in the basin has been *** will largely decrease if precipitation decreases and temperature rises continuously,whereas runoff will increase if temperature is invariable and precipitation increases largely;the increase magnitude of runoff may be more than that of precipitation because of the synchronously increasing supply of meltwater from snow,glacier,and frozen soils in future several decades.

关键词： global climate change upper Yellow River runoff variation circulation

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Research on SAR data integrated processing methodology oriented on earth environment factor inversions

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International Journal of Digital Earth 2017年第7期10卷 657-674页

作者： Huadong Guo Jie Chen Xinwu Li Lu Zhang wenjin Wu Huiying Liu Kai Wang Zhuo Li Xinwei Gu Qingrong Hu Xinmin Wang Jun Li Chunming Han junjie Zhu Guozhuang Shen Guang Liu wenxue Fu Zhongchang Sun Xiaoyang wen Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijingChina School of Electronics and Information Engineering Beihang UniversityBeijingChina Beijing Institute of Radio Measurement BeijingChina

As an important advanced technique in the field of Earth observations,Synthetic Aperture Radar(SAR)plays a key role in the study of global environmental change,resources exploration,disaster mitigation,urban environments,and even lunar ***,studies on imaging,image processing,and Earth factor inversions have often been conducted independently for a long time,which significantly limits the application effectiveness of SAR remote sensing due to the lack of an overall integrated design scheme and integrated information *** on this SAR application issue,this paper proposes and describes a new SAR data processing methodology–SAR data integrated processing(DIP)oriented on Earth environment factor *** simple definition,typical integrated modes and overall implementation ideas are ***,focusing on building information extraction(man-made targets)and sea ice classification(natural targets)applications,three SAR DIP methods and experiments are *** results are obtained under the guidance of the SAR DIP ***,the SAR DIP theoretical framework and methodology represent a new SAR science application mode that has the capability to improve the SAR remote sensing quantitative application level and promote the development of new theories and methodologies.

关键词： SAR data integrated processing mode and theoretical framework building detection sea ice classification

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Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta?

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Protein & Cell 2021年第6期12卷 502-510页

作者： Fangqiao Wei Xiangyu Sun Yufeng Gao Haoyu Dou Yang Liu Lili Su Haofei Luo Ce Zhu Qian Zhang Peiyuan Tong wen Ren Zhe Xun Ruochun Guo Yuanlin Guan Shenghui Li Yijun Qi junjie Qin Feng Chen Shuguo Zheng Department of Preventive Dentistry Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Promegene Institute Shenzhen 518110China Tsinghua-Peking Center for Life Sciences Beijing 100084China

Dear Editor,A series of studies had focused on the ecological stability of human microbiome(Lozupone et al.,2012;Faith et al.,2013;Moya and Ferrer,2016).Despite the continuous perturbation and the highly personalized composition within the human microbiome(Human Microbiome Project,2012),healthy adults stably maintain their microbial communities in terms of space and time(Faith et al.,2013;Moya and Ferrer,2016;Oh et al.,2016).This stability is proved to be critical for the well-being of human body(Lozupone et al.,2012).On the contrary,major shifts in microbial community composition are often related to diseases(Lynch and Pedersen,2016).

关键词： stability maintain perturbation

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血栓弹力图在创伤领域的应用进展

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中华急诊医学杂志 2016年第5期25卷 563-567页

作者：冯筑生李俊杰尹文第四军医大学西京医院急诊科西安710032

创伤系45岁以下人群死亡的主要原因，全球范围内有1／10的死亡由创伤造成，每年创伤相关性死亡超过六百万并造成大量患者残疾，给社会和家庭造成了巨大的医疗经济负担。近年来，创伤相关研究领域取得了一系列进展，涌现出了许多新的诊... 详细信息

创伤系45岁以下人群死亡的主要原因，全球范围内有1／10的死亡由创伤造成，每年创伤相关性死亡超过六百万并造成大量患者残疾，给社会和家庭造成了巨大的医疗经济负担。近年来，创伤相关研究领域取得了一系列进展，涌现出了许多新的诊治手段和方法，致力于提高患者生存率和降低创伤相关并发症的发生风险。

关键词：血栓弹力图创伤应用相关并发症经济负担发生风险死亡相关性

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MicroRNA-206 functions as a potential oligonucleotide therapeutics in preterm birth

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Chinese Medical Journal 2024年第8期137卷 1000-1002页

作者： wenfeng Deng Lina Chen Bolun wen Xiaodi Wang Lele Wang Fan Yang Yunshan Chen junjie Bao Guozheng Zhang Kaiyuan Ji Huishu Liu Guangzhou Key Laboratory of Maternal-Fetal Medicine Department of Obstetrics and GynecologyGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdong 510623China School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China

To the Editor:Spontaneous preterm labor(PTL)causes infant morbidity and *** uterine contractions were the common characteristics in spontaneous labor at term or ***,effective decrease or suppression of myometrial contraction could prevent preterm *** discovered that microRNA-206(miR-206)was a myometrium contraction-associated miRNA based on the transcriptome data of human laboring myometrium and indicated that miR-206 suppressed myometrial contractility by targeting junction protein alpha 1(GJA1)in the myometrium and would be a new potential therapeutic for preterm *** of miR-206 in RU486-induced PTL decreased myometrial contractility,prolonged pregnancy,reversed PTL to term labor,and improved perinatal outcomes.

关键词： mortality contraction RU486

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