检索结果-南通市图书馆

MicroRNAs in heart and circulation during physical exercise

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2018年第4期7卷 433-441页

作者： Lijun Wang Yicheng Lv Guoping Li junjie xiao Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444Chin Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02215USA Corresponding author.E-mail address.junjiexiao@***

Exercise training is beneficial to the cardiovascular system. MicroRNAs （miRNAs, miRs） are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression. Exercise training alters the expression levels of large amounts ofmiRNAs in the heart. In addition, circulating miRNAs appear to be regulated by exercise training. In this review, we will summarize recent advances in the regulation of miRNAs during physical exercise intervention in various cardiovascular diseases, including pathologic cardiac hypertrophy, myocardial fibrosis, ischemia-reperfusion injury, myocardial infarction, and heart failure. The regulatory role of circulating miRNAs after exercise training was also reviewed. In conclusion, miRNAs might be a valuable target for treatment of cardiovascular diseases and have great potential as biomarkers for assessment of physical performance.2018 Published by Elsevier *** behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. （http：//***/licenses/by-nc-nd/4.0/）.

关键词： Cardiovascular diseases Circulating microRNAs Exercise MicroRNAs

Synthesis and Antitumor Activities of Novel 4-Morpholinothieno [3,2-d]pyrimidine Derivatives

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2014年第1期30卷 75-81页

作者： SONG Kaizhen MA junjie WANG xiao GONG Ping ZHAO Yanfang Key Laboratory of Structure-based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives was designed and *** of them were screened for their cytotoxic activities against large cell lung cancer（H460）,colon cancer （HT-29） and adenocarcinomic lung cancer（A549） cell lines in *** pharmacological results indicate that most of the target compounds show moderate to significant *** compound 17 exhibits the most potent antitumor activities against H460,HT-29 and A549 cell lines with IC50 values of 0.57,0.45 and 1.45 μmol/L,respectively.

关键词： 2-Hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine Antitumor activity Cytotoxic activity

Relationship between Microstructure Evolution and the Luminescent Properties of Eu^(3+)-doped Yttrium Aluminum Garnet and Y_2O_3 Nano-powders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2013年第3期29卷 225-230页

作者： Jie Zhang Yongyi Gao junjie xiao Changfu Xu Yunxin Liu Qibin Yang Institute of Modern Physics Xiangtan University Department of Physics Hunan University of Science and Technology

Eu3＋-doped yttrium aluminum garnet （YAG） and Y2O3 composite phase nanoparticles were synthesized using a modified hydrothermal method. Sintering was performed at 800 ℃, which is considerably lower than the sintering temperature used in the conventional method, y3＋ in YAG and Y2O3 was partially substituted with Na＋ by adding NaNO3 into the solution during sample synthesis. The microstructures and phase transformation process were characterized through X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The obtained results verified that the addition of Na＋ promoted crystallinity and grain growth of the three phases, namely, Y2O3, Y4Al2O9, and Y3Al5O12. Highly efficient luminescence properties excited by 254 and 365 nm ultraviolet were achieved. In conclusion, the remarkable enhancement of the luminescence intensity with the addition of Na＋ should be attributed to grain growth and improvement of crystallinity.

关键词： Nanostructure Chemical synthesis Optical properties Luminescence

Exercise-mediated regulation of autophagy in the cardiovascular system

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2020年第3期9卷 203-210页

作者： Lijun Wang Jiaqi Wang Dragos Cretoiu Guoping Li junjie xiao Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Department of Cell and Molecular Biology and Histology Carol Davila University of Medicine and PharmacyBucharest 050474Romania Alessandrescu-Rusescu National Institute of Mother and Child Health Fetal Medicine Excellence Research CenterBucharest 020395Romania Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02215USA

Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway,which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting *** is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular *** in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways,as well as autophagy-dependent beneficial effects of exercise in cardiovascular system.

关键词： Autophagy Cardiovascular diseases Exercise

The landscape of epigenetic regulation and therapeutic application of N^(6)-methyladenosine modifications in non-coding RNAs

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 236-251页

作者： Gui-e Xu Xuan Zhao Guoping Li Priyanka Gokulnath Lijun Wang junjie xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)and School of Life SciencesShanghai UniversityNantongJiangsu 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

RNA N^(6)-methyladenosine(m^(6)A)methylation is the most abundant and conserved RNA modification in *** participates in the regulation of RNA metabolism and various pathophysiological ***-coding RNAs(ncRNAs)are defined as small or long transcripts which do not encode proteins and display numerous biological regulatory *** to mRNAs,m^(6)A deposition is observed in *** RNA m^(6)A modifications on ncRNAs is of great importance specifically to deepen our understanding of their biological roles and clinical *** this review,we summarized the recent research findings regarding the mutual regulation between RNA m^(6)A modification and ncRNAs(with a specific focus on microRNAs,long non-coding RNAs,and circular RNAs)and their *** also discussed the challenges of m^(6)A-containing ncRNAs and RNA m^(6)A as therapeutic targets in human diseases and their future perspective in translational roles.

关键词： Circular RNA Epigenetic regulation Long non-coding RNA MicroRNA Non-coding RNA RNA m^(6)A modification

Exercise training maintains cardiovascular health:signaling pathways involved and potential therapeutics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第10期7卷 3709-3726页

作者： Huihua Chen Chen Chen Michail Spanos Guoping Li Rong Lu Yihua Bei junjie xiao School of Basic Medical Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases(CVD).Functional and mechanistic studies that employ animal exercise models as well as observational and interventional cohort studies with human participants,have contributed considerably in delineating the essential signaling pathways by which exercise promotes cardiovascular fitness and ***,this review summarizes the beneficial impact of exercise on multiple aspects of cardiovascular *** then discuss in detail the signaling pathways mediating exercise’s benefits for cardiovascular *** exercise-regulated signaling cascades have been shown to confer myocardial protection and drive systemic *** signaling molecules that are necessary for exercise-induced physiological cardiac hypertrophy have the potential to attenuate myocardial injury and reverse cardiac ***-regulated noncoding RNAs and their associated signaling pathways are also discussed in detail for their roles and mechanisms in exercise-induced cardioprotective ***,we address the exercise-mediated signaling pathways and molecules that can serve as potential therapeutic targets ranging from pharmacological approaches to gene therapies in *** also discuss multiple factors that influence exercise’s effect and highlight the importance and need for further investigations regarding the exercise-regulated molecules as therapeutic targets and biomarkers for CVD as well as the cross talk between the heart and other tissues or organs during *** conclude that a deep understanding of the signaling pathways involved in exercise’s benefits for cardiovascular health will undoubtedly contribute to the identification and development of novel therapeutic targets and strategies for CVD.

关键词： cardiovascular protective organs

Circular RNAs in Cardiovascular Diseases:Regulation and Therapeutic Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2023年第3期6卷 389-407页

作者： Lijun Wang Gui-e Xu Michail Spanos Guoping Li Zhiyong Lei Joost P.G.Sluijter junjie xiao Cardiac Regeneration and Ageing Lab Institute of Geriatrics(Shanghai University)Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Department of Cardiology Laboratory of Experimental CardiologyUniversity Medical Center UtrechtUtrecht 3508GAThe Netherlands CDL Research University Medical Center UtrechtUtrecht 3584CXThe Netherlands Regenerative Medicine Center Circulatory Health LaboratoryUniversity Medical Center UtrechtUniversity UtrechtUtrecht 3508GAThe Netherlands

Cardiovascular disease is one of the leading causes of mortality *** studies have shown that circular RNAs(circRNAs)have emerged as important players in the prevention and treatment of cardiovascular *** are a class of endogenous noncoding RNAs that are generated by back-splicing and are involved in many pathophysiological *** this review,we outline the current research progress on the regulatory roles of circRNAs in cardiovascular ***,new technologies and methods available for identifying,validating,synthesizing,and analyzing circRNAs,as well as their applications in therapeutics,are highlighted ***,we summarize the increasing insights into the potential use of circRNAs as circulating diagnostic and prognostic ***,we discuss the prospects and challenges of circRNA therapeutic applications for cardiovascular disease therapy,with a particular focus on developing circRNA synthesis and engineering delivery systems.

关键词： cardiovascular prevention Cardiovascular

Zebrafish facilitates drug screening: potential of 3-deoxy-andrographoside from Chuanxinlian(Herba Andrographitis Paniculatae) as an anti-inflammatory agent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2022年第5期42卷 749-757页

作者： HE Xuemei xiao junjie FAN Chunlin LU Zibin CAO Huihui YU Linzhong ZHENG Yuanru LIU Junshan Third Level Research Laboratory of State Administration of Traditional Chinese Medicine School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics Guangzhou 510515China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Pharmacy Guangdong Pharmaceutical universityGuangzhou 510006China Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510515China

OBJECTIVE: To systematically evaluate the in vivo antiinflammatory potential of diterpene lactones from Chuanxinlian(Herba Andrographitis Paniculatae)(AP). METHODS: We firstly adopted zebrafish, a novel and ideal animal model for high-throughput drug screening, to investigate the in vivo anti-inflammatory activities of 17 diterpene lactones isolated from ***: The results showed that most of diterpene lactones displayed significant anti-inflammatory effects in lipopolysaccharide microinjection-, copper sulfate exposure-or tail transection-induced zebrafish inflammation models. Moreover, diterpene lactone 3-deoxy-andrographoside(AP-5) was firstly found to attenuate inflammatory responses, which was closely associated with the myeloid differentiation primary response 88/nuclear factor-kappa B and signal transducer and activator of transcription 3 pathways. CONCLUSION: Our research sheds light on the inestimable roles of zebrafish in high-throughput drug screening, elucidates the potent inhibitory effects of diterpene lactones against inflammation and indicates that AP-5 may serve as a potential alternative agent for the treatment of inflammatory diseases.

关键词： diterpenes lactones inflammation zebrafish myeloid differentiation factor 88 NF-kappa B STAT3 transcription factor

Exercise sustains the hallmarks of health

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2023年第1期12卷 8-35页

作者： Yan Qiu Benjamin Fernández-García H.Immo Lehmann Guoping Li Guido Kroemer Carlos López-Otín junjie xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Health Research Institute of the Principality of Asturias(ISPA) Oviedo 33011Spain Department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Centre de Recherche des Cordeliers Equipe labellisee par la Ligue contre le cancerUniversite de Paris CiteSorbonne UniversiteInserm U1138Institut Universitaire de FranceParis 75231France Metabolomics and Cell Biology Platforms Institut Gustave RoussyVillejuif 94805France Institut du Cancer Paris CARPEM Department of BiologyHopital Europeen Georges PompidouAP-HPParis 75015France Departamento de Bioquımica y Biologıa Molecular Facultad de MedicinaInstituto Universitario de OncologıaUniversidad de OviedoOviedo 33006Spain Centro de Investigacion Biomedica en Red Enfermedades Cancer(CIBERONC) Oviedo 33006Spain

Exercise has long been known for its active role in improving physical fitness and sustaining *** moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various *** is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological *** we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and ***,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to *** review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health *** hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.

关键词： Beneficial effects of exercise Exercise-related physiological adaptations Hallmarks of health Moderate-intensity exercise Therapeutic exercise