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Biocompatible and antibacterial soy protein isolate/quaternized chitosan composite sponges for acute upper gastrointestinal hemostasis

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Regenerative Biomaterials 2021年第4期8卷 107-118页

作者： Zijian Wang MeiFang Ke Liu He Qi Dong Xiao Liang Jun Rao junjie ai Chuan Tian Xinwei Han Yanan Zhao Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Clinical Laboratory Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China

Innovative biomedical applications have high requirements for biomedical ***,a series of biocompatible,antibacterial and hemostatic sponges were successfully fabricated for the treatment of acute upper gastrointestinal bleeding(AUGB).Quaternized chitosan(QC)and soy protein isolate(SPI)were chemically cross-linked to obtain porous SPI/QC sponges(named SQS-n,with n¼30,40,50 or 60 corresponding to the weight percentage of the QC content).The chemical composition,physical properties and biological activity of SQS-n were ***-n could support the adhesion and proliferation of L929 cells while triggering no obvious blood ***,SQS-n exhibited good broad-spectrum antibacterial activity against both grampositive bacteria(Staphylococcus aureus)and gram-negative bacteria(Escherichia coli).The in vivo hemostatic effect of SQS-n was evaluated using three different bleeding *** results revealed that SQS-50 performed best in reducing blood loss and hemostatic *** overall hemostatic effect of SQS-50 was comparable to that of a commercial gelatin *** enhanced antibacterial and hemostatic activities of SQS-n were mainly attributed to the QC *** conclusion,this work developed a QC-functionalized hemostatic sponge that is highly desirable for innovative biomedical applications,such as AUGB.

关键词： quaternized chitosan soy protein isolate biocompatibility antibacterial hemostasis

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Facile fabrication of quaternized chitosan-incorporated biomolecular patches for non-compressive haemostasis and wound healing

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Fundamental Research 2024年第5期4卷 1243-1253页

作者： Zesheng Chen Yixuan Zhang Kexin Feng Tao Hu Bohan Huang Jinlan Tang junjie ai Liang Guo Weikang Hu Zijian Wang Department of Urology Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China Ministry of Education Key Laboratory of the Green Preparation and Application for Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China Department of Plastic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China

Cell-free wound dressings (WDs) with desirable effectiveness and safety have received much attention in the field of regenerative medicine. However, the weak linkages between bioactive polymers and the spatial structure of WDs frequently result in interventional treatment failure. Herein, we create a series of quaternized chitosan (QCS)-incorporated composite hydrogels (referred to as GHCH-n) by UV cross-linking and then convert them into microneedle patches (MNPs). QCS, which is positively charged and amphiphilic, is essential for broad-spectrum antibacterial and haemostatic activities. QCS is proven to be slightly toxic, so it is immobilized into the methacrylate gelatine (GelMA) molecular cage to minimize adverse effects. A polydimethylsiloxane micro-mould is used to shape the MNPs. MNPs can pierce tissue, seal off bleeding sites, and cling to wounds securely. Thus, MNPs can cooperate with GHCH-n hydrogels to halt bleeding and accelerate wound healing. This study recommends GHCH-10 MNPs as an advanced biomaterial. Several preclinical research models have thoroughly validated the application effect of GHCH-10 MNPs. This research also proposes a novel strategy for integrating the nature of bioactive polymers and the structure of composite biomaterials. This strategy is not only applicable to the fabrication of next-generation WDs but also shows great potential in expanding interdisciplinary domains.

关键词： Quaternized chitosan Patches Biocompatible Antibacterial Haemostatic Wound healing

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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： junjie Shi Changle Hou Jingjing Dong Dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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当前重要目标反爆炸袭击的主要防护措施

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爆破器材 2009年第3期38卷 38-40页

作者：艾俊杰方向薛利春沈彤解放军理工大学工程兵工程学院江苏南京210007

通过近几年世界各国发生恐怖活动的事例来看,党政机关、学校、商场以及具有地方经济代表性的建筑物,已成为恐怖组织实施犯罪的首选目标。文章从加强重要目标的安全保障出发,重点从技术装备方面对加强重要目标的安全防护措施进行了必要... 详细信息

通过近几年世界各国发生恐怖活动的事例来看,党政机关、学校、商场以及具有地方经济代表性的建筑物,已成为恐怖组织实施犯罪的首选目标。文章从加强重要目标的安全保障出发,重点从技术装备方面对加强重要目标的安全防护措施进行了必要的阐述,为进一步做好重要目标的安全保障工作提供了有效途径。

关键词：重要目标反爆炸袭击防护措施

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Elafibranor对前列腺癌细胞增殖、迁移和凋亡行为的影响及机制研究

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现代泌尿外科杂志 2023年第9期28卷 813-817页

作者：艾俊杰王子健倪维林晓娟湖北省中医院检验科湖北武汉430061 武汉大学中南医院泌尿外科湖北武汉430071

目的探究Elafibranor(ELA)对人前列腺癌DU145细胞肿瘤生物学行为的影响,初步揭示其分子机制。方法采用含有不同剂量ELA的培养基处理DU145细胞,通过细胞增殖实验、划痕实验、Transwell实验和细胞凋亡实验评估受试细胞的增殖、迁移和凋亡... 详细信息

目的探究Elafibranor(ELA)对人前列腺癌DU145细胞肿瘤生物学行为的影响,初步揭示其分子机制。方法采用含有不同剂量ELA的培养基处理DU145细胞,通过细胞增殖实验、划痕实验、Transwell实验和细胞凋亡实验评估受试细胞的增殖、迁移和凋亡能力,进一步通过荧光定量多聚酶链反应检测受试细胞内脂代谢相关基因的表达变化。结果与空白组(0μmol/L)相比:低剂量组(5μmol/L)和高剂量组(15μmol/L)的48 h相对细胞增殖率由100%分别降低至(86.9±7.8)%和(58.5±9.4)%;24 h划痕愈合率由(74.7±3.2)%分别降低至(61.8±2.9)%和(53.2±3.3)%;24 h相对迁移细胞数由100%分别减少至(32.4±11.2)%和(15.4±3.2)%;48 h细胞凋亡率由(9.3±1.4)%分别上升至(11.3±0.3)%和(15.2±4.5)%,差异均具有统计学意义(P<0.05)。经ELA处理48 h后,高剂量组中脂肪酸摄取(SCPX、PLTP)和脂肪酸氧化分解(PDK1、ACOX2)相关基因表达量显著下调,脂肪酸储存(PLIN2)相关基因表达量显著上调,说明脂代谢途径受到了严重干扰。结论ELA可能通过脂代谢途径抑制前列腺癌细胞增殖和迁移,并促进细胞凋亡,在抗肿瘤化疗领域具有一定的临床转化潜力。

关键词：前列腺癌 Elafibranor 增殖迁移凋亡脂代谢

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帕金森病的多学科非药物管理策略

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神经疾病与精神卫生 2023年第7期23卷 504-508页

作者：吴玉芙艾军杰郝单单郭琳琳北京老年医院神经内科 100095 解放军61035部队卫生科北京102205

帕金森病是中老年人常见的神经系统退行性病变。多学科管理是其有效的治疗方法。非药物管理是多学科管理的重要组成部分,贯穿帕金森病的全程。现从帕金森病多学科非药物管理的维度、管理的内容、角色的分工、管理的措施等方面分别进行... 详细信息

帕金森病是中老年人常见的神经系统退行性病变。多学科管理是其有效的治疗方法。非药物管理是多学科管理的重要组成部分,贯穿帕金森病的全程。现从帕金森病多学科非药物管理的维度、管理的内容、角色的分工、管理的措施等方面分别进行了论述,并提出展望和思考,希望对帕金森病多学科非药物管理有一定的指导意义。

关键词：帕金森病多学科管理非药物综述

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Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test

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Structural Durability & Health Monitoring 2025年第1期19卷 145-166页

作者： Yushan Ye Tao Gao Liankun Wang junjie Ma Yingchun Cai Heng Liu Xiaoge Liu China Construction Seventh Engineering Division Corp. Ltd.Zhengzhou450004China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China

To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete *** on the measurement and ana-lysis of beam deﬂection,strain,and crack development under various loading levels during the research tests,combined with the veriﬁcation coefﬁcient indicators speciﬁed in the codes,the veriﬁcation coefﬁcients of bridges at different stages of damage can be *** results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test *** the complete linear elastic stage,both the deﬂection and bottom strain veriﬁcation coefﬁcients comply with the speciﬁcations,indicating a good structural load-bearing capacity no longer adheres to the code’s *** the non-linear stage,both coefﬁcients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing *** to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s speciﬁed *** strain veriﬁcation coefﬁcient sourced from the compression zone at the bottom of theﬂange is not recommended for assessing the bridge’s load-bearing capacity.

关键词： Pre-stressed T-beams whole process destructive test bearing capacity veriﬁcation coefﬁcient

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Fast neutron radiation inactivation of Bacillus subtilis:Absorbed dose determination

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Nuclear Science and Techniques 2011年第3期22卷 156-159页

作者： SONG Lingli ZHENG Chun ai Zihui LI junjie Dai Shaofeng Institute of Nuclear Physics and Chemistry CAEP MianYang 621900 China

In this paper,fast neutron inactivation effects of Bacillus subtilis were investigated with fission fast neutrons from CFBR-Ⅱreactor of INPC(Institute of Nuclear Physics and Chemistry)and mono-energetic neutrons from the Van de Graaff accelerator at Peking *** method for determining the absorbed dose in the Bacillus subtilis suspension contained in test tubes is *** absorbed dose,on account of its dependence on the volume and the form of confined state,was determined by combined experiments and Monte Carlo *** the calculation results of absorbed dose,the fast neutron inactivation effects on Bacillus subtilis were *** survival rates and absorbed dose curve was constructed.

关键词：枯草芽孢杆菌吸收剂量中子辐射测定失活蒙特卡罗方法灭活效果化学研究所

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