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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang junjie yang Ganggang Zhang Chen Wang Yanlian yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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民用燃气工程进场施工时间节点及施工要点探讨

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天津科技 2025年第1期52卷 90-94页

作者：杨君杰大连海洋大学海洋与土木工程学院辽宁大连116023

燃气工程是城市能源建设的基础性工程,其管道施工安全尤为重要。只有掌握恰当的进场施工时间节点,才能极大保障后续施工的安全可靠性。通过对目前民用燃气工程的进场施工时间节点进行调查,分析施工过程中存在的实际问题,探讨改进措施,... 详细信息

燃气工程是城市能源建设的基础性工程,其管道施工安全尤为重要。只有掌握恰当的进场施工时间节点,才能极大保障后续施工的安全可靠性。通过对目前民用燃气工程的进场施工时间节点进行调查,分析施工过程中存在的实际问题,探讨改进措施,以期为今后民用燃气工程施工提供理论依据和实践指导。

关键词：民用燃气工程施工时间节点改进措施

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基于云储能容量动态分配的微电网系统双层优化模型

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现代电力 2025年第1期42卷 19-27页

作者：陆宝奇蒋伟杨俊杰高崧峻上海电力大学电子与信息工程学院上海市浦东新区201306 上海电机学院上海市浦东新区201306

储能系统(energy storage system,ESS)其本身所具有的可快速充放电能的特性可以解决可再生能源间歇性、不确定性及其就地消纳问题。但由于初期投资造价高、储能容量空置等原因,储能设备无法大规模使用。为了增加储能设备的利用率,减少... 详细信息

储能系统(energy storage system,ESS)其本身所具有的可快速充放电能的特性可以解决可再生能源间歇性、不确定性及其就地消纳问题。但由于初期投资造价高、储能容量空置等原因,储能设备无法大规模使用。为了增加储能设备的利用率,减少储能容量空置率的问题,基于传统云储能,提出一种计及需求响应的云储能容量动态分配模型。首先,从云储能租赁服务的本质出发,提出云储能容量动态分配策略并建立模型;而后对接入云储能带有可再生能源的用户进行建模。为了考虑用户和云储能运营商之间的牵制,深入探究其耦合关系,建立双层优化模型。上层以云储能运营商盈利最大为目标函数;下层以用户日运行成本最低为目标函数。仿真结果表明,所提出的储能容量动态分配策略和模型可以增加储能设备的利用率,减少储能容量空置情况,还同时拥有良好的经济性。

关键词：微电网云储能需求响应动态容量分配双层优化

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A Residual Carrier Tolerant QAM Receiver Architecture Based on Time-Varying Blind Source Separation

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Chinese Journal of Electronics 2016年第6期25卷 1040-1044页

作者： WANG Dan LIU Hailin yang junjie Guangdong University of Technology

In case of Quadrature amplitude modulated(QAM) transmission, the residual carrier affects the quality of the received signal. We show that the carrier tracking problem is equivalent to a time-varying Blind source separation(BSS) problem if there exists a residual carrier. This motivates us to propose a new receiver architecture, that is tolerant to residual carrier, based on a Recursive least squares(RLS) BSS algorithm. Simulations are provided to show the promising performance of the proposed algorithm for tracking the residual carrier and for improving the quality of the received signal.

关键词： Quadrature amplitude modulated receiver Residual carrier Blind source separation Recursive least squares

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Posture Control of Legged Locomotion Based on Virtual Pivot Point Concept

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Journal of Bionic Engineering 2023年第6期20卷 2683-2702页

作者： Hao Sun junjie yang Yinghao Jia Changhong Wang Space Control and Inertial Technology Research Center Harbin Institute of TechnologyHarbin150001China

This paper presents a novel control approach for achieving robust posture control in legged locomotion,specifically for SLIP-like bipedal running and quadrupedal bounding with trunk *** approach is based on the virtual pendulum concept observed in human and animal locomotion experiments,which redirects ground reaction forces to a virtual support point called the Virtual Pivot Point(VPP)during the stance *** the hybrid averaging theorem,we prove the upright posture stability of bipedal running with a fixed VPP position and propose a VPP angle feedback controller for online VPP adjustment to improve performance and convergence ***,we present the first application of the VPP concept to quadrupedal posture control and design a VPP position feedback control law to enhance robustness in quadrupedal *** evaluate the effectiveness of the proposed VPP-based controllers through various simulations,demonstrating their effectiveness in posture control of both bipedal running and quadrupedal *** performance of the VPP-based control approach is further validated through experimental validation on a quadruped robot,SCIT Dog,for stable bounding motion generation at different forward speeds.

关键词： Legged robots Bionic control Virtual pivot point Posture stability Dynamic locomotion

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From past to future:on-chip laser sources for photonic integrated circuits

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Light(Science & Applications) 2023年第1期12卷 20-22页

作者： junjie yang Mingchu Tang Siming Chen Huiyun Liu Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUnited Kingdom

The realisation of on-chip light sources paves the way towards the full integration of Si-based photonic integrated circuits(PICs).

关键词： laser chip sources

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Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

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Frontiers of Environmental Science & Engineering 2023年第1期17卷 33-47页

作者： Haoduo Zhao Min Liu junjie yang Yuyang Chen Mingliang Fang School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore Nanyang Environment&Water Research Institute Nanyang Technological UniversitySingapore 637141Singapore School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Environmental Science and Engineering Fudan UniversityShanghai 200433China

The biochemical consequences induced by xenobiotic stress are featured in dose-response and timeresolved *** the dynamic process of cellular adaptations is crucial in conducting the risk assessment for chemical *** one of the most phenotype-related omics,metabolome in response to environmental stress can vary from seconds to *** to now,very few dynamic metabolomics studies have been conducted to provide time-dependent mechanistic interpretations in understanding xenobiotics-induced cellular *** study aims to explore the time-resolved metabolite dysregulation manner and dynamically perturbed biological functions in MCF-7 cells exposed to bisphenol A(BPA),a well-known endocrine-disrupting *** sampling at 11 time points from several minutes to hours,thirty seven significantly dysregulated metabolites were identified,ranging from amino acids,fatty acids,carboxylic acids and nucleoside phosphate *** metabolites in different pathways basically showed distinct time-resolved changing patterns,while those within the common class or same pathways showed similar and synchronized dysregulation *** pathway enrichment analysis suggested that purine metabolism,pyrimidine metabolism,aminoacyl-tRNA biosynthesis as well as glutamine/glutamate(GABA)metabolism pathways were heavily *** exposure event continued,MCF-7 cells went through multiple sequential metabolic adaptations from cell proliferation to energy metabolism,which indicated an enhancing cellular requirement for elevated energy homeostasis,oxidative stress response and ER-αmediated cell *** further focused on the time-dependent metabolite dysregulation behavior in purine and pyrimidine metabolism,and identified the impaired glycolysis and oxidative phosphorylation by redox ***,we established a restricted cubic splinebased model to fit and predict metabolite’s full range dysregulation cartography,with metabolite’sensitivity c

关键词： Metabolomics BPA MCF-7 Temporal profiling Metabolic adaption Dysregulation correlation

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Ultrathin molybdenum disulfide(MoS_(2)) film obtained in atomic layer deposition: A mini-review

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Science China(Technological Sciences) 2021年第11期64卷 2347-2359页

作者： yang junjie XING YouQiang WU Ze HUANG Peng LIU Lei School of Mechanical Engineering Southeast UniversityNanjing 211189China

Atomic layer deposition(ALD) as a flexible surface-controlled fabrication technique has attracted widespread interest in numerous nanotechnology applications, which can obtain ultrathin or two-dimensional molybdenum disulfide(2D MoS2) *** ALD technique possesses the characteristics of precise thickness control, excellent uniformity, and conformality, relying on the self-limiting surface reaction. In this mini-review, the knowledge about the fabrication mechanisms and applications of ALD prepared MoS2 films is reviewed. The surface reaction pathway about ALD synthesis MoS2 is elaborated, and the corresponding factors causing saturation adsorption are discussed. Two possible growth mechanisms of ALD-MoS2 film based on the building blocks and MoS2 islands are compared. For both, the deposition process of MoS2 can be divided into two stages, heterogeneous deposition stage and homogeneous deposition stage. The mismatch between the as-deposited MoS2 in the heterodeposition and the lattice structure of the substrate surface is a key factor leading to the poor crystallinity of as-deposited MoS2. In addition, the extensions of ALD MoS2 technique to improve the as-deposited film quality are discussed. Finally, the applications of ALD deposited MoS2 film are summarized, and future perspectives are outlined.

关键词： atomic layer deposition MoS2 film self-limiting surface reaction growth mechanism

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Optimization via response surface methodology of the synthesis of a dust suppressant and its performance characterization for use in open cut coal mines

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Journal of Environmental Sciences 2022年第11期34卷 211-223页

作者： Hu Jin Yansong Zhang Guangan Wu junjie yang Nan Li College of Energy and Mining Engineering Shandong University of Science and TechnologyQingdao 266590China College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China Qingdao Intelligent Control Engineering Center for Production Safety Fire Accident Qingdao 266590China

To relieve dust pollution in open cut coal mines and reduce the hazards of coal dust pollution to the environment and workers we optimized the synthesis of a dust suppressant by graft copolymerization of environmentally friendly soy protein isolate with methyl *** dust suppressant could effectively control dust pollution in open cut coal mines. The optimized conditions for graft copolymerization in this case were determined by a response surface experiment designed with Design-Expert 10 software. Characterization by scanning electron microscopy showed a significant morphology change of the dust suppressant and the generation of a rigid and dense layer on its surface after interacting with coal *** layer exhibited good bonding and dust suppression performance. The analysis with Fourier-transform infrared spectroscopy revealed the appearance of new absorption peaks near 1300, 1072, and 1631 cm, demonstrating effective graft copolymerization. The proposed dust suppressant exhibited excellent wind erosion resistance, with a resistance that exceeded 90% at a wind speed of 6.5 m/sec. The successful graft copolymerization and effective bonding and curing of the dust suppressant on coal dust were experimentally *** is of great significance to the control of coal dust pollution.

关键词： Environmental dust control Dust suppressant Response surface method Graft copolymerization Performance characterization Single factor method

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Spring-Loaded Inverted Pendulum Hopping via Hybrid Averaging and Control Lyapunov Function

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Journal of Bionic Engineering 2023年第1期20卷 291-307页

作者： Hao Sun junjie yang Yinghao Jia Qinghua Li Changhong Wang Space Control and Inertial Technology Research Center Harbin Institute of TechnologyHarbin150001China

The Spring-Loaded Inverted Pendulum(SLIP)has been regarded as a canonical model for hopping and running dynamics of legged *** paper presents a novel control of the actuated-SLIP hopping on unknown *** propose that in the neighborhood of the desired stable hybrid limit cycle,the local dynamical behavior of a hybrid system can be expressed by a set of phase coordinates and transverse *** some acceptable assumptions,the hybrid averaging theorem is applied on the SLIP non-integrable dynamics to simplify the controller *** the inherent symmetry of SLIP dynamics,a control Lyapunov function-based hybrid averaging controller is developed to ensure the exponential stability of the desired gait *** results in a set of linear constraints on the control signal,which can be readily solved by a quadratic programming ***,a novel method is introduced to improve the robustness against unknown disturbances through the online constraint *** proposed controller is evaluated in various simulations,demonstrating the SLIP hopping on diverse terrains,including flat,sin-wave,and unregular *** performance of the approach is also validated on a quadruped robot SCIT Dog for generating dynamic gaits such as pronking.

关键词： Legged robots-Spring-Loaded Inverted Pendulum Control Lyapunov function Dynamic hopping

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